LOCUS       NM_001290258            4605 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 15 (ASB15),
            transcript variant 2, mRNA.
ACCESSION   NM_001290258 XM_005250145
VERSION     NM_001290258.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4605)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4605)
  AUTHORS   Farias Tempaku,P., Leite Santoro,M., Bittencourt,L., D'Almeida,V.,
            Iole Belangero,S. and Tufik,S.
  TITLE     Genome-wide association study reveals two novel risk alleles for
            incident obstructive sleep apnea in the EPISONO cohort
  JOURNAL   Sleep Med 66, 24-32 (2020)
   PUBMED   31786426
  REMARK    GeneRIF: Genome-wide association study reveals two novel risk
            alleles for incident obstructive sleep apnea in the EPISONO cohort.
REFERENCE   3  (bases 1 to 4605)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: The apparent occurrence of an unusual TG 3' splice site in
            intron 9 is critically discussed.
REFERENCE   4  (bases 1 to 4605)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   5  (bases 1 to 4605)
  AUTHORS   Yoshida,K.
  TITLE     Identification and characterization of ankyrin repeat and SOCS
            box-containing gene ASB15 in silico
  JOURNAL   Int J Mol Med 16 (2), 343-347 (2005)
   PUBMED   16012773
  REMARK    GeneRIF: ASB15 gene, consisting of 12 exons, was identified by
            using bio-informatics.
REFERENCE   6  (bases 1 to 4605)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006333.3, AK125360.1,
            BC100874.2, AF403033.1 and CR749595.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001290258.1.
            
            SUMMARY: This gene encodes a member of the suppressor of cytokine
            signaling box superfamily. The proteins in this superfamily
            participate in the ubiquitin-proteasome system for the degradation
            of proteins in the cell cycle and signal transduction pathways.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125360.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451215.6/ ENSP00000416433.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC006333.3         36614-36659
            47-160              AK125360.1         1-114
            161-161             AC006333.3         38891-38891
            162-507             AK125360.1         116-461
            508-517             BC100874.2         212-221
            518-970             AK125360.1         472-924
            971-1061            BC100874.2         675-765
            1062-1374           AK125360.1         1016-1328
            1375-2108           AF403033.1         576-1309
            2109-2135           AK125360.1         2063-2089
            2136-2242           CR749595.1         1617-1723
            2243-2571           AK125360.1         2196-2524
            2572-2639           CR749595.1         2053-2120
            2640-3002           AK125360.1         2593-2955
            3003-3021           CR749595.1         2484-2502
            3022-4605           AC006333.3         72691-74274
FEATURES             Location/Qualifiers
     source          1..4605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31.32"
     gene            1..4605
                     /gene="ASB15"
                     /note="ankyrin repeat and SOCS box containing 15"
                     /db_xref="GeneID:142685"
                     /db_xref="HGNC:HGNC:19767"
                     /db_xref="MIM:619757"
     exon            1..94
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            95..275
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            276..336
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            337..445
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..2105
                     /gene="ASB15"
                     /note="epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 15"
