LOCUS       NM_001270601            2036 bp    mRNA    linear   PRI 30-APR-2024
DEFINITION  Homo sapiens achaete-scute family bHLH transcription factor 5
            (ASCL5), mRNA.
ACCESSION   NM_001270601
VERSION     NM_001270601.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2036)
  AUTHORS   He,B., Chiba,Y., Li,H., de Vega,S., Tanaka,K., Yoshizaki,K.,
            Ishijima,M., Yuasa,K., Ishikawa,M., Rhodes,C., Sakai,K., Zhang,P.,
            Fukumoto,S., Zhou,X. and Yamada,Y.
  TITLE     Identification of the Novel Tooth-Specific Transcription Factor
            AmeloD
  JOURNAL   J Dent Res 98 (2), 234-241 (2019)
   PUBMED   30426815
REFERENCE   2  (bases 1 to 2036)
  AUTHORS   Wang,C.Y., Shahi,P., Huang,J.T., Phan,N.N., Sun,Z., Lin,Y.C.,
            Lai,M.D. and Werb,Z.
  TITLE     Systematic analysis of the achaete-scute complex-like gene
            signature in clinical cancer patients
  JOURNAL   Mol Clin Oncol 6 (1), 7-18 (2017)
   PUBMED   28123722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139159.10.
            
            On Sep 30, 2020 this sequence version replaced NM_001270601.1.
            
            Sequence Note:.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000449188.3/ ENSP00000472681.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL139159.10        67869-67969         c
            102-2036            AL139159.10        54728-56662         c
FEATURES             Location/Qualifiers
     source          1..2036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2036
                     /gene="ASCL5"
                     /gene_synonym="AmeloD; ASH-5; bHLHa47"
                     /note="achaete-scute family bHLH transcription factor 5"
                     /db_xref="GeneID:647219"
                     /db_xref="HGNC:HGNC:33169"
                     /db_xref="MIM:620809"
     exon            1..101
                     /gene="ASCL5"
                     /gene_synonym="AmeloD; ASH-5; bHLHa47"
                     /inference="alignment:Splign:2.1.0"
     exon            102..2036
                     /gene="ASCL5"
                     /gene_synonym="AmeloD; ASH-5; bHLHa47"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..1227
                     /gene="ASCL5"
                     /gene_synonym="AmeloD; ASH-5; bHLHa47"
                     /note="achaete-scute complex homolog 5; class A basic
                     helix-loop-helix protein 47"
                     /codon_start=1
                     /product="achaete-scute homolog 5"
                     /protein_id="NP_001257530.1"
                     /db_xref="CCDS:CCDS59202.1"
                     /db_xref="GeneID:647219"
                     /db_xref="HGNC:HGNC:33169"
                     /db_xref="MIM:620809"
                     /translation="MNNNFCRALVDRRPLGPPSCMQLGVMPPPRQAPLPPAEPLGNVP
                     FLLYPGPAEPPYYDAYAGVFPYVPFPGAFGVYEYPFEPAFIQKRNERERQRVKCVNEG
                     YARLRGHLPGALAEKRLSKVETLRAAIRYIKYLQELLSSAPDGSTPPASRGLPGTGPC
                     PAPPATPRPDRPGDGEARAPSSLVPESSESSCFSPSPFLESEESWH"
     regulatory      2005..2010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASCL5"
                     /gene_synonym="AmeloD; ASH-5; bHLHa47"
                     /note="hexamer: AATAAA"
     polyA_site      2036
                     /gene="ASCL5"
                     /gene_synonym="AmeloD; ASH-5; bHLHa47"
                     /note="major polyA site"
ORIGIN      
        1 ctgctgggca ggcgggcagc cccggagatt ccgcagtccc cccaggaggt tcaagagcca
       61 ctgatcagga taagcgctgc cggaggaaca aacccagaga gaaatgttcc cggggactcc
      121 ctccactgag ctggcgcact cctaacagca gccatcagtt tggggacccc ggacagcccg
      181 gggatcccga aggccgcgag gaccaaggac caggcgctgg ggtgggtgtg gaggacatgg
      241 agcccgtggt ttaggcctga ggtgcccatg ttgggtggca gcaagaggca gggtgggcgg
      301 gtctgtggcc atgcccatgg gtgctgcgga acggggtgcg ggccctcaga gttccgcggc
      361 gccatgggct ggctctgaga aggcgtgcac cgacctcctg agaggggcca cacttgtcta
      421 gggcgatggc tcttgttagg gagtcattgg aagccaccct aaagggcgaa aagaggccct
      481 agcaagtcct ggtacccaag agctgctgct agcgatgtga cttgccccac tggtggagac
      541 ggtgcagacc ccaagccggg gccattcggt ggaggcctcg ctctgggtcc agctccacgc
      601 ggcaccatga acaataactt ctgccgggct ctggtggacc ggaggcctct ggggcccccc
      661 agctgcatgc agctgggcgt catgccccct ccccggcagg cgcccctgcc ccccgccgag
      721 cccctgggca acgtgccctt cctgctgtac ccgggcccag cagagccgcc ctactacgac
      781 gcctatgcgg gggtgttccc ctacgtgccc ttccccggcg ccttcggggt ctacgaatac
      841 cccttcgagc cagccttcat ccagaagcgc aacgagcgcg agaggcagcg agtcaagtgc
      901 gtcaacgagg gctacgctcg cctccgcggc cacctccccg gcgccctggc tgagaagcga
      961 ctcagcaagg tggagacgct gcgcgccgcc atccgctaca taaagtacct gcaagagctg
     1021 ctgagctcgg cccccgacgg ctcgacgccc cccgcttccc gcggcctccc gggcaccggg
     1081 ccctgccccg cgccgcccgc caccccccgt cccgaccgcc ctggcgacgg cgaggcccgg
     1141 gcgccctcct ccctggtgcc ggagtcatcc gagtcctcct gcttctcccc gtcgcctttc
     1201 ttggagtcgg aggaatcctg gcattgatcg ggcctgtggc cgcccccggc ttggaggatg
     1261 atccgccggc cccgtcccac tttcgggagc agcgggaggc tgttgggtca cccgcgatgc
     1321 gccgcaggac ggtgactgta ggaggtccgc ggcgctcccg tgtctgcgac accctccctc
     1381 ctccaccagc ttggggcgga agtgcagggc agcgggtacg atgggcacga tagagaccta
     1441 ggagctccgt gggtgaagcg aggggcaggg cctgggactg ctccgggcgt cctgcgtccc
     1501 ctccggggtg cagaggggct ccccaggacg gtcatccctg ggtctggctc ccgctcggcc
     1561 tcaggtggct ctgctccgtc cttccttgcc gcaggcgcag tccagtctct gcgagtcccc
     1621 gggatgcgag cccgactttg agccctcggt taccatgcca ctgctctcca ccagatggcc
     1681 tcagatacta gcgacttctt tgggagcacg cttactcctc gagaaaggaa cccagaggaa
     1741 gggatgggag gccagattgc tgctggcgct cagcccagac cgaacctaca gactcagcag
     1801 aggcgacctg tgtgccccgg tggcgttctc tggcttcctg ggttgggagg gggggttact
     1861 ccctccccgc atccccccca tgaggtcgtc tagttttgtc ccaggttggg tggggactgt
     1921 ggtttttttc cctcagactg taagccttgg gggagggggg cgtgcatata ggtacatagg
     1981 cactgcgtcg gcaccaaaga gctaaataaa aggattgttg aattttctca ttccta
//
