LOCUS       NM_017873               4603 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 6 (ASB6),
            transcript variant 1, mRNA.
ACCESSION   NM_017873
VERSION     NM_017873.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4603)
  AUTHORS   Zeng,W., Zhu,J.F., Guo,J., Huang,G.J., Ai,L.S., Zeng,Y. and
            Liao,W.J.
  TITLE     m6A-modified circFNDC3B inhibits colorectal cancer stemness and
            metastasis via RNF41-dependent ASB6 degradation
  JOURNAL   Cell Death Dis 13 (11), 1008 (2022)
   PUBMED   36446779
  REMARK    GeneRIF: m[6]A-modified circFNDC3B inhibits colorectal cancer
            stemness and metastasis via RNF41-dependent ASB6 degradation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4603)
  AUTHORS   Gong,L., Wang,K., Wang,M., Hu,R., Li,H., Gao,D. and Lin,M.
  TITLE     CUL5-ASB6 Complex Promotes p62/SQSTM1 Ubiquitination and
            Degradation to Regulate Cell Proliferation and Autophagy
  JOURNAL   Front Cell Dev Biol 9, 684885 (2021)
   PUBMED   34164402
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4603)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4603)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4603)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4603)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   7  (bases 1 to 4603)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 4603)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   9  (bases 1 to 4603)
  AUTHORS   Wilcox,A., Katsanakis,K.D., Bheda,F. and Pillay,T.S.
  TITLE     Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts
            with APS to enable recruitment of elongins B and C to the insulin
            receptor signaling complex
  JOURNAL   J Biol Chem 279 (37), 38881-38888 (2004)
   PUBMED   15231829
REFERENCE   10 (bases 1 to 4603)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590369.18.
            
            On Nov 23, 2018 this sequence version replaced NM_017873.3.
            
            Summary: The protein encoded by this gene belongs to a family of
            ankyrin repeat proteins that, along with four other protein
            families, contain a C-terminal SOCS box motif. Growing evidence
            suggests that the SOCS box, similar to the F-box, acts as a bridge
            between specific substrate-binding domains and the more generic
            proteins that comprise a large family of E3 ubiquitin protein
            ligases. Alternatively spliced transcript variants have been
            identified for this gene. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.254876.1,
                                           SRR1803617.22872.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277458.5/ ENSP00000277458.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AL590369.18        26302-26566         c
            266-447             AL590369.18        24956-25137         c
            448-554             AL590369.18        23817-23923         c
            555-663             AL590369.18        23617-23725         c
            664-750             AL590369.18        22988-23074         c
            751-4603            AL590369.18        19020-22872         c
FEATURES             Location/Qualifiers
     source          1..4603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..4603
                     /gene="ASB6"
                     /note="ankyrin repeat and SOCS box containing 6"
                     /db_xref="GeneID:140459"
                     /db_xref="HGNC:HGNC:17181"
                     /db_xref="MIM:615051"
     exon            1..265
                     /gene="ASB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1418
                     /gene="ASB6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and SOCS box protein 6"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 6 isoform 1"
