LOCUS       NM_021071               5160 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ADP-ribosyltransferase 4 (inactive) (Dombrock blood
            group) (ART4), transcript variant 1, mRNA.
ACCESSION   NM_021071
VERSION     NM_021071.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5160)
  AUTHORS   Wangmo,T., Intharanut,K., Leetrakool,N., Mitundee,S.,
            Bejrachandra,S. and Nathalang,O.
  TITLE     Development of DO*A and DO*B Allele Detections to Predict
            Transfusion-Induced Alloimmunization Risks in Thai Populations
  JOURNAL   Clin Lab 67 (10) (2021)
   PUBMED   34655192
  REMARK    GeneRIF: Development of DO*A and DO*B Allele Detections to Predict
            Transfusion-Induced Alloimmunization Risks in Thai Populations.
REFERENCE   2  (bases 1 to 5160)
  AUTHORS   Morin,P.A., Ethier,C., Lavoie,J., Robitaille,N. and Baillargeon,N.
  TITLE     A novel variant DO*A allele with a c.370delT mutation leading to a
            DO-null phenotype in a Syrian family
  JOURNAL   Transfusion 61 (2), E16-E17 (2021)
   PUBMED   33206405
  REMARK    GeneRIF: A novel variant DO*A allele with a c.370delT mutation
            leading to a DO-null phenotype in a Syrian family.
REFERENCE   3  (bases 1 to 5160)
  AUTHORS   Durousseau de Coulgeans,C., Chiaroni,J., Bailly,P. and
            Chapel-Fernandes,S.
  TITLE     Sequencing of the ART4 gene in sub-Saharan cohorts reveals ethnic
            differences and two new DO alleles: DO*B-Ile5Thr and DO*B-Trp266Arg
  JOURNAL   Transfusion 55 (10), 2376-2383 (2015)
   PUBMED   25988428
  REMARK    GeneRIF: Characterization of two novel DO*B alleles highlights the
            value of testing selected ethnic groups in understanding DO allele
            diversity.
REFERENCE   4  (bases 1 to 5160)
  AUTHORS   Rios,M., Hue-Roye,K., Oyen,R., Miller,J. and Reid,M.E.
  TITLE     Insights into the Holley- and Joseph- phenotypes
  JOURNAL   Transfusion 42 (1), 52-58 (2002)
   PUBMED   11896313
REFERENCE   5  (bases 1 to 5160)
  AUTHORS   Wu,G.G., Jin,S.Z., Deng,Z.H. and Zhao,T.M.
  TITLE     Polymerase chain reaction with sequence-specific primers-based
            genotyping of the human Dombrock blood group DO1 and DO2 alleles
            and the DO gene frequencies in Chinese blood donors
  JOURNAL   Vox Sang 81 (1), 49-51 (2001)
   PUBMED   11520417
REFERENCE   6  (bases 1 to 5160)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Wojda,U., Pack,S.D., Rios,M., Reid,M.E.
            and Miller,J.L.
  TITLE     Identification of the dombrock blood group glycoprotein as a
            polymorphic member of the ADP-ribosyltransferase gene family
  JOURNAL   Blood 96 (7), 2621-2627 (2000)
   PUBMED   11001920
REFERENCE   7  (bases 1 to 5160)
  AUTHORS   Mauthe,J., Coghlan,G. and Zelinski,T.
  TITLE     Confirmation of the assignment of the Dombrock blood group locus
            (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2
  JOURNAL   Vox Sang 79 (1), 53-56 (2000)
   PUBMED   10971215
REFERENCE   8  (bases 1 to 5160)
  AUTHORS   Koch-Nolte,F., Haag,F., Braren,R., Kuhl,M., Hoovers,J.,
            Balasubramanian,S., Bazan,F. and Thiele,H.G.
  TITLE     Two novel human members of an emerging mammalian gene family
            related to mono-ADP-ribosylating bacterial toxins
  JOURNAL   Genomics 39 (3), 370-376 (1997)
   PUBMED   9119374
  REMARK    Erratum:[Genomics 1999 Jan 1;55(1):130]
REFERENCE   9  (bases 1 to 5160)
  AUTHORS   Eiberg,H. and Mohr,J.
  TITLE     Dombrock blood group (DO): assignment to chromosome 12p
  JOURNAL   Hum Genet 98 (5), 518-521 (1996)
   PUBMED   8882867
REFERENCE   10 (bases 1 to 5160)
  AUTHORS   Tippett,P.
