LOCUS       NM_017707               4051 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
            (ASAP3), transcript variant 1, mRNA.
ACCESSION   NM_017707
VERSION     NM_017707.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4051)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4051)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4051)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4051)
  AUTHORS   Song,X., Xu,W., Xu,G., Kong,S., Ding,L., Xiao,J., Cao,X. and
            Wang,F.
  TITLE     ACAP4 interacts with CrkII to promote the recycling of integrin
            beta1
  JOURNAL   Biochem Biophys Res Commun 516 (1), 8-14 (2019)
   PUBMED   31182282
  REMARK    GeneRIF: ACAP4 physically interacts with CrkII. Functional
            characterization showed that the interaction is required for the
            recruitment of ACAP4 to the plasma membrane where ACAP4 functions
            to regulate the recycling of the signal transducer integrin beta1.
REFERENCE   5  (bases 1 to 4051)
  AUTHORS   Guo,L., Fu,J., Sun,S., Zhu,M., Zhang,L., Niu,H., Chen,Z., Zhang,Y.,
            Guo,L. and Wang,S.
  TITLE     MicroRNA-143-3p inhibits colorectal cancer metastases by targeting
            ITGA6 and ASAP3
  JOURNAL   Cancer Sci 110 (2), 805-816 (2019)
   PUBMED   30536996
  REMARK    GeneRIF: MiR-143-3p acts as an anti-oncogene by downregulating
            ITGA6/ASAP3 protein expression and could offer new insight into
            potential therapeutic targets for CRC.
REFERENCE   6  (bases 1 to 4051)
  AUTHORS   Ismail,S.A., Vetter,I.R., Sot,B. and Wittinghofer,A.
  TITLE     The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory
            mechanism
  JOURNAL   Cell 141 (5), 812-821 (2010)
   PUBMED   20510928
  REMARK    GeneRIF: The ArfGAP catalytic mechanism and shows a glutamine from
            Arf6 and an arginine fingerASAP3 as the important catalytic
            residues; unexpectedly the structure shows a calcium ion, liganded
            by both proteins in the complex interface.
            Erratum:[Cell. 2010 Dec 23;143(7):1190]
REFERENCE   7  (bases 1 to 4051)
  AUTHORS   Brehme,M., Hantschel,O., Colinge,J., Kaupe,I., Planyavsky,M.,
            Kocher,T., Mechtler,K., Bennett,K.L. and Superti-Furga,G.
  TITLE     Charting the molecular network of the drug target Bcr-Abl
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7414-7419 (2009)
   PUBMED   19380743
REFERENCE   8  (bases 1 to 4051)
  AUTHORS   Ha,V.L., Bharti,S., Inoue,H., Vass,W.C., Campa,F., Nie,Z., de
            Gramont,A., Ward,Y. and Randazzo,P.A.
  TITLE     ASAP3 is a focal adhesion-associated Arf GAP that functions in cell
            migration and invasion
  JOURNAL   J Biol Chem 283 (22), 14915-14926 (2008)
   PUBMED   18400762
  REMARK    GeneRIF: ASAP3 functions nonredundantly with ASAP1 to control cell
            movement and may have a role in cancer cell invasion.
REFERENCE   9  (bases 1 to 4051)
  AUTHORS   Fang,Z., Miao,Y., Ding,X., Deng,H., Liu,S., Wang,F., Zhou,R.,
            Watson,C., Fu,C., Hu,Q., Lillard,J.W. Jr., Powell,M., Chen,Y.,
            Forte,J.G. and Yao,X.
  TITLE     Proteomic identification and functional characterization of a novel
            ARF6 GTPase-activating protein, ACAP4
  JOURNAL   Mol Cell Proteomics 5 (8), 1437-1449 (2006)
   PUBMED   16737952
  REMARK    GeneRIF: ACAP4 is involved in ARF6-mediated cell migration.
            Erratum:[Mol Cell Proteomics. 2006 Sep;5(9):1718]
REFERENCE   10 (bases 1 to 4051)
  AUTHORS   Okabe,H., Furukawa,Y., Kato,T., Hasegawa,S., Yamaoka,Y. and
            Nakamura,Y.
  TITLE     Isolation of development and differentiation enhancing factor-like
            1 (DDEFL1) as a drug target for hepatocellular carcinomas
  JOURNAL   Int J Oncol 24 (1), 43-48 (2004)
   PUBMED   14654939
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021154.1, AB056749.1,
            AL357134.13 and AK000206.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017707.3.
            
            Summary: This gene encodes a member of a subfamily of
            ADP-ribosylation factor(Arf) GTPase-activating proteins that
            contain additional ankyrin repeat and pleckstrin homology domains.