                     /protein_id="NP_060343.1"
                     /db_xref="CCDS:CCDS6924.1"
                     /db_xref="GeneID:140459"
                     /db_xref="HGNC:HGNC:17181"
                     /db_xref="MIM:615051"
                     /translation="MPFLHGFRRIIFEYQPLVDAILGSLGIQDPERQESLDRPSYVAS
                     EESRILVLTELLERKAHSPFYQEGVSNALLKMAELGLTRAADVLLRHGANLNFEDPVT
                     YYTALHIAVLRNQPDMVELLVHHGADVNRRDRIHESSPLDLASEEPERLPCLQRLLDL
                     GADVNAADKHGKTALLHALASSDGVQIHNTENIRLLLEGGADVKATTKDGDTVFTCII
                     FLLGETVGGDKEEAQMINRFCFQVTRLLLAHGADPSECPAHESLTHICLKSFKLHFPL
                     LRFLLESGAAYNCSLHGASCWSGFHIIFERLCSHPGCTEDESHADLLRKAETVLDLMV
                     TNSQKLQLPENFDIHPVGSLAEKIQALHFSLRQLESYPPPLKHLCRVAIRLYLQPWPV
                     DVKVKALPLPDRLKWYLLSEHSGSVEDDI"
     exon            266..447
                     /gene="ASB6"
                     /inference="alignment:Splign:2.1.0"
     exon            448..554
                     /gene="ASB6"
                     /inference="alignment:Splign:2.1.0"
     exon            555..663
                     /gene="ASB6"
                     /inference="alignment:Splign:2.1.0"
     exon            664..750
                     /gene="ASB6"
                     /inference="alignment:Splign:2.1.0"
     exon            751..4603
                     /gene="ASB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB6"
                     /note="hexamer: ATTAAA"
     polyA_site      2316
                     /gene="ASB6"
                     /note="major polyA site"
     regulatory      4583..4588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB6"
                     /note="hexamer: AATAAA"
     polyA_site      4603
                     /gene="ASB6"
                     /note="major polyA site"
ORIGIN      
        1 gcggcttgga ctgaggagcg gacccggccg ggcgcagggg ctggactggc ggagcaggtg
       61 gggtccgcgg ccgccggagc gttccggtcg gcgtctgggc atctcggcct cggcagaaag
      121 cgcgacggcc ctgctgcgcg gggcccgcgg cgatgccgtt cctgcacggc ttccggagga
      181 tcatcttcga gtaccagccg ctggtggatg cgattctggg ctccctgggg atccaggacc
      241 ccgagcggca ggagtctctg gaccggccca gttatgtcgc cagcgaggag agccgaatcc
      301 ttgttctcac tgagctgctg gagaggaaag cccactctcc cttttaccag gaaggcgtga
      361 gcaacgccct gctcaagatg gctgagctgg ggctgacgcg ggcggccgac gttctcttgc
      421 ggcatggggc caatctcaac tttgaagacc cagtcaccta ctacacggcc ttgcacatcg
      481 ccgtcctgcg gaaccagccg gacatggtgg agctgctggt gcatcacggg gccgacgtta
      541 atcggaggga ccggatccac gagagtagcc ccttggacct ggccagcgag gagcctgagc
      601 gcctgccctg cctgcagcgc ctcctggacc ttggagctga tgtcaatgcc gctgacaagc
      661 atggaaaaac tgctctgctc catgctctgg ccagcagcga cggggtgcag atccacaata
      721 ctgagaacat tcgtctctta ctggaaggag gggcagacgt caaggccacc accaaagatg
      781 gggacacagt gttcacctgc atcatcttcc tgcttggtga gaccgtggga ggggacaaag
      841 aggaggccca gatgatcaac cgcttctgct tccaagtcac acggctgctg ctggcacacg
      901 gggccgaccc cagcgagtgc ccagcccacg agtccctcac ccacatctgc ctgaagagct
      961 ttaaactgca cttccctctc ctgcgcttcc tcctggagtc cggagccgcc tacaactgct
     1021 ccctgcacgg tgcgtcctgc tggtctggct ttcacatcat ctttgagagg ctctgttccc
     1081 acccaggctg cacggaagac gagagccatg cggacctcct gcgcaaagct gagactgtcc
     1141 tggatctcat ggtgaccaac tctcagaaac tccagctgcc cgaaaacttc gatatccacc
     1201 ctgtgggcag cctggcggaa aagatccagg ccctccactt ctccttgagg cagctggaga
     1261 gctatccccc gcccctcaag cacctgtgcc gtgtggccat ccggctctac cttcagccgt
     1321 ggcctgtgga tgtgaaggtc aaagccctgc ctctgcccga caggctgaag tggtacctcc
     1381 ttagcgagca cagtggctcc gtggaagatg acatctgata ggtctcaggc tacaggaacg
     1441 ggggacacgg gcagctcagg tcagcctgtt ggtagatgct gggacagcat tagaagaggg
     1501 tctttttgat ctgggagatg agacgggatc cttcatgaga aaagccagcc aggtagagcc
