LOCUS       NM_212556               2875 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 18 (ASB18),
            mRNA.
ACCESSION   NM_212556
VERSION     NM_212556.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2875)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   2  (bases 1 to 2875)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019068.8 and AC079135.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 23, 2021 this sequence version replaced NM_212556.3.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and a SOCS box domain. The
            SOCS box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. [provided by
            RefSeq, Feb 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. The extent of this transcript is supported
            by orthologous data.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2148874, SAMEA2151741
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409749.8/ ENSP00000386532.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC019068.8         45229-45494         c
            267-389             AC019068.8         22368-22490         c
            390-657             AC019068.8         18777-19044         c
            658-1162            AC079135.6         82105-82609         c
            1163-1276           AC079135.6         64015-64128         c
            1277-2875           AC079135.6         61202-62800         c
FEATURES             Location/Qualifiers
     source          1..2875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.2"
     gene            1..2875
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /note="ankyrin repeat and SOCS box containing 18"
                     /db_xref="GeneID:401036"
                     /db_xref="HGNC:HGNC:19770"
     exon            1..266
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1462
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 18"
                     /protein_id="NP_997721.2"
                     /db_xref="CCDS:CCDS46548.1"
                     /db_xref="GeneID:401036"
                     /db_xref="HGNC:HGNC:19770"
                     /translation="MSNSDYLPDYPLNSDLVKRLKSALDAKDEERVRDLICTEITPVD
                     AVIELANDDWMKDPSAQLPTGMLLGDLDHLKPLMDQFFQDANVVFEINKDEMEWQVKS
                     PATFGLSGLWTLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEAC
                     LGGHTACVRLLLQHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTG
                     RDTPLHVAAQRGLDEHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLC
                     ALLLRRGAEADARDEDERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVL
                     QTASCALQASPQRTVQALLNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLS
                     ESWKEVIPEEVFQMHKPFYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLP
                     KPLQNYLLLEPQGVLH"
     exon            267..389
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /inference="alignment:Splign:2.1.0"
     exon            390..657
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /inference="alignment:Splign:2.1.0"
     exon            658..1162
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1276
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..2875
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2849..2854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /note="hexamer: AATAAA"
     polyA_site      2875
                     /gene="ASB18"
                     /gene_synonym="ASB-18"
                     /note="major polyA site"
ORIGIN      
        1 gactttggag tcgctttaga ggaagaaaag aagggctggt cactgcagaa acgacgtaac
