LOCUS       NM_080874               3031 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 5 (ASB5),
            transcript variant 1, mRNA.
ACCESSION   NM_080874
VERSION     NM_080874.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3031)
  AUTHORS   Liu,P., Verhaar,A.P. and Peppelenbosch,M.P.
  TITLE     Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in
            Action
  JOURNAL   Trends Biochem Sci 44 (1), 64-74 (2019)
   PUBMED   30446376
  REMARK    Review article
REFERENCE   2  (bases 1 to 3031)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647857.1 and AC093605.3.
            
            On Nov 22, 2018 this sequence version replaced NM_080874.3.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and SOCS box domain. The SOCS
            box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. Multiple
            alternatively spliced transcript variants have been described for
            this gene but their full length sequences are not known. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647857.1, AK096441.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159368 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296525.7/ ENSP00000296525.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1208              BX647857.1         2-1209
            1209-2235           AC093605.3         151754-152780       c
            2236-3031           BX647857.1         2236-3031
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.2"
     gene            1..3031
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /note="ankyrin repeat and SOCS box containing 5"
                     /db_xref="GeneID:140458"
                     /db_xref="HGNC:HGNC:17180"
                     /db_xref="MIM:615050"
     exon            1..310
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1104
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /note="isoform 1 is encoded by transcript variant 1; SOCS
                     box protein ASB-5; ankyrin repeat and SOCS box protein 5"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 5 isoform 1"
                     /protein_id="NP_543150.1"
                     /db_xref="CCDS:CCDS3827.1"
                     /db_xref="GeneID:140458"
                     /db_xref="HGNC:HGNC:17180"
                     /db_xref="MIM:615050"
                     /translation="MSVLEENRPFAQQLSNVYFTILSLFCFKLFVKISLAILSHFYIV
                     KGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLD
                     HVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGA
                     KAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIW
                     KLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSS
                     SMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR"
     exon            311..390
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            391..498
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            499..649
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            650..784
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            785..976
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /inference="alignment:Splign:2.1.0"
     exon            977..3031
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2999..3004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /note="hexamer: ATTAAA"
     polyA_site      3031
                     /gene="ASB5"
                     /gene_synonym="ASB-5"
                     /note="major polyA site"
ORIGIN      
        1 accagctgat attttctttc ctcaggacca gctgttcagg agcatcccgg acgagagcca
       61 ggcacatttg agacttggat ccaactaaag accgccgcag attcttctgc agcaatgtcg
