LOCUS       NM_020646                627 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens achaete-scute family bHLH transcription factor 3
            (ASCL3), mRNA.
ACCESSION   NM_020646
VERSION     NM_020646.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 627)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 627)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 627)
  AUTHORS   Jonsson,M., Bjorntorp Mark,E., Brantsing,C., Brandner,J.M.,
            Lindahl,A. and Asp,J.
  TITLE     Hash4, a novel human achaete-scute homologue found in fetal skin
  JOURNAL   Genomics 84 (5), 859-866 (2004)
   PUBMED   15475265
REFERENCE   4  (bases 1 to 627)
  AUTHORS   Yoshida,S., Ohbo,K., Takakura,A., Takebayashi,H., Okada,T., Abe,K.
            and Nabeshima,Y.
  TITLE     Sgn1, a basic helix-loop-helix transcription factor delineates the
            salivary gland duct cell lineage in mice
  JOURNAL   Dev Biol 240 (2), 517-530 (2001)
   PUBMED   11784080
REFERENCE   5  (bases 1 to 627)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   6  (bases 1 to 627)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026894.7.
            
            On Mar 25, 2021 this sequence version replaced NM_020646.2.
            
            Summary: Basic helix-loop-helix transcription factors, such as
            ASCL3, are essential for the determination of cell fate and the
            development and differentiation of numerous tissues (Jonsson et
            al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968832,
                              SAMEA2150585 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000531618.2/ ENSP00000435770.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC026894.7         45011-45041
            32-627              AC026894.7         49854-50449
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..627
                     /gene="ASCL3"
                     /gene_synonym="bHLHa42; HASH3; SGN1"
                     /note="achaete-scute family bHLH transcription factor 3"
                     /db_xref="GeneID:56676"
                     /db_xref="HGNC:HGNC:740"
                     /db_xref="MIM:609154"
     exon            1..31
                     /gene="ASCL3"
                     /gene_synonym="bHLHa42; HASH3; SGN1"
                     /inference="alignment:Splign:2.1.0"
     exon            32..627
                     /gene="ASCL3"
                     /gene_synonym="bHLHa42; HASH3; SGN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..589
                     /gene="ASCL3"
                     /gene_synonym="bHLHa42; HASH3; SGN1"
                     /note="bHLH transcription factor Sgn-1 (Salivary Glands
                     1); bHLH transcriptional regulator Sgn-1; class A basic
                     helix-loop-helix protein 42; achaete-scute complex homolog
                     3"
                     /codon_start=1
                     /product="achaete-scute homolog 3"
                     /protein_id="NP_065697.1"
                     /db_xref="CCDS:CCDS7795.1"
                     /db_xref="GeneID:56676"
                     /db_xref="HGNC:HGNC:740"
                     /db_xref="MIM:609154"
                     /translation="MMDNRGNSSLPDKLPIFPDSARLPLTRSFYLEPMVTFHVHPEAP
                     VSSPYSEELPRLPFPSDSLILGNYSEPCPFSFPMPYPNYRGCEYSYGPAFTRKRNERE
                     RQRVKCVNEGYAQLRHHLPEEYLEKRLSKVETLRAAIKYINYLQSLLYPDKAETKNNP
                     GKVSSMIATTSHHADPMFRIV"
ORIGIN      
        1 caaaatacag catcctgacg acaaaactca ggttaaagag gaaatgatgg acaacagagg
       61 caactctagt ctacctgaca aacttcctat cttccctgat tctgcccgct tgccactgac
      121 caggtccttc tatctggagc ccatggtcac tttccacgtg cacccagagg ccccggtgtc
      181 atccccttac tctgaggagc tgccacggct gccttttccc agcgactctc ttatcctggg
      241 aaattacagt gaaccctgcc ccttctcttt cccgatgcct tatccaaatt acagagggtg
      301 cgagtactcc tacgggccag ccttcacccg gaaaaggaat gagcgggaaa ggcagcgggt
      361 gaaatgtgtc aatgaaggct acgcccagct ccgccatcat ctgccagagg agtatttgga
      421 gaagcgactc agcaaagtgg aaaccctcag agctgcgatc aagtacatta actacctgca
      481 gtctcttctg taccctgata aagctgagac caagaataac cctggaaaag tttcctccat
      541 gatagcaacc accagccacc atgctgaccc tatgttcaga attgtttgag ttgctgtttc
      601 caaatagaaa tgaataatat cacaaaa
//
