LOCUS       NM_024701               2717 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 13 (ASB13),
            transcript variant 1, mRNA.
ACCESSION   NM_024701
VERSION     NM_024701.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2717)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2717)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2717)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2717)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   5  (bases 1 to 2717)
  AUTHORS   Rodriguez,J., Pilkington,R., Garcia Munoz,A., Nguyen,L.K.,
            Rauch,N., Kennedy,S., Monsefi,N., Herrero,A., Taylor,C.T. and von
            Kriegsheim,A.
  TITLE     Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct
            Signaling Pathways
  JOURNAL   Cell Rep 14 (11), 2745-2760 (2016)
   PUBMED   26972000
REFERENCE   6  (bases 1 to 2717)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   7  (bases 1 to 2717)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   8  (bases 1 to 2717)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP249999.1, AK292071.1,
            AF403031.1 and AI377400.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024701.3.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and a SOCS box domain. The
            SOCS box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. Multiple
            alternatively spliced transcript variants, both protein-coding and
            not protein-coding, have been described for this gene. [provided by
            RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.164679.1,
                                           SRR1660803.203968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357700.11/ ENSP00000350331.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BP249999.1         1-15
            16-889              AK292071.1         2-875
            890-2716            AF403031.1         872-2698
            2717-2717           AI377400.1         20-20               c
FEATURES             Location/Qualifiers
     source          1..2717
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..2717
                     /gene="ASB13"
                     /note="ankyrin repeat and SOCS box containing 13"
                     /db_xref="GeneID:79754"
                     /db_xref="HGNC:HGNC:19765"
                     /db_xref="MIM:615055"
     exon            1..87
                     /gene="ASB13"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..881
                     /gene="ASB13"
                     /note="ankyrin repeat domain-containing SOCS box protein
                     Asb-13"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 13"
                     /protein_id="NP_078977.2"
                     /db_xref="CCDS:CCDS7070.1"
                     /db_xref="GeneID:79754"
                     /db_xref="HGNC:HGNC:19765"
                     /db_xref="MIM:615055"
                     /translation="MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGAC
                     VNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVK
                     LLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAR
                     EHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKP
                     SDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLS
                     YN"
     exon            88..275
                     /gene="ASB13"
                     /inference="alignment:Splign:2.1.0"
     exon            276..426
                     /gene="ASB13"
                     /inference="alignment:Splign:2.1.0"
     exon            427..561
                     /gene="ASB13"
                     /inference="alignment:Splign:2.1.0"
     exon            562..753
                     /gene="ASB13"
