LOCUS       NM_020682               2450 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens arsenite methyltransferase (AS3MT), mRNA.
ACCESSION   NM_020682
VERSION     NM_020682.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2450)
  AUTHORS   Zhang,M., Xu,H., Lou,Q., Zhang,Z., Zhang,X., Yin,F., Lv,M.,
            Zhang,Y., Yin,Y., Gao,Y., Liu,X. and Yang,Y.
  TITLE     Association between arsenic (+3 oxidation state) methyltransferase
            gene polymorphisms and arsenic methylation capacity in rural
            residents of northern China: a cross-sectional study
  JOURNAL   Arch Toxicol 97 (11), 2919-2928 (2023)
   PUBMED   37658865
  REMARK    GeneRIF: Association between arsenic (+3 oxidation state)
            methyltransferase gene polymorphisms and arsenic methylation
            capacity in rural residents of northern China: a cross-sectional
            study.
REFERENCE   2  (bases 1 to 2450)
  AUTHORS   Qiu,T., Wu,C., Yao,X., Han,Q., Wang,N., Yuan,W., Zhang,J., Shi,Y.,
            Jiang,L., Liu,X., Yang,G. and Sun,X.
  TITLE     AS3MT facilitates NLRP3 inflammasome activation by m6A modification
            during arsenic-induced hepatic insulin resistance
  JOURNAL   Cell Biol Toxicol 39 (5), 2165-2181 (2023)
   PUBMED   35226250
  REMARK    GeneRIF: AS3MT facilitates NLRP3 inflammasome activation by m[6]A
            modification during arsenic-induced hepatic insulin resistance.
REFERENCE   3  (bases 1 to 2450)
  AUTHORS   Wen,W., Zha,S., Cheng,H., Qi,J., Chen,Q. and Gu,Y.
  TITLE     As3MT is related to relative RNAs and base modifications of p53 in
            workers exposed to arsenic
  JOURNAL   Environ Sci Pollut Res Int 30 (22), 62094-62103 (2023)
   PUBMED   36940027
  REMARK    GeneRIF: As3MT is related to relative RNAs and base modifications
            of p53 in workers exposed to arsenic.
REFERENCE   4  (bases 1 to 2450)
  AUTHORS   Liang,X., Guo,G., Wang,Y., Wang,M., Chen,X., Zhang,J., Li,S.,
            Liu,L., Huang,Q., Cui,B., Zhang,M., Sun,G., Tang,N., Zhang,X. and
            Zhang,Q.
  TITLE     Arsenic metabolism, N6AMT1 and AS3MT single nucleotide
            polymorphisms, and their interaction on gestational diabetes
            mellitus in Chinese pregnant women
  JOURNAL   Environ Res 221, 115331 (2023)
   PUBMED   36681142
  REMARK    GeneRIF: Arsenic metabolism, N6AMT1 and AS3MT single nucleotide
            polymorphisms, and their interaction on gestational diabetes
            mellitus in Chinese pregnant women.
REFERENCE   5  (bases 1 to 2450)
  AUTHORS   Washer,S.J., Flynn,R., Oguro-Ando,A., Hannon,E., Burrage,J.,
            Jeffries,A., Mill,J. and Dempster,E.L.
  TITLE     Functional characterization of the schizophrenia associated gene
            AS3MT identifies a role in neuronal development
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 189 (5), 151-162 (2022)
   PUBMED   35719055
  REMARK    GeneRIF: Functional characterization of the schizophrenia
            associated gene AS3MT identifies a role in neuronal development.
REFERENCE   6  (bases 1 to 2450)
  AUTHORS   Wood,T.C., Salavagionne,O.E., Mukherjee,B., Wang,L., Klumpp,A.F.,
            Thomae,B.A., Eckloff,B.W., Schaid,D.J., Wieben,E.D. and
            Weinshilboum,R.M.
  TITLE     Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene
            resequencing and functional genomics studies
  JOURNAL   J Biol Chem 281 (11), 7364-7373 (2006)
   PUBMED   16407288
  REMARK    GeneRIF: inherited variation in AS3MT may contribute to variation
            in arsenic metabolism
REFERENCE   7  (bases 1 to 2450)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2450)
  AUTHORS   Meza,M.M., Yu,L., Rodriguez,Y.Y., Guild,M., Thompson,D.,
            Gandolfi,A.J. and Klimecki,W.T.
