LOCUS       NM_006828               8111 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens activating signal cointegrator 1 complex subunit 3
            (ASCC3), transcript variant 1, mRNA.
ACCESSION   NM_006828
VERSION     NM_006828.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8111)
  AUTHORS   Ao,Y.Q., Gao,J., Jin,C., Wang,S., Zhang,L.C., Deng,J., Chen,Z.W.,
            Wang,H.K., Jiang,J.H. and Ding,J.Y.
  TITLE     ASCC3 promotes the immunosuppression and progression of non-small
            cell lung cancer by impairing the type I interferon response via
            CAND1-mediated ubiquitination inhibition of STAT3
  JOURNAL   J Immunother Cancer 11 (12), e007766 (2023)
   PUBMED   38148115
  REMARK    GeneRIF: ASCC3 promotes the immunosuppression and progression of
            non-small cell lung cancer by impairing the type I interferon
            response via CAND1-mediated ubiquitination inhibition of STAT3.
            Erratum:[J Immunother Cancer. 2024 Jul 10;12(7):e007766corr1. doi:
            10.1136/jitc-2023-007766corr1.. PMID: 38986545]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8111)
  AUTHORS   Narita,M., Denk,T., Matsuo,Y., Sugiyama,T., Kikuguchi,C., Ito,S.,
            Sato,N., Suzuki,T., Hashimoto,S., Machova,I., Tesina,P.,
            Beckmann,R. and Inada,T.
  TITLE     A distinct mammalian disome collision interface harbors K63-linked
            polyubiquitination of uS10 to trigger hRQT-mediated subunit
            dissociation
  JOURNAL   Nat Commun 13 (1), 6411 (2022)
   PUBMED   36302773
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8111)
  AUTHORS   Wollen,K.L., Hagen,L., Vagbo,C.B., Rabe,R., Iveland,T.S., Aas,P.A.,
            Sharma,A., Sporsheim,B., Erlandsen,H.O., Palibrk,V., Bjoras,M.,
            Fonseca,D.M., Mosammaparast,N. and Slupphaug,G.
  TITLE     ALKBH3 partner ASCC3 mediates P-body formation and selective
            clearance of MMS-induced 1-methyladenosine and 3-methylcytosine
            from mRNA
  JOURNAL   J Transl Med 19 (1), 287 (2021)
   PUBMED   34217309
  REMARK    GeneRIF: ALKBH3 partner ASCC3 mediates P-body formation and
            selective clearance of MMS-induced 1-methyladenosine and
            3-methylcytosine from mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8111)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 8111)
  AUTHORS   Li,J., Ding,S.C., Cho,H., Chung,B.C., Gale,M. Jr., Chanda,S.K. and
            Diamond,M.S.
  TITLE     A short hairpin RNA screen of interferon-stimulated genes
            identifies a novel negative regulator of the cellular antiviral
            response
  JOURNAL   mBio 4 (3), e00385-e00313 (2013)
   PUBMED   23781071
  REMARK    GeneRIF: Silencing of ASCC3 resulted in upregulation of multiple
            antiviral interferon-stimulated genes, which correlated with
            inhibition of infection of several positive-strand RNA viruses.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8111)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 8111)
  AUTHORS   Dango,S., Mosammaparast,N., Sowa,M.E., Xiong,L.J., Wu,F., Park,K.,
            Rubin,M., Gygi,S., Harper,J.W. and Shi,Y.
  TITLE     DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA
            alkylation repair and cancer cell proliferation
  JOURNAL   Mol Cell 44 (3), 373-384 (2011)
   PUBMED   22055184
  REMARK    GeneRIF: DNA unwinding by ASCC3 helicase is coupled to
            ALKBH3-dependent DNA alkylation repair and cancer cell
            proliferation.
REFERENCE   8  (bases 1 to 8111)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 8111)
  AUTHORS   Jung,D.J., Sung,H.S., Goo,Y.W., Lee,H.M., Park,O.K., Jung,S.Y.,
            Lim,J., Kim,H.J., Lee,S.K., Kim,T.S., Lee,J.W. and Lee,Y.C.