                     /protein_id="NP_001277187.1"
                     /db_xref="CCDS:CCDS34742.1"
                     /db_xref="GeneID:142685"
                     /db_xref="HGNC:HGNC:19767"
                     /db_xref="MIM:619757"
                     /translation="MDTNDDPDEDHLTSYDIQLSIQESIEASKTALCPERFVPLSAQN
                     RKLVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKT
                     LWEFKTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMV
                     STLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAA
                     EYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAG
                     HLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDV
                     NTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANN
                     YEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMH
                     GDIFGNSFVWSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYV
                     PLCAKLKSALEVQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLP
                     PAIQRYILFKEYDLYGQELKLT"
     exon            446..498
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            499..630
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            631..789
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1035
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1207
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1778
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1932
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..4605
                     /gene="ASB15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4536..4541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB15"
                     /note="hexamer: AATAAA"
     polyA_site      4561
                     /gene="ASB15"
                     /note="major polyA site"
     regulatory      4585..4590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB15"
                     /note="hexamer: ATTAAA"
     polyA_site      4605
                     /gene="ASB15"
ORIGIN      
        1 agatacacag aagcacacat tggctccagg gcacttcctc tgatttagga aggcaagtcc
       61 ctggataaga atgacaagat gatcattcca aaaggaaagc agtcaagaca gtgcaggagg
      121 tgaggccatc ttataggaag agcagttgtc cagcctctgg aagaaaaagc tcagtggaga
      181 tctgacagcc ttcctggggg atattaacag ggctcctgtg ttgcagagga acactacttt
      241 ctcagtgtag ctctgagaaa gagaaccaga aaaaggattt ctcttcagta gaaaaggcaa
      301 ataccataaa gaaggaatcg ctgtaactta ttgcttgaat ggatactaat gatgaccctg
      361 atgaagacca tcttacaagt tatgatattc agctaagtat tcaagaatcc attgaagcca
      421 gcaagactgc actttgtcct gaaagatttg tacccctaag tgctcaaaac agaaaacttg
      481 tggaggccat aaaacaaggt cacattcctg agctccagga gtatgtaaaa tataaatatg
      541 caatggatga agctgatgaa aaaggatggt ttccattgca tgaagctgtt gttcaaccca
      601 ttcaacaaat acttgagatt gttctggatg catcctataa gacactctgg gaattcaaga
      661 cctgtgatgg agaaacaccc ttgactttgg cagtcaaagc tggtctggtg gaaaatgtaa
      721 gaactttatt agaaaaggga gtgtggccca acacaaaaaa tgataaagga gagacccccc
      781 ttctgattgc tgtgaaaaag ggctcctatg acatggtgtc gactctgatc aaacataaca
      841 ctagcctaga ccagccctgt gtcaagcgat ggtcagcaat gcatgaagca gccaagcaag
      901 gccgaaaaga tatcgtagct ctgctgctga aacatggagg caatgtccac ctgagagatg
      961 gatttggagt cacaccacta ggcgtcgctg ccgagtatgg tcactgtgac gtgttagaac
     1021 atctaatcca caaaggtggt gatgtgcttg ctttggcgga tgatggggcg tcggtgctgt
     1081 ttgaggcagc aggaggtggc aatcccgact gcatttccct cctgctggaa tatggaggaa
     1141 gcggaaatgt acctaaccga gcaggacatc ttcctataca ccgagctgcc tatgaggggc
     1201 attatcttgc actgaaatat cttatcccag taacatctaa aaatgcaatt cggaaaagtg
     1261 ggctaacacc aattcactca gcagcagatg gacaaaatgc acagtgtcta gaactgctca
     1321 ttgaaaatgg ttttgatgtc aacactctac ttgctgacca catttcccag agctatgacg
     1381 atgagaggaa gactgcgctg tattttggcg tttctaataa tgacgttcat tgcacagaag
     1441 tccttctggc tgcaggtgca gacccaaact tagatcccct caactgtcta cttgttgcag
