LOCUS       NM_001040445            6891 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ankyrin repeat and SOCS box containing 1 (ASB1),
            transcript variant 1, mRNA.
ACCESSION   NM_001040445
VERSION     NM_001040445.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6891)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6891)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6891)
  AUTHORS   Emeny,R.T., Baumert,J., Zannas,A.S., Kunze,S., Wahl,S., Iurato,S.,
            Arloth,J., Erhardt,A., Balsevich,G., Schmidt,M.V., Weber,P.,
            Kretschmer,A., Pfeiffer,L., Kruse,J., Strauch,K., Roden,M.,
            Herder,C., Koenig,W., Gieger,C., Waldenberger,M., Peters,A.,
            Binder,E.B. and Ladwig,K.H.
  TITLE     Anxiety Associated Increased CpG Methylation in the Promoter of
            Asb1: A Translational Approach Evidenced by Epidemiological and
            Clinical Studies and a Murine Model
  JOURNAL   Neuropsychopharmacology 43 (2), 342-353 (2018)
   PUBMED   28540928
  REMARK    GeneRIF: Epigenetic regulation of the stress-responsive Asb1 gene
            in anxiety-related phenotypes.
REFERENCE   4  (bases 1 to 6891)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 6891)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   6  (bases 1 to 6891)
  AUTHORS   Kohroki,J., Nishiyama,T., Nakamura,T. and Masuho,Y.
  TITLE     ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin
            ligase complexes
  JOURNAL   FEBS Lett 579 (30), 6796-6802 (2005)
   PUBMED   16325183
REFERENCE   7  (bases 1 to 6891)
  AUTHORS   Kile,B.T., Schulman,B.A., Alexander,W.S., Nicola,N.A., Martin,H.M.
            and Hilton,D.J.
  TITLE     The SOCS box: a tale of destruction and degradation
  JOURNAL   Trends Biochem Sci 27 (5), 235-241 (2002)
   PUBMED   12076535
  REMARK    Review article
REFERENCE   8  (bases 1 to 6891)
  AUTHORS   Kile,B.T., Metcalf,D., Mifsud,S., DiRago,L., Nicola,N.A.,
            Hilton,D.J. and Alexander,W.S.
  TITLE     Functional analysis of Asb-1 using genetic modification in mice
  JOURNAL   Mol Cell Biol 21 (18), 6189-6197 (2001)
   PUBMED   11509662
REFERENCE   9  (bases 1 to 6891)
  AUTHORS   Kile,B.T., Viney,E.M., Willson,T.A., Brodnicki,T.C., Cancilla,M.R.,
            Herlihy,A.S., Croker,B.A., Baca,M., Nicola,N.A., Hilton,D.J. and
            Alexander,W.S.
  TITLE     Cloning and characterization of the genes encoding the ankyrin
            repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and
            Asb-4
  JOURNAL   Gene 258 (1-2), 31-41 (2000)
   PUBMED   11111040
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016999.8 and BC014528.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001040445.2.
            
            Summary: The protein encoded by this gene contains an ankyrin
            repeat sequence and SOCS box domain. The SOCS box serves to couple
            suppressor of cytokine signalling (SOCS) proteins and their binding
            partners with the elongin B and C complex, targeting them for
            ubiquitination and degradation. [provided by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.15560.1,
                                           SRR1660803.17137.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264607.9/ ENSP00000264607.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC016999.8         18238-18295
            59-1373             BC014528.2         1-1315
            1374-6891           AC016999.8         38044-43561
FEATURES             Location/Qualifiers
     source          1..6891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..6891
