LOCUS       NM_016116               3784 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 4 (ASB4),
            transcript variant 1, mRNA.
ACCESSION   NM_016116
VERSION     NM_016116.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3784)
  AUTHORS   Wang,Y., Ssengonzi,R., Townley-Tilson,W.H.D., Kayashima,Y.,
            Maeda-Smithies,N. and Li,F.
  TITLE     The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis
  JOURNAL   Int J Mol Sci 25 (16), 9017 (2024)
   PUBMED   39201703
  REMARK    GeneRIF: The Roles of Obesity and ASB4 in Preeclampsia
            Pathogenesis.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3784)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3784)
  AUTHORS   Miyamoto,S., Kochin,V., Kanaseki,T., Hongo,A., Tokita,S.,
            Kikuchi,Y., Takaya,A., Hirohashi,Y., Tsukahara,T., Terui,T.,
            Ishitani,K., Hata,F., Takemasa,I., Miyazaki,A., Hiratsuka,H.,
            Sato,N. and Torigoe,T.
  TITLE     The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL
            Immunotherapy of Colorectal Cancer
  JOURNAL   Cancer Immunol Res 6 (3), 358-369 (2018)
   PUBMED   29371260
  REMARK    GeneRIF: This analysis identified an antigen, ASB4, which was
            processed and presented by a cancer stem cell (CSC) subset but not
            by non-CSCs. The ASB4 gene was expressed in CSCs of colorectal
            cancer, but not in cells that had differentiated into non-CSCs.ASB4
            is a tumor-associated antigen that can elicit CTL responses
            specific to CSCs and can discriminate between two cellular subsets
            of colorectal cancer.
REFERENCE   4  (bases 1 to 3784)
  AUTHORS   Ferguson,J.E. 3rd, Wu,Y., Smith,K., Charles,P., Powers,K., Wang,H.
            and Patterson,C.
  TITLE     ASB4 is a hydroxylation substrate of FIH and promotes vascular
            differentiation via an oxygen-dependent mechanism
  JOURNAL   Mol Cell Biol 27 (18), 6407-6419 (2007)
   PUBMED   17636018
REFERENCE   5  (bases 1 to 3784)
  AUTHORS   Li,J.Y., Kuick,R., Thompson,R.C., Misek,D.E., Lai,Y.M., Liu,Y.Q.,
            Chai,B.X., Hanash,S.M. and Gantz,I.
  TITLE     Arcuate nucleus transcriptome profiling identifies ankyrin repeat
            and suppressor of cytokine signalling box-containing protein 4 as a
            gene regulated by fasting in central nervous system feeding
            circuits
  JOURNAL   J Neuroendocrinol 17 (6), 394-404 (2005)
   PUBMED   15929745
  REMARK    GeneRIF: Based on its differential expression, neuroanatomical
            distribution and colocalisation, we hypothesise that rat Asb-4 is a
            gene involved in energy homeostasis.
REFERENCE   6  (bases 1 to 3784)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   7  (bases 1 to 3784)
  AUTHORS   Kile,B.T., Viney,E.M., Willson,T.A., Brodnicki,T.C., Cancilla,M.R.,
            Herlihy,A.S., Croker,B.A., Baca,M., Nicola,N.A., Hilton,D.J. and
            Alexander,W.S.