     1561 tgaagctgtg atcactccag tggtgaaggg tgcagctctg gttcttccag agagactgcc
     1621 cccttccctc cagcggcact ccaagtcccc cccatgttgg aaagaggaac agggcttgga
     1681 ttgatgttta taccctctga attggagggc agtgccaggg catttgcaga agctgggaag
     1741 gaccaagcct cagcacccca gggctgcggg gctcttgttg gccgcacgtg gcagtgcagc
     1801 tggagaggaa gcctggggca cgtcctgtgc ggtgccacca aggccccacc cctgcccctt
     1861 ttccttccag gttctgttac tcacagaagt gtttctggtg ggctctgcgg gagaagacac
     1921 taagggcccc acaggcttgt ttcatggtgt tgcaagccaa gctggcccct gcctgttcct
     1981 gtagctctgg ggccaggtca gccgtggccc cacctaccag aactgtgctc tgctggcagc
     2041 tgtgcttttg ccaaacccag ggcctcagcg accatgactt ctgctaaaaa gcaatcatga
     2101 gtgcgtggct ggggacagac ctctctgaag tgtctcctgt tgtgaggggc tcactttgga
     2161 gccactgaag agccgactgt gccacccact tgcgagcctc agtcccttcc aagctgcact
     2221 ggtcattggg aattgtgtaa acacctctgg ggataagctg aggtgactaa atgatatatt
     2281 tatattataa gattaaactg actttcttgg ccttaacaag gtccttatat aaaatttcca
     2341 ccccgcccct ccatagttca ggatagaggc tcccacagca gccggtaagg aagtgggtgg
     2401 caggtgtgag gggatgctgt gtttgggggg ttgtttccaa gtccctgcaa agaagcacca
     2461 ctctagactg gcaagggcct ccacagtgtg gaggtcccat tttattattt ttttttttcg
     2521 agacactctg tcacccaggc tggagtgcaa tggtgcaatc tcggctcact gcgacctctg
     2581 cctcccaggt tcaagcagtt ctcctgcctc agcctcctga gtagctggca ttataggtgc
     2641 ccaccaccat gcctggctga tttttgtatt tttagtagag acggggtttc gccatgttgg
     2701 tcaggctggt ctcaaactcc tgacctcagg tgattcgcct gcctcggcct ttcaaagtgc
     2761 tgggattaca gacatgagcc actgtgcccg gcccccattt tattttagtt ttattttgag
     2821 acagagtctc gctctgtcac ctaggctgga gtgcagtggc gcaatctcac ctcactgcaa
     2881 gctctgcctc ccgggctcac cccattctcc tgcctcagcc tcctgagtag ctgggactac
     2941 aggcgcccgc catcacgcct ggctaatttt tttttttttt gtattttaag tagagacggg
     3001 gtttcacctg ttagccagga tggtctcaat ctcctgacct cgtgatctgc ccgcctcggc
     3061 ctcccaaagt gctgggatta caggcgtgag ccaccgcgcc cagccccatt ttatttttta
     3121 ctttaaatgc ctgccaagga gcagcctcaa gcccagagaa gactgaggct acggggaact
     3181 tcccttgctg caggctgttg taacacttta agggccccag gtctccactg ccaagcagga
     3241 cttggcacat gagcacccac cccacagcac catcaggcag cacccatggg ctccaccagc
     3301 ccagctctgt ccctccccta ggtaaagatc acactgaagt cttcaagtcc ccagcaacca
     3361 agttgggggt ggtttccttc ctcttcaggc agccaggccc atggctggaa ggccgggctg
     3421 gaggcccagg gaatcggtta ctgatgtggc caccctattc ccacatgggg agcaccagga
     3481 gccctggagc cccttccacc caatcccatc tcgcaggaga gcagggtctg ggctcctgcc
     3541 tcaccgctgg ttcagcagca ccctccccgc cgggtcccac cttgcctttt gaagaagagc
     3601 ccgcataatg agtggacggc agacagctat atttagtggt gcctcgacac tcacgaaccg
     3661 ccagcgtggc gcctggatct tgcccagctg ccagctcccc ccaccaggac tgtggttcct
     3721 cagtttctcc tgccagcccc ggctcatctc agggcaaagc tatagacatg gtagatctca
     3781 tcggggaggt tctcctgcct ctcctcggcc aggaggctga ggcctgcact gcagatgatc
     3841 ctgcggacca cgtcaaggtc ccggcacacg ctgctgtcca cgtcgtccag aatcacgccc
     3901 tcctgggcca tgttgtcttt gatgacgatg atgccgttgg ggcggaggct gcccttgcag
     3961 cgccgcagga actcggccag gtgctgatcg gtgaggtggc ctggggaggg cagaggcaag
     4021 gttaccaggg caccatgcaa gcggatgtcg gcactggatg ggatgtactt ctcagccccg
     4081 ctgagcccct catttgtgcc cagcattttg tgtgcacaca tggcctcatt ggctctcagt
     4141 cccgagagat ttactaaacc ccaattcata gaataggaaa ctgtggctca gaggtcatct
     4201 acctaaagac acattaagcc agaatttgac ttgacgggat ggcttacaag tcctgcctga
     4261 tacctacaca ccatgatgcc ccacccctgc caggcttgga tcggaggagt gaacctgggc
     4321 taagagtttg gcattgcagg agctcccaga gagactgcct tccctacact agaagtcccc
     4381 acaaaggctt ctgagaccac aaaatacaag gccagaccta gagtgtccac agcaggcctg
     4441 tgctgcccgc ctcaggaggt ggccgactgc tgctagcggc ctgccgccac gtcagcagcc
     4501 cagggcacag cgctcgaggt gtgctgttag gctaagaggg tgcagggcta gacacgaagc
     4561 ttaaactatt catcttatta aaaataaaac ccttataaaa ctc
//