  TITLE     Novel transcription coactivator complex containing activating
            signal cointegrator 1
  JOURNAL   Mol Cell Biol 22 (14), 5203-5211 (2002)
   PUBMED   12077347
REFERENCE   10 (bases 1 to 8111)
  AUTHORS   Coulie,P.G., Ikeda,H., Baurain,J.F. and Chiari,R.
  TITLE     Antitumor immunity at work in a melanoma patient
  JOURNAL   Adv Cancer Res 76, 213-242 (1999)
   PUBMED   10218103
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK299117.1, AL133338.8,
            AL834463.1, AL356122.9, AL121965.19, Z86062.1, BX415629.2 and
            AA788717.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006828.3.
            
            Summary: This gene encodes a protein that belongs to a family of
            helicases that are involved in the ATP-dependent unwinding of
            nucleic acid duplexes. The encoded protein is the largest subunit
            of the activating signal cointegrator 1 complex that is involved in
            DNA repair and resistance to alkylation damage. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Sep
            2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.199510.1,
                                           SRR1803615.270251.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369162.7/ ENSP00000358159.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AK299117.1         44-75
            33-33               AL133338.8         69004-69004         c
            34-272              AK299117.1         77-315
            273-745             AL834463.1         1-473
            746-746             AL133338.8         36220-36220         c
            747-1639            AL834463.1         475-1367
            1640-1640           AL356122.9         59240-59240         c
            1641-2557           AL834463.1         1369-2285
            2558-2558           AL121965.19        21990-21990
            2559-3879           AL834463.1         2287-3607
            3880-3880           AL121965.19        54968-54968
            3881-6108           AL834463.1         3609-5836
            6109-6109           Z86062.1           117710-117710       c
            6110-7571           AL834463.1         5838-7299
            7572-7886           BX415629.2         191-505             c
            7887-8111           AA788717.1         11-235              c
FEATURES             Location/Qualifiers
     source          1..8111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.3"
     gene            1..8111
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /note="activating signal cointegrator 1 complex subunit 3"
                     /db_xref="GeneID:10973"
                     /db_xref="HGNC:HGNC:18697"
                     /db_xref="MIM:614217"
     exon            1..269
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            270..400
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..6919
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /EC_number="3.6.4.12"
                     /note="isoform a is encoded by transcript variant 1; RNA
                     helicase family; ASC-1 complex subunit P200; helicase, ATP
                     binding 1; trip4 complex subunit p200"
                     /codon_start=1
                     /product="activating signal cointegrator 1 complex subunit
                     3 isoform a"
                     /protein_id="NP_006819.2"
                     /db_xref="CCDS:CCDS5046.1"
                     /db_xref="GeneID:10973"
                     /db_xref="HGNC:HGNC:18697"
                     /db_xref="MIM:614217"
                     /translation="MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLG
                     LTWKKIIKFLNEKLEKSKMQSINEDLKDILHAAKQIVGTDNGREAIESGAAFLFMTFH
                     LKDSVGHKETKAIKQMFGPFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDR
                     VFFGKNLAFSFDMHDLDHFDELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKT
                     NGSFLWCEVEKYLNSTLKEMTEVPRVEDLCCTLYDMLASIKSGDELQDELFELLGPEG
