LOCUS       NM_080863               2142 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 16 (ASB16),
            mRNA.
ACCESSION   NM_080863
VERSION     NM_080863.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Fu,T., Ji,K., Jin,L., Zhang,J., Wu,X., Ji,X., Fan,B., Jia,Z.,
            Wang,A., Liu,J., Bu,Z. and Ji,J.
  TITLE     ASB16-AS1 up-regulated and phosphorylated TRIM37 to activate
            NF-kappaB pathway and promote proliferation, stemness, and
            cisplatin resistance of gastric cancer
  JOURNAL   Gastric Cancer 24 (1), 45-59 (2021)
   PUBMED   32572790
  REMARK    GeneRIF: ASB16-AS1 up-regulated and phosphorylated TRIM37 to
            activate NF-kappaB pathway and promote proliferation, stemness, and
            cisplatin resistance of gastric cancer.
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004596.2.
            
            On May 17, 2019 this sequence version replaced NM_080863.4.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and a SOCS box domain. The
            SOCS box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.140319.1,
                                           SRR1803615.154188.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151405, SAMEA2155550
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000293414.6/ ENSP00000293414.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               AC004596.2         50736-51122         c
            388-655             AC004596.2         49513-49780         c
            656-1148            AC004596.2         44596-45088         c
            1149-1262           AC004596.2         44104-44217         c
            1263-2142           AC004596.2         42742-43621         c
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2142
                     /gene="ASB16"
                     /note="ankyrin repeat and SOCS box containing 16"
                     /db_xref="GeneID:92591"
                     /db_xref="HGNC:HGNC:19768"
                     /db_xref="MIM:615056"
     exon            1..387
                     /gene="ASB16"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1448
                     /gene="ASB16"
                     /note="ankyrin repeat and SOCS box-containing protein 16"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 16"
                     /protein_id="NP_543139.4"
                     /db_xref="CCDS:CCDS11478.1"
                     /db_xref="GeneID:92591"
                     /db_xref="HGNC:HGNC:19768"
                     /db_xref="MIM:615056"
                     /translation="MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSS
                     PRARLTRPHRSCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGF
                     WVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVR
                     LLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAA
                     ARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGAD
                     ARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNW
                     EPEVLFAALLDYGAQPVRPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWK
                     EHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEG
                     CIQ"
     exon            388..655
                     /gene="ASB16"
                     /inference="alignment:Splign:2.1.0"
     exon            656..1148
                     /gene="ASB16"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1262
                     /gene="ASB16"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..2142
                     /gene="ASB16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggctcctc agagcaaggg aggtagtcgg gtcgagggaa cctggctctg cccaggtgcc
       61 actgcccaaa cccctgggcc ccatccatgg caagagagac cttccccttc acctcctcca
      121 tgctgcgctc tctccgcctg cagcaggagt ggctggaatg ggaggaccgg cggcgggcgg
      181 ctgcccagca gtgccggagc cgcaggtgcc cgtcaagtcc ccgggcccga ctcactaggc
      241 ctcaccgttc ctgccgagac ccagctgtcc accaagccct cttctccggc aacctgcagc
      301 aggtccaagc cctgttccaa gatgaagagg ccgccaacat gattgtggag actgtgagca
      361 accagctggc ctggtcggct gaacaggggt tctgggtgct gacccccaag accaagcaga
      421 cggcacccct cgccatcgct acagcccgag gctacacaga ctgtgctcga cacctgatcc
      481 ggcagggagc tgagctggat gcccgtgtcg ggggtcgcgc tgccttgcat gaggcctgtg
      541 cccgagccca gtttgactgt gtgcggctgc tgctgacctt cggagccaag gctaatgtgc
      601 tgactgagga gggcacgact cctttgcacc tctgcacgat ccccgagtcc ttgcagtgcg
      661 ccaagttgct gctggaagca ggagcgacgg tgaacctggc agcaggcgag agccaggaga
      721 cgcccctgca cgtggcggcg gcgcgcggcc tggagcaaca tgtggctctg tacctggagc
      781 atggcgccga cgtgggcctg cgcaccagcc agggcgagac tgcgctgaac acggcgtgcg
      841 ctggggccga gggcccaggt agctgcaggc gacaccaggc tgcggcgcgc cggctcctgg
      901 aggctggagc tgatgcccgg gcggccgggc gcaagcgcca cacgccgctg cacaacgctt
      961 gtgccaacgg ctgcgggggc ctggccgagc tgctgctgcg ttacggggcc cgcgctgagg
     1021 tccccaatgg ggcgggccac acgcccatgg actgtgcgct gcaggccgtc caggactccc
     1081 ccaactggga gcctgaagtc cttttcgccg cactgctgga ctacggggcg cagccagtgc
     1141 gccctgagat gctgaaacac tgcgccaact tccctcgggc cctggaagtc ctgcttaatg
     1201 cctatccttg tgtcccatcc tgtgagacct gggtggaggc ggtgctccca gagctgtgga
     1261 aggagcacga agccttctac agctcggccc tgtgcatggt gaaccagcca aggcagctgc
     1321 agcacctggc ccgactagct gtgcgcgctc ggttgggaag ccgctgccgg cagggtgcca
     1381 cccggctgcc actgcccccg ctcctcaggg actacctgct gctgcgtgtg gaggggtgca
     1441 tccagtgaac cccatgtcag gctgtcccat ggtgtgttct gcccctccca cctgtccccg
     1501 cctccaactg cggaggacca gttcctggcc ctcttttctt ttctttttga gacctagtct
     1561 cactctgttg cccaggctgg agtgcagtgg cgctatctcg gctcactgca acttctacca
     1621 cctaggttca agcgattctt gtgccccaaa cttccgagta gctgggacta caggcatgag
     1681 tcaccacacc tggctgattt tgtattttta gtagagacag ggtctcacca tgttggccag
     1741 gctggtctca cactgacctc aggtgatcca cccgccttgg cctcccaaag tgttgggatt
     1801 acaggcatga gccactgcgc ctggttgcct gcccctcttt tctgtactcc acgtgctgtc
     1861 ctggtccacc tcactcctcc atgggcttct tgagacacct gctgacctct agccggacct
     1921 gagcttcaga ccctctctcc agcaggaagg gctgcagact cggcctgttc ccagactcgg
     1981 ccttcacctc ccttctcctc ctgtgtttaa gtggatggcc cctctatcca tccaggtccc
     2041 atgccaagaa ccagtgattc tagtggccca ccacctccct ctcctgccac ccttatacct
     2101 gttcagcctc ctaaagaggg acaaactctg tctctgcgtg ca
//