       61 aatgtccaac tcggattacc ttcccgacta cccactcaac tcagatttag tgaagagatt
      121 aaagtctgcc ctggatgcca aagatgagga gagagtgagg gatttaatct gcactgaaat
      181 cacgcctgtg gacgctgtga tagaactggc caatgacgac tggatgaaag acccctcggc
      241 tcagctgccc accggcatgc tgctagggga cctcgaccat ctgaagcccc tcatggacca
      301 gttcttccag gatgccaacg tggtgtttga gatcaataag gatgagatgg aatggcaggt
      361 gaaatctcca gccacgtttg gactatcagg cctctggacc ctggagtaca agcgtgagct
      421 caccacgccc ctgtgcatcg ccgcggccca cggccacacc gcctgcgtgc gacacctgct
      481 cggccgcggc gcagacccag acgccagccc cggcggccgc ggcgccctgc acgaggcctg
      541 cctcgggggc cacaccgcct gcgtccgcct gctgctgcag caccgcgccg accccgacct
      601 gctcagcgcc gagggcctgg cgcctctgca cctctgccgc acggccgcct cgctcgggtg
      661 cgcgcaggcg ctgctggagc acggggcctc ggtgcagcgc gtgggcggca cgggccggga
      721 cacgccgctg cacgtggcgg cgcagcgcgg cctggacgag cacgcgcgcc tgtacctggg
      781 ccgcggggcg cacgtggacg cgaggaacgg ccgcggagag acggctctga gcgcggcctg
      841 cggtgcggcg cggaggcccg acgagcacgg gcgctgcctg cgcctgtgcg cgctgctgct
      901 gcggcgcggg gcggaggcgg acgcgcgcga cgaggacgag cgcagcccgc tgcacaaagc
      961 ctgcggccac gcgagccaca gcctggcgcg cctcctactg cggcacggcg ccgacgcggg
     1021 cgcgctcgac tatggcgggg cctcgccgct gggccgcgtg ctccagaccg catcctgcgc
     1081 tctccaggcc tcaccgcagc gcacggtgca ggcgctgctc aaccacggct ctcccaccgt
     1141 gtggcccgac gccttcccca aggtgctgaa gacctgtgca tctgtccccg cagtcatcga
     1201 ggtgcttttc aactcctacc ctcagctctg cttgtcagag tcctggaagg aagtgattcc
     1261 tgaggaagta ttccagatgc acaagccgtt ctaccagtcc ctctttgcct tggccctcac
     1321 cccacgctgc ctgcagcatc tttgccgctg tgctcttcgc agactgtttg gcaaaaggtg
     1381 ctttgacctc atccccctgt tacccttgcc aaagcccctg cagaattacc tacttttgga
     1441 gccacagggt gttttgcact gaaacgcaga acgctgcaac caatactgtt gttctcctcg
     1501 ctgaccttcc atggaggccg tgtgttggag agtgccctga tgcagatgga ggtgatggga
     1561 gttcccttcc cacttgctct ccgtgggacc gggtgaagca cagaccttgc caagcttcag
     1621 gttcacctcg aaatggaatt ggcaacaaaa gccctttctg cctctcaggg tcgcttgtga
     1681 aaatccagtg aaatcgtgac tatcacagca cttggtctgg gaaagtacct ttcaacaaca
     1741 gttaagccaa aaggtacagt gagtcctcac ttaaggtctt cgataggttc tagggaacca
     1801 gctttaagct aaatgaggta taacaatgcc agttttccca aggttaattg atataaacaa
     1861 gaatgatgtt cctacagcat atttctggtc acaaaaagat caccacactt ctaaataaag
     1921 accaatacaa ttctaatagt aaagattgaa ataaaggcaa gctacacata cctttaaaag
     1981 agattaataa caagtaagat aattatttac ccaatttttg gtgaatcagt atgtgatggt
     2041 ggttgtcctg ctggtgggtt agatcaagga ataaatgttt gcaaaacgaa ccttgtcagg
     2101 agcacctcct accaccacga agttcagaac agtcaccaat gtggcaggct tgctaggccc
     2161 tctcataccg catcatttat tgtcatgcat ttggatgatt attgtatgcc ttatgaattt
     2221 ttactttaca ataatttgta ttcattcatt cattcattca ttcatattct aatgtgctta
     2281 ttctagttca gggtcgtgcg tggccagagt ccaccccagc aactcagtgt gcagggcagg
     2341 aaccaggcct ggacggggtg ctattccatc gcagggtgct cacacacccc cacacccacc
     2401 cacccacaca caacactggg acaattcaga cacgacagct cacctcactt gctcagcttt
     2461 gggatgtggg tgggaactgg agcacccaga gaaaacccat acagacagtg gccttgccca
     2521 ggaatcagtc ttgtttcttt tttgtttttt tgtttgtttg tttgtttgtt ttgagactgg
     2581 cgcaatcttg gctcaccgca acctccgcct cccaggttca agcaattctc ctgcttcagc
     2641 cttcctggta gctgggataa caggcatgtg ccagcacgcc cggctaattt tttattttta
     2701 gtagagacgg ggtttctcca tgttcgtcag gctggtctca aactcccgat ctcaggtgat
     2761 ctgcccgcct cggcctccca aagtgctggg attacaggca tgagtcacca tgccctgccg
     2821 aatcagtttt gtttcttatc ggtgttataa taaaatgaca ttaaacaaaa catta
//
