LOCUS       NM_080868               1080 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 17 (ASB17),
            transcript variant 1, mRNA.
ACCESSION   NM_080868
VERSION     NM_080868.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Wan,P., Yang,G., Zhang,S., Zhang,Y., Jia,Y., Che,X., Luo,Z.,
            Pan,P., Li,G., Chen,X., Zhang,Q., Zhang,W., Tan,Q., Li,Y. and Wu,J.
  TITLE     ASB17 Facilitates the Burst of LPS-Induced Inflammation Through
            Maintaining TRAF6 Stability
  JOURNAL   Front Cell Infect Microbiol 12, 759077 (2022)
   PUBMED   35174103
  REMARK    GeneRIF: ASB17 Facilitates the Burst of LPS-Induced Inflammation
            Through Maintaining TRAF6 Stability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Guo,J.H., Saiyin,H., Wei,Y.H., Chen,S., Chen,L., Bi,G., Ma,L.J.,
            Zhou,G.J., Huang,C.Q., Yu,L. and Dai,L.
  TITLE     Expression of testis specific ankyrin repeat and SOCS
            box-containing 17 gene
  JOURNAL   Arch Androl 50 (3), 155-161 (2004)
   PUBMED   15204681
  REMARK    GeneRIF: expressed exclusively in testis
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036573.2.
            
            On May 17, 2019 this sequence version replaced NM_080868.2.
            
            Transcript Variant: This variant (1) is the longer transcript and
            is thought to encode the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036573.2, AF429968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284142.7/ ENSP00000284142.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              BC036573.2         6-1085
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..1080
                     /gene="ASB17"
                     /gene_synonym="Asb-17"
                     /note="ankyrin repeat and SOCS box containing 17"
                     /db_xref="GeneID:127247"
                     /db_xref="HGNC:HGNC:19769"
                     /db_xref="MIM:619936"
     exon            1..514
                     /gene="ASB17"
                     /gene_synonym="Asb-17"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1001
                     /gene="ASB17"
                     /gene_synonym="Asb-17"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 17"
                     /protein_id="NP_543144.1"
                     /db_xref="CCDS:CCDS671.1"
                     /db_xref="GeneID:127247"
                     /db_xref="HGNC:HGNC:19769"
                     /db_xref="MIM:619936"
                     /translation="MSKSTKLCGKTSCPRSNIFCNLLDKIVKRPSLQFLGQWGYHCYE
                     PRIYRSLAKILRYVDLDGFDALLTDYIAFVEKSGYRFEVSFNLDFTEICVNTILYWVF
                     ARKGNPDFVELLLKKTKDYVQDRSCNLALIWRTFTPVYCPSPLSGITPLFYVAQTRQS
                     NIFKILLQYGILEREKNPINIVLTIVLYPSRVRVMVDRELADIHEDAKTCLVLCSRVL
                     SVISVKEIKTQLSLGRHPIISNWFDYIPSTRYKDPCELLHLCRLTIRNQLLTNNMLPD
                     GIFSLLIPARLQNYLNLEI"
     exon            515..794
                     /gene="ASB17"
                     /gene_synonym="Asb-17"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1080
                     /gene="ASB17"
                     /gene_synonym="Asb-17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1059..1064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB17"
                     /gene_synonym="Asb-17"
                     /note="hexamer: AATAAA"
     polyA_site      1080
                     /gene="ASB17"
                     /gene_synonym="Asb-17"
                     /note="major polyA site"
ORIGIN      
        1 aaagggcact tctgtttgtg gagtaaagcc tgccacattg tcaaaatatg taactggagg
       61 attacagtat gcttacctct gattttattt ctacagtgct gctataagta acaatgagta
      121 aatctactaa attatgtggt aagacttctt gtccaagaag caatatattc tgcaatctcc
      181 ttgacaaaat tgttaaaaga ccctccctac agtttttggg tcagtgggga tatcactgtt
      241 acgaaccaag gatttacaga tcactggcaa aaattctgag gtatgtggac ttggatggtt
      301 ttgacgcact actcacagat tacattgcat ttgtggaaaa atcaggatac cgttttgaag
      361 taagttttaa cctcgacttc actgaaatat gtgtgaatac aattctgtac tgggtttttg
      421 ccagaaaagg taatcctgac tttgtggaat tgcttctcaa gaagacaaaa gactatgttc
      481 aagacagaag ttgtaacctg gcactgatat ggagaacttt cacaccagta tactgtccaa
      541 gcccattaag tggcatcaca cctctctttt atgtagctca gacaagacag tctaatatct
      601 tcaaaatact actgcaatat ggaatcttag aaagagaaaa aaaccctatc aacattgtct
      661 taacaatagt actctaccct tcgagagtaa gagtaatggt tgatcgtgaa ttggctgaca
      721 tccatgaaga tgccaaaaca tgtttggtac tatgttccag agtgctttct gtcatttcag
      781 tcaaggaaat aaagacacag ctgagtttag gaagacatcc aattatttca aattggtttg
      841 attacattcc ttcaacaaga tacaaagatc catgtgaact attacatctt tgcagactaa
      901 ccatcaggaa tcaactatta accaacaata tgctcccaga tggaatattt tcacttctaa
      961 ttcctgctcg tctacaaaac tatctgaatt tagaaatcta acatacgtca gtgtcctaag
     1021 ttccttaaca atgcttacca atgtatggct tagaagttaa taaaaattca cttcatgtaa
//
