LOCUS       NM_001130016            1557 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ADP-ribosyltransferase 3 (inactive) (ART3), transcript
            variant 1, mRNA.
ACCESSION   NM_001130016 XM_005262998
VERSION     NM_001130016.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Tan,L., Song,X., Sun,X., Wang,N., Qu,Y. and Sun,Z.
  TITLE     ART3 regulates triple-negative breast cancer cell function via
            activation of Akt and ERK pathways
  JOURNAL   Oncotarget 7 (29), 46589-46602 (2016)
   PUBMED   27374177
  REMARK    GeneRIF: knockdown of ART3 in breast cancer cells inhibited cell
            proliferation and invasion.
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Okada,H., Tajima,A., Shichiri,K., Tanaka,A., Tanaka,K. and Inoue,I.
  TITLE     Genome-wide expression of azoospermia testes demonstrates a
            specific profile and implicates ART3 in genetic susceptibility
  JOURNAL   PLoS Genet 4 (2), e26 (2008)
   PUBMED   18266473
  REMARK    GeneRIF: genome-wide gene expression analyses were used to identify
            genes involved in the pathogenesis of non-obstructive azoospermia,
            and ART3 was subsequently identified as a susceptibility gene
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   Friedrich,M., Grahnert,A., Klein,C., Tschop,K., Engeland,K. and
            Hauschildt,S.
  TITLE     Genomic organization and expression of the human
            mono-ADP-ribosyltransferase ART3 gene
  JOURNAL   Biochim Biophys Acta 1759 (6), 270-280 (2006)
   PUBMED   16934346
  REMARK    GeneRIF: ART3 expression appears to be governed by a combination of
            differential splicing and tissue-preferential use of two
            alternative promoters.
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Friedrich,M., Grahnert,A., Paasch,U., Tannapfel,A., Koch-Nolte,F.
            and Hauschildt,S.
  TITLE     Expression of toxin-related human mono-ADP-ribosyltransferase 3 in
            human testes
  JOURNAL   Asian J Androl 8 (3), 281-287 (2006)
   PUBMED   16625277
  REMARK    GeneRIF: ART3 protein is expressed in testes in particular on
            spermatocytes, indicating that ART3 exerts a specific function only
            required at a particular stage of spermatogenesis.
REFERENCE   5  (bases 1 to 1557)
  AUTHORS   Friedrich,M., Grahnert,A. and Hauschildt,S.
  TITLE     Analysis of the 3' UTR of the ART3 and ART4 gene by 3' inverse
            RACE-PCR
  JOURNAL   DNA Seq 16 (1), 53-57 (2005)
   PUBMED   16040347
REFERENCE   6  (bases 1 to 1557)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   7  (bases 1 to 1557)
  AUTHORS   Grahnert,A., Friedrich,M., Pfister,M., Haag,F., Koch-Nolte,F. and
            Hauschildt,S.
  TITLE     Mono-ADP-ribosyltransferases in human monocytes: regulation by
            lipopolysaccharide
  JOURNAL   Biochem J 362 (Pt 3), 717-723 (2002)
   PUBMED   11879200
REFERENCE   8  (bases 1 to 1557)
  AUTHORS   Balducci,E., Horiba,K., Usuki,J., Park,M., Ferrans,V.J. and Moss,J.
  TITLE     Selective expression of RT6 superfamily in human bronchial
            epithelial cells
  JOURNAL   Am J Respir Cell Mol Biol 21 (3), 337-346 (1999)
   PUBMED   10460751
REFERENCE   9  (bases 1 to 1557)
  AUTHORS   Koch-Nolte,F., Haag,F., Braren,R., Kuhl,M., Hoovers,J.,
            Balasubramanian,S., Bazan,F. and Thiele,H.G.
  TITLE     Two novel human members of an emerging mammalian gene family
            related to mono-ADP-ribosylating bacterial toxins
  JOURNAL   Genomics 39 (3), 370-376 (1997)
   PUBMED   9119374
  REMARK    Erratum:[Genomics 1999 Jan 1;55(1):130]
REFERENCE   10 (bases 1 to 1557)
  AUTHORS   Levy,I., Wu,Y.Q., Roeckel,N., Bulle,F., Pawlak,A., Siegrist,S.,
            Mattei,M.G. and Guellaen,G.
