LOCUS       NM_001031739            1613 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 9 (ASB9),
            transcript variant 1, mRNA.
ACCESSION   NM_001031739
VERSION     NM_001031739.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1613)
  AUTHORS   Li,N., Zhou,Q., Yi,Z., Zhang,H. and Zhou,D.
  TITLE     Ubiquitin protein E3 ligase ASB9 suppresses proliferation and
            promotes apoptosis in human spermatogonial stem cell line by
            inducing HIF1AN degradation
  JOURNAL   Biol Res 56 (1), 4 (2023)
   PUBMED   36683111
  REMARK    GeneRIF: Ubiquitin protein E3 ligase ASB9 suppresses proliferation
            and promotes apoptosis in human spermatogonial stem cell line by
            inducing HIF1AN degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1613)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1613)
  AUTHORS   Lumpkin,R.J., Ahmad,A.S., Blake,R., Condon,C.J. and Komives,E.A.
  TITLE     The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases
  JOURNAL   Mol Cell Proteomics 20, 100019 (2021)
   PUBMED   33268465
REFERENCE   4  (bases 1 to 1613)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1613)
  AUTHORS   Lumpkin,R.J., Baker,R.W., Leschziner,A.E. and Komives,E.A.
  TITLE     Structure and dynamics of the ASB9 CUL-RING E3 Ligase
  JOURNAL   Nat Commun 11 (1), 2866 (2020)
   PUBMED   32513959
  REMARK    GeneRIF: Structure and dynamics of the ASB9 CUL-RING E3 Ligase.
            Erratum:[Nat Commun. 2023 Nov 17;14(1):7463. doi:
            10.1038/s41467-023-43056-x.. PMID: 37978300]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1613)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   7  (bases 1 to 1613)
  AUTHORS   Fei,X., Zhang,Y., Gu,X., Qiu,R., Mao,Y. and Ji,C.
  TITLE     Crystallization and preliminary X-ray analysis of the splice
            variant of human ankyrin repeat and suppressor of cytokine
            signaling box protein 9 (hASB9-2)
  JOURNAL   Protein Pept Lett 15 (6), 647-649 (2008)
   PUBMED   18680464
  REMARK    GeneRIF: The splice variant of hASB9, hASB9-2 protein, was cloned,
            overexpressed, and crystallized and the data showed that the cubic
            hASB9-2 crystal belongs to space group P4(3)32 with unit-cell
            parameters.
REFERENCE   8  (bases 1 to 1613)
  AUTHORS   Debrincat,M.A., Zhang,J.G., Willson,T.A., Silke,J., Connolly,L.M.,
            Simpson,R.J., Alexander,W.S., Nicola,N.A., Kile,B.T. and
            Hilton,D.J.
  TITLE     Ankyrin repeat and suppressors of cytokine signaling box protein
            asb-9 targets creatine kinase B for degradation
  JOURNAL   J Biol Chem 282 (7), 4728-4737 (2007)
   PUBMED   17148442
REFERENCE   9  (bases 1 to 1613)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   10 (bases 1 to 1613)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA943920.1, BC013172.1 and
            BC001244.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001031739.2.
