LOCUS       NM_057091               1439 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens artemin (ARTN), transcript variant 2, mRNA.
ACCESSION   NM_057091
VERSION     NM_057091.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1439)
  AUTHORS   Li,T.J., Li,H., Zhang,W.H., Xu,S.S., Jiang,W., Li,S., Gao,H.L.,
            Han,X., Xu,H.X., Wu,C.T., Wang,W.Q., Yu,X.J. and Liu,L.
  TITLE     Human splenic TER cells: A relevant prognostic factor acting via
            the artemin-GFRalpha3-ERK pathway in pancreatic ductal
            adenocarcinoma
  JOURNAL   Int J Cancer 148 (7), 1756-1767 (2021)
   PUBMED   33236361
  REMARK    GeneRIF: Human splenic TER cells: A relevant prognostic factor
            acting via the artemin-GFRalpha3-ERK pathway in pancreatic ductal
            adenocarcinoma.
REFERENCE   2  (bases 1 to 1439)
  AUTHORS   Marvastizadeh,N., Dabirmanesh,B., Sajedi,R.H. and Khajeh,K.
  TITLE     Anti-amyloidogenic effect of artemin on alpha-synuclein
  JOURNAL   Biol Chem 401 (10), 1143-1151 (2020)
   PUBMED   32673279
  REMARK    GeneRIF: Anti-amyloidogenic effect of artemin on alpha-synuclein.
REFERENCE   3  (bases 1 to 1439)
  AUTHORS   Pineda-Cirera,L., Shivalikanjli,A., Cabana-Dominguez,J.,
            Demontis,D., Rajagopal,V.M., Borglum,A.D., Faraone,S.V., Cormand,B.
            and Fernandez-Castillo,N.
  TITLE     Exploring genetic variation that influences brain methylation in
            attention-deficit/hyperactivity disorder
  JOURNAL   Transl Psychiatry 9 (1), 242 (2019)
   PUBMED   31582733
  REMARK    GeneRIF: Attention-deficit/hyperactivity disorder risk alleles
            correlated with increased expression (and decreased methylation) of
            ARTN and PIDD1 and with a decreased expression (and increased
            methylation) of C2orf82.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1439)
  AUTHORS   Li,J., Shang,G., Chen,Y.J., Brautigam,C.A., Liou,J., Zhang,X. and
            Bai,X.C.
  TITLE     Cryo-EM analyses reveal the common mechanism and diversification in
            the activation of RET by different ligands
  JOURNAL   Elife 8, e47650 (2019)
   PUBMED   31535977
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1439)
  AUTHORS   Silvian,L., Jin,P., Carmillo,P., Boriack-Sjodin,P.A., Pelletier,C.,
            Rushe,M., Gong,B., Sah,D., Pepinsky,B. and Rossomando,A.
  TITLE     Artemin crystal structure reveals insights into heparan sulfate
            binding
  JOURNAL   Biochemistry 45 (22), 6801-6812 (2006)
   PUBMED   16734417
  REMARK    GeneRIF: This study suggests that ART binds heparan sulfate
            proteoglycans (HSPG) and identifies residues that may be involved
            in HSPG binding.
REFERENCE   6  (bases 1 to 1439)
  AUTHORS   Quartu,M., Serra,M.P., Manca,A., Mascia,F., Follesa,P. and Del
            Fiacco,M.
  TITLE     Neurturin, persephin, and artemin in the human pre- and full-term
            newborn and adult hippocampus and fascia dentata
  JOURNAL   Brain Res 1041 (2), 157-166 (2005)
   PUBMED   15829225
  REMARK    GeneRIF: The results obtained suggest the involvement of NTN, PSP,
            and ART in processes subserving both the organization of this
            cortical region during development and the functional activity and
            maintenance of the mature human hippocampal neurons.