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /note="ankyrin repeat and SOCS box containing 1"
                     /db_xref="GeneID:51665"
                     /db_xref="HGNC:HGNC:16011"
                     /db_xref="MIM:605758"
     exon            1..193
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1152
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ankyrin repeat and SOCS box protein 1"
                     /codon_start=1
                     /product="ankyrin repeat and SOCS box protein 1 isoform 1"
                     /protein_id="NP_001035535.1"
                     /db_xref="CCDS:CCDS33416.1"
                     /db_xref="GeneID:51665"
                     /db_xref="HGNC:HGNC:16011"
                     /db_xref="MIM:605758"
                     /translation="MAEGGSPDGRAGPGSAGRNLKEWLREQFCDHPLEHCEDTRLHDA
                     AYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGA
                     EVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL
                     KALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP
                     DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESR
                     GRRKVDPEALQVFKEARSVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLH
                     E"
     exon            194..335
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..638
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..1024
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..6891
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /note="hexamer: ACTAAA"
     polyA_site      1373
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /note="major polyA site"
     regulatory      1539..1544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1561
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
     regulatory      6863..6868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /note="hexamer: AATAAA"
     polyA_site      6891
                     /gene="ASB1"
                     /gene_synonym="ASB-1"
                     /note="major polyA site"
ORIGIN      
        1 agtgaggccg gcgcgcgccc gccggaagcc gcgaccccga cgcgcccccc attgccctcg
       61 gcgccggaag tggtcgcggg tcgttctgct tcctgcccga ggggcgtgcg cgggtcaggg
      121 gcggccgcgg aggcggaagc atccatggcg gagggcggca gcccagacgg gcgggcaggg
      181 ccgggctccg caggtcgtaa tctgaaggag tggctgaggg agcaattttg tgatcatccg
      241 ctggagcact gtgaggacac gaggctccat gatgcagctt acgtcgggga cctccagacc
      301 ctcaggagcc tattgcaaga ggagagctac cggagccgca tcaacgagaa gtctgtctgg
      361 tgctgtggct ggctcccctg cacaccgttg cgaatcgcgg ccactgcagg ccatgggagc
      421 tgtgtggact tcctcatccg gaagggggcc gaggtggatc tggtggacgt aaaaggacag
      481 acggccctgt atgtggctgt ggtgaacggg cacctagaga gtacccagat ccttctcgaa
      541 gctggcgcgg accccaacgg aagccggcac catcgcagca cccctgtcta ccacgcctct
      601 cgcgtgggcc gggcagacat cctgaaggcc ctcatcaggt acggggctga tgttgacgtc
      661 aaccaccacc tgactcctga tgtccagcct cgattctccc ggcggctcac ctccttggtg
      721 gtctgcccct tgtacatcag cgcagcctac cacaacctcc agtgcttccg gctgctcctc
      781 ctggctggcg cgaaccctga cttcaactgc aatggtcctg tcaacacaca gggattctac
      841 aggggctccc ctgggtgcgt catggatgct gttctgcgcc acggctgtga ggcagccttc
      901 gtgagcctgc tggtagaatt tggagccaac ctgaatctag tgaagtggga atcgctgggc
      961 ccagagtcga gaggaagaag aaaagtggac cctgaggcct tgcaggtctt taaagaggcc
     1021 agaagtgttc ccagaacctt gctgtgtctg tgccgtgtgg ctgtgagaag agctcttggc
     1081 aaacaccggc ttcatctgat tccttcgctg cctctgccag accccataaa gaagtttcta
     1141 ctccatgagt agactccaag tgctgcggtt gattccagtg agggagaaag tgatctgcag