      121 gtgttagaag aaaatcggcc gtttgctcaa caattatcca atgtctactt tacaatactt
      181 tcgctgttct gttttaagct ttttgtgaaa atcagccttg ccatcctcag tcatttctac
      241 atagtgaaag gcaaccgcaa ggaagcggca aggatagcag ctgaatttta tggagtaacc
      301 caaggacaag gttcctgggc agatcgatca ccactacatg aagcagcaag tcaaggtcgc
      361 cttcttgctc tgagaacatt attatcacag ggttataatg taaatgcagt aaccttagac
      421 catgtcaccc cattgcacga agcctgcctt ggagatcacg tggcatgtgc cagaactctg
      481 ctggaagcag gagctaatgt aaatgcaatc acgatagatg gcgtgactcc gttattcaac
      541 gcatgctccc aaggcagtcc aagctgtgca gagctgcttc tggagtatgg tgccaaagcc
      601 cagctggagt catgtcttcc atccccaacg catgaggccg ccagtaaagg tcaccatgaa
      661 tgtcttgaca tcctgatatc ctggggcata gatgttgacc aagaaattcc tcatttggga
      721 actcctctct atgtagcttg tatgtcacag caattccatt gcatctggaa gcttctttat
      781 gctggtgctg acgtacagaa aggcaaatat tgggatactc cattacatgc tgctgctcaa
      841 caatccagca cagaaattgt aaacttactg ctagaatttg gagcagatat caatgccaaa
      901 aatacagagc ttctgcgacc tatagatgta gctacgtcta gcagtatggt ggaaaggata
      961 ttgcttcaac atgaagctac cccaagctct ctttaccaac tttgccgact ctgtatccga
     1021 agctacatag gaaaaccaag attgcacctt atcccacaac tccagctgcc aacgttactg
     1081 aagaatttct tacagtatcg ataaaacagt aaagtaattc taaatacctt gaaaatcaaa
     1141 atttctattt cttttgctta aggaatagtt catataaaaa tatgctaaag ataggataaa
     1201 agtgagtgtg agatcaccca gggaagcagt aaaatatcaa ttttcatttt aagtgtatta
     1261 gtactattgt tttatcattt atgctgtctt tggattatag catatttata atatctattt
     1321 tttgttattt caatataccc tcctgtttat tcaggaaaaa ataataaagt cactatctta
     1381 tgttttcttt tggattggaa agaaataaag ctcctagtaa agttattcat attatattta
     1441 aaaaggtcta tgttcttcaa ctaatgggtt aactttttaa ttttggctat tgtaattggc
     1501 taacttgtta ctgatattga cataaaatat gaatatggct tagcaaagag caactaatat
     1561 gttttctgaa accaggatga tgctcattca ggaaatccac tatgttgaat gtccactggt
     1621 cattagaatg aacacttcat aaagataaat tgcccccctc tcccccactt acccctggca
     1681 aaggactcac aagtcacttc tcttctccat agtacatgga cttgttacag aaaagtgata
     1741 ggatgaaagg tcaatactgc cctctcaccc tgagatattt agaacattac acaccttcta
     1801 aggctatgtt aagactgcct ccttctcagg agtagcccct gatgatctct tatcaaggcg
     1861 gttatatgca tattactcca gccttcttcc atttcagaaa ttgtcaatag ctagtgatac
     1921 ttggacttaa gaaaatgaac tatatatcta attaacaaac aggccctgga tcatattccg
     1981 gggatcatca catcagtcca aggatataaa aaaatggaag attaaaaact caaattgtgg
     2041 agtttttaaa gagtgggtgc cacttaacac attggagacc ttaaaaaatg tatatagaga
     2101 acttaatcgc actgtttcta attcttttta cacaaaacaa gggcttagag tatactgtat
     2161 ttgcaagtaa tagcaagaga gtattgtata aaagaagata ttactaagct agtcctctgc
     2221 aagggtaaat actacgttta ttctcttcag ctttaactat acttgagtgc aataaaaaac
     2281 ttaataaaat tttatgcctg ttttgtaatt cagggcctat tatgatttta gaaataagat
     2341 aatcaacgta caactctttg taaaacaaaa gcaactttgg gtgagtttta tagatttatt
     2401 aaattttgat aaagtaaata ttttgaccac tattttcaac aacccagggc ttattttctt
     2461 ctgacttctt ggctaacttc cagactatgg gaaaataaat tatgattgta tgtgaccccc
     2521 agatcactaa gcttgcattt tggcagaaag aaaaaaaatc agttgtgatt taaaacgttt
     2581 gttgagattt tcaaacatag aaataaagct gtagcatatt cactaaacaa tgttttatat
     2641 gaggataggg acctttaaat atgtgtttta tagaatatct cacacatttg taatggataa
     2701 cgtgcattaa aatggagttc ttattataga ataacctggt taaacagata ttaaagctgc
     2761 ttttgggtaa aacaggtttc caccagtatt ttccctgagc tagaggagaa gtcttagatt
     2821 ttaagagtaa tacaacccat ctatcttatt agtcttgtgc caataagaga agtaaatatc
     2881 aaacattaaa atggtcactt tacaatttca gtatgtctgt accttgtatc ttagcttgag
     2941 tatgattgtc ttatcaaagt agtgttctaa ctttaatgta ttgtatgttt gttattatat
     3001 taaagtgtga ttattattca ttggaataaa a
//