                     /inference="alignment:Splign:2.1.0"
     exon            754..2717
                     /gene="ASB13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB13"
                     /note="hexamer: AATAAA"
     polyA_site      2717
                     /gene="ASB13"
                     /note="major polyA site"
ORIGIN      
        1 aggtcccggc gcccagagtc gccgcgcggc cgccggtgag ccgcatggag ccccgggcgg
       61 cggacggctg cttcctgggc gacgtgggtt tctgggtgga gcggacccct gtgcacgagg
      121 cagcccagcg gggtgagagc ctgcagctgc aacagctgat cgagagcggc gcctgcgtga
      181 accaggtcac cgtggactcc atcacgcccc tgcacgcagc cagtctgcag ggccaggcgc
      241 ggtgtgtgca gctgctgctg gcggctgggg cccaggtgga tgctcgcaac atcgacggca
      301 gcaccccgct ctgcgatgcc tgcgcctcgg gcagcatcga gtgtgtgaag ctcttgctgt
      361 cctacggggc caaggtcaac cctcccctgt acacagcgtc ccccctgcac gaggcctgca
      421 tgagcgggag ttccgaatgt gtgaggcttc ttattgacgt cggggccaat ctggaagcgc
      481 acgattgcca ttttgggacc cctctgcacg ttgcctgtgc ccgggagcat ctggactgtg
      541 tcaaagtgct gctcaatgca ggggccaacg tgaatgcggc aaagcttcat gagactgccc
      601 ttcaccacgc ggccaaggtc aagaatgttg acctcatcga gatgcttatc gagtttggcg
      661 gcaacatcta cgcccgggac aaccgcggga agaagccgtc tgactacacg tggagcagca
      721 gcgctcccgc caagtgcttc gagtactacg aaaagacacc tctgactctg tcacagctct
      781 gcagggtgaa cttgaggaag gccactggcg tccgagggct ggagaagatt gccaagttaa
      841 acatcccgcc ccggctcatt gattacctct cctacaactg aattgcaggt ggggtccgga
      901 ccgtggctgc ccccgttgtg cccagcattg cccgggtgag ggctctgcct gttcctctga
      961 agcagcgtga ttgctgtaga tagaacaacg ctccttcgag tcccttcctg cgatcctgtt
     1021 taggcttctc tcctggatcc tggataatgt ttccagggtg ttgggaaggc ctgcgtctca
     1081 ggtcacagtt gtgggtgtgg ccctgcgctg ttctacagaa cctaccctct caatgggcat
     1141 gggcccaacc atccagtttt cctcttttac ggaccatcct caaaggcact ctcaggacag
     1201 acggcgtggg gagcacagag gaggctggca gagctgggga ctgagggcat tgttgctgat
     1261 tctcactcac cggggcagcc tgccgcagat gcacaggccc caggtgcagg ccaccacctc
     1321 cgggtcggca ccaggactgc cctcggtgct catagggaat ggctgggccc acggaaggtc
     1381 ggcctgggat gtggcctggg actgctgctc tgctggctgc tgtgtggatg cttttcctgg
     1441 agcactttcc aaggcatccc ccagccccaa gcctgcgcgc atctgtcact cagggacttt
     1501 ctatgggtct ttgtggggga aggccctggc tttgtattcc ccacaagtag cactgagttt
     1561 cttaggaaat ttgtcttcag tattaggtct ccaactcttg taaaaagttt atatgtagga
     1621 taaaaacctt ttagaggaca cgtaggcggt accactaagg ttttggtaat gagccattca
     1681 aaccgacagc agtgtgaagg tgtgtcaagg tgtatattct cgtggctcgg cattctcagt
     1741 gcaaaggcct gtttggagac tctgtgggaa ttgtttttca tctgtttcta tggttgtcaa
     1801 atgaattctt cacccaccct acagtttgct aactccttga agctatcaaa ttagtaagac
     1861 catctatcac atccagcatt gtcccagtgc tttgagttgg acgggaatgg gactctgcag
     1921 ccaaggcagg ataagaaaat cttgcaatcc cgtcctgcag tgatagaaac aggtcgttct
     1981 gcattataag ccataggtgg agcattcggt agcgtattca gactgcatgg gccggcctag
     2041 gagtctttgc cttcataaat tttaagaacc ccgcccacaa cagggagtta aactggagga
     2101 ctttgcatga ttagttcagg gatgagtggt ttctggggca tctgaggtca ggagtttgaa
     2161 accagcctgg ccaacttgat gaaaccccat ctctacccat tctggagaac aggtcacgcc
     2221 tgtcctggag acagtgtgcc gggaaaaggg aacgtggtac tcactggatg cacccaggcc
     2281 ggcccgagcc tcccaccgca gacagtgtgg aacagagtga gcctgagctg cccaaggcga
     2341 tgccctttgt gctgtatgac tggaggcctc tccgcgtggg tacttggggg tggggccaca
     2401 aatctggcga aaaacttcat gctggccgcc gtgaggtttt actccagcgt tcccgccatt
     2461 gtcatggcgg gtcttcgtcc taaactgaga agaaaagcat tcctgtttga tcaccgcctt
     2521 agttaccagt tctggatcag tcagtgtttc tgcatggaat aacaaccatt aaaaaaagca
     2581 ctgggttctg ccctttcatc tttgtaagag attcttgcct ctagcaatga caacctgtga
     2641 tgtctcacag tagagcactt agcgcagaat caggtcccca cggctgttgc tcaataaaag
     2701 tggcggaata aagtgca
//
