LOCUS       NM_016115               2226 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 3 (ASB3),
            transcript variant 1, mRNA.
ACCESSION   NM_016115
VERSION     NM_016115.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Cheng,M., Xu,B., Sun,Y., Wang,J., Lu,Y., Shi,C., Pan,T., Zhao,W.,
            Li,X., Song,X., Wang,J., Wang,N., Yang,W., Jiang,Y., Huang,H.,
            Yang,G., Zeng,Y., Yang,D., Wang,C. and Cao,X.
  TITLE     ASB3 expression aggravates inflammatory bowel disease by targeting
            TRAF6 protein stability and affecting the intestinal microbiota
  JOURNAL   mBio 15 (9), e0204324 (2024)
   PUBMED   39162488
  REMARK    GeneRIF: ASB3 expression aggravates inflammatory bowel disease by
            targeting TRAF6 protein stability and affecting the intestinal
            microbiota.
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Huang,L., Che,Z., Liu,F., Ge,M., Wu,Z., Wu,L., Chen,W., Wang,Z.,
            Zhu,Z., Xu,W., Dong,Q. and Yang,D.
  TITLE     ASB3 promotes hepatocellular carcinoma progression by mediating DR5
            ubiquitination in TRAIL resistance
  JOURNAL   FASEB J 38 (4), e23475 (2024)
   PUBMED   38334450
  REMARK    GeneRIF: ASB3 promotes hepatocellular carcinoma progression by
            mediating DR5 ubiquitination in TRAIL resistance.
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Chung,A.S., Guan,Y.J., Yuan,Z.L., Albina,J.E. and Chin,Y.E.
  TITLE     Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and
            degradation of tumor necrosis factor receptor II
  JOURNAL   Mol Cell Biol 25 (11), 4716-4726 (2005)
   PUBMED   15899873
  REMARK    GeneRIF: ASB3 is a negative regulator of TNF-R2-mediated cellular
            responses to TNF-alpha by direct targeting of TNF-R2 for
            ubiquitination and proteasome-mediated degradation.
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Kile,B.T., Metcalf,D., Mifsud,S., DiRago,L., Nicola,N.A.,
            Hilton,D.J. and Alexander,W.S.
  TITLE     Functional analysis of Asb-1 using genetic modification in mice
  JOURNAL   Mol Cell Biol 21 (18), 6189-6197 (2001)
   PUBMED   11509662
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Kile,B.T., Viney,E.M., Willson,T.A., Brodnicki,T.C., Cancilla,M.R.,
            Herlihy,A.S., Croker,B.A., Baca,M., Nicola,N.A., Hilton,D.J. and
            Alexander,W.S.
  TITLE     Cloning and characterization of the genes encoding the ankyrin
            repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and
            Asb-4
  JOURNAL   Gene 258 (1-2), 31-41 (2000)
   PUBMED   11111040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA038561.1, AK000985.1 and
            DB558848.1.
            
            On Jun 2, 2019 this sequence version replaced NM_016115.4.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and SOCS box domain. The SOCS
            box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. Alternatively
            spliced transcript variants have been described for this gene.