                     LELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENAKPNYGCQVTIQSEQEK
                     QLMKQYRREEKRIARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQ
                     RDADVEKIHYPHVYDSQAEAMKTSAFIAGAKMILPEGIQRENNKLYEEVRIPYSEPMP
                     LSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNI
                     AMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTG
                     DMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLLHEDRGPVL
                     ESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLG
                     QTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVRTAMSLIERAK
                     NCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLF
                     SNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRP
                     QFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAV
                     KWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEER
                     TGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEE
                     IEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAAR
                     IVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKL
                     TVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYA
                     DFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEP
                     LPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEA
                     LYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYI
                     APLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSR
                     SWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALA
                     NARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSH
                     SPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKL
                     TLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYY
                     DGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESS
                     LLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFL
                     SHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECST
                     EELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLS
                     RAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKD
                     SSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVES
                     ELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKL
                     HADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKR
                     VGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQYDIYLNVTQASLSAQVNT
                     KVSDSLTDLALK"
     exon            401..551
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            552..1111
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1232
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1437
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1579
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1705
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1906
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2047
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2212
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2389
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2461
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2596
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2788
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..3013
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3133
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3298
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3385
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3562
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3788
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3789..3943
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4042
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4043..4211
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4432
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4433..4518
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..4685
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4686..4831
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4832..4952
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            4953..5095
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5096..5233
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5234..5354
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5355..5487
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5488..5613
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5614..5725
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5726..5860
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            5861..6085
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6086..6237
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6238..6385
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6386..6595
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6596..6771
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     exon            6772..8111
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7552..7557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /note="hexamer: AATATA"
     polyA_site      7571
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /note="major polyA site"
     regulatory      7834..7839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /note="hexamer: AAGAAA"
     polyA_site      7860
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
     regulatory      8089..8094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
                     /note="hexamer: AATAAA"
     polyA_site      8111
                     /gene="ASCC3"
                     /gene_synonym="ASC1p200; HELIC1; MRT81; RNAH"
ORIGIN      
        1 actctgtccc tcctcgccgg gtctgtgcgt ctttgcgtct gtctgtctga ctgatggtcc
       61 tcacacgcgg ttccctgtga ctgggcgcga ccccggcaag cgcggcttgg agggcggacg
      121 gggcgcggcg atacagctgc ccgctcgcat ctttggccct gcgctcagct cctcacccgg
      181 cgtgggaagt taaagtaaaa ccgaaaggga agaaggcgcg gtggcaggag ctgacagagt
      241 gatgggaaac gcgtgagcca ggccgagagt ttcaggtttc ttgctgtatg gatcactgat
      301 tgaataatag atggctttac ctcgtctcac aggagccttg cgttcctttt caaatgtcac
      361 caagcaagat aattataatg aagaagtggc tgacttaaag ataaagcgat ctaaacttca
      421 tgaacaagtt ttagatttgg gcctgacatg gaagaagata ataaaatttt tgaatgaaaa
      481 actggagaag agtaaaatgc aaagtataaa tgaagactta aaagatatat tacatgctgc
      541 aaagcagata gttggaactg ataatgggag agaagcaatt gaaagtgggg ctgcatttct
      601 cttcatgaca tttcacttga aggactctgt tggtcacaag gaaacaaagg ctatcaaaca
      661 gatgtttggc ccctttcctt catcatctgc cactgcagct tgtaatgcta ctaatcgaat
      721 tatttctcat tttagtcaag atgatcttac tgctcttgtg cagatgacag aaaaagaaca
      781 tggcgatagg gttttttttg gtaaaaattt agcattttca tttgacatgc atgatttgga
      841 ccactttgac gaactgccaa taaatggtga aactcagaaa actataagcc tagattataa
      901 gaagtttctg aatgaacatc tccaggaggc ttgcacccca gaactcaagc ctgtggaaaa
      961 aacaaatggc tcctttttgt ggtgtgaagt tgaaaagtac ctaaattcaa ctttgaagga
     1021 aatgactgaa gtgccaagag tagaagatct ttgctgtact ttatatgata tgcttgcttc
     1081 tattaaaagt ggtgatgaac ttcaggatga gctatttgaa ctgctgggac ctgaaggact
     1141 tgaacttatt gagaaactcc tccagaacag aattacaatt gtggatagat ttcttaattc
     1201 ttcaaatgat cataggtttc aggctcttca agacaattgt aaaaaaattt taggagaaaa
     1261 tgctaaaccc aattatggtt gtcaagtcac tattcagtct gaacaagaaa agcagttaat
     1321 gaaacaatat cgacgtgaag aaaaaagaat tgccagacga gaaaaaaagg ctggagaaga
     1381 tttagaagtt tcagaaggac ttatgtgctt tgatcctaag gaattgcgga tacaaagaga
     1441 acaggcactt ctgaatgcta gaagtgttcc aattctgagc aggcagagag atgcagacgt
     1501 tgaaaaaata cattatcccc atgtgtatga ttcccaggct gaagccatga aaacatcagc
     1561 atttattgct ggtgcaaaga tgattttgcc agaaggaatc caaagagaga ataacaagct
     1621 ttatgaagaa gtaaggattc cctacagcga accaatgcca ctcagctttg aggaaaagcc
     1681 agtttatatc caagacttag atgagatcgg acagctggct tttaaaggaa tgaagagact
