LOCUS       NM_203436               1941 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens achaete-scute family bHLH transcription factor 4
            (ASCL4), mRNA.
ACCESSION   NM_203436 XM_062690
VERSION     NM_203436.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1941)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1941)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1941)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1941)
  AUTHORS   Brown,C.W., Amante,J.J., Goel,H.L. and Mercurio,A.M.
  TITLE     The alpha6beta4 integrin promotes resistance to ferroptosis
  JOURNAL   J Cell Biol 216 (12), 4287-4297 (2017)
   PUBMED   28972104
REFERENCE   5  (bases 1 to 1941)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1941)
  AUTHORS   Mele,P.G., Duarte,A., Paz,C., Capponi,A. and Podesta,E.J.
  TITLE     Role of intramitochondrial arachidonic acid and acyl-CoA synthetase
            4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R
            adrenocortical cell line
  JOURNAL   Endocrinology 153 (7), 3284-3294 (2012)
   PUBMED   22549224
  REMARK    GeneRIF: intramitochondrial arachidonic acid and acyl-CoA
            synthetase 4 in angiotensin II-regulated aldosterone synthesis have
            roles in NCI-H295R adrenocortical cell line
REFERENCE   7  (bases 1 to 1941)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1941)
  AUTHORS   Meloni,I., Parri,V., De Filippis,R., Ariani,F., Artuso,R.,
            Bruttini,M., Katzaki,E., Longo,I., Mari,F., Bellan,C., Dotti,C.G.
            and Renieri,A.
  TITLE     The XLMR gene ACSL4 plays a role in dendritic spine architecture
  JOURNAL   Neuroscience 159 (2), 657-669 (2009)
   PUBMED   19166906
  REMARK    GeneRIF: In neuron reduced levels of ACSL4 led to a significant
            reduction in dendritic spine density and an alteration in
            spine/filopodia distribution.
REFERENCE   9  (bases 1 to 1941)
  AUTHORS   Jonsson,M., Bjorntorp Mark,E., Brantsing,C., Brandner,J.M.,
            Lindahl,A. and Asp,J.
  TITLE     Hash4, a novel human achaete-scute homologue found in fetal skin
  JOURNAL   Genomics 84 (5), 859-866 (2004)
   PUBMED   15475265
  REMARK    GeneRIF: HASH4 is involved in skin development.
REFERENCE   10 (bases 1 to 1941)
  AUTHORS   McLellan,A.S., Langlands,K. and Kealey,T.
  TITLE     Exhaustive identification of human class II basic helix-loop-helix
            proteins by virtual library screening
  JOURNAL   Mech Dev 119 Suppl 1, S285-S291 (2002)
   PUBMED   14516699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007622.28.
            
            On Aug 10, 2020 this sequence version replaced NM_203436.2.
            
            Summary: Basic helix-loop-helix transcription factors, such as
            ASCL4, are essential for the determination of cell fate and the
            development and differentiation of numerous tissues (Jonsson et
            al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY238895.1, BC128212.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000342331.5/
                                                ENSP00000345420.5
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1941              AC007622.28        15640-17580         c
FEATURES             Location/Qualifiers
     source          1..1941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..1941
                     /gene="ASCL4"
                     /gene_synonym="ASH-4; bHLHa44; HASH4"
                     /note="achaete-scute family bHLH transcription factor 4"
                     /db_xref="GeneID:121549"
                     /db_xref="HGNC:HGNC:24311"
