LOCUS       NM_001377177            1448 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ADP-ribosyltransferase 3 (inactive) (ART3), transcript
            variant 8, mRNA.
ACCESSION   NM_001377177
VERSION     NM_001377177.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Tan,L., Song,X., Sun,X., Wang,N., Qu,Y. and Sun,Z.
  TITLE     ART3 regulates triple-negative breast cancer cell function via
            activation of Akt and ERK pathways
  JOURNAL   Oncotarget 7 (29), 46589-46602 (2016)
   PUBMED   27374177
  REMARK    GeneRIF: knockdown of ART3 in breast cancer cells inhibited cell
            proliferation and invasion.
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Okada,H., Tajima,A., Shichiri,K., Tanaka,A., Tanaka,K. and Inoue,I.
  TITLE     Genome-wide expression of azoospermia testes demonstrates a
            specific profile and implicates ART3 in genetic susceptibility
  JOURNAL   PLoS Genet 4 (2), e26 (2008)
   PUBMED   18266473
  REMARK    GeneRIF: genome-wide gene expression analyses were used to identify
            genes involved in the pathogenesis of non-obstructive azoospermia,
            and ART3 was subsequently identified as a susceptibility gene
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Friedrich,M., Grahnert,A., Klein,C., Tschop,K., Engeland,K. and
            Hauschildt,S.
  TITLE     Genomic organization and expression of the human
            mono-ADP-ribosyltransferase ART3 gene
  JOURNAL   Biochim Biophys Acta 1759 (6), 270-280 (2006)
   PUBMED   16934346
  REMARK    GeneRIF: ART3 expression appears to be governed by a combination of
            differential splicing and tissue-preferential use of two
            alternative promoters.
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Friedrich,M., Grahnert,A., Paasch,U., Tannapfel,A., Koch-Nolte,F.
            and Hauschildt,S.
  TITLE     Expression of toxin-related human mono-ADP-ribosyltransferase 3 in
            human testes
  JOURNAL   Asian J Androl 8 (3), 281-287 (2006)
   PUBMED   16625277
  REMARK    GeneRIF: ART3 protein is expressed in testes in particular on
            spermatocytes, indicating that ART3 exerts a specific function only
            required at a particular stage of spermatogenesis.
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Friedrich,M., Grahnert,A. and Hauschildt,S.
  TITLE     Analysis of the 3' UTR of the ART3 and ART4 gene by 3' inverse
            RACE-PCR
  JOURNAL   DNA Seq 16 (1), 53-57 (2005)
   PUBMED   16040347
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Grahnert,A., Friedrich,M., Pfister,M., Haag,F., Koch-Nolte,F. and
            Hauschildt,S.
  TITLE     Mono-ADP-ribosyltransferases in human monocytes: regulation by
            lipopolysaccharide
  JOURNAL   Biochem J 362 (Pt 3), 717-723 (2002)
   PUBMED   11879200
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Balducci,E., Horiba,K., Usuki,J., Park,M., Ferrans,V.J. and Moss,J.
  TITLE     Selective expression of RT6 superfamily in human bronchial
            epithelial cells
  JOURNAL   Am J Respir Cell Mol Biol 21 (3), 337-346 (1999)
   PUBMED   10460751
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Koch-Nolte,F., Haag,F., Braren,R., Kuhl,M., Hoovers,J.,
            Balasubramanian,S., Bazan,F. and Thiele,H.G.
  TITLE     Two novel human members of an emerging mammalian gene family
            related to mono-ADP-ribosylating bacterial toxins
  JOURNAL   Genomics 39 (3), 370-376 (1997)
   PUBMED   9119374
  REMARK    Erratum:[Genomics 1999 Jan 1;55(1):130]
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   Levy,I., Wu,Y.Q., Roeckel,N., Bulle,F., Pawlak,A., Siegrist,S.,
            Mattei,M.G. and Guellaen,G.
  TITLE     Human testis specifically expresses a homologue of the rodent T
            lymphocytes RT6 mRNA
  JOURNAL   FEBS Lett 382 (3), 276-280 (1996)
   PUBMED   8605984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112719.4.