     1741 caatagaatc cagtcaatag tgtttgagac tgcctacaac accaatgaga acatgctgat
     1801 ttgtgcccct acaggagctg gaaaaaccaa cattgcaatg ctgacagtct tgcatgaaat
     1861 tcgccaacat tttcaacaag gtgttatcaa aaagaatgaa tttaagattg tatatgttgc
     1921 tccaatgaaa gccttggcag ctgaaatgac agattacttc agcagacgtc tagagccact
     1981 aggcatcatt gtgaaagaat tgactggtga catgcagttg tccaaaagtg aaattttacg
     2041 aactcagatg cttgtgacca caccagaaaa atgggatgta gtgacaagaa agagtgttgg
     2101 ggatgtagct ctttcccaga ttgtaaggct ccttattctt gatgaagttc atttgctgca
     2161 tgaagataga ggaccagtat tagaaagcat agttgcccgt actttacggc aggtggaatc
     2221 cacacagagt atgataagga ttctcggact gtctgcaact ttacctaact acctcgatgt
     2281 tgccacattt ttacatgtta atccatacat tggacttttc ttctttgatg gccgttttcg
     2341 accagtacct cttggacaga catttttggg gattaaatgt gcaaataaga tgcagcagtt
     2401 gaataacatg gatgaagtat gttatgaaaa tgttttgaag caagtaaagg ctggacacca
     2461 ggtgatggtg tttgtacatg ctcgaaatgc cactgtaaga acagctatgt ctctaataga
     2521 aagagcaaaa aattgtggcc atattccctt cttttttcct acccaaggac atgactatgt
     2581 acttgcagaa aaacaggtac aaaggtcgag aaataagcaa gtacgagaat tattcccaga
     2641 tggttttagt attcatcatg caggaatgct tcggcaggac agaaatttag ttgaaaactt
     2701 gttttctaat gggcatatca aagtcctagt gtgtacagct acgttagcct ggggtgtcaa
     2761 tcttcccgcc catgctgtta ttattaaggg aacacaaata tatgctgcaa aaagaggctc
     2821 ctttgttgac cttggaattt tagatgtcat gcagatattt ggtcgagctg gacgaccaca
     2881 atttgacaaa tttggggaag gaataattat aacaacgcat gataaactca gccattacct
     2941 cactttgctc actcaacgaa acccaattga gagtcagttt ctggaaagcc ttgcagataa
     3001 cctaaatgca gagattgctc tgggaacagt tactaatgtg gaagaagcag tgaagtggat
     3061 aagttacact tatctttatg tacggatgag agcaaatcca ttagcatatg gcatcagtca
     3121 caaggcttat cagattgacc caacattaag aaagcatcga gaacagttgg tcattgaagt
     3181 tggacgaaaa ctagacaaag ctcagatgat tcgttttgag gagcgaactg gatatttttc
     3241 ctcaactgat ttgggtagaa ctgccagcca ttactatatt aaatacaaca ccattgagac
     3301 ctttaatgaa ctctttgatg ctcacaaaac agaaggtgat atctttgcca tagtctccaa
     3361 agctgaagaa tttgatcaaa ttaaggtcag agaagaggaa atagaggagt tagatacctt
     3421 attaagcaat ttttgtgaac tctccactcc tggaggtgta gagaatagtt atgggaaaat
     3481 aaacatctta cttcaaactt atatcagccg aggagaaatg gacagtttct cccttatatc
     3541 agattctgca tatgttgcac agaatgcagc tagaattgtc cgtgctcttt ttgaaattgc
     3601 tctgaggaaa cgttggccta ccatgaccta caggctcctg aatcttagta aagtcattga
     3661 caagaggctt tggggttggg ctagcccttt gagacaattt tcaatcctac caccacacat
     3721 cctaacaaga ttagaagaaa aaaagcttac tgtggataag ctgaaagaca tgaggaaaga
     3781 tgaaataggt cacattttac atcatgtgaa tattggactg aaggtcaaac aatgtgttca
     3841 tcagattcct tctgttatga tggaagcatc cattcagcct atcacaagga ctgtcctccg
     3901 agtgacactc agcatctatg ctgatttcac ttggaatgat caggtacatg ggacagtagg
     3961 agaaccttgg tggatttggg tagaagatcc tacaaatgat catatttatc attcagagta
     4021 ttttctagct ctaaaaaaac aagtcattag taaagaagcc caactactgg tatttacaat
     4081 ccctattttt gagcctttgc cttcccaata ctacatccga gcagtgtctg atagatggtt
     4141 gggtgctgag gcagtatgta ttatcaactt tcaacatcta attctaccag agagacatcc
     4201 tcctcataca gaattactgg atcttcagcc tttaccaatc acagctttgg gatgtaaagc
     4261 atatgaagcc ctgtacaact tcagccactt taaccctgta cagacacaaa tatttcatac
     4321 attgtatcac acggattgta atgtcctact tggagcacct actggatcgg gaaagactgt
     4381 tgcagctgaa ttagccattt tcagagtctt caacaaatac cctacttcaa aggcggtata
     4441 tattgcaccc ctaaaagccc tagtacgtga aagaatggat gattggaaag ttagaataga
     4501 agaaaaactt ggtaaaaaag ttattgaact aacaggggat gtgactcctg atatgaaatc
     4561 cattgccaag gctgacctta tcgtcactac gccagagaag tgggatggag tcagcagaag
     4621 ctggcaaaat aggaactatg ttcagcaagt cactattctc atcatagatg agatccatct
     4681 gcttggggag gaaagaggcc ctgttctaga ggtcattgta tctcgaacaa attttatctc
     4741 atcacacaca gaaaagcctg ttagaatagt tggactatct actgcattag ctaatgccag
     4801 agaccttgct gattggctca atattaagca gatgggcttg tttaacttcc gaccatcagt
     4861 acgcccagtt ccactggaag ttcacattca aggctttcca ggtcaacatt actgtcctcg
