LOCUS       NM_001095               3886 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens acid sensing ion channel subunit 1 (ASIC1), transcript
            variant 2, mRNA.
ACCESSION   NM_001095
VERSION     NM_001095.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3886)
  AUTHORS   Wang,Y.M., Tang,H., Tang,Y.J., Liu,J., Yin,Y.F., Tang,Y.L.,
            Feng,Y.G. and Gu,H.F.
  TITLE     ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy
  JOURNAL   J Adv Res 63, 195-206 (2024)
   PUBMED   37931656
  REMARK    GeneRIF: ASIC1/RIP1 accelerates atherosclerosis via disrupting
            lipophagy.
REFERENCE   2  (bases 1 to 3886)
  AUTHORS   Lai,K., Pritisanac,I., Liu,Z.Q., Liu,H.W., Gong,L.N., Li,M.X.,
            Lu,J.F., Qi,X., Xu,T.L., Forman-Kay,J., Shi,H.B., Wang,L.Y. and
            Yin,S.K.
  TITLE     Glutamate acts on acid-sensing ion channels to worsen ischaemic
            brain injury
  JOURNAL   Nature 631 (8022), 826-834 (2024)
   PUBMED   38987597
  REMARK    GeneRIF: Glutamate acts on acid-sensing ion channels to worsen
            ischaemic brain injury.
REFERENCE   3  (bases 1 to 3886)
  AUTHORS   Liu,Y., Wang,B., Cheng,Y., Fang,Y., Hou,Y., Mao,Y., Wu,X.,
            Jiang,D., He,Y. and Jin,C.
  TITLE     ASIC1 promotes migration and invasion of hepatocellular carcinoma
            via the PRKACA/AP-1 signaling pathway
  JOURNAL   Carcinogenesis 45 (6), 399-408 (2024)
   PUBMED   38306794
  REMARK    GeneRIF: ASIC1 promotes migration and invasion of hepatocellular
            carcinoma via the PRKACA/AP-1 signaling pathway.
REFERENCE   4  (bases 1 to 3886)
  AUTHORS   Pissas,K.P., Grunder,S. and Tian,Y.
  TITLE     Functional expression of the proton sensors ASIC1a, TMEM206, and
            OGR1 together with BKCa channels is associated with cell volume
            changes and cell death under strongly acidic conditions in DAOY
            medulloblastoma cells
  JOURNAL   Pflugers Arch 476 (6), 923-937 (2024)
   PUBMED   38627262
  REMARK    GeneRIF: Functional expression of the proton sensors ASIC1a,
            TMEM206, and OGR1 together with BKCa channels is associated with
            cell volume changes and cell death under strongly acidic conditions
            in DAOY medulloblastoma cells.
REFERENCE   5  (bases 1 to 3886)
  AUTHORS   Wang,T., Wang,Q., Pan,G., Jia,G., Li,X., Wang,C., Zhang,L. and
            Zuo,C.
  TITLE     ASIC1a involves the acid-mediated activation of pancreatic stellate
            cells associated with autophagy induction
  JOURNAL   Physiol Res 72 (1), 49-57 (2023)
   PUBMED   36545882
  REMARK    GeneRIF: ASIC1a involves the acid-mediated activation of pancreatic
            stellate cells associated with autophagy induction.
REFERENCE   6  (bases 1 to 3886)
  AUTHORS   Bubien,J.K., Keeton,D.A., Fuller,C.M., Gillespie,G.Y., Reddy,A.T.,
            Mapstone,T.B. and Benos,D.J.
  TITLE     Malignant human gliomas express an amiloride-sensitive Na+
            conductance
  JOURNAL   Am J Physiol 276 (6), C1405-C1410 (1999)
   PUBMED   10362604
REFERENCE   7  (bases 1 to 3886)
  AUTHORS   Bassilana,F., Champigny,G., Waldmann,R., de Weille,J.R.,
            Heurteaux,C. and Lazdunski,M.
  TITLE     The acid-sensitive ionic channel subunit ASIC and the mammalian
            degenerin MDEG form a heteromultimeric H+-gated Na+ channel with
            novel properties
  JOURNAL   J Biol Chem 272 (46), 28819-28822 (1997)
   PUBMED   9360943
REFERENCE   8  (bases 1 to 3886)
  AUTHORS   Waldmann,R., Champigny,G., Bassilana,F., Heurteaux,C. and
            Lazdunski,M.
  TITLE     A proton-gated cation channel involved in acid-sensing
  JOURNAL   Nature 386 (6621), 173-177 (1997)
   PUBMED   9062189
REFERENCE   9  (bases 1 to 3886)
  AUTHORS   Garcia-Anoveros,J., Derfler,B., Neville-Golden,J., Hyman,B.T. and
            Corey,D.P.
  TITLE     BNaC1 and BNaC2 constitute a new family of human neuronal sodium
            channels related to degenerins and epithelial sodium channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (4), 1459-1464 (1997)
   PUBMED   9037075
REFERENCE   10 (bases 1 to 3886)
  AUTHORS   Corey,D.P. and Garcia-Anoveros,J.