  TITLE     Genetics of the Dombrock blood group system
  JOURNAL   J Med Genet 4 (1), 7-11 (1967)
   PUBMED   6034522
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007655.1, CR746266.1,
            AF290204.1 and BX096478.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021071.3.
            
            Summary: This gene encodes a protein that contains a
            mono-ADP-ribosylation (ART) motif. It is a member of the
            ADP-ribosyltransferase gene family but enzymatic activity has not
            been demonstrated experimentally. Antigens of the Dombrock blood
            group system are located on the gene product, which is
            glycosylphosphatidylinosotol-anchored to the erythrocyte membrane.
            Allelic variants, some of which lead to adverse transfusion
            reactions, are known. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291662.1, AY829434.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228936.6/ ENSP00000228936.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC007655.1         54205-54251         c
            48-314              CR746266.1         1-267
            315-790             AF290204.1         1-476
            791-1418            BX096478.1         132-759
            1419-5160           AC007655.1         36294-40035         c
FEATURES             Location/Qualifiers
     source          1..5160
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..5160
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /note="ADP-ribosyltransferase 4 (inactive) (Dombrock blood
                     group)"
                     /db_xref="GeneID:420"
                     /db_xref="HGNC:HGNC:726"
                     /db_xref="MIM:110600"
     exon            1..557
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..1358
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /EC_number="2.4.2.31"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ADP-ribosyltransferase 4 (DO blood group);
                     ecto-ADP-ribosyltransferase 4; mono-ADP-ribosyltransferase
                     4; Dombrock blood group carrier molecule;
                     NAD(P)(+)--arginine ADP-ribosyltransferase 4;
                     ADP-ribosyltransferase C2 and C3 toxin-like 4; Dombrock
                     glycoprotein; NAD(+)--protein-arginine
                     ADP-ribosyltransferase 4; Do glycoprotein;
                     ADP-ribosyltransferase 4 (Dombrock blood group)"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 4 isoform 1
                     precursor"
                     /protein_id="NP_066549.2"
                     /db_xref="CCDS:CCDS8668.1"
                     /db_xref="GeneID:420"
                     /db_xref="HGNC:HGNC:726"
                     /db_xref="MIM:110600"
                     /translation="MGPLINRCKKILLPTTVPPATMRIWLLGGLLPFLLLLSGLQRPT
                     EGSEVAIKIDFDFAPGSFDDQYQGCSKQVMEKLTQGDYFTKDIEAQKNYFRMWQKAHL
                     AWLNQGKVLPQNMTTTHAVAILFYTLNSNVHSDFTRAMASVARTPQQYERSFHFKYLH
                     YYLTSAIQLLRKDSIMENGTLCYEVHYRTKDVHFNAYTGATIRFGQFLSTSLLKEEAQ
                     EFGNQTLFTIFTCLGAPVQYFSLKKEVLIPPYELFKVINMSYHPRGDWLQLRSTGNLS
                     TYNCQLLKASSKKCIPDPIAIASLSFLTSVIIFSKSRV"
     exon            558..1266
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..5160
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /note="hexamer: AATAAA"
     polyA_site      1418