REFERENCE   7  (bases 1 to 1439)
  AUTHORS   Bolon,B., Jing,S., Asuncion,F., Scully,S., Pisegna,M., Van,G.Y.,
            Hu,Z., Yu,Y.B., Min,H., Wild,K., Rosenfeld,R.D., Tarpley,J.,
            Carnahan,J., Duryea,D., Hill,D., Kaufman,S., Yan,X.Q., Juan,T.,
            Christensen,K., McCabe,J. and Simonet,W.S.
  TITLE     The candidate neuroprotective agent artemin induces autonomic
            neural dysplasia without preventing peripheral nerve dysfunction
  JOURNAL   Toxicol Pathol 32 (3), 275-294 (2004)
   PUBMED   15204970
REFERENCE   8  (bases 1 to 1439)
  AUTHORS   Rosenblad,C., Gronborg,M., Hansen,C., Blom,N., Meyer,M.,
            Johansen,J., Dago,L., Kirik,D., Patel,U.A., Lundberg,C., Trono,D.,
            Bjorklund,A. and Johansen,T.E.
  TITLE     In vivo protection of nigral dopamine neurons by lentiviral gene
            transfer of the novel GDNF-family member neublastin/artemin
  JOURNAL   Mol Cell Neurosci 15 (2), 199-214 (2000)
   PUBMED   10673327
  REMARK    Erratum:[Mol Cell Neurosci 2001 Sep;18(3):332-3]
REFERENCE   9  (bases 1 to 1439)
  AUTHORS   Masure,S., Geerts,H., Cik,M., Hoefnagel,E., Van Den Kieboom,G.,
            Tuytelaars,A., Harris,S., Lesage,A.S., Leysen,J.E., Van Der
            Helm,L., Verhasselt,P., Yon,J. and Gordon,R.D.
  TITLE     Enovin, a member of the glial cell-line-derived neurotrophic factor
            (GDNF) family with growth promoting activity on neuronal cells.
            Existence and tissue-specific expression of different splice
            variants
  JOURNAL   Eur J Biochem 266 (3), 892-902 (1999)
   PUBMED   10583383
REFERENCE   10 (bases 1 to 1439)
  AUTHORS   Baloh,R.H., Tansey,M.G., Lampe,P.A., Fahrner,T.J., Enomoto,H.,
            Simburger,K.S., Leitner,M.L., Araki,T., Johnson,E.M. Jr. and
            Milbrandt,J.
  TITLE     Artemin, a novel member of the GDNF ligand family, supports
            peripheral and central neurons and signals through the
            GFRalpha3-RET receptor complex
  JOURNAL   Neuron 21 (6), 1291-1302 (1998)
   PUBMED   9883723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF120274.1 and BC062375.1.
            
            On Nov 22, 2018 this sequence version replaced NM_057091.2.
            
            Summary: This gene encodes a secreted ligand of the glial cell
            line-derived neurotrophic factor (GDNF) subfamily and TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein signals through the RET
            receptor and GFR alpha 3 coreceptor, and supports the survival of a
            number of peripheral neuron populations and at least one population
            of dopaminergic CNS neurons. This protein has also been shown to
            promote tumor growth, metastasis, and drug resistance in mammary
            carcinoma. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (2) encodes the shorter isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF120274.1, AI829054.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372359.10/ ENSP00000361434.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AF120274.1         482-837
            357-361             BC062375.1         197-201
            362-1091            AF120274.1         843-1572
            1092-1439           BC062375.1         956-1303
FEATURES             Location/Qualifiers
     source          1..1439
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..1439
                     /gene="ARTN"
                     /gene_synonym="ART; ENOVIN; EVN; NBN"
                     /note="artemin"
                     /db_xref="GeneID:9048"
                     /db_xref="HGNC:HGNC:727"
                     /db_xref="MIM:603886"
     exon            1..85