            [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009569.1, AK000985.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263634.8/ ENSP00000263634.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA038561.1         57-75
            20-1887             AK000985.1         2-1869
            1888-2226           DB558848.1         111-449
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.2"
     gene            1..2226
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /note="ankyrin repeat and SOCS box containing 3"
                     /db_xref="GeneID:51130"
                     /db_xref="HGNC:HGNC:16013"
                     /db_xref="MIM:605760"
     exon            1..133
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            134..342
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1703
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /note="isoform a is encoded by transcript variant 1;
                     ankyrin repeat and SOCS box protein 3"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 3 isoform a"
                     /protein_id="NP_057199.1"
                     /db_xref="CCDS:CCDS1846.1"
                     /db_xref="GeneID:51130"
                     /db_xref="HGNC:HGNC:16013"
                     /db_xref="MIM:605760"
                     /translation="MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGW
                     MPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAG
                     ADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAE
                     IIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFI
                     AAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDT
                     GLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIV
                     NILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYK
                     EWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSARASNAW
                     ILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYE
                     VPELAAIQDG"
     exon            343..501
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..614
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            615..750
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            751..928
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1126
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1384
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1515
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..2226
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /note="hexamer: AATAAA"
     polyA_site      2051
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /note="major polyA site"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /note="hexamer: ATTAAA"
     polyA_site      2226
                     /gene="ASB3"
                     /gene_synonym="ASB-3"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcctgcg cgtctctcgt tttcggacgg ctgcagcatc gcggtgggga tcgaaagcgg
       61 gggcttctgg gacgcagctc tggagacgcg gcctcggacc agccatttcg gtgtagaagt
      121 ggcagcacgg cagactggtc aaacaaatgg attttacaga ggcttacgcg gacacgtgct
      181 ctacagttgg acttgctgcc agggaaggca atgttaaagt cttaaggaaa ctgctcaaaa
      241 agggccgaag tgtcgatgtt gctgataaca ggggatggat gccaattcat gaagcagctt
      301 atcacaactc tgtagaatgt ttgcaaatgt taattaatgc agattcatct gaaaactaca
      361 ttaagatgaa gacctttgaa ggtttctgtg ctttgcatct cgctgcaagt caaggacatt
      421 ggaaaatcgt acagattctt ttagaagctg gggcagatcc taatgcaact actttagaag
      481 aaacgacacc attgttttta gctgttgaaa atggacagat agatgtgtta aggctgttgc
      541 ttcaacacgg agcaaatgtt aatggatccc attctatgtg tggatggaac tccttgcacc
      601 aggcttcttt tcaggaaaat gctgagatca taaaattgct tcttagaaaa ggagcaaaca
      661 aggaatgcca ggatgacttt ggaatcacac ctttatttgt ggctgctcag tatggcaagc
      721 tagaaagctt gagcatactt atttcatcgg gtgcaaatgt caattgtcaa gccttggaca
      781 aagctacacc cttgttcatt gctgctcaag agggacacac aaaatgtgtg gagcttttgc
      841 tctccagtgg ggcagatcct gatctttact gtaatgagga cagttggcag ttacctattc
      901 atgcagctgc acaaatgggc catacaaaaa tcttggactt gttaatacca cttactaacc
      961 gggcctgtga cactgggcta aacaaagtaa gccctgttta ctcagcagtg tttgggggac
     1021 atgaagattg cctagaaata ttactccgga atggctacag cccagacgcc caggcgtgcc
     1081 ttgtttttgg attcagttct cctgtgtgca tggctttcca aaaggactgt gagttctttg
     1141 gaattgtgaa cattcttttg aaatatggag cccagataaa tgaacttcat ttggcatact
     1201 gcctgaagta cgagaagttt tcgatatttc gctacttttt gaggaaaggt tgctcattgg
     1261 gaccatggaa ccatatatat gaatttgtaa atcatgcaat taaagcacaa gcaaaatata
     1321 aggagtggtt gccacatctt ctggttgctg gatttgaccc actgattcta ctgtgcaatt
     1381 cttggattga ctcagtcagc attgacaccc ttatcttcac tttggagttt actaattgga
     1441 agacacttgc accagctgtt gaaaggatgc tctctgctcg tgcctcaaac gcttggattc
     1501 tacagcaaca tattgccact gttccatccc tgacccatct ttgtcgtttg gaaattcggt
     1561 ccagtctaaa atcagaacgt ctacggtctg acagttatat tagtcagctg ccacttccca
     1621 gaagcctaca taattatttg ctctatgaag acgttctgag gatgtatgaa gttccagaac
     1681 tggcagctat tcaagatgga taaatcagtg aaactactta acacagctaa tttttttctc
     1741 tgaaaaatca tcgagacaaa agagccacag agtacaagtt tttatgattt tatagtcaaa
     1801 agatgattat tgattgtgag ataggttagg ttttgggggg ccagtagttc agtgagaatg
     1861 tttatgttta caactagcct tcccagtaaa aaaaaaaaaa aaaaaaaaaa aaattgtaaa
     1921 catcacttat attactttat tgcagcttca tcaccagtac attatatgtt gtaatattta
     1981 tttacctgat cattttgatc attttctgct ttattttgct aataaactgt gatgttactt
     2041 ctagtgctaa acatggcata tttccaccta tgattcgtgt ttacctggta ttaggagctc
     2101 agaatggaat gcataaagct tcactggaag tgtatacaac tgtggtgtag aatctgttat
     2161 tattatcatt attattttat ttagacttga ctatctctta tgtttattaa agaacatgtt
     2221 ttccta
//
