LOCUS       NM_032204               2790 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens activating signal cointegrator 1 complex subunit 2
            (ASCC2), transcript variant 1, mRNA.
ACCESSION   NM_032204
VERSION     NM_032204.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2790)
  AUTHORS   Narita,M., Denk,T., Matsuo,Y., Sugiyama,T., Kikuguchi,C., Ito,S.,
            Sato,N., Suzuki,T., Hashimoto,S., Machova,I., Tesina,P.,
            Beckmann,R. and Inada,T.
  TITLE     A distinct mammalian disome collision interface harbors K63-linked
            polyubiquitination of uS10 to trigger hRQT-mediated subunit
            dissociation
  JOURNAL   Nat Commun 13 (1), 6411 (2022)
   PUBMED   36302773
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2790)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2790)
  AUTHORS   Yang,Y. and Xu,X.
  TITLE     Identification of key genes in coronary artery disease: an
            integrative approach based on weighted gene co-expression network
            analysis and their correlation with immune infiltration
  JOURNAL   Aging (Albany NY) 13 (6), 8306-8319 (2021)
   PUBMED   33686958
  REMARK    GeneRIF: Identification of key genes in coronary artery disease: an
            integrative approach based on weighted gene co-expression network
            analysis and their correlation with immune infiltration.
REFERENCE   4  (bases 1 to 2790)
  AUTHORS   Jia,J., Absmeier,E., Holton,N., Pietrzyk-Brzezinska,A.J.,
            Hackert,P., Bohnsack,K.E., Bohnsack,M.T. and Wahl,M.C.
  TITLE     The interaction of DNA repair factors ASCC2 and ASCC3 is affected
            by somatic cancer mutations
  JOURNAL   Nat Commun 11 (1), 5535 (2020)
   PUBMED   33139697
  REMARK    GeneRIF: The interaction of DNA repair factors ASCC2 and ASCC3 is
            affected by somatic cancer mutations.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2790)
  AUTHORS   Juszkiewicz,S., Speldewinde,S.H., Wan,L., Svejstrup,J.Q. and
            Hegde,R.S.
  TITLE     The ASC-1 Complex Disassembles Collided Ribosomes
  JOURNAL   Mol Cell 79 (4), 603-614 (2020)
   PUBMED   32579943
REFERENCE   6  (bases 1 to 2790)
  AUTHORS   Soll,J.M., Brickner,J.R., Mudge,M.C. and Mosammaparast,N.
  TITLE     RNA ligase-like domain in activating signal cointegrator 1 complex
            subunit 1 (ASCC1) regulates ASCC complex function during alkylation
            damage
  JOURNAL   J Biol Chem 293 (35), 13524-13533 (2018)
   PUBMED   29997253
REFERENCE   7  (bases 1 to 2790)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   8  (bases 1 to 2790)
  AUTHORS   Knierim,E., Hirata,H., Wolf,N.I., Morales-Gonzalez,S.,
            Schottmann,G., Tanaka,Y., Rudnik-Schoneborn,S., Orgeur,M.,
            Zerres,K., Vogt,S., van Riesen,A., Gill,E., Seifert,F., Zwirner,A.,
            Kirschner,J., Goebel,H.H., Hubner,C., Stricker,S., Meierhofer,D.,
            Stenzel,W. and Schuelke,M.
  TITLE     Mutations in Subunits of the Activating Signal Cointegrator 1
            Complex Are Associated with Prenatal Spinal Muscular Atrophy and
            Congenital Bone Fractures
  JOURNAL   Am J Hum Genet 98 (3), 473-489 (2016)
   PUBMED   26924529
REFERENCE   9  (bases 1 to 2790)
  AUTHORS   Lee,J.H., Cheng,R., Honig,L.S., Feitosa,M., Kammerer,C.M.,
            Kang,M.S., Schupf,N., Lin,S.J., Sanders,J.L., Bae,H., Druley,T.,
            Perls,T., Christensen,K., Province,M. and Mayeux,R.
  TITLE     Genome wide association and linkage analyses identified three
            loci-4q25, 17q23.2, and 10q11.21-associated with variation in
            leukocyte telomere length: the Long Life Family Study
  JOURNAL   Front Genet 4, 310 (2014)
   PUBMED   24478790
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2790)
  AUTHORS   Jung,D.J., Sung,H.S., Goo,Y.W., Lee,H.M., Park,O.K., Jung,S.Y.,
            Lim,J., Kim,H.J., Lee,S.K., Kim,T.S., Lee,J.W. and Lee,Y.C.