  TITLE     Developmentally restricted genetic determinants of human arsenic
            metabolism: association between urinary methylated arsenic and
            CYT19 polymorphisms in children
  JOURNAL   Environ Health Perspect 113 (6), 775-781 (2005)
   PUBMED   15929903
  REMARK    GeneRIF: a strong genetic association between polymorphisms of
            CYT19 and D:M ratio (urinary dimethylarsenic(V) to
            monomethylarsenic(V))in drinking water exposed Mexican children,
            not adults.
            GeneRIF: Observational study of gene-disease association and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
REFERENCE   9  (bases 1 to 2450)
  AUTHORS   Li,J., Waters,S.B., Drobna,Z., Devesa,V., Styblo,M. and Thomas,D.J.
  TITLE     Arsenic (+3 oxidation state) methyltransferase and the inorganic
            arsenic methylation phenotype
  JOURNAL   Toxicol Appl Pharmacol 204 (2), 164-169 (2005)
   PUBMED   15808521
  REMARK    GeneRIF: Heterologous expression of rat AS3MT in human urothelial
            cells...confers capacity to methylate inorganic arsenic and alters
            its cytotoxicity and that of methylated arsenicals.
REFERENCE   10 (bases 1 to 2450)
  AUTHORS   Lin,S., Shi,Q., Nix,F.B., Styblo,M., Beck,M.A., Herbin-Davis,K.M.,
            Hall,L.L., Simeonsson,J.B. and Thomas,D.J.
  TITLE     A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from
            rat liver cytosol
  JOURNAL   J Biol Chem 277 (13), 10795-10803 (2002)
   PUBMED   11790780
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA368970.1, BC119638.2, AL358790.22 and AW139845.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020682.3.
            
            Summary: AS3MT catalyzes the transfer of a methyl group from
            S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may
            play a role in arsenic metabolism (Lin et al., 2002 [PubMed
            11790780]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.53989.1,
                                           SRR3476690.844720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369880.8/ ENSP00000358896.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                DA368970.1         18-96
            80-1222             BC119638.2         1-1143
            1223-2278           AL358790.22        127722-128777
            2279-2450           AW139845.1         15-186              c
FEATURES             Location/Qualifiers
     source          1..2450
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..2450
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /note="arsenite methyltransferase"
                     /db_xref="GeneID:57412"
                     /db_xref="HGNC:HGNC:17452"
                     /db_xref="MIM:611806"
     exon            1..124
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1251
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /EC_number="2.1.1.137"
                     /note="S-adenosylmethionine:arsenic (III)
                     methyltransferase; arsenic (+3 oxidation state)
                     methyltransferase; methylarsonite methyltransferase;
                     methyltransferase cyt19;
                     S-adenosyl-L-methionine:arsenic(III) methyltransferase"
                     /codon_start=1
                     /product="arsenite methyltransferase"
                     /protein_id="NP_065733.2"
                     /db_xref="CCDS:CCDS41567.1"
                     /db_xref="GeneID:57412"
                     /db_xref="HGNC:HGNC:17452"
                     /db_xref="MIM:611806"
                     /translation="MAALRDAEIQKDVQTYYGQVLKRSADLQTNGCVTTARPVPKHIR
                     EALQNVHEEVALRYYGCGLVIPEHLENCWILDLGSGSGRDCYVLSQLVGEKGHVTGID
                     MTKGQVEVAEKYLDYHMEKYGFQASNVTFIHGYIEKLGEAGIKNESHDIVVSNCVINL
                     VPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGGALYWKELAV
                     LAQKIGFCPPRLVTANLITIQNKELERVIGDCRFVSATFRLFKHSKTGPTKRCQVIYN
                     GGITGHEKELMFDANFTFKEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGC
                     SALELKDIITDPFKLAEESDSMKSRCVPDAAGGCCGTKKSC"
     exon            125..165