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /note="major polyA site"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /note="hexamer: AATAAA"
     polyA_site      2321
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
     regulatory      5141..5146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /note="hexamer: AATAAA"
     polyA_site      5160
                     /gene="ART4"
                     /gene_synonym="ARTC4; CD297; DO; DO/ART4; DOK1"
                     /note="major polyA site"
ORIGIN      
        1 gctacttggc cccaaacgct ggacagagca tgctttttcc tgtttggctg ggaaagggaa
       61 ggctgaactg ctgagtctga cacttaacag gacttcggca ttcccctgaa tacagactag
      121 atcagagatt ttattttttt aattgaaaag taacttgggt tctctttaga aacccttatt
      181 tggtgtgcgc atctggctat ttcacagaga tttcagtttt gcaaagaagt cggagttgat
      241 ttcttccctc agacaagcta ttggttgttg gtgggcaaca gaagttgctc agcatagaca
      301 ggggaaaaaa cggttacgga tgagactgaa agaaaacctc aaaggagaac tctgagaatt
      361 catctcagga tgaagctgca agggcaaagg agaagtactt gtgacacaag caaatgggtc
      421 cattgatcaa cagatgcaag aagattcttc tcccaactac tgtacctcct gcaacgatga
      481 gaatctggct ccttggaggc ctgctgccat tcctgctgct cctctctggc ctgcagagac
      541 ccacagaggg ttctgaggtt gcaattaaaa tcgacttcga cttcgcacca ggttcttttg
      601 atgatcagta ccaaggctgt agcaaacagg ttatggagaa actaactcaa ggggattatt
      661 tcacaaaaga catagaagcc cagaagaatt attttaggat gtggcaaaaa gcccacttag
      721 cctggcttaa ccaaggaaaa gttctacccc agaacatgac taccacacac gctgtggcta
      781 ttttgtttta tacattgaac agcaatgttc attctgactt tactagagcc atggcctctg
      841 ttgccaggac tccacagcag tatgaacgtt cattccactt caaatattta cactactacc
      901 tcacctcagc aatccagctg ctgaggaaag acagcatcat ggagaatggc actctgtgct
      961 atgaggtgca ttataggacg aaggatgtcc actttaatgc ctacacaggg gccaccattc
     1021 gatttggcca attcctctcc acatccctcc tgaaagaaga ggcacaggag tttgggaacc
     1081 agacactatt taccatattc acctgcctgg gtgcacctgt acagtacttc tccctcaaga
     1141 aggaagtctt gatccctccc tatgagctgt ttaaagttat aaatatgagc taccacccaa
     1201 gaggagactg gttgcagttg aggtcaactg ggaacctgag cacatataac tgtcagctgc
     1261 taaaagcttc cagcaagaaa tgcatccctg atcctatagc tattgcatct ctctcctttt
     1321 tgaccagtgt catcatcttt tccaaaagca gagtataaag aaatcttgtg gctcctttta
     1381 tttaaaaaaa atatttaaat aaaatctttt ttattggcct tttggctaga aatggacatt
     1441 tattttccag gaaggatgat cccatcatac ttctgctgaa accagtgcat ggcctcctct
     1501 ttgctaattc tcttatgcct ttccttgtac ccctttgcct tatttcaatc tgggcaccct
     1561 aagtactctt ggggaaatca ctctgcccag ctagcaactg atgcagagct ggctcagccc
     1621 actgactgtg attggcctgt aactcaggcc ttagccaatc agtatatttc ttcttcatgg
     1681 acacaaagat tcatgctgga atagaaaatg atccaatcag agcctgtgag atacaatcag
     1741 ggtacttttg tggaattgca attggaaata gaatgggagc ttcttttctg aatggatatt
     1801 aatgaaagca gggtaggagc ttatagctgc cagcaaagat cccgccacca ggagaggaga
     1861 ccccatctcc ttgagaaagg atctaacaca acaaaggaag agctgataag tgaaaagaaa
     1921 ctgagacctg atgagaatgt ataagcctct ggatccaact ttgcctaaag ctgaatacta
     1981 caagattttt cattacataa atcaataatt tatgtttttg cttgcataat ttgaattaga
     2041 ttttctatgt caagcatcaa gcagttgaag ttccaacgaa tacaagcact cttccttatt
     2101 ttttttaatt tagttattct aaataggaac aaatcaaaga agattaaatt agaaagcaaa
     2161 ggacaaattc ttcaccaaac agaaaagctt tgaaccccag agattaacca aggtgtgaat
     2221 tttcttcaga gattttttat gagcattcaa gattaagcta gtatggcctc agatgagaag
     2281 acacatggaa acttgagaaa taaaagggaa agttaatgaa agatgttagt gaaatttcat
     2341 tcaccagcag taatgggtgt tcatgcatgt tcctaagaca ttacaaaagt taaaatttaa