                     /db_xref="MIM:609155"
     exon            1..1941
                     /gene="ASCL4"
                     /gene_synonym="ASH-4; bHLHa44; HASH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..1034
                     /gene="ASCL4"
                     /gene_synonym="ASH-4; bHLHa44; HASH4"
                     /note="achaete-scute-like protein 4; class II bHLH protein
                     ASCL4; class A basic helix-loop-helix protein 44;
                     achaete-scute complex-like 4; achaete-scute complex
                     homolog 4"
                     /codon_start=1
                     /product="achaete-scute homolog 4"
                     /protein_id="NP_982260.3"
                     /db_xref="CCDS:CCDS31894.3"
                     /db_xref="GeneID:121549"
                     /db_xref="HGNC:HGNC:24311"
                     /db_xref="MIM:609155"
                     /translation="METRKPAERLALPYSLRTAPLGVPGTLPGLPRRDPLRVALRLDA
                     ACWEWARSGCARGWQYLPVPLDSAFEPAFLRKRNERERQRVRCVNEGYARLRDHLPRE
                     LADKRLSKVETLRAAIDYIKHLQELLERQAWGLEGAAGAVPQRRAECNSDGESKASSA
                     PSPSSEPEEGGS"
ORIGIN      
        1 cactttccct ccgccgccag atctgcaggt tcctgggagg agctcttctc aaatcctgaa
       61 gattgctagg ctcttggcga acgactcatc tcttgaagac ctagagtggt ggattacagg
      121 cattgaaaag cttttggtgg ctttggaaga tgactctggt gtgagctcac ctttccaggc
      181 tgggggacca ggcagaggaa ccccctttgt tatcttctga aagaagatca gtggggaaga
      241 cggggtttga agtgtggatt aggagatcct acgtctttgc ctaccacctc tgcctaaatc
      301 ataaaaagat cgaggagtgc aatgaacttc aggaatcatg caccgtttcc ctgaagcctg
      361 tccaggaacc taacttctgg acccagaaac ttctgcaaag acagacccac tgagccaggc
      421 agtctgcacc agcacctctg cttctaagat tctgtttcgt cttcttctat tgagagattg
      481 acctcttgag tgatttgtgt gctttccggc aaatgatgga gacgcgtaaa ccggcggaac
      541 ggctggcctt gccatactcg ctgcgcaccg cgcccctggg cgttccgggg accctgcccg
      601 gactcccgcg gagggacccc ctcagggtcg ccctgcgtct ggacgccgcg tgctgggagt
      661 gggcgcgcag cggctgcgca cggggatggc agtacttgcc cgtgccgctg gacagcgcct
      721 tcgagcccgc cttcctccgc aagcgcaacg agcgcgagcg gcagcgggtg cgctgcgtga
      781 acgagggcta tgcgcgcctc cgagaccacc tgccccggga gctggcagac aagcgcctca
      841 gcaaagtgga gacgctccgc gctgccatcg actacatcaa gcacctgcag gagctgctgg
      901 agcgccaggc ctgggggctc gagggcgcgg ccggcgccgt cccccagcgc agggcggaat
      961 gcaacagcga cggggagtcc aaggcctctt cggcgccttc gcccagcagc gagcccgagg
     1021 aggggggcag ctagcgagcg cccgaactgg ccaggacccc cgcgcccgcc gcacagcgcg
     1081 cagccgggcg ctcaacctaa ggtcctcttc gaaggtggtt tgcattctta atctggcatc
     1141 ttctccaggc ctaaatctta agaaaaagaa atgggtgctg gggtttgggg gatgggggag
     1201 ttgttttgac atttgggaat ttctcccctg cccttattgg ttacgtgcct gcaacttata
     1261 ggtgcttatt aaggagactc ttttcctata cttctaaaat gcaaactgtt tcagattctg
     1321 agcacctcat tgtaaatacg attattctaa aaactcaaag ggcgagaaca actggaattt
     1381 cccaccttcc gtggtgtggg taaatggtat acataaacat taaaccttaa ccaaagaaga
     1441 actttaccgc caccaaaaca gaaacaaccc caaacagcca aaaacagtcc ttaaaaatga
     1501 gaggaacatt ttcttgcatt ccttccttcg ggaattgtat tcaaaatgta atggaaagta
     1561 attgttgacc tcctgctttg ggtgaaggag actgtaagct ggtacttgag aacgaatttg
     1621 ccagcatgtg ctgttgttga ctgtgtgaat gatggtgcca gggaatccgt ggcttggtac
     1681 acactgtttc atccagtggc cacgtggaag ctttgtagca ttgagcagat agtaaaatat
     1741 cttagaatta atgatctctt tggaagagag cccagatttg tatgaaaact tgtttttcct
     1801 ctcaattgtt ttgtccactg ttttcttcat tttccttttc tctgcatacc ccccgccccc
     1861 caacgtgtag ctctccatct aagttttgga taaactgaag tggcactgtg actttaaaaa
     1921 taaaaaagaa atctacttgg a
//
