LOCUS       NM_014034               2434 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens anti-silencing function 1A histone chaperone (ASF1A),
            mRNA.
ACCESSION   NM_014034
VERSION     NM_014034.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Liu,Y., Liu,S., Jing,R., Li,C., Guo,Y., Cai,Z., Xi,P., Dai,P.,
            Jia,L., Zhu,H. and Zhang,X.
  TITLE     Identification of ASF1A and HJURP by global H3-H4 histone chaperone
            analysis as a prognostic two-gene model in hepatocellular carcinoma
  JOURNAL   Sci Rep 14 (1), 7666 (2024)
   PUBMED   38561384
  REMARK    GeneRIF: Identification of ASF1A and HJURP by global H3-H4 histone
            chaperone analysis as a prognostic two-gene model in hepatocellular
            carcinoma.
            Erratum:[Sci Rep. 2024 Sep 5;14(1):20726. doi:
            10.1038/s41598-024-71753-0.. PMID: 39251799]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Yin,X., Zhou,M., Zhang,L., Fu,Y., Xu,M., Wang,X., Cui,Z., Gao,Z.,
            Li,M., Dong,Y., Feng,H., Ma,S. and Chen,C.
  TITLE     Histone chaperone ASF1A accelerates chronic myeloid leukemia blast
            crisis by activating Notch signaling
  JOURNAL   Cell Death Dis 13 (10), 842 (2022)
   PUBMED   36184659
  REMARK    GeneRIF: Histone chaperone ASF1A accelerates chronic myeloid
            leukemia blast crisis by activating Notch signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Tang,M., Chen,Z., Wang,C., Feng,X., Lee,N., Huang,M., Zhang,H.,
            Li,S., Xiong,Y. and Chen,J.
  TITLE     Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in
            BRCA1-deficient cells
  JOURNAL   J Biol Chem 298 (6), 101979 (2022)
   PUBMED   35472331
  REMARK    GeneRIF: Histone chaperone ASF1 acts with RIF1 to promote DNA end
            joining in BRCA1-deficient cells.
REFERENCE   4  (bases 1 to 2434)
  AUTHORS   Feng,S., Ma,S., Li,K., Gao,S., Ning,S., Shang,J., Guo,R., Chen,Y.,
            Blumenfeld,B., Simon,I., Li,Q., Guo,R. and Xu,D.
  TITLE     RIF1-ASF1-mediated high-order chromatin structure safeguards genome
            integrity
  JOURNAL   Nat Commun 13 (1), 957 (2022)
   PUBMED   35177609
  REMARK    GeneRIF: RIF1-ASF1-mediated high-order chromatin structure
            safeguards genome integrity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2434)
  AUTHORS   Simon,B., Lou,H.J., Huet-Calderwood,C., Shi,G., Boggon,T.J.,
            Turk,B.E. and Calderwood,D.A.
  TITLE     Tousled-like kinase 2 targets ASF1 histone chaperones through
            client mimicry
  JOURNAL   Nat Commun 13 (1), 749 (2022)
   PUBMED   35136069
  REMARK    GeneRIF: Tousled-like kinase 2 targets ASF1 histone chaperones
            through client mimicry.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2434)
  AUTHORS   Chimura,T., Kuzuhara,T. and Horikoshi,M.
  TITLE     Identification and characterization of CIA/ASF1 as an interactor of
            bromodomains associated with TFIID
  JOURNAL   Proc Natl Acad Sci U S A 99 (14), 9334-9339 (2002)
   PUBMED   12093919
REFERENCE   7  (bases 1 to 2434)
  AUTHORS   Mello,J.A., Sillje,H.H., Roche,D.M., Kirschner,D.B., Nigg,E.A. and
            Almouzni,G.