            
            Summary: This gene encodes an arginine-specific
            ADP-ribosyltransferase. The encoded protein catalyzes a reversible
            reaction which modifies proteins by the addition or removal of
            ADP-ribose to an arginine residue to regulate the function of the
            modified protein. An ADP-ribosyltransferase pseudogene is located
            on chromosome 11. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.402468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC112719.4         36950-37080
            132-209             AC112719.4         101641-101718
            210-921             AC112719.4         107584-108295
            922-954             AC112719.4         123404-123436
            955-987             AC112719.4         124715-124747
            988-1017            AC112719.4         126555-126584
            1018-1047           AC112719.4         126750-126779
            1048-1448           AC112719.4         138146-138546
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..1448
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /note="ADP-ribosyltransferase 3 (inactive)"
                     /db_xref="GeneID:419"
                     /db_xref="HGNC:HGNC:725"
                     /db_xref="MIM:603086"
     exon            1..131
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            132..209
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1181
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /EC_number="2.4.2.31"
                     /note="isoform f precursor is encoded by transcript
                     variant 8; ecto-ADP-ribosyltransferase 3;
                     mono-ADP-ribosyltransferase; mono(ADP-ribosyl)transferase
                     3; NAD(P)(+)--arginine ADP-ribosyltransferase 3;
                     ADP-ribosyltransferase C2 and C3 toxin-like 3"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 3 isoform f
                     precursor"
                     /protein_id="NP_001364106.1"
                     /db_xref="GeneID:419"
                     /db_xref="HGNC:HGNC:725"
                     /db_xref="MIM:603086"
                     /translation="MKTGHFEIVTMLLATMILVDIFQVKAEVLDMADNAFDDEYLKCT
                     DRMEIKYVPQLLKEEKASHQQLDTVWENAKAKWAARKTQIFLPMNFKDNHGIALMAYI
                     SEAQEQTPFYHLFSEAVKMAGQSREDYIYGFQFKAFHFYLTRALQLLRKPCEASSKTV
                     VYRTSQGTSFTFGGLNQARFGHFTLAYSAKPQAANDQLTVLSIYTCLGVDIENFLDKE
                     SERITLIPLNEVFQVSQEGAGNNLILQSINKTCSHYECAFLGGLKTENCIENLEYFQP
                     IYVYNPGEKNWKLEDHGEKNQKLEDHAPGPVPVPGPKSHPSASSGKLLLPQFGMVIIL
                     ISVSAINLFVAL"
     exon            210..921
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..954
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            955..987
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1017
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1047
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1448
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1429..1434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /note="hexamer: AATAAA"
     polyA_site      1448
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /note="major polyA site"
ORIGIN      
        1 aaccttcttc agtgaggagg ttatacccgg aggtctcgac gctcgctcgt gctgctcgtg
       61 ttgccgctgg gtacgtttgc tgccagtgct gatccagccg gaggcgaaga gaagcacttt
      121 gggggcaaaa gaagagaaaa atgaagacgg gacattttga aatagtcacc atgctgctgg
      181 caaccatgat tctagtggac attttccagg tgaaggctga agtgttagac atggcagata
      241 atgcatttga tgatgaatac ctgaaatgta cggacaggat ggaaattaaa tacgttcccc
      301 aactgctaaa ggaggaaaaa gcaagccacc agcaattaga tactgtgtgg gaaaatgcaa
      361 aagccaaatg ggcagcccga aagactcaaa tctttctccc tatgaatttt aaggataacc
      421 atggaatagc cctgatggca tatatttccg aagctcaaga gcaaactccc ttttaccatc
      481 tgttcagtga agctgtgaag atggctggcc aatctcgaga agattatatc tatggcttcc
      541 agttcaaagc tttccacttt tacctcacaa gagccctgca gttgctgaga aaaccttgtg
      601 aggccagttc caaaactgtg gtatatagaa caagccaggg cacttcattt acatttggag
      661 ggctaaacca agccaggttt ggccatttta ccttggcata ttcagccaaa cctcaggctg
      721 ctaatgacca gctcactgtg ttatccatct acacatgcct tggagttgac attgaaaatt
      781 ttcttgataa agaaagtgaa agaattactt taatacctct gaatgaggtt tttcaagtgt
      841 cacaggaggg ggctggcaat aaccttatcc ttcaaagcat aaacaagacc tgcagccatt
      901 atgagtgtgc atttctaggt ggactaaaaa ccgaaaactg tattgagaac ctagaatatt
      961 ttcaacccat ctatgtctac aaccctggtg agaaaaactg gaagcttgaa gaccatggtg
     1021 agaaaaacca gaagcttgaa gaccatgctc caggtccagt tcctgttcca ggtcccaaaa
     1081 gccatccttc tgcatcctcg ggcaaactgc tgcttccaca gtttgggatg gtcatcattt
     1141 taatcagtgt ttctgctata aatctctttg ttgctctgta gtttgatgca ttgtttatct
     1201 ttcttattct ttacttgaaa taactatagg gatccacagg agatcaaaag gaatgatgta
     1261 ttttttacgt gttggccaaa gtcactggat aaaatgagaa ttgtatattt gttattcatt
     1321 ttgcaaattc agaaagttgg tccagatata tgtcacagaa cttttcactt gtatactact
     1381 cttacaatgg aaaaaaatcc cgaaaactgt atacttctga ttaaattcaa taaaagattt
     1441 tgattaga
//