                     /gene="ARTN"
                     /gene_synonym="ART; ENOVIN; EVN; NBN"
                     /inference="alignment:Splign:2.1.0"
     exon            86..234
                     /gene="ARTN"
                     /gene_synonym="ART; ENOVIN; EVN; NBN"
                     /inference="alignment:Splign:2.1.0"
     exon            235..361
                     /gene="ARTN"
                     /gene_synonym="ART; ENOVIN; EVN; NBN"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..964
                     /gene="ARTN"
                     /gene_synonym="ART; ENOVIN; EVN; NBN"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 2; neublastin"
                     /codon_start=1
                     /product="artemin isoform 1 preproprotein"
                     /protein_id="NP_476432.2"
                     /db_xref="CCDS:CCDS501.1"
                     /db_xref="GeneID:9048"
                     /db_xref="HGNC:HGNC:727"
                     /db_xref="MIM:603886"
                     /translation="MELGLGGLSTLSHCPWPRQQPALWPTLAALALLSSVAEASLGSA
                     PRSPAPREGPPPVLASPAGHLPGGRTARWCSGRARRPPPQPSRPAPPPPAPPSALPRG
                     GRAARAGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSP
                     HDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGC
                     LG"
     exon            362..500
                     /gene="ARTN"
                     /gene_synonym="ART; ENOVIN; EVN; NBN"
                     /inference="alignment:Splign:2.1.0"
     exon            501..1439
                     /gene="ARTN"
                     /gene_synonym="ART; ENOVIN; EVN; NBN"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1439
                     /gene="ARTN"
                     /gene_synonym="ART; ENOVIN; EVN; NBN"
                     /note="major polyA site"
ORIGIN      
        1 agacaaggcc cgggggctcc gccagcagca ggtccctcgg gccccagccc tcgctgccac
       61 ccgggcctgg agccccacac ccgagggtgc agactggctg ccaaggccac acttttggct
      121 aaaagaggca ctgccaggtg tacagtcctg ggcatgcgct gtttgagctt cgggggagag
      181 cccagcactg gtccccggaa aggtgcctag aagaacaagg tgcaggaccc cgtgctgcct
      241 caacaggagg gtgggggaac agctcaacaa tggctgatgg gcgctcctgg tgttgataga
      301 gatggaactt ggacttggag gcctctccac gctgtcccac tgcccctggc ctaggcagca
      361 gcctgccctg tggcccaccc tggccgctct ggctctgctg agcagcgtcg cagaggcctc
      421 cctgggctcc gcgccccgca gccctgcccc ccgcgaaggc cccccgcctg tcctggcgtc
      481 ccccgccggc cacctgccgg ggggacgcac ggcccgctgg tgcagtggaa gagcccggcg
      541 gccgccgccg cagccttctc ggcccgcgcc cccgccgcct gcacccccat ctgctcttcc
      601 ccgcgggggc cgcgcggcgc gggctggggg cccgggcagc cgcgctcggg cagcgggggc
      661 gcggggctgc cgcctgcgct cgcagctggt gccggtgcgc gcgctcggcc tgggccaccg
      721 ctccgacgag ctggtgcgtt tccgcttctg cagcggctcc tgccgccgcg cgcgctctcc
      781 acacgacctc agcctggcca gcctactggg cgccggggcc ctgcgaccgc ccccgggctc
      841 ccggcccgtc agccagccct gctgccgacc cacgcgctac gaagcggtct ccttcatgga
      901 cgtcaacagc acctggagaa ccgtggaccg cctctccgcc accgcctgcg gctgcctggg
      961 ctgagggctc gctccagggc tttgcagact ggacccttac cggtggctct tcctgcctgg
     1021 gaccctcccg cagagtccca ctagccagcg gcctcagcca gggacgaagg cctcaaagct
     1081 gagaggcccc tgccggtggg tgatggatat catccccgaa caggtgaagg gacaactgac
     1141 tagcagcccc agagccctca ccctgcggat cccagcctaa aagacaccag agacctcagc
     1201 tatggagccc ttcggaccca cttctcacag actctggcac tggccaggcc tcgaacctgg
     1261 gacccctcct ctgatgaaca ctacagtggc tgaggcatca gcccccgccc aggccctgta
     1321 gggacagcat ttgaaggaca catattgcag ttgcttggtt gaaagtgcct gtgctggaac
     1381 tggcctgtac tcactcatgg gagctggccc ctatttatta tttctaagtt atttattta
//