     4921 tatggctagt atgaacaagc ctgcatttca ggcaattaga agccattctc cagccaaacc
     4981 tgttttgata tttgtctcat caagacgtca aactcgtctt actgctttgg aattgatcgc
     5041 cttcctggct actgaagaag atccaaagca gtggttaaac atggatgaaa gagagatgga
     5101 gaacatcatt gcaacagtaa gagattccaa cctcaagctg acccttgctt tcgggatagg
     5161 aatgcatcat gctggactac atgagaggga ccgaaaaaca gtagaggaac tatttgtaaa
     5221 ctgtaaagtt caggttctta ttgctacaag cacattagcc tggggtgtaa actttccagc
     5281 tcatttagta attattaagg gaacagaata ctatgatgga aaaacaagac gttatgtgga
     5341 ttttcccatt acagatgtcc tccagatgat ggggcgtgct gggaggccgc agttcgatga
     5401 ccaaggcaaa gctgtaattc tagttcatga cataaagaaa gacttttata aaaaatttct
     5461 ttatgaacct ttcccagtag aatcaagttt attaggagtg ctctctgacc acttaaatgc
     5521 agagattgct ggtggtacaa ttacatctaa gcaagatgca ttggattata tcacctggac
     5581 ttactttttc cgacgtctta tcatgaatcc cagctattac aatttgggtg atgtgagcca
     5641 tgattctgtg aacaagtttc tgtcccatct gattgagaag tccctgattg aattggaact
     5701 ttcctactgt attgaaattg gagaggataa tcgcagcatt gaacctctaa cttatggccg
     5761 aattgcctcc tattactatt tgaagcatca aacagttaaa atgttcaagg accgcttgaa
     5821 gcctgaatgc agtactgaag aactgctttc aattctaagt gatgcagaag aatatacaga
     5881 tttgccagtg agacacaatg aagatcatat gaatagtgaa ctggcaaaat gtcttcccat
     5941 tgaatcaaat cctcattcat ttgacagccc tcacaccaaa gcacatctcc tgctacaggc
     6001 acatctcagc cgagccatgc taccctgccc agattatgac actgatacca aaacagtctt
     6061 ggaccaagct ctcagagtat gtcaggcaat gctggacgtg gctgcaaacc agggctggct
     6121 ggtgactgtc ctgaatatca ccaacctgat tcagatggtg atccagggtc ggtggttaaa
     6181 ggactcttct cttcttacac taccaaacat agaaaaccat catcttcacc ttttcaagaa
     6241 atggaagccg attatgaagg gcccacatgc taggggtcgg acctccatcg agtcccttcc
     6301 tgaactgatc catgcctgtg gagggaaaga ccatgtattt agctccatgg tagaaagtga
     6361 gctacatgct gcaaaaacga aacaggcatg gaatttctta tctcacttgc cagtgataaa
     6421 tgttggcata agtgttaaag gctcgtggga tgacttagtt gaaggacata atgaactctc
     6481 tgtctcaact ctgactgcag acaaacgaga tgacaacaaa tggatcaaat tgcatgctga
     6541 ccaagagtat gtgcttcaag tgagcttgca gagagtccac tttgggttcc acaagggaaa
     6601 gccagagagc tgtgcagtta ctcctcgatt tcccaaatca aaagacgaag gatggttttt
     6661 gatattagga gaagtggata agagagaact tattgctttg aaaagagtag gatatattcg
     6721 aaatcatcat gttgcttccc tttcttttta tacccctgaa atacctggaa ggtatatcta
     6781 cacattatat ttcatgagtg actgctacct tggcctggac cagcagtatg acatctatct
     6841 caacgttaca caagcgagtc tttctgcaca ggtcaacacc aaggtctctg attccctgac
     6901 tgacctggca ttaaagtaac ttgacctgaa caatccattt gaaaggagtg gctaagaatt
     6961 ctctctgttc agtcatctag acaaatcgaa ttacttgatg tttgccttga aagaatcaac
     7021 ttctaacctc aaccatccag gaaattgaca gtggctgcag tattgactcc agtgacataa
     7081 agttaaccac agtggccttt taacaaatgt tgccttttat aatgttatct ttatgagttt
     7141 cttgatatgt aagatgaaaa agcatttaga ataatctttt aatttgtgta tatttgggat
     7201 gatatttagg agctatcaat caaattttac atctcacaat gtactgttta catggatatt
     7261 ggctgctttt tttaaggaaa accacattga gatgtgacaa gtgttaggac ttgtcacaga
     7321 tttctaactc tgccgcataa actataaatc tgtaaggtgg tacacagcgt gtcttgttag
     7381 caaaatttat actttgatat gatcacatgt agaagtagct tcaagaattt cttgtagtca
     7441 taaatgttta ataatatatg atgtaaaatt atattatgga gcctaatgat gataacaaag
     7501 aaaacaatat actgatctta gaaaatgtag acatggttaa ctgggaaata aaatatagag
     7561 tggcacttca agacaagctg actcaatgtt ttcttctgct tcctttaaat aatatcccct
     7621 tactcatctg ttcttctttt ctttcccttc tacttcaagg ctttatttct attatctttc
     7681 tgacatattt atttacagaa gtagagaagt ataatctaat tcatgttgta gcacttacag
     7741 atcatatagt acaattattt gtctttatgc tctccaggaa aaatctgaga cagaaaattt
     7801 ttcaccccta tggataggtt ttcacctgta ataaagaaaa tttctctatg tccaaacaaa
     7861 ttccttcttg aaaaatactt tttcaaacta aaaacttgtt aaaattcaat gttcatataa
     7921 tatgcattct agtggaatga aattctacct ttgtgaaata atttcagttt tcttagccct
     7981 aaaatgaatt attttaaaac attttccaat gtcattgtta caaatactag aatttaagtg
     8041 tttctgaaat tggaatgtat tgcttgtata tatccttttc catgcttaaa taaaaaagaa
     8101 gaagaaataa a
//