            The Arf GAP domain of this protein catalyzes the hydrolysis of GTP
            bound to Arf proteins. The encoded protein promotes cell
            differentiation and migration and has been implicated in cancer
            cell invasion. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060786.1, SRR1803614.136563.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336689.8/ ENSP00000338769.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL021154.1         33931-33945         c
            16-2951             AB056749.1         15-2950
            2952-3594           AL357134.13        43250-43892         c
            3595-4051           AK000206.1         2097-2553
FEATURES             Location/Qualifiers
     source          1..4051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..4051
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /note="ArfGAP with SH3 domain, ankyrin repeat and PH
                     domain 3"
                     /db_xref="GeneID:55616"
                     /db_xref="HGNC:HGNC:14987"
                     /db_xref="MIM:616594"
     exon            1..175
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2758
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /note="isoform a is encoded by transcript variant 1;
                     development and differentiation enhancing factor-like 1;
                     ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1;
                     centaurin, beta 6; ARF6 GTPase-activating protein; arf-GAP
                     with SH3 domain, ANK repeat and PH domain-containing
                     protein 3; up-regulated in liver cancer 1 (UPLC1); protein
                     up-regulated in liver cancer 1"
                     /codon_start=1
                     /product="arf-GAP with SH3 domain, ANK repeat and PH
                     domain-containing protein 3 isoform a"
                     /protein_id="NP_060177.2"
                     /db_xref="CCDS:CCDS235.1"
                     /db_xref="GeneID:55616"
                     /db_xref="HGNC:HGNC:14987"
                     /db_xref="MIM:616594"
                     /translation="MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEI
                     LEGDQAILQRIKKAVRAIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNL
                     AVFTREVAALFKNLIQNLNNIVSFPLDSLMKGQLRDGRQDSKKQLEKAWKDYEAKMAK
                     LEKERDRARVTGGIPGEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKF
                     FHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLES
                     REEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTI
                     SHSTINRPPVKLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNS
                     KDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPT
                     WLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEA
                     QLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCTPEPQRLWTAICNRDLLSVLEA
                     FANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFIIQNGGHLDAKAADGNT
                     ALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQAQAGTF
                     AFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAHWASGRLDISNKTYETVASLG
                     AATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVSSLSSEAPETPESLGSPAS
                     SSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPSEMYLPVRFSSESTRSY
                     RRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQLLQD"
     exon            176..248
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..394
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..469
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..519
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..631
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            632..717
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..793
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..880
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..990
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1060
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1148
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1197
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1388
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1522
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1617
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1795
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1881
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1997
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2065
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2173
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2369
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2592
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2683
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..4051
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4029..4034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /note="hexamer: AATAAA"
     polyA_site      4051
                     /gene="ASAP3"