  TITLE     Cloning and characterization of the genes encoding the ankyrin
            repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and
            Asb-4
  JOURNAL   Gene 258 (1-2), 31-41 (2000)
   PUBMED   11111040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC113479.1, AF156779.1,
            AC003079.2, AK096449.1 and AC002451.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016116.2.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and SOCS box domain. The SOCS
            box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. Multiple
            alternatively spliced transcript variants have been described for
            this gene but some of the full length sequences are not known.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.77408.1, AF156779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325885.6/ ENSP00000321388.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BC113479.1         43-71
            30-1310             AF156779.1         1-1281
            1311-2640           AC003079.2         60155-61484
            2641-3782           AK096449.1         1366-2507
            3783-3784           AC002451.1         496-497
FEATURES             Location/Qualifiers
     source          1..3784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..3784
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /note="ankyrin repeat and SOCS box containing 4"
                     /db_xref="GeneID:51666"
                     /db_xref="HGNC:HGNC:16009"
                     /db_xref="MIM:605761"
     exon            1..216
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1310
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /note="isoform a is encoded by transcript variant 1;
                     ankyrin repeat and SOCS box protein 4"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 4 isoform a"
                     /protein_id="NP_057200.1"
                     /db_xref="CCDS:CCDS5641.1"
                     /db_xref="GeneID:51666"
                     /db_xref="HGNC:HGNC:16009"
                     /db_xref="MIM:605761"
                     /translation="MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDV
                     DTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATIN
                     CRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLV
                     WRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYW
                     ALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGA
                     EANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSC
                     PKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAI
                     RRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY"
     exon            217..516
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            517..1007
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1121
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..3784
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3760..3765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /note="hexamer: AATAAA"
     polyA_site      3784
                     /gene="ASB4"
                     /gene_synonym="ASB-4"
                     /note="major polyA site"
ORIGIN      
        1 acaacaaagc ttccagaggg agaggaagga tggacggcac cactgcccct gtcactaaat
       61 ctggagctgc caagttagtt aagagaaatt tccttgaggc gctaaagtcc aatgacttcg
      121 gaaaattgaa ggctattttg atccaaaggc aaatagatgt ggacactgtt tttgaagtcg
      181 aagatgagaa tatggttttg gcatcttata aacaaggtta ctggttgcct agctataaat
      241 tgaagtcttc ctgggccaca ggcctccatc tctctgtctt gtttggccat gtggaatgtc
      301 ttctggtgct actggaccac aatgctacaa tcaactgtag acccaatggg aaaacccctc
      361 ttcacgtggc ttgtgaaatg gccaatgtgg attgtgttaa gatcctctgt gatcgtgggg
      421 caaagctcaa ttgctactcc ttaagtggac acacagcttt gcacttttgt acaactccaa
      481 gttccattct ctgtgccaag caattggttt ggagaggggc gaatgtgaac atgaagacca
      541 acaaccaaga tgaggagacg cccttgcaca cggctgccca cttcggcctt tcggagctgg