     1501 tgagggccaa taattatgaa attgtcaggc tgcttctctc ccatggagct aatgtcaatt
     1561 gttattttat gcatgtgaat gacactcgtt tccccagtgt cattcaatat gctctaaacg
     1621 acgaggtaat gctgaggcta ttgctgaata atggctatca agtggagatg tgctttgact
     1681 gcatgcatgg tgacatcttt ggaaattcat ttgtgtggtc agagatacag gaagaggtgc
     1741 tgccaggatg gacatcttgt gtaataaaag ataacccgtt ctgtgagttt attacagttc
     1801 cttggatgaa gcacttggta ggcagagtta ctcgtgtact aatagattac atggattatg
     1861 ttcctctgtg tgctaaactg aagtctgcac tagaagtaca gagagaatgg ccagaaatcc
     1921 gccaaatact agagaatcct tgttcattga agcatttgtg tcggttaaaa attcgaaggc
     1981 ttatgggtct ccagaaactc tgccagccag cctcagtgga gaagcttcct ctaccaccag
     2041 ctattcaaag atacatatta tttaaagagt atgatctcta tggacaagag ctaaaattga
     2101 cataacttaa tattttaaaa tgtgatttaa aaaaaatgtt gaaatgtgat tccctcagat
     2161 aatttcttgt aaccatttta catccttaat tgtaaagtgt atttaaattc attgacagtt
     2221 ttataggtta tcatgtgttc ttatgggaac accatgattt atgtctttaa agacatttgc
     2281 attttttaaa gatagtattt tgaacttaga tttgtatctt tgtttgctac aagtcatcaa
     2341 actctcccta tcaagtggct cctacaatat ccacaatcaa gtctctatgt ttaaaaaaca
     2401 gataaccact ttctcaaacc cacatctgcc agttgctggc cagattctcc tgtctttcac
     2461 ggtcttgctg tgtaaaagag ctcctcctgc ctgtaagttc acagactgtg atctggcatc
     2521 tgaccctcca ctgcttttct caaggtccct gacaatctct ttgttggtaa attcagtgaa
     2581 cattcttcag tccctcttcc aatcgattcc tacagcatct aacattgttg cctgttcctt
     2641 gcttgaaatg atatctcttt ccttgtttct cgcaaaacct gttctcttgg gtgtcctccc
     2701 acctccctgg acactctgtc tctggcttct ttctgcctag ctcatctcta gccaatctta
     2761 cagttatata tcttaagccc tcttctcttt gttctttaag ttatatatcc taagccctct
     2821 ttgctttgtt ctctgggata ttttatccac atccatggtc ttaatcattt tgctagagac
     2881 tacaaaattt ccatccaaag ctcagctctt tctctcatgt tctcctgacc tatgtagaca
     2941 attggcctca tgaacatttg aacacaaaga cacctcaaat tcaacatgtc cccagatgaa
     3001 ctaaaaaaaa aaaaaaaaaa aaaacctctt tcccgagctc agtagttagc acaatgctca
     3061 attcagtttc caaagaaaaa agcctggaca ttaggtttga ccatcccatt ttcctcaccc
     3121 aataagacaa atcaccaaat cctattaagt ttatctcctg aagtcatctt ccactcagca
     3181 gccccccacc acccaccccg catttggccc taagtctatt atcttctttt tcctgggata
     3241 atacaatgct gcttatctgg ctcccctgac tctgtcttgc cctgtcccaa acactttcta
     3301 catacagcat ctcagaagag tcttttacaa atataataga gtttcacttc tctgcttaag
     3361 atcattccca ttgctcttaa attccaaagt tcttacttga actttcatga tctaactcct
     3421 gccttcttct ttagcctcat ctctggatgt ctacctttcc tcctttccct tgaaccttct
     3481 agaattttat tttttaaaca ctgattccca gacttcaagg tgtcatacac taataggttt
     3541 tattgtgttt atttttcaaa aagagtcatt aaaaaatacc atctactatc accatcattt
     3601 cataaaagag gggtcatttt aatgccagaa agtaagatgg tcataaattc agtcattcaa
     3661 gttgaatgac ttttaccttg aaaagacctc acactgctct catttcccca ttgacgagtg
     3721 agaatttcac tgtgggccat caaatatctg aggacctttg tatggggaac ctctgctgta
     3781 gaatagacca tgctctcttt taacctcagg gtcttcgcat ttccttctct catctggaac
     3841 tctctttccg ctttttttgc accctttcac ctgatcaact cccacttacc ctataggtct
     3901 cagctgagat gttgcttcct ctaggatggg aagcctcagc acagaacttg tcatgccata
     3961 ttatagatgc ctgtgttccc tgctgtcttc ccactagact ataagctcta tgagggtagg
     4021 ttctatgttt gttttgtttt ccagtgcttt ctcagggcca aacacattcc ctagagcatg
     4081 gagttcaata attgtttgtt gaaatatatt gaataagtga caaaaataat cagtgacatc
     4141 atggtgaaat aatagtttta aatttctgag tgagttatgt aatcttgtaa ttatttaatg
     4201 ctattattct tagattttaa tagtgtattt ttcttatatt tatttttacc ttgttaccgt
     4261 attctttaaa cagtaatatc tcactggtct gtaaagtttt caagttgtat ttagctttag
     4321 ttacctttga aagataaata agtatgaaaa aaatcgtaca attagggcta taattttaac
     4381 ttcttgtatt ccctagagga tatattttat atgtaagtta aactgtaatg tatttatatt
     4441 taattgcaac atcttgtata caagatttta ttattcttgt gttgcactct tagacgtggt
     4501 taaatgtatt gttacctaaa aatattactc taatgaataa aaaatcatat tgaggttata
     4561 agtctgcttt atgatacttc atatattaaa cttttgctca ctaaa
//
