LOCUS       NM_080873               2815 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 11 (ASB11),
            transcript variant 1, mRNA.
ACCESSION   NM_080873
VERSION     NM_080873.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2815)
  AUTHORS   Chang,Y., Chen,Q., Li,H., Xu,J., Tan,M., Xiong,X. and Sun,Y.
  TITLE     The UBE2F-CRL5ASB11-DIRAS2 axis is an oncogene and tumor suppressor
            cascade in pancreatic cancer cells
  JOURNAL   Dev Cell 59 (10), 1317-1332 (2024)
   PUBMED   38574733
REFERENCE   2  (bases 1 to 2815)
  AUTHORS   Chen,F.Y., Huang,M.Y., Lin,Y.M., Ho,C.H., Lin,S.Y., Chen,H.Y.,
            Hung,M.C. and Chen,R.H.
  TITLE     BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate
            during cellular stress
  JOURNAL   J Cell Biol 218 (9), 3002-3018 (2019)
   PUBMED   31387940
  REMARK    GeneRIF: study reveals that different cellular stresses regulate
            BIK ubiquitination by ASB11 in opposing directions, which
            determines whether or not cells survive, and that blocking BIK
            degradation has the potential to be used as an anti-cancer
            strategy.
REFERENCE   3  (bases 1 to 2815)
  AUTHORS   Andresen,C.A., Smedegaard,S., Sylvestersen,K.B., Svensson,C.,
            Iglesias-Gato,D., Cazzamali,G., Nielsen,T.K., Nielsen,M.L. and
            Flores-Morales,A.
  TITLE     Protein interaction screening for the ankyrin repeats and
            suppressor of cytokine signaling (SOCS) box (ASB) family identify
            Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase
  JOURNAL   J Biol Chem 289 (4), 2043-2054 (2014)
   PUBMED   24337577
  REMARK    GeneRIF: ASB11 is a novel endoplasmic reticulum-associated
            ubiquitin ligase with the ability to interact and promote the
            ubiquitination of Ribophorin 1, an integral protein of the
            oligosaccharyltransferase (OST) glycosylation complex.
REFERENCE   4  (bases 1 to 2815)
  AUTHORS   Diks,S.H., Bink,R.J., van de Water,S., Joore,J., van Rooijen,C.,
            Verbeek,F.J., den Hertog,J., Peppelenbosch,M.P. and Zivkovic,D.
  TITLE     The novel gene asb11: a regulator of the size of the neural
            progenitor compartment
  JOURNAL   J Cell Biol 174 (4), 581-592 (2006)
   PUBMED   16893969
REFERENCE   5  (bases 1 to 2815)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC095351.5, BX537857.1 and
            AF425642.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_080873.2.
            
            Summary: The protein encoded by this gene is a member of the
            ankyrin repeat and SOCS box-containing (ASB) family of proteins.
            They contain ankyrin repeat sequence and SOCS box domain. The SOCS
            box serves to couple suppressor of cytokine signalling (SOCS)
            proteins and their binding partners with the elongin B and C
            complex, possibly targeting them for degradation. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC103875.1, AF425642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267756 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000480796.6/ ENSP00000417914.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC095351.5         99898-99913
            17-35               BX537857.1         1-19
            36-1007             AF425642.1         1-972
            1008-1331           BX537857.1         941-1264
            1332-2654           AC095351.5         132358-133680
            2655-2815           BX537857.1         2586-2746
FEATURES             Location/Qualifiers
     source          1..2815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..2815
                     /gene="ASB11"
                     /note="ankyrin repeat and SOCS box containing 11"
                     /db_xref="GeneID:140456"
                     /db_xref="HGNC:HGNC:17186"
                     /db_xref="MIM:300626"
     exon            1..216
                     /gene="ASB11"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1007
                     /gene="ASB11"
                     /note="isoform a is encoded by transcript variant 1;
                     ankyrin repeat domain-containing SOCS box protein ASB11;
                     ASB-11; ankyrin repeat and SOCS box containing 11, E3
                     ubiquitin protein ligase"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 11 isoform
                     a"
                     /protein_id="NP_543149.1"
                     /db_xref="CCDS:CCDS14164.1"
                     /db_xref="GeneID:140456"
                     /db_xref="HGNC:HGNC:17186"
                     /db_xref="MIM:300626"
                     /translation="MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGN
                     RKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSL
                     HEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLE
                     VHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLEL
                     GASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQ
                     ALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ"
     exon            217..296
                     /gene="ASB11"
                     /inference="alignment:Splign:2.1.0"
     exon            297..404
                     /gene="ASB11"
                     /inference="alignment:Splign:2.1.0"
     exon            405..555
                     /gene="ASB11"
                     /inference="alignment:Splign:2.1.0"
     exon            556..690
                     /gene="ASB11"
                     /inference="alignment:Splign:2.1.0"
     exon            691..882
                     /gene="ASB11"
                     /inference="alignment:Splign:2.1.0"
     exon            883..2815
                     /gene="ASB11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtcctag gaccctatac agagcataag ccaaaatgga agatggtcct gttttctatg
       61 gctttaaaaa catttttatt acaatgtttg ctacgttttt tttctttaag cttttaatta
      121 aagttttttt ggctctccta acccatttct atatcgtcaa aggaaataga aaagaagcgg
      181 ctaggatagc agaagagatc tatggtggaa tttcagattg ctgggctgat cgatccccac
      241 ttcatgaagc tgcagctcag gggcgcttac tggcccttaa aactttaatt gcacaaggtg
      301 tcaatgtgaa ccttgtgaca attaaccggg tgtcttctct ccacgaggca tgccttggag
      361 gtcacgtggc ctgtgccaaa gccttattgg aaaatggtgc acacgtcaat ggagtgacag
      421 ttcacggagc cacacccctc ttcaatgctt gctgcagcgg cagtgctgca tgtgtcaatg
      481 tgctgctgga gttcggagcc aaggcccagt tggaggtgca cctggcctcg cccatccatg
      541 aggcagtgaa gagaggtcac agagagtgca tggagatcct gctggcaaat aatgttaaca
      601 ttgaccatga ggtgcctcag ctcggaactc ccctatatgt ggcctgcacc taccagaggg
      661 tagactgtgt gaagaaactt ctagaattag gagccagtgt cgaccatggc cagtggctgg
      721 acaccccact ccatgctgca gcgaggcagt ccaatgtgga ggtcatccac ctgctaaccg
      781 actatggagc taacctgaag cgtagaaatg ctcagggcaa aagtgcgctt gatctggcgg
      841 ctccaaaaag cagcgtggag caggcactct tgctccgtga aggcccacct gctctttccc
      901 agctctgccg cctgtgtgtc cggaagtgtc tcggtcgagc atgtcatcaa gccatccaca
      961 agctacatct gccagagcca ctcgaacgat tcctcctata ccaatagtcc taagtgttcc
     1021 tgggaagata cttggaatga cacagattgt tgtctgctgt acctagagta cctaatgtag
     1081 aagctcaaca gcttagactc ctagtatctt taaatgagct cagtcgaagt aaatccccca
     1141 tgagctagaa cacttgagga gtggaaactc ctggttagtt taatgttctc attaaccaag
     1201 gggcaagtag aaaccattta gcttttagct cttgttgtta agaaacttaa aagaactgtg
     1261 aagtagagtg aaaacaatag gctgtttttt gatgattcgg gatcttcttg tacctaaaag
     1321 tcaacattct gaatattgta tagacacata taaattcagg tggataagat tataacaaat
     1381 gttaggtatt ccaagatatg ttcttgattt agttccttcc ttcagccctt ccccactttt
     1441 tttctttctt tccttgaata aatctggtat aattttgatt ttttgtatat atatacgtat
     1501 atatatatac atacatatac gtatatatat atacgtatat atatacacac acacacatgc
     1561 actcatatat ttaatgtttt caaagtcctt aatatatata gttcatatat gttttcaaag
     1621 tccttaatat atgtataaag cttatatata tatgttttca aagttcttta tatataaagt
     1681 tatatatatt tatatagact ttatatatat atacatatat aaagttaagg acttcagaaa
     1741 cattgtagtt aactgaggct tccagttact gcggtcctgg ttgataagag agactttgga
     1801 agagatcagt gcacccagag gttggcatct attgcttatt gcttctgata ttaaatgctg
     1861 ttatttgaag taagcagttc taggattgag aacactgggt gtccccaaca acctgaaccc
     1921 acaggcattg tctgaggcat gttgcaaccc aagcactggc ttattttcaa agtcaagatg
     1981 ctcagggttt ttgaaataat tacatactga tgccagccac caaagtgggc tcaatgctgg
     2041 gtcaatattt ttttctgtgg ataggggccc aaaataagca caaaggtata taaaaagagg
     2101 cttctccttt tctgtcttct ccttcttctc atttctctct ccttctgtca cccctcctct
     2161 tcctctattc tttctctttt ttgtgaattt agaacatggg aactggatag acttttaatt
     2221 attgtaagta ttactgtcat ggttcagtat tcagttctaa aatgaaaatt ccctctcaga
     2281 tcatcctaag actcatttca cacatgtttt tttttccccc aatttttcta gacctttggc
     2341 tctcaactgg agacaatttt gccccactcc cactgagaca tttgtcaatg tctgcagaca
     2401 tgtttagttg caacaactgg gggagaattg ctactatcat ctagacggtg gagatcaggg
     2461 atgcagctaa tcaccctaca gtgcacagga gccagcaaca aagaattatc agatctggcc
     2521 gggcatggtg gctcacgcct gtaatcccag cattttggga ggccgaggca ggcagatcgc
     2581 actgtcagga gttcgagaac cgcctggcca ctatggtgaa accctgtctc tactaaaaat
     2641 acaaaagtta gccaggcgtg gtggcaggtg cctatagtcc cagctacttg ggaggctgag
     2701 gcaggagaat cacttgaacc cgggaggcgg agattgcagt aagccaagat cacgccactg
     2761 cactccagcc tgggtgacag agcgagactc cgtctcaaaa caaaaaaaaa aaaaa
//
