LOCUS       NM_001142733            3187 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 14 (ASB14),
            transcript variant 1, mRNA.
ACCESSION   NM_001142733
VERSION     NM_001142733.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093928.2 and AL832472.1.
            
            On May 17, 2019 this sequence version replaced NM_001142733.2.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and a SOCS box domain. The
            SOCS box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms.[provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832472.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000487349.6/ ENSP00000419199.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC093928.2         122437-122439       c
            4-26                AL832472.1         2-24
            27-27               AC093928.2         122413-122413       c
            28-1351             AL832472.1         26-1349
            1352-1352           AC093928.2         108334-108334       c
            1353-2741           AL832472.1         1351-2739
            2742-2742           AC093928.2         98541-98541         c
            2743-3178           AL832472.1         2741-3176
            3179-3187           AC093928.2         98096-98104         c
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..3187
                     /gene="ASB14"
                     /note="ankyrin repeat and SOCS box containing 14"
                     /db_xref="GeneID:142686"
                     /db_xref="HGNC:HGNC:19766"
     exon            1..53
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            54..246
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..1888
                     /gene="ASB14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat domain-containing SOCS box protein Asb-14;
                     ankyrin repeat and SOCS box protein 14"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 14 isoform
                     1"
                     /protein_id="NP_001136205.2"
                     /db_xref="CCDS:CCDS46856.2"
                     /db_xref="GeneID:142686"
                     /db_xref="HGNC:HGNC:19766"
                     /translation="MDNYTSDEDIDEDFDTQLIIQQSLQDIYKPGTAQHAPKDESLHS
                     FLSADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITL
                     SASDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLR
                     DCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFT
                     PLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADAN
                     IPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLI
                     QAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQI
                     ALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERC
                     FDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRIC
                     SKLKAVLQKQGIWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRL
                     KAYVLYKEYDLYGQGIFTGTW"
     exon            247..302
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            303..434
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            435..593
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            594..839
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1011
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1555
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1709
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1910
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..3187
                     /gene="ASB14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3160..3165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB14"
                     /note="hexamer: ATTAAA"
     polyA_site      3187
                     /gene="ASB14"
                     /note="major polyA site"
ORIGIN      
        1 gttagtcctt aacagtgaaa acttcactgc tgtcctagag gataaaacaa aagttgatct