  TITLE     Human Asf1 and CAF-1 interact and synergize in a repair-coupled
            nucleosome assembly pathway
  JOURNAL   EMBO Rep 3 (4), 329-334 (2002)
   PUBMED   11897662
  REMARK    GeneRIF: model is proposed in which the synergism between hAsf1 and
            CAF-1 for nucleosome formation during DNA repair is achieved
            through a transient physical interaction allowing histone delivery
            from Asf1 to CAF-1
REFERENCE   8  (bases 1 to 2434)
  AUTHORS   Sillje,H.H. and Nigg,E.A.
  TITLE     Identification of human Asf1 chromatin assembly factors as
            substrates of Tousled-like kinases
  JOURNAL   Curr Biol 11 (13), 1068-1073 (2001)
   PUBMED   11470414
REFERENCE   9  (bases 1 to 2434)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 2434)
  AUTHORS   Munakata,T., Adachi,N., Yokoyama,N., Kuzuhara,T. and Horikoshi,M.
  TITLE     A human homologue of yeast anti-silencing factor has histone
            chaperone activity
  JOURNAL   Genes Cells 5 (3), 221-233 (2000)
   PUBMED   10759893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA902777.1, AK025738.1 and
            AA481056.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014034.2.
            
            Summary: This gene encodes a member of the H3/H4 family of histone
            chaperone proteins and is similar to the anti-silencing function-1
            gene in yeast. The protein is a key component of a histone donor
            complex that functions in nucleosome assembly. It interacts with
            histones H3 and H4, and functions together with a chromatin
            assembly factor during DNA replication and repair. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.80138.1,
                                           SRR1660805.154207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229595.6/ ENSP00000229595.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               DA902777.1         76-560
            486-2071            AK025738.1         418-2003
            2072-2434           AA481056.1         17-379              c
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..2434
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /note="anti-silencing function 1A histone chaperone"
                     /db_xref="GeneID:25842"
                     /db_xref="HGNC:HGNC:20995"
                     /db_xref="MIM:609189"
     exon            1..371
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..877
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /note="ASF1 anti-silencing function 1 homolog A;
                     CCG1-interacting factor A; hCIA; hAsf1; hAsf1a;
                     anti-silencing function protein 1 homolog A"
                     /codon_start=1
                     /product="histone chaperone ASF1A"
                     /protein_id="NP_054753.1"
                     /db_xref="CCDS:CCDS47469.1"
                     /db_xref="GeneID:25842"
                     /db_xref="HGNC:HGNC:20995"
                     /db_xref="MIM:609189"
                     /translation="MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIY
                     VGSAESEEYDQVLDSVLVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYR
                     GQEFIRVGYYVNNEYTETELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKL
                     EDAESSNPNLQSLLSTDALPSASKGWSTSENSLNVMLESHMDCM"
     exon            372..487
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /inference="alignment:Splign:2.1.0"
     exon            488..664
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /inference="alignment:Splign:2.1.0"
     exon            665..2434
