LOCUS       NM_018154               1689 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens anti-silencing function 1B histone chaperone (ASF1B),
            mRNA.
ACCESSION   NM_018154
VERSION     NM_018154.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Zhang,P., Wang,P. and Wang,Y.
  TITLE     ASF1B is an essential prognostic indicator linked to the growth and
            resistance characteristics of bladder cancer
  JOURNAL   Tissue Cell 89, 102477 (2024)
   PUBMED   39018712
  REMARK    GeneRIF: ASF1B is an essential prognostic indicator linked to the
            growth and resistance characteristics of bladder cancer.
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Xiao,F., Zhu,H., Guo,Y., Zhang,Z., Sun,G., Xiao,Y., Hu,G., Huang,K.
            and Guo,H.
  TITLE     CIA-II is associated with lower-grade glioma survival and cell
            proliferation
  JOURNAL   CNS Neurosci Ther 30 (2), e14340 (2024)
   PUBMED   37452510
  REMARK    GeneRIF: CIA-II is associated with lower-grade glioma survival and
            cell proliferation.
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Zhang,Z. and Liu,S.
  TITLE     The interaction between ASF1B and TLK1 promotes the malignant
            progression of low-grade glioma
  JOURNAL   Ann Med 55 (1), 1111-1122 (2023)
   PUBMED   36947060
  REMARK    GeneRIF: The interaction between ASF1B and TLK1 promotes the
            malignant progression of low-grade glioma.
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   Qiu,F., Ou,D., Tan,H., Gao,Y. and Zi,D.
  TITLE     The circCDK17/miR-122-5p/ASF1B axis regulates the progression of
            cervical cancer
  JOURNAL   Histol Histopathol 38 (3), 359-371 (2023)
   PUBMED   36178207
  REMARK    GeneRIF: The circCDK17/miR-122-5p/ASF1B axis regulates the
            progression of cervical cancer.
REFERENCE   5  (bases 1 to 1689)
  AUTHORS   Zhang,M., Zhang,L., Zhou,M., Wang,E., Meng,B., Li,Q., Wang,X.,
            Wang,Y. and Li,Q.
  TITLE     Anti-silencing function 1B promotes the progression of pancreatic
            cancer by activating c-Myc
  JOURNAL   Int J Oncol 62 (1) (2023)
   PUBMED   36416310
  REMARK    GeneRIF: Antisilencing function 1B promotes the progression of
            pancreatic cancer by activating cMyc.
REFERENCE   6  (bases 1 to 1689)
  AUTHORS   Groth,A., Ray-Gallet,D., Quivy,J.P., Lukas,J., Bartek,J. and
            Almouzni,G.
  TITLE     Human Asf1 regulates the flow of S phase histones during
            replicational stress
  JOURNAL   Mol Cell 17 (2), 301-311 (2005)
   PUBMED   15664198
REFERENCE   7  (bases 1 to 1689)
  AUTHORS   Loyola,A. and Almouzni,G.
  TITLE     Histone chaperones, a supporting role in the limelight
  JOURNAL   Biochim Biophys Acta 1677 (1-3), 3-11 (2004)
   PUBMED   15020040
  REMARK    Review article
REFERENCE   8  (bases 1 to 1689)
  AUTHORS   Tagami,H., Ray-Gallet,D., Almouzni,G. and Nakatani,Y.
  TITLE     Histone H3.1 and H3.3 complexes mediate nucleosome assembly
            pathways dependent or independent of DNA synthesis
  JOURNAL   Cell 116 (1), 51-61 (2004)
   PUBMED   14718166
REFERENCE   9  (bases 1 to 1689)
  AUTHORS   Umehara,T. and Horikoshi,M.
  TITLE     Transcription initiation factor IID-interactive histone chaperone
            CIA-II implicated in mammalian spermatogenesis
  JOURNAL   J Biol Chem 278 (37), 35660-35667 (2003)
   PUBMED   12842904
  REMARK    GeneRIF: data suggest that CIA-II is a histone chaperone and is
            implicated in the regulation of mammalian spermatogenesis
REFERENCE   10 (bases 1 to 1689)
  AUTHORS   Sillje,H.H. and Nigg,E.A.
  TITLE     Identification of human Asf1 chromatin assembly factors as
            substrates of Tousled-like kinases
  JOURNAL   Curr Biol 11 (13), 1068-1073 (2001)
   PUBMED   11470414
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK001466.1 and BC036521.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018154.2.