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            166..293
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            294..444
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            445..581
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            582..651
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            652..733
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            734..865
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1008
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1143
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..2450
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2391..2396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /note="hexamer: AACAAA"
     regulatory      2434..2439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /note="hexamer: AACAAA"
     polyA_site      2435
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
     polyA_site      2450
                     /gene="AS3MT"
                     /gene_synonym="CYT19"
                     /note="major polyA site"
ORIGIN      
        1 acaggagctg gctgcgggag cccgccgtcc tgagtcgcag gccgaggaga cagtgagtgc
       61 gcgccctgag tcgcaggccg aggagacagt gagtgcgcgc cctgagtcgc aggccgagga
      121 gacatggctg cacttcgtga cgctgagata cagaaggacg tgcagaccta ctacgggcag
      181 gtgctgaaga gatcggcaga cctccagacc aacggctgtg tcaccacagc caggccggtc
      241 cccaagcaca tccgggaagc cttgcaaaat gtacacgaag aagtagccct aagatattat
      301 ggctgtggtc tggtgatccc tgagcatcta gaaaactgct ggattttgga tctgggtagt
      361 ggaagtggca gagattgcta tgtacttagc cagctggttg gtgaaaaagg acacgtgact
      421 ggaatagaca tgaccaaagg ccaggtggaa gtggctgaaa agtatcttga ctatcacatg
      481 gaaaaatatg gcttccaggc atctaatgtg acttttattc atggctacat tgagaagttg
      541 ggagaggctg gaatcaagaa tgagagccat gatattgttg tatcaaactg tgttattaac
      601 cttgtgcctg ataaacaaca agtgcttcag gaggcatatc gggtgctgaa gcatggtggg
      661 gagttatatt tcagtgacgt ctatacgagc cttgaactgc cagaagaaat caggacacac
      721 aaagttttat ggggtgagtg tctgggtggt gctttatact ggaaggaact tgctgtcctt
      781 gctcaaaaaa ttgggttctg ccctccacgt ttggtcactg ccaatctcat tacaattcaa
      841 aacaaggaac tggaaagagt tatcggtgac tgtcgttttg tttctgcaac atttcgcctc
      901 ttcaaacact ctaagacagg accaaccaag agatgccaag ttatttacaa tggaggaatt
      961 acaggacatg aaaaagaact aatgtttgat gccaatttta catttaagga aggtgaaatt
     1021 gttgaagtgg atgaagaaac agcagctatc ttgaagaatt caagatttgc tcaagatttt
     1081 ctgatcagac caattggaga gaagttgcca acatctggag gctgttctgc tttggagtta
     1141 aaggatataa tcacagatcc atttaagctt gcagaagagt ctgacagtat gaagtccaga
     1201 tgtgtccctg atgctgctgg aggctgctgt ggcacaaaga aaagctgcta aatctatagc
     1261 caaccagggg accacagtag tgggcaagag tgatctgcat gttttttaac ctgcttttcc
     1321 ccatagcaca gaccataaga aacaacaaat ggggccgggc acagtggctc atgcctataa
     1381 tcccagcact ttgggaggcc gaggcaggca gatcacctga ggtcaggagt ttgataccag
     1441 cctggccaac atggtgaaat cctgtctcta ccaaaaatac aaaaaaaatt agctgggcat
     1501 ggtggtgcac acctatagtc tcagctactc gggaggctga ggcaggagaa ttgcttgaac
     1561 ccaggaagta gaggctgcag tgagtaagca tcacgccact gtactccagc ctgggcaaca
     1621 gagcaagact ctgtctcaaa agcaaaaaaa aaaaaaaaaa aagaaagaaa gaaaaagaaa
     1681 acaacaaatg gcagagagcc accatattcc aaatcactga aaaaaataaa tgaattattt
     1741 ttatttattt atttattttt ttgagatgga gtctcggtct gttgcccagg ctgaagtgca
     1801 gtggccccat ctcaactcac tgcaagctcc acctcctggg ttcacgccat tctcctgcct
     1861 cagactccca agtagctggg actacaggca cctaccacca tgcccagcta attttttgta
     1921 tttttagtag agacggggtt tcaccatgtt agccaggatg gtcttgatct cctgacctcg
     1981 tgatccgccc gcctcggcct cccaaagtgc tgggattaca agcatgagcc actgcgcccg
     2041 gccataaatg aattattttt aagaggcatt gattaaagat tcacagcaaa tcactagtta
     2101 agcagatttt ttttctattt cctacttcaa agttctggtg ccacatagtg gtcagaaatg
     2161 gaacagagaa gctgtcttaa gccttgttca agaagcagga aaggcatcag aagaagtaac
     2221 agttggcaga gggtctcagg aaaaacatct tccttctgat cttttgcata gcaccttttg
     2281 gaattttcat catgtttgct tattaaacaa agctcctact gccatcatac taatcatgca
     2341 aaaagattgc caaatcatgt ttggtaggag gacttttgag gtagcttttg aacaaatgtt
     2401 tttttctttt ttcttttttt ttgcaataaa gaaaacaaat taatcataaa
//