            
            Summary: This gene encodes a member of the ankyrin repeat and
            suppressor of cytokine signaling (SOCS) box protein family. Members
            of this family can interact with the elongin B-C adapter complex
            via their SOCS box domain and further complex with the cullin and
            ring box proteins to form E3 ubiquitin ligase complexes. They may
            function to mediate the substrate-recognition of the E3 ubiquitin
            ligases. A transcribed pseudogene of this gene has been identified
            on chromosome 15. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013172.1, SRR5189658.107568.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380488.9/ ENSP00000369855.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DA943920.1         89-101
            14-1289             BC013172.1         52-1327
            1290-1613           BC001244.1         1289-1612
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..1613
                     /gene="ASB9"
                     /note="ankyrin repeat and SOCS box containing 9"
                     /db_xref="GeneID:140462"
                     /db_xref="HGNC:HGNC:17184"
                     /db_xref="MIM:300890"
     exon            1..303
                     /gene="ASB9"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..1094
                     /gene="ASB9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and SOCS box protein 9; ankyrin repeat and
                     suppressor of cytokine signaling box protein 9; ASB-9;
                     testis tissue sperm-binding protein Li 57p"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 9 isoform 1"
                     /protein_id="NP_001026909.1"
                     /db_xref="CCDS:CCDS35208.1"
                     /db_xref="GeneID:140462"
                     /db_xref="HGNC:HGNC:17184"
                     /db_xref="MIM:300890"
                     /translation="MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAA
                     IHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADW
                     HTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNI
                     DHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLL
                     MDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHH
                     KITKLVLPEDLKQFLLHL"
     exon            304..383
                     /gene="ASB9"
                     /inference="alignment:Splign:2.1.0"
     exon            384..491
                     /gene="ASB9"
                     /inference="alignment:Splign:2.1.0"
     exon            492..642
                     /gene="ASB9"
                     /inference="alignment:Splign:2.1.0"
     exon            643..777
                     /gene="ASB9"
                     /inference="alignment:Splign:2.1.0"
     exon            778..969
                     /gene="ASB9"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1613
                     /gene="ASB9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB9"
                     /note="hexamer: AATAAA"
     regulatory      1587..1592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB9"
                     /note="hexamer: AAGAAA"
     polyA_site      1610
                     /gene="ASB9"
     polyA_site      1613
                     /gene="ASB9"
                     /note="major polyA site"
ORIGIN      
        1 gtacacgagc gcatgcctct ctctgatcac aggtagcact cagattaccc tgcctgctct
       61 gtgctttgct gcagaccatt tgaccagaac gtgtgcagct cagccagcca cagaactgga
      121 atttttcagg agcaggggga gcatggagtt tggactttgc tgagcaactg aagtggagcg
      181 cagagcttgc tcgcttagga gagagcatca tggatggcaa acaagggggc atggatggga
      241 gcaagcccgc ggggccaagg gactttcctg gcatcaggct tctttcaaac ccattgatgg
      301 gcgatgctgt gtctgattgg tctcctatgc atgaagctgc aatccacgga catcagctgt
      361 ctctgaggaa cctcatcagc caggggtggg ctgtgaacat catcacggca gatcatgttt
      421 ccccactcca tgaagcctgt cttggaggtc atctctcttg tgtgaagatt ttattaaagc
      481 atggagctca ggtgaatggt gtgacagcag actggcacac tccactgttt aatgcttgtg
      541 tcagcggcag ctgggattgt gtgaatttgc ttctgcagca cggagccagc gttcaacctg
      601 agagtgatct ggcatccccc atccatgaag ctgctaggag aggccacgtg gagtgtgtca
      661 actctcttat agcttatggg ggcaacattg accataagat cagccacctg ggcactccac
      721 tctatttggc ttgtgaaaac caacagagag cctgtgtcaa gaagcttctg gagtcaggag
      781 cggacgtgaa ccaagggaaa ggtcaggatt ccccacttca tgcagtggcc aggacagcca
      841 gtgaagagct ggcctgcctg ctcatggatt ttggagcgga cacccaggcc aagaatgctg
      901 aaggcaaacg tcctgtggag ctggtgcctc cagagagccc cttggcccag ctcttcttgg
      961 agagagaagg gcccccttct ttgatgcagt tatgccgcct tagaattcgg aagtgttttg
     1021 gaatccagca gcatcataag ataaccaaac tcgtcctccc agaggatctg aaacagtttc
     1081 tcctacatct ttaaatgcat ctagggaatg gattcacaaa cgatgtgaaa acattattga
     1141 gtgttgtagc cactagaatt ttaaaatcaa gttggattta tagagtttga ctagtttttt
     1201 cgattagatt tgtatttgtt ataaacttgt ttatggagtt tgactaattt tttctattca
     1261 atttgtattt gttaaactca agccagggtt gaaagacact gcatacgttt gtattattag
     1321 ttagaaggca tgaagacttt tttccctgca tggagagtgt cataagttat tgttttgcat
     1381 atctactgca tgccaagcac tttctgcatc atctaattta gccctcacag ccactgggtc
     1441 aagatgtcca attttccaga gtaaggatag aggagtcaaa ttcaaataca ggttttctga
     1501 cattaactta tgtgatgact tgatcgaggc aggcttttcc agcatcactg tcctggttcc
     1561 atctctgcta tatgggaatg aaaataaaga aacatatttc ttggcttgtc taa
//