            
            Summary: This gene encodes a member of the H3/H4 family of histone
            chaperone proteins and is similar to the anti-silencing function-1
            gene in yeast. The encoded protein is the substrate of the
            tousled-like kinase family of cell cycle-regulated kinases, and may
            play a key role in modulating the nucleosome structure of chromatin
            by ensuring a constant supply of histones at sites of nucleosome
            assembly. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.93938.1, BC036521.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263382.8/ ENSP00000263382.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1591              AK001466.1         31-1621
            1592-1689           BC036521.1         1595-1692
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1689
                     /gene="ASF1B"
                     /gene_synonym="CIA-II"
                     /note="anti-silencing function 1B histone chaperone"
                     /db_xref="GeneID:55723"
                     /db_xref="HGNC:HGNC:20996"
                     /db_xref="MIM:609190"
     exon            1..242
                     /gene="ASF1B"
                     /gene_synonym="CIA-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..742
                     /gene="ASF1B"
                     /gene_synonym="CIA-II"
                     /note="CCG1-interacting factor A-II; hAsf1; hAsf1b;
                     hCIA-II; anti-silencing function protein 1 homolog B; ASF1
                     anti-silencing function 1 homolog B"
                     /codon_start=1
                     /product="histone chaperone ASF1B"
                     /protein_id="NP_060624.1"
                     /db_xref="CCDS:CCDS12306.1"
                     /db_xref="GeneID:55723"
                     /db_xref="HGNC:HGNC:20996"
                     /db_xref="MIM:609190"
                     /translation="MAKVSVLNVAVLENPSPFHSPFRFEISFECSEALADDLEWKIIY
                     VGSAESEEFDQILDSVLVGPVPAGRHMFVFQADAPNPSLIPETDAVGVTVVLITCTYH
                     GQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDNNMDRL
                     EAIETQDPSLGCGLPLNCTPIKGLGLPGCIPGLLPENSMDCI"
     exon            243..358
                     /gene="ASF1B"
                     /gene_synonym="CIA-II"
                     /inference="alignment:Splign:2.1.0"
     exon            359..535
                     /gene="ASF1B"
                     /gene_synonym="CIA-II"
                     /inference="alignment:Splign:2.1.0"
     exon            536..1689
                     /gene="ASF1B"
                     /gene_synonym="CIA-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1668..1673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASF1B"
                     /gene_synonym="CIA-II"
                     /note="hexamer: ATTAAA"
     polyA_site      1689
                     /gene="ASF1B"
                     /gene_synonym="CIA-II"
                     /note="major polyA site"
ORIGIN      
        1 gcacttcagt tctcggagag aagaggcggg agtggacctg gtcagcccta ccccactgac
       61 cccaccggac ccaggcgcgg cctccgccac agccacagcc cctgcccctg ctgcggcgcg
      121 gcgaggcgag gcgatggcca aggtgtcggt gctgaacgtg gcggtcctgg agaacccgag
      181 ccctttccac agccccttcc ggttcgagat cagcttcgag tgcagtgaag ccctggcgga
      241 cgacctggag tggaagatca tttatgttgg ctcggctgag agtgaggaat ttgatcagat
      301 cctagactcg gtgctggtgg gccctgtgcc agcagggaga cacatgtttg tctttcaggc
      361 cgacgccccc aacccatccc tcatcccaga gactgatgcc gtgggtgtga ctgtggtcct
      421 catcacctgc acctaccatg gacaggagtt catccgagtg ggctactacg tcaacaacga
      481 gtacctcaac cctgagctgc gtgagaaccc gcccatgaag ccagatttct cccagctcca
      541 gcggaacatc ttggcctcga acccccgggt gacccgcttc catatcaact gggacaacaa
      601 catggacagg ctggaggcca tagagaccca ggacccctcc ctgggctgcg gcctcccact
      661 caactgcact cctatcaagg gcttggggct ccctggctgc atccctggcc tcctccctga
      721 gaactccatg gactgcatct aactgcagga acccagagtg tcccagcacg ccgggagggg
      781 caaccaggcc tcccagcgag tcctgcaggg cccatctaga ggactttggg ggccatcagc
      841 tgcaatccag gtctgtcaaa ctcagcccct aggaaagaac aggccttggg tctcccctag
      901 tcctggccag aaggatgatc tcgcttttcc tctacaggcc tataagaagc aggtacttca
      961 gttctaaatt ctgacttgtg ttcttttcgt cttcataaat tctaactaag gccactgtgc
     1021 cactgtgcac ccttgagtac cattgatcca aagctttccc acagacctcc ctggcccacc
     1081 tagaggcttt cttggtcagt gcctgtcaag gctccagtcc tgctgagcca aaggctttgt
     1141 cattcctttc tcttcctgta catctgagca gacccactcc agctttctgg tgtcacaggc
     1201 gggaatgtta gttagtaggt agacttagat cccatttctg tcctgctccc aggaagattc
     1261 ttaggtcctc ttcaatccag cagcccctcc cagaggtgtg atcagcagga tgctgaggaa
     1321 ccatgttgcc tttcctgtca atcacagcca ccttcctgtt atctcctaaa tggatctggc
     1381 ttttcctgga ggctgccatg gttggaagat ggtatcagag ggcctgcctg ggcagtctgt
     1441 ctccgggcca gggtcaggga ccctctgcct ctggcagcct taacctgtcc tctgctagga
     1501 ccagggtgat ttcaagccag ggaagcaact gggaccctga aaactgtccc tccccagccc
     1561 gctccccctc tctgtgccct ggtccccttg ctgccatgtg gatgctgttg tgattgctgt
     1621 ttgtatatta tcaaaatgtt tttatattaa aaatgtttgg tctgaaaatt aaaagcactt
     1681 catttagaa
//