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1043..1048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /note="hexamer: AATACA"
     polyA_site      1063
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /note="major polyA site"
     regulatory      1109..1114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /note="hexamer: ATTAAA"
     polyA_site      1126
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
     regulatory      2410..2415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
                     /note="hexamer: AATAAA"
     polyA_site      2434
                     /gene="ASF1A"
                     /gene_synonym="CGI-98; CIA; HSPC146"
ORIGIN      
        1 agaactcggg tgcagccaat cgagggcaac gctgctactt atcagagcag aatgggctgt
       61 agtttagtga aataggaaag ctgcaaaaca ctgtggagtg ctcccgtgta aataaaaaga
      121 ggaaaaaagt ttctcaagtc gccgctgcac gacgtctggc cggcgctgga gcgggggtct
      181 gcgctctccc gagcggccgc gcgctggact ttattgtgcc gcaaccagcc ccagttccca
      241 ttgtttgtgt ttttttcaaa atatggcaaa ggttcaggtg aacaatgtag tggtgctgga
      301 taacccttct cctttctaca acccgttcca gttcgagatc accttcgagt gcatcgagga
      361 cctgtctgaa gacttggaat ggaaaattat ctatgtgggc tctgcagaaa gtgaagaata
      421 cgatcaagtt ttagactctg ttttagtggg tcctgttccc gcaggaaggc atatgtttgt
      481 atttcaggct gatgcaccta atccaggact cattccagat gcagatgcag taggcgtaac
      541 tgttgtgcta attacttgta cctatcgagg acaagaattt attagagttg gctattatgt
      601 aaataatgaa tatactgaga cagaattaag ggaaaatcca ccagtaaaac cagacttttc
      661 taagcttcaa aggaatattt tggcatctaa tcccagggtc acaagattcc acattaattg
      721 ggaagataac acagaaaaac tggaagatgc agagagcagt aatccaaatc tacagtcact
      781 tctttcaaca gatgcattac cttcagcatc aaagggatgg tccacatcag aaaactcact
      841 aaatgtcatg ttagaatccc acatggactg catgtgacca cctaccatcc ctttagtaca
      901 aattaagcta ttaaaaatac acagaactat ttccctgaaa ttccgtaagt acatagtcaa
      961 aacacaatgt gaagaatttg tttaaaaaca tcctgtagaa agtttataag aaaaccagta
     1021 tttgaacaaa ttgtggaata taaatacaac tatttttaag taattttttt ctctaatgtg
     1081 ttattttatt tgttctgaaa ctaatctgat taaagcatat atattatttt cttctccttt
     1141 atatgtaatg aaagcactta taaagaaaca ggaatcatta gaccaggttg taaagatgtc
     1201 ttggcctccc agacagtctt tggaccacta ttttactggc ctttgaaaga acaaagttta
     1261 cttcaactaa aatgtttctt cctgtgaaga catatggtat cattttaatt taaggggcag
     1321 atttccattc ttttttggca tgtccttaaa aagaggattt gaaatcaact atatgctacc
     1381 aagaacttta ggatccaatt ttccaagcca ccgtgaagcc tcttatggct actattatag
     1441 ttcatgagat gttggacagc atttggtttg tttggtaaga gaagaacaaa tatggctaat
     1501 tgttaataag gtcccctggc tatggttttt gttcttataa cagagtttag aatatcagag
     1561 catttcttga atcatacatc attattgtcc agtgaattca agaccaaata caatatcggg
     1621 agaaaataca aactccctgt gtttaagaat aggggattac aatggctcaa attggttcat
     1681 ttgatttcta aaaataccat gacctttaaa aattctttta atagatcatg ttattggcag
     1741 tatttatata aaaaccatgg atttagaaag gtatatttag ctttattata atagatacgt
     1801 tactattttg gaaatatata tattttcaca cctgtagtac tcttccccat ttcctctgac
     1861 actcatgcag aatgagatca ggcatatttg tggttgacat actctagata gcttttccaa
     1921 caaatctttg aaaagcaatc ttggaaagga attcattaac taaatggggt aaaaggtttc
     1981 tttttctttg agagttaagt ccttcctcaa aaaattttct tatgctccat aaaattgagg
     2041 tagaatattt tcattattct tgcagctaag caagacagcc atatgatgca ggttatgcag
     2101 tgccttcata tctaaaactt ttatactgca ctttttaaag cttttatgtt gaggaaagga
     2161 aaagggcatt tgtctaaaca tggattctga gttgtatata tttcctatca ttctaaaaaa
     2221 gtgaatttgt gaagcaaagt tttgccagat gttaaacttt gaatttaata taccagatta
     2281 ttaaaatatt gtccattaac tagttcatag attttaaaag taaaatactt ctgactgtta
     2341 aaactatata aagaaaatct catttgtcta attgcaatta aaagaaaaat gttaaaatat
     2401 taaaatgaaa ataaaagcat tactttccaa caaa
//