     2401 actcatatgt taattcatag agaacttgat ggcaaattta agtcttcata gcaaatttaa
     2461 atattaggaa aacatgaggg tatgtgtgaa ggttaacaga gagtatgaga gaaaaaaaca
     2521 ctgattacaa acaaatatca gcaatatagc gaggtctcat tacatgtaaa ctagtacatg
     2581 caaagaagta taaattgttg aattgtatag ctggaaatgt cctctaacgc ttccctcagg
     2641 tagtaattta ggtagcgaca taagggatta tttaacccga tcacgatcac tgaagaccct
     2701 ggtatcaggc taaatggagt aaagatgagg gctagctcta taattttgga ttttgaaagt
     2761 ccatgctcct tatccctttt aagatttgga taagaaacag caaaactgaa aatcggtcca
     2821 tctatttact ctccatagga cttcctgaat ggcctgtgtc atgatcaaag aaatggaatg
     2881 gggaataagc tacataaaat tacctggcag ggagttcagg catctctgta ctatcattct
     2941 ttaaattggg atttgaaact aacagggcca aatcacctct gtcacctagt tgcagtagcc
     3001 tctacagtca ataaaggaaa gaatttctgc caggcatggt ggctcacccc tgtaatccca
     3061 gcactttggg aggccgagga ggacggatca cgaggtcagg agttcaagac cagcctggcc
     3121 agcatggtga aaccccgtct ctactacaaa tacaaaaatt agccaggcat ggtggcacgc
     3181 acctgtaatc ccagctactt gggaggctga ggcaggaaaa ttgcctaaac ccaggaggcg
     3241 gaggtagtgc agtgagccaa gttcacacca ctgcactcca gcctgggcaa cagagtgaga
     3301 ctcgatctca aaaaaagaaa aaaagaaaga atttctacaa acagacaatt tatgtgactt
     3361 gcataggata gggtctttgg cagtttggtg gctacctagt agagagtcct ggggacatgg
     3421 ctctgggagc aagcttttcc agtgagcatc gatgagtcag taatgacatg ctatgttggt
     3481 aaaagccacc caacatctta agtacatttt tcctgtgcca tataaatgca tgtattgagc
     3541 catactgtgt acaaagcact ttggggatta aaagttaaga acactaggcc agatctctca
     3601 tgagtttaca atctcttagg agaaattaag aacataaagc aagccacaag tgaaatgcca
     3661 aaaaaaaaaa aggcaaaaat caagttttct gttcataaca attcaaaaga aagatttctt
     3721 ccaactgagg caagaagaga cacccggaag gctttaagta agaggctgca tttgaaccag
     3781 ccgttagggc tctaggctgg gagaaggggt gagcagaagg agaaaaaaac aagaaagagt
     3841 atgtgccaag tgcgtagtgc ccaaaacaag gccaaatatt aaatgcttgg agctgagaga
     3901 aaaatgtgat tcctctggcc tatggttaga taaagctttc tatcagagat gatgttttac
     3961 ttagaggaaa gcagaaaata gaagcgaata cggaatgatc gatgtatgta cagcataagg
     4021 tcagggagca gataggtctg gcagagagtg aggggtaatg tgggctggag aggaaattgg
     4081 aagccactca gtgaagctaa aaagtcagcc aaaagcattt gatttccatg agaagtcata
     4141 attttctgag taagacaatt ctcctaaagc gttgactctc taggcacaag cagcaatagc
     4201 atcctttaag aactcattag aaatgtgaat tttagggcct gatcccagac tacagactac
     4261 agaaattgaa cagtctgttt taataagtcc tctagatgat tctgctatac accaacattt
     4321 gagaacactg tgacttacac aattatgatc cttaagggaa tagccaagtt tctaaaaaag
     4381 ataacttagt tctaactcct gctgctgttt tacagatcaa atctctggag acagaaacta
     4441 ttctcttaaa attatgtaga ttcatgagtt tggttaagga taaatgtaca tagctcacat
     4501 cccctcagtc tctccctata gtccaaagtt gttgagcaag gaatctgtag agtattgatt
     4561 taaattgatt aagttacatg tttatgaaac tctaagagac tagttttaga aatttcactg
     4621 taatttctgc tgggataaat ttgttagcct gggatatctt ccaaagataa ggcggatgct
     4681 caaatatgtg taaattcatg caactgttaa cagagactgt gctgtaagga gtacttatgt
     4741 cctatagtaa ttttattaaa caaatacatg tatgtctcct tttgatgtgt acagaaatat
     4801 actgtttaat ctgaagaagc tgattgaaac aggaaaaatt taaaaagtaa aaacactcaa
     4861 cccatgtaat actttatttt tataacaagg tgttctcttt aatacgccta ttagattatc
     4921 ctgaagttct ctatttactc ttactttaaa aaaaatccaa tgaaagaaaa tttcagtaaa
     4981 gtttgttttg ctagaagaat caggattctt gtactgagtt gtctaataat atgaatcaaa
     5041 ttgatttaca ctgaatgaac tagctcttga tttggtaaaa ttcaacaagc atttattagg
     5101 tgctttcaga aataccaaga tgcagcaaac actggcaact aataaaaaaa attacaagta
//