     1201 ggaggtggac accgagccct gagtgctgtg ctgctgctgg tctcctgatg gctgttgctg
     1261 cagaagatgt cctcgtagac tgtcattgct cctcaggtgc ctgggccgct gaacagtcct
     1321 tgggtcattg tcagctgaga ggcttatact aaagttatta ttgtttttcc caagttctct
     1381 gttctggatt ttcagttgca tattaatgta acgggccatg gggtatgtac atgtaggggc
     1441 tgaggttgga ggcctactaa tttccctgta gggaagactc ccagcacttc tggaactgtg
     1501 cttctcttta tttttctact tctcaatttg atggttcgat taaagccttc tagtatctca
     1561 atgaaaaggg agtttcgtaa gcaaaataga ggacagaaat gcagttcatg aacttgctgg
     1621 ttggtttttc ctgctcctgg ggtaacacat gcgcttgtca tacacgcccc ttccttgccc
     1681 cttcagtatt ctctctttgc gatggaggtc tcatagtgag tgtcttcact caagggtggt
     1741 ttcctggctg cacggcacct gttccaacac ctactgtgcc tctcatcagg tgtcacgatt
     1801 tttctgccac ttcaccttag ggagcttcca gtgattgatt ttaggaggcc cacaccaaac
     1861 tccccaggaa atgactgcct tccttgggac caaggaccgt tccaacagca ttcactgcca
     1921 gttctaatag gcgaggaaaa tgcccgaggc gctgtcttct gtcccccaca cgtaccagaa
     1981 agtgaaaaat gcagcgagtc ctctgggtgg ttatgagcct ccaggcgcat gctgtccagt
     2041 ggacagaaca tctggcggtt ggttgattgc tctcttttgt cttggtcgct gcttctagaa
     2101 tctatgcagg ggatagcagt gaggtcagaa gtctttcccg ggagagagat ggcctgggtt
     2161 atcattgctg atagctttgg ctgcatgagt tgggcttccc cttacccagg gctgcacagc
     2221 caggtgtgag ggtcaccggc aggtgggctg gtggctgcag cctcagagcc ctcccaggtt
     2281 gctgctgttt ccagtgaatc acatttcgtc atttgaagcc catgaggacc attgtgtgga
     2341 tccatggtga ttctagactt cagatatatt taggaaggcg cagatttcaa atctgtgttt
     2401 gattttctgt aataagagaa atccaatttg taaaacttga acaatgatac cgttttattt
     2461 acttagtagc atcactgtgt gtcttagcag gcaggcagtg tctggccatt attgcgttct
     2521 acagccagag gatagaattc tataccccca accccttgtg tcacaaatgg gctctgtgtg
     2581 ggtcacccca gctgacccgt gtatgtgcag atgcagttcc gaagggaaga acagtcctcg
     2641 ggtgattcag aggggaaaat gcaatccggg aggtgtttcc tcagctgagg tgacactgtt
     2701 agaagctgtg atggttgtgt aaatgtgggc tgtgtgctgt tcccgagggg agcttgggat
     2761 tgggtcctgc tgaagccagg agggtcttcc caagatagga gaggaaccgc aggtggtgag
     2821 cggctgggga gggccaggac agccggggct gggtgctgca ggggcttcag cccgggagag
     2881 ggggtgggcg tgttctttgt ggtaccaaag tgggactagg acaaaaattg ggctgtggct
     2941 ggggcaggag ctatagggag ttaaggaatg atgatacgga agttggagcc accaccgtgg
     3001 actgggcctt gtcactggag gtcgtaggca gtggctcatc accctggtag ggctgatagg
     3061 ggctttcagg gaggctggtt agctccctgc actctggctc tttactggct tactgtttag
     3121 ctcctcccac ctcgaggctc ttcttcctgc caccctttgg gctcagagga gggtggcttt
     3181 tttcgaggtg agccatgttg tagacacatg atacgctctg cgtctgctct actgagtact
     3241 ttctgcaggg gcctgttaag gacgaggcct ccccagccct gcccggtgca ggaggtggct
     3301 cagttattga accttttggg aagcagcacc tgggaatgct gcctcgtggg agtcccatgc
     3361 gtgagtgtgg tggtgtgacc ttcaggctgc acagaggcaa ggacccagat gtggcagcat
     3421 gggcgtcatg ctcctttgca cagcccaggg cctgttttgg agggaccagg tcactgcccc
     3481 tggtctctct aggaggagtg gactgaatgg atcgttgcag agaagactca cccagacctg
     3541 gccagggaat gatgtatctg gggagagaat gagctggagg agggggcctc tcatggccct
     3601 tccctggcct gtggcccagc ctggctggcc tgcaggtgtc tagggtctca gcttttcatt
     3661 tgcagaggac atgttcaact tcctctctgt tcaagccagc ctttgccaat tttttcagaa
     3721 tccaaacaat ttggaggttt ggtatcttgt ttcatagctg ccaaatatga atctgaaaac
     3781 agggtgggta gctaaggtca ttcctcctgg gttttagtgg cattgccttc cttcactaaa
     3841 gctccctttt ttttctgttg gcaaggacag gttacagaat aggaagagta gcactttccg
     3901 cctaagcact ttaggaaatc acctttctaa gccctggggc gcccaagtcc catgggacag
     3961 ggaaacgtgg tcctcagtga ggctgctgcc tggctggccc ggagtcctcc ctaggagagg
