LOCUS       NM_053017               1232 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens ADP-ribosyltransferase 5 (ART5), transcript variant 1,
            mRNA.
ACCESSION   NM_053017
VERSION     NM_053017.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Shi,F., Wu,L., Cui,D., Sun,M., Shen,Y., Zhou,Z., Deng,Z., Han,B.,
            Xia,S., Zhu,Z. and Sun,F.
  TITLE     LncFALEC recruits ART5/PARP1 and promotes castration-resistant
            prostate cancer through enhancing PARP1-meditated self PARylation
  JOURNAL   Cell Oncol (Dordr) 46 (3), 761-776 (2023)
   PUBMED   36913068
  REMARK    GeneRIF: LncFALEC recruits ART5/PARP1 and promotes
            castration-resistant prostate cancer through enhancing
            PARP1-meditated self PARylation.
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   5  (bases 1 to 1232)
  AUTHORS   Glowacki,G., Braren,R., Cetkovic-Cvrlje,M., Leiter,E.H., Haag,F.
            and Koch-Nolte,F.
  TITLE     Structure, chromosomal localization, and expression of the gene for
            mouse ecto-mono(ADP-ribosyl)transferase ART5
  JOURNAL   Gene 275 (2), 267-277 (2001)
   PUBMED   11587854
REFERENCE   6  (bases 1 to 1232)
  AUTHORS   Okazaki,I.J. and Moss,J.
  TITLE     Characterization of glycosylphosphatidylinositiol-anchored,
            secreted, and intracellular vertebrate mono-ADP-ribosyltransferases
  JOURNAL   Annu Rev Nutr 19, 485-509 (1999)
   PUBMED   10448534
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC060812.15 and BC014577.1.
            
            On May 17, 2019 this sequence version replaced NM_053017.4.
            
            Summary: The protein encoded by this gene belongs to the
            ARG-specific ADP-ribosyltransferase family. Proteins in this family
            regulate the function of target proteins by attaching ADP-ribose to
            specific amino acid residues in their target proteins. The mouse
            homolog lacks a glycosylphosphatidylinositol-anchor signal sequence
            and is predicted to be a secretory enzyme. Several transcripts
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014577.1, ERR3218370.443733.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397068.8/ ENSP00000380258.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC060812.15        138203-138255
            54-203              BC014577.1         66-215
            204-257             BC014577.1         219-272
            258-258             AC060812.15        139894-139894
            259-648             BC014577.1         274-663
            649-649             AC060812.15        140285-140285
            650-1232            BC014577.1         665-1247
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1232
                     /gene="ART5"
                     /gene_synonym="ARTC5"
                     /note="ADP-ribosyltransferase 5"
                     /db_xref="GeneID:116969"
                     /db_xref="HGNC:HGNC:24049"
                     /db_xref="MIM:610625"
     exon            1..187
                     /gene="ART5"
                     /gene_synonym="ARTC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1006
                     /gene="ART5"
                     /gene_synonym="ARTC5"
                     /EC_number="2.4.2.31"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; mono(ADP-ribosyl)transferase 5;
                     NAD(P)(+)--arginine ADP-ribosyltransferase 5;
                     ADP-ribosyltransferase C2 and C3 toxin-like 5;
                     ecto-ADP-ribosyltransferase 5"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 5 isoform a
                     precursor"
                     /protein_id="NP_443750.2"
                     /db_xref="CCDS:CCDS7743.1"
                     /db_xref="GeneID:116969"
                     /db_xref="HGNC:HGNC:24049"
                     /db_xref="MIM:610625"
                     /translation="MALAALMIALGSLGLHTWQAQAVPILPLGLAPDTFDDTYVGCAE
                     EMEEKAAPLLKEEMAHHALLRESWEAAQETWEDKRRGLTLPPGFKAQNGIAIMVYTNS
                     SNTLYWELNQAVRTGGGSRELYMRHFPFKALHFYLIRALQLLRGSGGCSRGPGEVVFR
                     GVGSLRFEPKRLGDSVRLGQFASSSLDKAVAHRFGNATLFSLTTCFGAPIQAFSVFPK
                     EREVLIPPHEVFLVTRFSQDGAQSLVTLWSYNQTCSHFNCAYLGGEKRRGCVSAPGAL
                     GTGDLHMTKRHLQQP"
     exon            188..917
                     /gene="ART5"
                     /gene_synonym="ARTC5"
                     /inference="alignment:Splign:2.1.0"
     exon            918..950
                     /gene="ART5"
                     /gene_synonym="ARTC5"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1232
                     /gene="ART5"
                     /gene_synonym="ARTC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ART5"
                     /gene_synonym="ARTC5"
                     /note="hexamer: ATTAAA"
     polyA_site      1232
                     /gene="ART5"
                     /gene_synonym="ARTC5"
                     /note="major polyA site"
ORIGIN      
        1 aatcctggac ccgggatccc gtgcgcctgg agacagggtc cagatctgcc tccagcccct
       61 cgaaaccagg actccagcac ctctggtccc gccctcaccc ggacccctgg ccctcacgtc
      121 tcctccaggg atggcgctgg cggctttgat gatcgccctc ggcagcctcg gcctccacac
      181 ctggcaggcc caggctgttc ccatcctgcc cctgggcctg gctccagaca cctttgacga
      241 tacctatgtg ggttgtgcag aggagatgga ggagaaggca gcccccctgc taaaggagga
      301 aatggcccac catgccctgc tgcgggaatc ctgggaggca gcccaggaga cctgggagga
      361 caagcgtcga gggcttacct tgccccctgg cttcaaagcc cagaatggaa tagccattat
      421 ggtctacacc aactcatcga acaccttgta ctgggagttg aatcaggccg tgcggacggg
      481 cggaggctcc cgggagctct acatgaggca ctttcccttc aaggccctgc atttctacct
      541 gatccgggcc ctgcagctgc tgcgaggcag tgggggctgc agcaggggac ctggggaggt
      601 ggtgttccga ggtgtgggca gccttcgctt tgaacccaag aggctgggag actctgtccg
      661 cttgggccag tttgcctcca gctccctgga taaggcagtg gcccacagat ttggtaatgc
      721 caccctcttc tctctaacaa cttgctttgg ggcccctata caggccttct ctgtctttcc
      781 caaggagcgc gaggtgctga ttccccccca tgaagtcttt ttggttacca gattctctca
      841 ggatggagcc cagagcttgg tgactctctg gagctataat cagacctgta gccattttaa
      901 ctgcgcctat ctgggtgggg agaagaggcg gggctgtgtg tctgcgccag gagccctggg
      961 aacgggtgac cttcatatga cgaagaggca cctccagcag ccttgagaag caagaacatg
     1021 gttccggacc cagccctagc agccttctcc ccaaccagga tgttggcctg gggaggccac
     1081 agcagggctg agggaactct gctatgtgat ggggacttcc tgggacaagc aaggaaagta
     1141 ctgaggcagc cacttgattg aacggtgttg caatgtggag acatggagtt ttattgaggt
     1201 agctacgtga ttaaatggta ttgcagtgtg ga
//