      601 tggccttcta cgtggaacac ggggccatag tggacagcgt gaatgcccac atggagaccc
      661 ccctggccat cgccgcctac tgggccctcc gctttaagga gcaggagtac agcacggagc
      721 accacctggt ctgccgcatg ctgcttgact acaaagccga agtcaatgcc cgagatgacg
      781 actttaaatc tcccctccac aaggcagcct ggaactgtga ccacgtgctc atgcacatga
      841 tgctggaagc tggcgccgaa gccaatctca tggatatcaa cggctgtgct gccatccagt
      901 acgtgctgaa ggtcacctcc gtgcgccctg ctgcccagcc tgagatctgc taccagctcc
      961 tgttgaacca tggggctgcc cgaatatacc ctccacagtt ccataaggtg atacaggcct
     1021 gccattcttg tcctaaagca attgaagttg tagtcaatgc ctatgaacac atcagatgga
     1081 acacaaagtg gagaagagct atccccgatg atgacttgga gaaatactgg gatttttacc
     1141 actctctctt tactgtgtgc tgtaactctc caaggactct catgcactta tcgagatgtg
     1201 ccattagaag aacattacac aacagatgcc atagagcaat tcctttgctt tccctcccat
     1261 tgtcattgaa aaagtacttg cttttagagc cagagggaat tatttattaa gccttatgag
     1321 acagcagttc ccaatcctag gtatttaagt ggacttgctg ggtagacaca gtttgcctaa
     1381 ataaaatggt acttgggttg attataacac ttcagggatt tcaaaacact ttacaaacac
     1441 tgccattaat cctagaatat catggtatgg ggaaataaag aagaagtaaa gttaaggaat
     1501 tttcaaagac aaggatgtat tcagaatgta ctgatagaac agtaataact aatatgtata
     1561 gtgttcttac taagtacctg aaatattttt gtaaaacttc ttatatctta tctcatctga
     1621 aatgggaccc aggttttctt ccaaccaata taattctgtg ccttatcagt aatatgttta
     1681 cattctcatt caaatggcca tatagcaggc tttgcaattg gcctcttaaa cttggtgttt
     1741 tcccccatta ccccttagca gtaattactg tcactagttt tgcaaactcc tactccccaa
     1801 accaagctac tcaagtttat ttcagtgatg aaggcatatg agcatagtca aaacaaggag
     1861 atcttggagt caaattagaa atgagaaaga aacatcagtc cagttaatag tcaagaatgg
     1921 acatttgaac cagacatcac tgagccagag actggagatg caaagatgag tcccatgtga
     1981 ctcctgcctt ccaggatctc accatttagc agaggatcca gacatacaca cagctaactg
     2041 caatataaag tgatggggca agagtacagg tgcagactca cttttaatgc ttatctttca
     2101 aagttgtgtt tctgacatga agtgtgattt ttcttttaag catgaagtta aagagtgaag
     2161 gggttatgta aagtagaggg atctcctgct cttgttaggg tatttttaag gttttttcta
     2221 gatagtgtgt ctttttggta tggtttcttg gttagtatta atactttccc agactccttg
     2281 agaaaaatat tgcacactca atggctccag tgcatgtgac aaggaagcat aggaaaatgg
     2341 gggaaagaaa gtgtgtgagg ggacctagtt gattacttcg gtctttttat gtagcagact
     2401 gacatttcat agcattgtag ctaagagata aggagcactt tgctagtgac agtgggctac
     2461 gaaaagtaaa tagagagact ttttgaaaat ggtaaaagtt tgagaaactt gggaagatta
     2521 gtgtgttaat caggcttgct agttagtgga ttgcagaaag aaaaatgtag gtgattaagc
     2581 tctgggcctt gtggtttatg aggtcaattt tgcttcactt ttttttttgt tcttgctata
     2641 atcactttta gataagctca ttgctcttag catcattttt tagaggttaa agcagaagta
     2701 aattgcaaac aaatctgtca gttgtgagca gatttctttt atgtgtgtgg ttctccatca
     2761 tatttaactt tggatgctgg agtgttgaat agagatgatg tcagatattc caataggcta
     2821 tcatttaatg ttaactggca atcacctaac tggttaatct cagttgagac tgtgcttctg
     2881 aactgggatt gtcttactcc cagggctgtg taagaaaagt cataggtgga tacaataatc
     2941 tcttttaagt atcagtttta ctcagatatt ttggtggaga tattttgtac taaaacaaga
     3001 tctatatcat ggaatagaat gctgaatttg tatgaattat tcacataaag cttgatcttt
     3061 caaaaaatag tttgcttgca gcaagtggta ttagaacaca tcctaaaaca gaatgaaatg
     3121 atgtcttttg cagcaacttg gatggagctg gaggccatta ttctaagtga agtaactcag
     3181 gaatggaaag tgaaatacca tatgttctca cttataagtg ggagctaagc aatgaggatg
     3241 caaagacatc cagagtgata taatggacta tggggacttg caaggggaag cttgagagtg
     3301 gggtgaggga taaaagacta catattgggt acagtgtaca ctgctccagt gatgggtgca
     3361 ctaaaatctc aaaattcacc actaaagaat gtatccatgt aaccaaaaac cacctgtacc
     3421 cccaaaacta ttgaaatctt aaaatagtaa taattaacaa agtaaaacaa gatcacaccc
     3481 tggaacaatt ggaggattgc ttgctgccct gcatcttaag gcgtattcta gcagcaaagc
     3541 ttgtgatgca ctgacttggg gcaagtaaaa ctgatgctga ggacaaaggg agaagatgtt
     3601 cctcgcccag ggaaatgaaa acttttctta ttcaccttgc ttgtgcttaa acacttatgt
     3661 tcatctagtg tagaatacat ggctacttgt ttgtaatttt tttattggtg gaattaaagt
     3721 aatttttcct tatctttgaa cttttattta gagaacttaa ataaagctct tctgtctcct
     3781 ttca
//