  TITLE     Mechanosensation and the DEG/ENaC ion channels
  JOURNAL   Science 273 (5273), 323-324 (1996)
   PUBMED   8685718
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025154.31.
            
            On Jun 2, 2019 this sequence version replaced NM_001095.3.
            
            Summary: This gene encodes a member of the acid-sensing ion channel
            (ASIC) family of proteins, which are part of the
            degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members
            of the ASIC family are sensitive to amiloride and function in
            neurotransmission. The encoded proteins function in learning, pain
            transduction, touch sensation, and development of memory and fear.
            Alternatively spliced transcript variants have been described.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform b), compared to isoform a.
            Variants 2 and 6 both encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U78181.1, SRR1803616.116516.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447966.7/ ENSP00000400228.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC025154.31        109986-110306
            322-699             AC025154.31        111141-111518
            700-895             AC025154.31        112149-112344
            896-1046            AC025154.31        129603-129753
            1047-1174           AC025154.31        130390-130517
            1175-1331           AC025154.31        130811-130967
            1332-1388           AC025154.31        131314-131370
            1389-1542           AC025154.31        132292-132445
            1543-1634           AC025154.31        132888-132979
            1635-1714           AC025154.31        133492-133571
            1715-1819           AC025154.31        133650-133754
            1820-3886           AC025154.31        133935-136001
FEATURES             Location/Qualifiers
     source          1..3886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..3886
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="acid sensing ion channel subunit 1"
                     /db_xref="GeneID:41"
                     /db_xref="HGNC:HGNC:100"
                     /db_xref="MIM:602866"
     exon            1..321
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..699
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1924
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="isoform b is encoded by transcript variant 2;
                     Cation channel, amiloride-sensitive, neuronal, 2;
                     acid-sensing ion channel 1a protein; brain sodium channel
                     2; amiloride-sensitive cation channel 2, neuronal; acid
                     sensing (proton gated) ion channel 1"
                     /codon_start=1
                     /product="acid-sensing ion channel 1 isoform b"
                     /protein_id="NP_001086.2"
                     /db_xref="CCDS:CCDS44876.1"
                     /db_xref="GeneID:41"
                     /db_xref="HGNC:HGNC:100"
                     /db_xref="MIM:602866"
                     /translation="MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRA
                     LWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQ
                     VSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDR
                     AGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGL
                     EIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQ
                     EQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDA
                     PYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAK
                     KFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTV
                     LELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMT
                     YAANILPHHPARGTFEDFTC"
     exon            700..895
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1046
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1174
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1331
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1388
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1542
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1634
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1714
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1819
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..3886
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2984..2989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="hexamer: TATAAA"
     polyA_site      3002
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
     regulatory      3867..3872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="hexamer: AATAAA"
     polyA_site      3886
                     /gene="ASIC1"
                     /gene_synonym="ACCN2; ASIC; BNaC2"
                     /note="major polyA site"
ORIGIN      
