LOCUS       NM_001353493             643 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ASNSD1 upstream open reading frame (ASDURF),
            transcript variant 1, mRNA.
ACCESSION   NM_001353493
VERSION     NM_001353493.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 643)
  AUTHORS   Cloutier,P., Poitras,C., Faubert,D., Bouchard,A., Blanchette,M.,
            Gauthier,M.S. and Coulombe,B.
  TITLE     Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of
            the PAQosome
  JOURNAL   J Proteome Res 19 (1), 18-27 (2020)
   PUBMED   31738558
  REMARK    GeneRIF: ASDURF is a beta prefoldin and a subunit of the
            prefoldin-like module of the PAQosome/R2TP-PFDL complex.
REFERENCE   2  (bases 1 to 643)
  AUTHORS   Chu,Q., Ma,J. and Saghatelian,A.
  TITLE     Identification and characterization of sORF-encoded polypeptides
  JOURNAL   Crit Rev Biochem Mol Biol 50 (2), 134-141 (2015)
   PUBMED   25857697
  REMARK    Review article
REFERENCE   3  (bases 1 to 643)
  AUTHORS   Slavoff,S.A., Mitchell,A.J., Schwaid,A.G., Cabili,M.N., Ma,J.,
            Levin,J.Z., Karger,A.D., Budnik,B.A., Rinn,J.L. and Saghatelian,A.
  TITLE     Peptidomic discovery of short open reading frame-encoded peptides
            in human cells
  JOURNAL   Nat Chem Biol 9 (1), 59-64 (2013)
   PUBMED   23160002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012488.10 and BF508929.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001353493.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA530860.1, BF508929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000607829.6/ ENSP00000475224.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC012488.10        57760-57856
            98-328              BF508929.1         329-559             c
            329-611             AC012488.10        62388-62670
            612-643             BF508929.1         14-45               c
FEATURES             Location/Qualifiers
     source          1..643
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..643
                     /gene="ASDURF"
                     /gene_synonym="ASNSD1; ASNSD1-SEP; NS3TP1"
                     /note="ASNSD1 upstream open reading frame"
                     /db_xref="GeneID:110599588"
                     /db_xref="HGNC:HGNC:53619"
                     /db_xref="MIM:619740"
     exon            1..152
                     /gene="ASDURF"
                     /gene_synonym="ASNSD1; ASNSD1-SEP; NS3TP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..353
                     /gene="ASDURF"
                     /gene_synonym="ASNSD1; ASNSD1-SEP; NS3TP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alternative protein ASNSD1; Asparagine synthetase
                     domain-containing protein 1; HCV NS3-transactivated
                     protein 1; ASNSD1 upstream reading frame"
                     /codon_start=1
                     /product="ASNSD1 upstream open reading frame protein
                     isoform 1"
                     /protein_id="NP_001340422.1"
                     /db_xref="CCDS:CCDS86901.1"
                     /db_xref="GeneID:110599588"
                     /db_xref="HGNC:HGNC:53619"
                     /db_xref="MIM:619740"
                     /translation="MPSRGTRPEDSSVLIPTDNSTPHKEDLSSKIKEQKIVVDELSNL
                     KKNRKVYRQQQNSNIFFLADRTEMLSESKNILDELKKEYQEIENLDKTKIKK"
     exon            153..206
                     /gene="ASDURF"
                     /gene_synonym="ASNSD1; ASNSD1-SEP; NS3TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..282
                     /gene="ASDURF"
                     /gene_synonym="ASNSD1; ASNSD1-SEP; NS3TP1"
                     /inference="alignment:Splign:2.1.0"
     exon            283..643
                     /gene="ASDURF"
                     /gene_synonym="ASNSD1; ASNSD1-SEP; NS3TP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      620..625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASDURF"
                     /gene_synonym="ASNSD1; ASNSD1-SEP; NS3TP1"
                     /note="hexamer: AATAAA"
     polyA_site      643
                     /gene="ASDURF"
                     /gene_synonym="ASNSD1; ASNSD1-SEP; NS3TP1"
                     /note="major polyA site"
ORIGIN      
        1 gtggctaatg ccgtaggctc cttcagggct gagccatccc gcgtgtcttg cgctcggtgg
       61 aaatgcccag ccgagggacg cgaccagagg acagctctgt gctgatcccc accgacaatt
      121 cgaccccaca caaggaggat ctaagcagca agattaaaga acaaaaaatt gtggtggatg
      181 aactttctaa ccttaagaag aataggaaag tatataggca acaacagaac agcaatatat
      241 tctttcttgc agaccgaaca gaaatgctgt ctgagagcaa gaatatattg gatgaactga
      301 aaaaagaata ccaagaaata gaaaacttag acaagaccaa aatcaagaaa tagtcaacct
      361 gatttcacat aacaatgtgt ggcatttgtt gttctgtaaa cttttctgct gagcatttca
      421 gtcaagattt aaaagaggac ttactatata atcttaaaca gcggggaccc aatagtagta
      481 aacaattgtt aaagtctgat gttaactacc agtgtttatt ttctgctcac gtcctacact
      541 tgaggggtgt tttgactacc cagcctgtgg aagatgaaag aggcaatgtg tttctatgga
      601 atggagaaat ttttagtgga ataaaggttg aagctgaaga gaa
//