       61 cttcacaact ggaaaaatac ttttaattca ctctgacttt aaagtaaacc tgtccacgtt
      121 tcacatggat aattacacca gcgatgaaga catagatgaa gactttgaca cccagctcat
      181 cattcaacag agtttgcagg atatttataa gccaggaaca gcacaacatg cacctaagga
      241 tgagagtttg cattcctttt tgagcgctga ctataagaag atagttgaaa caatagagaa
      301 aggtaaggaa gatgcattgt cacacttaac caagtaccat tccgcatttg gtgaagcaga
      361 tgagataggc tggattcctc tgcataaggc tgcagtgcaa ttaaatagga aaattttgga
      421 aataacccta agcgcttcag accccagtct gtgggagcaa accactcaca atggtgaaac
      481 gccacttttt ttggctgtca gcagttgcct cttagaaaat gccacttttc ttcttctcaa
      541 tggctgcaat ccaaatgcta agaatttcga aggcaattct cctcttcttg cagctgtgct
      601 gcgtgactgc tatgacatgg ctgccttgct gatcaactat ggagcagatg tcaatctgcg
      661 ttgtgccaac gagaggacag ctctccacga agcagccaaa ctgggcagag aggacatggt
      721 gaagcttatg ctggtttctg gggcacaccc tgacccacag agcacgtatg gattcactcc
      781 tcttgctctt gctgcccaaa gtggacacac tgaaatcatg gaaatgttac tgcggaaagg
      841 agctaatgct catggtcagg cctctgattc ttcttccatc ttacttgaag ccgcaagtgg
      901 aggaaatcca gatgctgtgg ctctcttgct ggagtatgga gctgatgcca acatccctaa
      961 gaattcaggc cacctgccca tccatgtggc agctgacagg ggccacttac tagctctaaa
     1021 gatactgatt ccagttacgg atcttgctgc cattaagcag agtgggatca gtccagttca
     1081 ctgtgcagca gcaggagcac atcctcagtg cctggaactc ctcatccagg ctggatttga
     1141 tgtgaacttc atgctggatc agagaattaa caaacactac gatgaccaca ggaagtcagc
     1201 tttgtatttt gctgtatcaa acagtgacct ctcttcagtc aagctgcttc tgagtgctgg
     1261 agctctgcct aatcaagacc cggttaactg cctccagata gccctcagga tgggcaacta
     1321 tgagctgatc agtctgctgc taaggcatgg ggccaatgtc aattacttct gcagagttaa
     1381 ccctttacat ttcccatcag cactgcaata cactctgaaa gatgaagtca tgctcaggat
     1441 gctgctgaac tatgggtatg acacagagcg atgttttgat tgcccacatg gagacaaagt
     1501 ccatccttcc tatactgttg aaggctggac atctacagtt atcaaagata ctaagttctg
     1561 tgaagtaata actttgtcat ggctgcaaca tctctctgga aaggttgttc gagtgatgct
     1621 tgattatgtt gatcaagttc ggatctgttc aaagttgaaa gctgtgctcc aaaaacaggg
     1681 gatctggtca gaaatacatt ttatcttaac aaaccctcgc tccctaaaac atttgtgccg
     1741 cctaaagatc cggaaatgca tgggacggtt acatttgcgc tgccctgtct tcatgtcatt
     1801 tcttccatta cccaatcgtc taaaagcata tgtcctttac aaagaatacg acctttatgg
     1861 acaaggaatt tttacaggaa cctggtaatc aaaccattct aatggaaaag gacaacaaac
     1921 tgcccctcac tactggcttg gtttggtcta ctggaagcag ctatcaaccg actttgttct
     1981 tccaagtcct agtggaaaag acaaaaaaga aactaagtta cttgtctgca gtcaaatggc
     2041 aaattatgca gttaagatac attcttgaga gccacttctt ctgtcataaa tatgtatgca
     2101 tacttctgac aacttgataa aaagaaaagc tacacccaaa caatacaaca ccaaaatgaa
     2161 ttttggcacc atcctataaa agccagcatt caaactaaaa tctaatattt tatctttctt
     2221 tttttatgac caacaaccaa ataaagccca tcatcaatca tctctcacta tatattatag
     2281 taaaaccctc gaaagggatc acccccacac tcctttccct tcccctctcc agcccttttc
     2341 tccatccctg tccaattcat ctttgctaaa tcaggtgtca ccttccctca gcctcgccta
     2401 tcaagaaagc ctcacttcaa tgtcatcttt gccacttccc tcttctttgt ccagagagcc
     2461 agcccacagc caatgcttat tgatctgttc taagcatccc agctgtctcc tcttttctat
     2521 tcctactgtc aatctacaac ccataacacg ctcttacaat ttcatggatc atttaatgca
     2581 ttcttcaagt tttgctctga aatttgtctt ttaaaattat tctgttggat ggacaatgat
     2641 ttgacactcc tggcaatatt aaaaatatac atttcattat atatttcata taacatatat
     2701 atttatttat ttccccccca tagaaggcaa aatggctttc agcaatggca gttaagtcta
     2761 cacagcctct caactgcttt gacagagaca acctcctctg aaatattaaa gttctggtat
     2821 atttttgaaa cagtcatatt acatgtcaac gtaactataa tgtaaacatc atatcaaaaa
     2881 acagatgtga cccttttctg ctatggtatg aatcatctgt ttatgaagtg gctgaacaag
     2941 cagaaacagc ccttcatttg gaaattcaaa tctgaaagtc atagtgctga attaagtctt
     3001 cacaaacaac acataaagat ccagacatta ggactgtata ccttttcaat ctgtttttgt
     3061 ttattgagtt ctttctgttg cttctctttt actctctcta tttctttttg tttttctgat
     3121 gccctacgat cctaaagaac agatgaataa aactaatgaa ttaaatatga aataacttta
     3181 aatttta
//