        1 ccccctcccc tcccgccgcc tcccggccgg acgatggatc cctgcagatc ccagggctga
       61 gagcaccgcg caccgcgccg agcccgggca gaccgagccg aggcgagcga gccagcgagc
      121 cagcgcgcgc gggcgggcgg acagatcgga gccgagcggg gccgggcggg gcgctccctg
      181 cagggctctg cgcggcgtgc cgcggcggcc gcgggctccg gccccgggcc atgagcccct
      241 ccgcgactcg gcgctgagcc cgccaccggt ccagcgcccc aggacccgcc gccggctgcc
      301 ggcttgccga agccccctca ggatcccctc aacaaggatg gaactgaagg ccgaggagga
      361 ggaggtgggt ggcgtccagc cggtgagcat ccaggccttc gccagcagct ccacactgca
      421 cggcctggcc cacatcttct cctacgagcg gctgtctctg aagcgggcac tgtgggccct
      481 gtgcttcctg ggctccctgg ctgtgctgct gtgtgtgtgc acggagcgtg tgcagtacta
      541 cttccactac caccatgtca ccaagctcga cgaggtggct gcctctcagc ttaccttccc
      601 tgctgtcacg ctgtgcaacc tcaacgagtt ccgctttagc caagtctcca agaatgacct
      661 gtatcatgct ggggagctgc tggccctgct caacaacagg tatgagatac cagacacaca
      721 gatggcagat gaaaagcagc tggagatact gcaggacaaa gccaacttcc gcagcttcaa
      781 acccaaaccc ttcaacatgc gtgagttcta cgaccgagct gggcacgaca ttcgagacat
      841 gctgctctcc tgccacttcc ggggggaggt ctgcagcgct gaagacttca aggtggtctt
      901 cacacgctat ggaaagtgct acacgttcaa ctcgggccga gatgggcggc cgcggctgaa
      961 gaccatgaag ggtgggacgg gcaatgggct ggaaatcatg ctggacatcc agcaggacga
     1021 gtacctgcct gtgtgggggg agactgacga gacgtccttc gaagcaggca tcaaagtgca
     1081 gatccatagt caggatgaac ctcctttcat cgaccagctg ggctttggcg tggccccagg
     1141 cttccagacc tttgtggcct gccaggagca gcggctcatc tacctgcccc caccctgggg
     1201 cacctgcaaa gctgttacca tggactcgga tttggatttc ttcgactcct acagcatcac
     1261 tgcctgccgc atcgactgtg agacgcgcta cctggtggag aactgcaact gccgcatggt
     1321 gcacatgcca ggggatgccc catactgtac tccagagcag tacaaggagt gtgcagatcc
     1381 tgctctggac ttcctggtgg agaaggacca ggagtactgc gtgtgtgaaa tgccttgcaa
     1441 cctgacccgc tatggcaaag agctgtccat ggtcaagatc cccagcaaag cctcagccaa
     1501 gtacctggcc aagaagttca acaaatctga gcaatacata ggggagaaca tcctggtgct
     1561 ggacattttc tttgaagtcc tcaactatga gaccattgaa cagaagaagg cctatgagat
     1621 tgcagggctc ctgggtgaca tcgggggcca gatggggctg ttcatcgggg ccagcatcct
     1681 cacggtgctg gagctctttg actacgccta cgaggtcatt aagcacaagc tgtgccgacg
     1741 aggaaaatgc cagaaggagg ccaaaaggag cagtgcggac aagggcgtgg ccctcagcct
     1801 ggacgacgtc aaaagacaca acccgtgcga gagccttcgg ggccaccctg ccgggatgac
     1861 atacgctgcc aacatcctac ctcaccatcc ggcccgaggc acgttcgagg actttacctg
     1921 ctgagccccg caggccgctg aaccaaaggc ctagatgggg aggactagga gagcgagggg
     1981 gcccccagct gcctcctcac atctgccctg gggactcccc acactccggg gcagatcttt
     2041 cctcttgtct gtggtaagga aggagtcttg accatagagt cctctctctg cctctatccc
     2101 attcttttta catttaacaa aactaatcta aaaaagaact aaaaagggag aacggggcaa
     2161 gggacctcag gctgcccctc tctcctccat gctgcctccc ctagctccca gcctgaattc
     2221 tgtctatcta gctgtctgcc atctgagtgt ccatctacat tctgctgcca ccagtcacca
     2281 aaggcccttc ccagtgaggg gtggaaggga tctctggggt ctggaatttg gccccaaacc
     2341 agagaatgta ccttaagggg gagggctagt gtgggggagg gaggcttccc cagccttaag
     2401 agaccctctc agcccagtga ctgtccccaa acccaagtct cctggcagga actaaaacct
     2461 cagccccact ctctcacacc atgtggaatc tcgtgggggt cggggatccc cttaagaagt
     2521 ggtaatgggg acaagatgcg gccctggtgc tgtaggctac atcctgatac ctataagttc
     2581 acccccaccc cacagctgct ggagagaaat cccaagaggc agcccttcct caccatccca
     2641 ttaaagaccg ggctggttag cgtccagctc agggagaagg gcgctagtgc ctaacctcac
     2701 tggtccctct cccggaggcc cttgtagagg gccacgtcca taaattttct tatggaactc
     2761 tcccacatcc tcttccccaa cttcatttgc ttctctcaac aacctcatct gcattttcta
     2821 tttctatatg atacagactc tatattgcta tatctctgta tatactttcc cagccctgtc
     2881 tgtctccacc ccatcccctc ttgtctctga gaaccattct cccaccccaa gttccacctt
     2941 ctatgtttct actccctccc tggtctctga atgccttcgc ctgtataaag agttggactc
     3001 tctcccctgg tgtctgtact gtgtacacac atccctctga gaagcacaag gagacgacac
     3061 gcgcattgta acctttgcac tgtctcagtg gcgacaaagg aagctgtgaa tcacaagctc
     3121 tgcctctttc tggcctcacc ctctccccca acccgggcac cctcggccct ccctgcagcc
     3181 ttaacattct cttcccctgc tcctcctatc ccattgccct ctgcccagct gacagtggca
     3241 tccccaggga aggggttgct gtagagatag cccccaccca ggggatggag gtctaccctg
     3301 gacactaagc caagtgtgtc agagacagaa gggagctggg gattggcgac tcctgaagtt
     3361 ggggcagtgg gatgctgaca ggcagaagct gaggtcctca gtcagtggcc tttcctcctt
     3421 ctgggtgccc agcccccttt cctcacctga tacccaagcc caccactttt attttctggt
     3481 gaggtgggtt tgggaggaaa gagaggccta gaggaggagt tgaaagctct gctgttgtct
     3541 caccctatct taatgagaga caagtgaggt ggagggcctg ccccccctcc ctccaccaga
     3601 cactccttcc aggcctgagc cccaacccct cttcaggcct tccttcccta gctgtgtctt
     3661 ggtcttcaat cccagaacag gacctgtgag cagctgcatt ggcctggagc tggagagtaa
     3721 ggctgtagga tctttggaat ctcttggttc ctaagagttt cctcagagat catacctccc
     3781 cagagggaag caggaatgag gccaaaaagt gtgcattgga taggggaaca gcaggcaggg
     3841 ctctgggtga cgcatgcctc tggtctaata aactgggttt caacca
//