     4021 ggctcgatgg gctgggggaa ggagcctgaa ggttgcccct ggttgcatcc cagaagcatc
     4081 tgactgtcac cactgccagt ggctgtggaa cagtcctggg ccctgggcct tggctgctgt
     4141 caacagatgg gctgggctgg gctgtggtgg ggtgggggac aacgttggta actctgagaa
     4201 ttcagctttg gagtcccggg tgaggggttt tagataaacc catcaatatc acccacattc
     4261 tgtgactctt tgcatcactc gtgttattta tttatttatt tatattctgc cttgttccag
     4321 aaaagtgttt aaggcaacaa tgcttgtttt ttggtgtttt cttttgacat ttgaaaattt
     4381 agtacattgt taaaatgtac ttgttaaaca ggtaatttta aagagaagga acaattgttt
     4441 ttagtaagtt ttctttttcc tttttcaatg aattgattct tcaaattaaa agttcttgag
     4501 agaaggagag gaagatacag cagacatagg actgagccaa ggaagagtct gcctgagaga
     4561 gacgcttggc ctgtgctttg ctgccatccg tgcggccttg gccacatccc tattaacaga
     4621 ggcagctcca cttcagacag ggacaaggct tcctgctgtg cctttctggc agggttttgt
     4681 ggggtcacat gggaagcaat gtgttacgca agcagtctcc atgtgtgtgt aaactgctgt
     4741 cctggtgact tgtccctctt cttagtggaa atgcatttga gatggtgaca gggctggatg
     4801 aacgtgtgac cctgggagat ccgggctgga ctgtggaccc cgatgggcca gagtccttgt
     4861 ggcccacagc atagcactgg ggacagagcg ctctatgcag gtgaggcgta tgagaacagc
     4921 atggtaaata attgatgaag tcacatttgt tcaacttaaa ggattgttct ttattctgaa
     4981 gttattttct tccttatttg gatgataaaa tttcctttta tgtaatgaag gtaaaagtag
     5041 agggcaatat ttttgctttt tgaaatgctc ttggttgcaa aacaaaatgt tggttgctgt
     5101 ttgtcagccc cagaatttct tcttaagttc gcctgtctct gaaatcccaa agtcacggaa
     5161 ccgcagtcta gctgtggtgc atgtttacgt attggtgaga aattcctctt gggttcttga
     5221 acagcctgta cgctggcagg cagcactgca gcatttctgc tgctcatggc caagaacgag
     5281 tctggagatc gctgcgtgcg gttttaggaa gtgccaacac ccgtggtgat gggcctctgg
     5341 ccacccctgg atccatggga cacactcaca ggaagctgat gtggccttct cggtgaggac
     5401 tgcaccttaa cctgggcact gggagcctgt ggcccccctg tatgttggtg atgacactag
     5461 tgtgggtctt ctggctctgg ggctacagct tctgcctcct cacctggccg tcggtactcg
     5521 gcaagcaggc ctggcctccc ggggcctgga tccctaccgg ctgggattgg cctcctggaa
     5581 gtacctgttt gggccatgtg acctcctttc tcacttatgc ctcactcccc tcctcccgct
     5641 ccaaacccga acctctcagt gtggaatgaa cgctccaaac ccgaacctct cagtgtggaa
     5701 tgaacgctcc aaacccgaac ctctcagtgt ggaatgaaac agtttagatg tgtacatgat
     5761 gcacgtgggt gggattcaca tcccaggaga attccacgga gaggaatgtg cagattttga
     5821 agtgtacagt gatgtgtgga ataaatacta gaaattctca gcagacagtg ggatggagaa
     5881 gtgagtgggg gcaggagggg gatttctgtt gccttgacat gtcgttgctc agtgcctgga
     5941 ttgcaggcga gtctctcttt tttatgttgc tttgatttca agatctctta gatatactag
     6001 gtagtgtatg aatgtgcata aatccagttt gagaatggtg tttatgaaga agctgtttcg
     6061 tgtgtacagt tgctgctgta atttagccag cagtgccctg ccctgccctg cagtgtctgc
     6121 tcagctccca ctgcttctct ttgctgttgg gcatgtgagg catgacttgg aggggggcct
     6181 ggtgcctggg gacctgctga agagaatgct caccaccagc tctctgtttc cctttctgct
     6241 ttggtaatca acacgtgttt gcctgcagtg gccgggaccg tgactgtttc tgcccttgtg
     6301 cctagttaag agccttcaaa agcataatga acacttttga tatgatattg taactttagt
     6361 aaatgcttta cttccctcta attgccccca aatgccttaa ttttgtggac tgtttatttc
     6421 aacaggtgga agtgttggtc gtgcgaaatc ttggtattcg catttcaaga agggagttct
     6481 tttttctttc ttctttctat ggaacgtttc aagtgattgg atagaaagaa gggctctgaa
     6541 gcaggagttt tcacctgctc tgagggaact tggggctcca gggacgtacc ccaaatgttg
     6601 cccaggttga aactccctga cagcctgttc tacgtagtgg ctcgtggttt ccagtttgaa
     6661 gagagttgtg cccctaaaag tgtttgaaac ctgtggcttt caagcaaggt accgttgtcc
     6721 ccacagtgtt ccgtggggta gggggtgatg gagactgtgg gcaagcctgt tgtttttggc
     6781 cccctgttgt tacatgggac ctgttttgac ggtgggaggg tgagatgtga agatgtggga
     6841 tgaacctgga atgaacgaat taaataaaga catgcatcca tctgtcagcg a
//