  TITLE     Novel transcription coactivator complex containing activating
            signal cointegrator 1
  JOURNAL   Mol Cell Biol 22 (14), 5203-5211 (2002)
   PUBMED   12077347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP201867.1 and BC025368.2.
            
            On Nov 22, 2018 this sequence version replaced NM_032204.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025368.2, SRR1803613.190231.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307790.8/ ENSP00000305502.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BP201867.1         31-39
            10-2790             BC025368.2         1-2781
FEATURES             Location/Qualifiers
     source          1..2790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..2790
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /note="activating signal cointegrator 1 complex subunit 2"
                     /db_xref="GeneID:84164"
                     /db_xref="HGNC:HGNC:24103"
                     /db_xref="MIM:614216"
     exon            1..97
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            98..195
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2388
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /note="isoform 1 is encoded by transcript variant 1; ASC-1
                     complex subunit P100; trip4 complex subunit p100"
                     /codon_start=1
                     /product="activating signal cointegrator 1 complex subunit
                     2 isoform 1"
                     /protein_id="NP_115580.2"
                     /db_xref="CCDS:CCDS13869.1"
                     /db_xref="GeneID:84164"
                     /db_xref="HGNC:HGNC:24103"
                     /db_xref="MIM:614216"
                     /translation="MPALPLDQLQITHKDPKTGKLRTSPALHPEQKADRYFVLYKPPP
                     KDNIPALVEEYLERATFVANDLDWLLALPHDKFWCQVIFDETLQKCLDSYLRYVPRKF
                     DEGVASAPEVVDMQKRLHRSVFLTFLRMSTHKESKDHFISPSAFGEILYNNFLFDIPK
                     ILDLCVLFGKGNSPLLQKMIGNIFTQQPSYYSDLDETLPTILQVFSNILQHCGLQGDG
                     ANTTPQKLEERGRLTPSDMPLLELKDIVLYLCDTCTTLWAFLDIFPLACQTFQKHDFC
                     YRLASFYEAAIPEMESAIKKRRLEDSKLLGDLWQRLSHSRKKLMEIFHIILNQICLLP
                     ILESSCDNIQGFIEEFLQIFSSLLQEKRFLRDYDALFPVAEDISLLQQASSVLDETRT
                     AYILQAVESAWEGVDRRKATDAKDPSVIEEPNGEPNGVTVTAEAVSQASSHPENSEEE
                     ECMGAAAAVGPAMCGVELDSLISQVKDLLPDLGEGFILACLEYYHYDPEQVINNILEE
                     RLAPTLSQLDRNLDREMKPDPTPLLTSRHNVFQNDEFDVFSRDSVDLSRVHKGKSTRK
                     EENTRSLLNDKRAVAAQRQRYEQYSVVVEEVPLQPGESLPYHSVYYEDEYDDTYDGNQ
                     VGANDADSDDELISRRPFTIPQVLRTKVPREGQEEDDDDEEDDADEEAPKPDHFVQDP
                     AVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQSRETTQERRKKEANKATRANH
                     NRRTMADRKRSKGMIPS"
     exon            196..354
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            355..525
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            526..655
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            656..723
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            724..834
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            835..947
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1022
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1130
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1199
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1274
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1467
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1682
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1802
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1902
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2033
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2136
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2216