                     /gene_synonym="ACAP4; CENTB6; DDEFL1; UPLC1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcccccc gcgccccgct ccggcagctc cacgctcgcg cccgccatgc cggagcagtt
       61 cagcgtcgcc gagttcctgg ccgtcaccgc ggaggacctc agctccccgg ctggggccgc
      121 cgccttcgcc gccaagatgc cccggtaccg aggggcggcg ctggcgcggg aggagatctt
      181 ggaaggagac caagccatcc tgcagagaat aaagaaggct gtgcgggcaa tccatagctc
      241 cggccttggc catgtggaga atgaagagca gtaccgagag gccgtggaat ccttaggcaa
      301 cagccacctg tcccagaaca gccatgagct gtccacaggc ttcctaaact tggccgtgtt
      361 cacccgcgag gttgctgcgc tcttcaagaa cctgattcag aacttgaaca acattgtctc
      421 tttccccctg gacagtctga tgaaggggca gctgagggac ggtcgacagg attccaaaaa
      481 acagctggag aaggcatgga aggactatga agccaaaatg gccaagctgg agaaggagcg
      541 cgatcgggcc agggtgacag gagggatccc tggggaggtg gcccaggaca tgcagagaga
      601 gcggcgcatc ttccagctgc acatgtgtga gtatctgctc aaagccgggg agagccagat
      661 gaagcaaggt cctgacttcc ttcagagcct catcaagttc ttccacgccc agcacaactt
      721 tttccaagat ggctggaagg ctgcccagag cctgttcccc ttcatcgaga agctggcggc
      781 ctcagtacat gcactccatc aggcccagga ggacgagcta cagaagctga cccagctccg
      841 ggactccctc cgagggacac tgcagcttga gagcagagag gaacacctga gccggaagaa
      901 ctcaggatgt ggctatagca tccaccagca ccaaggcaac aagcagtttg ggacggagaa
      961 agtgggcttt ctatacaaga aaagtgacgg aattcgaaga gtctggcaga aaaggaagtg
     1021 tggagtcaag tatggctgcc tgaccatctc acacagcacg ataaaccggc ccccggtgaa
     1081 gctgaccctg ctgacgtgcc aagtgaggcc aaaccctgag gagaaaaagt gcttcgacct
     1141 ggtgacccac aaccggacgt accactttca ggcagaggac gagcacgagt gtgaggcgtg
     1201 ggtgtcagtg ttgcagaaca gcaaggacga agccctgagc agcgccttcc tcggggagcc
     1261 cagcgctggc ccggggtcct gggggtccgc cggccatgat ggggagccgc acgacctcac
     1321 aaagctgctc atcgcggagg tgaagagcag gcctgggaat agccagtgct gcgactgcgg
     1381 ggctgcagac cccacgtggc tcagcaccaa cctgggcgtg ctcacctgca tccagtgctc
     1441 gggcgtccac cgcgaactgg gcgtgcgctt ttcgcgcatg cagtcactca ccttggacct
     1501 gctgggcccc tccgagttgt tgctggcctt gaacatggga aacacgagct tcaatgaggt
     1561 catggaggcc cagctaccct cacacggcgg ccctaaaccc tcagctgaga gtgacatggg
     1621 cacccgcagg gactacatta tggccaagta tgtggagcat aggtttgcac gccggtgcac
     1681 acctgagcct cagcgactct ggacagccat ttgcaacagg gacctcctgt cggtactgga
     1741 ggcctttgcc aatgggcagg actttggaca gccgctgcca gggcctgatg cacaggcacc
     1801 tgaagaactc gtcttgcatt tggctgtcaa agtcgccaac caggcttccc tgcctctggt
     1861 ggatttcatc atccagaacg gtggtcacct ggatgccaag gctgctgacg ggaacacggc
     1921 tctgcactac gcagcactct acaaccagcc cgactgcctc aagctgctgc tgaaggggag
     1981 agctttggtt ggcacagtaa atgaagcagg cgagacagct ctggacatag ccaggaagaa
     2041 gcaccacaag gagtgtgagg agctgctgga gcaggcccag gcggggacct ttgccttccc
     2101 tctacatgtg gactactcct gggtaatttc cacagagcct ggctctgaca gtgaggagga
     2161 tgaggaagag aagcgctgct tgctgaagct cccggcccag gctcactggg ccagtgggag
     2221 gctggacatc agcaacaaga cctatgagac tgtcgccagc ctgggagcag ccacccctca
     2281 gggcgagagt gaggactgtc ccccgccctt gccagtcaaa aactcttctc ggactttggt
     2341 ccaagggtgt gcaagacatg ccagtggaga tcgttctgaa gtctccagcc tgagttcaga
     2401 ggcccctgag acccctgaga gcctgggcag tccagcctcc tcctccagtc tgatgagccc
     2461 cttggaacct ggggatccca gccaagcccc acccaactct gaagagggcc tccgagagcc
     2521 cccaggcacc tccagaccca gcctgacatc cgggaccacc ccttcggaga tgtacctccc
     2581 cgtcagattc agctccgaga gcactcgctc ctatcggcgg ggggcgcgga gccctgaaga
     2641 tggtccctca gccaggcagc ctctgcccag aaggaacgtg ccggttggca tcactgaagg
     2701 agatggctca aggactggga gtctcccagc aagttctgtg caacttttgc aagactagct
     2761 ccttgctggc ccccacatgc cccatgctag gccccaatgt tcagagctgg gacttgagct
     2821 cacaaaactg gggagctgag acatttgttc tcttggatct cactctctct gtcccttgtg
     2881 cctctgtagc tggccttctt cctgccacag gccatgcctc taccaaggac acatggcctt
     2941 tccctgttag gactgatggc ggttctttcc tatctcatta cccgctaggg gcctgggagc
     3001 cctgtggctg gatctgagtg ctcctgagct ggcttcagct gcagaactct cagtccctca
     3061 tcagatcgag actctatttc ccccgtcagt ctgggggctt cacaagggca ggagagccct
     3121 ccatcactga cttccagatc agggaccctg ccaagtaggg actgtcttct cagccagcca
     3181 tttattagtc taatattcct tcactaaatt ccaactctat gtctggacct gtgttaggca
     3241 cttcagatac cacacgagta agacaagggc cctgcagggg tggtcctttg gtggaaagct
     3301 ggtcttaagg gttgggcttg ggaataggca gggtcagatt ccagggcatg gctctggact
     3361 cagctggttt atacctatat gaccattaca attgtctaca gatcacatcc attctggctg
     3421 gtcaacatgc atgctgtact ggctgttaaa taaaaatatt ctgaatgtca ctccttttga
     3481 gggacagcac agccttccct aggcattctc ctatattccc cagccaaatt gtagagtcag
     3541 atgcacccac atttgcctgt gtccttgatt tagcaggaag gaaaggaata gtcagggttg
     3601 atggatgccc acttctcttc tctttctctt ggtcaactca ggagcctttt agtctgaggg
     3661 aatggagagg caaagaaaga agggagagta atagaattgg gagggcagag acttaagggt
     3721 tctgcttccc agccctagaa attctatcat tgctcagccc caatgagaaa gcagatacac
     3781 ctaagccatc atcaaccact aacatctcaa cttgccagtt gctgggtgct gggccctggc
     3841 aggaatgggc caagccaagc aggggagact agagagcacc aatggccaac acagctgcct
     3901 ggctggggag gctgtgctgt ttcccctgga gacctgactg gtctgtggtt cccacaggaa
     3961 cagggttgtc ttttgagccc ccagtgtctg gtttcattca tctcagactt gttatttcac
     4021 tcatctctaa taaaggattg gggggtcagt t
//
