LOCUS       NM_130388               1267 bp    mRNA    linear   PRI 22-DEC-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 12 (ASB12),
            mRNA.
ACCESSION   NM_130388
VERSION     NM_130388.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK096896.1, BC069555.1 and
            AA349954.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_130388.3.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and a SOCS box domain. The
            SOCS box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. [provided by
            RefSeq, Jan 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096896.1, SRR5189655.143303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2154361
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362002.3/ ENSP00000355195.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-641               AK096896.1         5-645
            642-1176            BC069555.1         446-980
            1177-1267           AA349954.1         3-93                c
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq11.2"
     gene            1..1267
                     /gene="ASB12"
                     /note="ankyrin repeat and SOCS box containing 12"
                     /db_xref="GeneID:142689"
                     /db_xref="HGNC:HGNC:19763"
                     /db_xref="MIM:300891"
     exon            1..145
                     /gene="ASB12"
                     /inference="alignment:Splign:2.1.0"
     exon            146..992
                     /gene="ASB12"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1126
                     /gene="ASB12"
                     /EC_number="3.1.3.95"
                     /note="ankyrin repeat domain-containing SOCS box protein
                     Asb-12"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 12"
                     /protein_id="NP_569059.3"
                     /db_xref="CCDS:CCDS14378.2"
                     /db_xref="GeneID:142689"
                     /db_xref="HGNC:HGNC:19763"
                     /db_xref="MIM:300891"
                     /translation="MRIVLQLAKMNLMDITKIFSLLQPDKEEEDTDTEEKQALNQAVY
                     DNDSYTLDQLLRQERYKRFINSRSGWGVPGTPLRLAASYGHLSCLQVLLAHGADVDSL
                     DVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGAVAILQELLD
                     HGAEANVKAKLPVWASNIASCSGPLYLAAVYGHLDCFRLLLLHGADPDYNCTDQGLLA
                     RVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPSLSLDLTSQDDKGIALLLQARAT
                     PRSLLSQVRLVVRRALCQAGQPQAINQLDIPPMLISYLKHQL"
     exon            993..1267
                     /gene="ASB12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1246..1251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB12"
                     /note="hexamer: AATAAA"
     polyA_site      1267
                     /gene="ASB12"
                     /note="major polyA site"
ORIGIN      
        1 attgttaaca gtgggaaacg agagccccag ctgctccagg ttggggccgt gggggctccc
       61 taaggagggg acaccagggc cccaatgttt cacagagggg cggggggcag cgaccctggg
      121 cagcatggcc tcaggctgaa gcccgatctg gcatttcctt gtgctcataa tgagaatagt
      181 tctccaatta gccaagatga acctcatgga catcaccaag atcttctccc tcctgcagcc
      241 cgacaaggag gaggaggaca ctgacacaga ggagaagcag gctctcaatc aagcagtgta
      301 tgacaacgac tcctatactt tggaccagct tttgcgccag gagcgttaca aacgtttcat
      361 caacagcagg agtggctggg gtgttcctgg gacacccttg cgcttggctg cttcttatgg
      421 ccacttgagc tgtttgcaag tcctcttagc ccatggtgct gatgttgaca gcttggatgt
      481 caaggcacag acgccacttt tcactgctgt cagtcatggc catctggact gtgtacgtgt
      541 gcttttggaa gctggtgcct ctcctggtgg tagcatctac aacaactgtt ctcccgtgct
      601 cacagctgcc cgtgatggtg ctgttgctat cctgcaggag ctcctagacc atggtgcaga
      661 ggccaacgtc aaagctaaac taccagtctg ggcatcaaac atagcttcat gttctggccc
      721 cctctatttg gccgcagtct acgggcacct ggactgtttc cgcctgcttt tgctccacgg
      781 ggcagaccct gactacaact gcactgacca gggcctattg gctcgtgtcc caagaccccg
      841 caccctcctt gaaatctgcc tccatcataa ttgtgagcca gagtatatcc agctgttaat
      901 cgattttggt gctaatatct accttccatc tctctccctt gacctgacct cacaagatga
      961 taaaggcatt gcattgctgc tacaggcccg agccactcca cggtcacttc tatcacaggt
     1021 ccgtttagtc gtccgcagag ccttgtgcca ggctggccag ccacaagcca tcaaccagct
     1081 ggatattcct cccatgttga ttagctacct aaaacaccaa ctgtaatctt gcagtctccc
     1141 caggaactta tgatgcctcc gaaaaccacc tggggactca cgtagctgga gagcattaca
     1201 gcctcatcca cttacctgga gctgctctcc tgtattatcc tccacaataa aattctccag
     1261 aaaataa
//