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2790
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /note="hexamer: AATAAA"
     polyA_site      2790
                     /gene="ASCC2"
                     /gene_synonym="ASC1p100; p100"
                     /note="major polyA site"
ORIGIN      
        1 agtttgaccc cggaagtgcg ggcgctcagg gagctgtcac cgtggtcggc ggcggcggcg
       61 gcggcggcgg cacagagccg gtggtggagc cgccgaggag ggtcacgcag cacaatgcca
      121 gctctgcccc tggaccaact ccagatcacc cacaaggacc cgaagacagg aaagctgagg
      181 acttcaccag cgctgcaccc cgagcagaag gcagaccggt attttgtgtt atacaaaccg
      241 ccccctaaag acaacattcc cgccctagtg gaggagtacc tggaacgcgc caccttcgta
      301 gccaatgacc tcgactggct cctggccttg cctcacgata aattctggtg ccaggtgatc
      361 tttgacgaga ctctacagaa gtgcctggac tcctacctgc gctatgtccc ccgcaaattc
      421 gacgaggggg tggcctcagc ccctgaggtt gttgacatgc agaagcgcct ccatcgaagt
      481 gtttttctca ccttcctccg catgtccact cacaaggaat ccaaagatca cttcatttcc
      541 ccttctgcgt ttggagaaat cctctacaat aacttcctct ttgacattcc aaagatcctg
      601 gacctctgcg tgctctttgg aaaaggcaac tcaccactgc tccagaagat gataggaaac
      661 atctttacac agcagccaag ttactacagt gacctggatg aaaccctgcc taccatcctt
      721 caggtcttca gcaatatcct ccagcactgt ggtttgcaag gggacggggc caataccaca
      781 ccccagaagc ttgaggagag gggccgattg acccccagtg acatgcctct cctggaatta
      841 aaggacattg ttctctacct ttgtgatacc tgcaccacac tttgggcctt tctggatatc
      901 ttccctttgg cttgccagac cttccagaag cacgactttt gttacagact agcttccttc
      961 tacgaagcag caattcccga aatggagtct gcaattaaga agaggaggct tgaagatagc
     1021 aagcttcttg gtgacctgtg gcagaggctc tcccattcca ggaagaagct aatggagatt
     1081 ttccacatca tcctgaacca gatctgcctc cttcccatcc tagaaagcag ctgtgacaac
     1141 attcagggct tcatcgaaga gttccttcag atcttcagct ccttgctgca ggagaagagg
     1201 ttcctccggg actatgatgc actcttcccc gtggccgaag acatcagctt gctgcagcag
     1261 gcctcatcag tcttggacga gacgcggact gcctacatcc tccaggcagt cgagagtgca
     1321 tgggaagggg tggacagacg gaaagccaca gatgctaaag acccatcggt gattgaggag
     1381 cctaatgggg agcctaacgg ggtcacggtg acagcagagg cagtcagtca agcatcatca
     1441 catccggaga actcggagga agaggagtgc atgggagcag ccgcggctgt gggccctgcc
     1501 atgtgtgggg tggaactgga ctctctcatc tcccaagtga aggacctgct gccagacctt
     1561 ggtgagggct tcatcctggc ctgcctggag tactaccact acgacccaga gcaggtgatc
     1621 aacaatatcc tggaggagcg gctggccccc accctcagcc agctggaccg caacctagac
     1681 agagaaatga aaccagaccc tacacccctg ctgacgtctc gccacaacgt cttccagaat
     1741 gacgagtttg atgtgttcag cagggactca gtagacctga gccgggtgca caagggcaag
     1801 agcaccagga aggaggaaaa cacgcggagt ttgctgaacg acaagcgtgc agtggcggca
     1861 cagcggcagc gctacgagca gtacagcgtg gtggtggagg aggtgccact gcagccaggc
     1921 gagagcctgc cctaccacag tgtctactac gaggatgagt acgatgacac atacgatggc
     1981 aaccaggtgg gcgccaatga tgcagactct gatgacgagc tcatcagccg caggccattc
     2041 accatccctc aggtgctgag aaccaaagtg cctagagaag ggcaggagga ggatgacgac
     2101 gatgaggaag acgatgctga cgaggaggct cccaagcccg accattttgt tcaggaccct
     2161 gcagtgctga gagagaaggc agaagccagg cgcatggcct ttctcgccaa gaaagggtac
     2221 cggcatgaca gctcaacagc agtggccggc agcccccgag gccatgggca gagccgcgag
     2281 acaacccagg aacgcaggaa gaaggaagcc aacaaggcga caagagccaa ccacaaccgg
     2341 agaaccatgg ccgaccgcaa gaggagcaaa ggcatgatcc catcctgaga cctggtgcag
     2401 ggccagtggg gaggcagcgg caccagactc accaggccgt gctcccatcg cctggggcct
     2461 cctcactagg ggccccaagt tcaactcaac ccctcaacag cctcagcttt gcagcccctg
     2521 agaaggccgc ctctcatcta ccagccagcc atgagcgcct tcctgcagaa cacacagtgc
     2581 cttatgccac agccgaagaa tccgtggggc cggcaagcag gcaccttccc ccagctgcgc
     2641 tagcgggaaa gagatgggga tggagtccca aggcaagcgc cccaaacctc gggccacaag
     2701 acaccacttc ccctttaccc tggacagcag gaaacctgta tattcaaaaa cacaaaaagt
     2761 cctgctaata aaatttttga ccctttcaaa
//