  TITLE     Human testis specifically expresses a homologue of the rodent T
            lymphocytes RT6 mRNA
  JOURNAL   FEBS Lett 382 (3), 276-280 (1996)
   PUBMED   8605984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112719.4.
            
            On Dec 17, 2019 this sequence version replaced NM_001130016.2.
            
            Summary: This gene encodes an arginine-specific
            ADP-ribosyltransferase. The encoded protein catalyzes a reversible
            reaction which modifies proteins by the addition or removal of
            ADP-ribose to an arginine residue to regulate the function of the
            modified protein. An ADP-ribosyltransferase pseudogene is located
            on chromosome 11. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Dec
            2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008397.1, SRR1803612.445017.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355810.9/ ENSP00000348064.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AC112719.4         100469-100579
            112-189             AC112719.4         101641-101718
            190-901             AC112719.4         107584-108295
            902-934             AC112719.4         123404-123436
            935-967             AC112719.4         124715-124747
            968-997             AC112719.4         126051-126080
            998-1027            AC112719.4         126555-126584
            1028-1057           AC112719.4         126750-126779
            1058-1090           AC112719.4         129697-129729
            1091-1123           AC112719.4         130357-130389
            1124-1156           AC112719.4         133521-133553
            1157-1557           AC112719.4         138146-138546
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..1557
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /note="ADP-ribosyltransferase 3 (inactive)"
                     /db_xref="GeneID:419"
                     /db_xref="HGNC:HGNC:725"
                     /db_xref="MIM:603086"
     exon            1..111
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            112..189
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1290
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /EC_number="2.4.2.31"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; ecto-ADP-ribosyltransferase 3;
                     mono-ADP-ribosyltransferase; mono(ADP-ribosyl)transferase
                     3; NAD(P)(+)--arginine ADP-ribosyltransferase 3;
                     ADP-ribosyltransferase C2 and C3 toxin-like 3"
                     /codon_start=1
                     /product="ecto-ADP-ribosyltransferase 3 isoform a
                     precursor"
                     /protein_id="NP_001123488.1"
                     /db_xref="CCDS:CCDS47079.1"
                     /db_xref="GeneID:419"
                     /db_xref="HGNC:HGNC:725"
                     /db_xref="MIM:603086"
                     /translation="MKTGHFEIVTMLLATMILVDIFQVKAEVLDMADNAFDDEYLKCT
                     DRMEIKYVPQLLKEEKASHQQLDTVWENAKAKWAARKTQIFLPMNFKDNHGIALMAYI
                     SEAQEQTPFYHLFSEAVKMAGQSREDYIYGFQFKAFHFYLTRALQLLRKPCEASSKTV
                     VYRTSQGTSFTFGGLNQARFGHFTLAYSAKPQAANDQLTVLSIYTCLGVDIENFLDKE
                     SERITLIPLNEVFQVSQEGAGNNLILQSINKTCSHYECAFLGGLKTENCIENLEYFQP
                     IYVYNPGEKNQKLEDHSEKNWKLEDHGEKNQKLEDHGVKILEPTQIPGMKIPEPFPLP
                     EDKSQGNINNPTPGPVPVPGPKSHPSASSGKLLLPQFGMVIILISVSAINLFVAL"
     exon            190..901
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            902..934
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            935..967
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..997
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1027
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1057
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1090
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1123
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1156
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1557
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1538..1543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /note="hexamer: AATAAA"
     polyA_site      1557
                     /gene="ART3"
                     /gene_synonym="ARTC3"
                     /note="major polyA site"
ORIGIN      
        1 tctcactgtc aacaacatcc catcctgaag acttgcttac cacaactgag agtggggagt
       61 cagtttgagg cctagcatca cttaaacttc ctccaaaggc acaaaagcca gaagagaaaa
      121 atgaagacgg gacattttga aatagtcacc atgctgctgg caaccatgat tctagtggac
      181 attttccagg tgaaggctga agtgttagac atggcagata atgcatttga tgatgaatac
      241 ctgaaatgta cggacaggat ggaaattaaa tacgttcccc aactgctaaa ggaggaaaaa
      301 gcaagccacc agcaattaga tactgtgtgg gaaaatgcaa aagccaaatg ggcagcccga
      361 aagactcaaa tctttctccc tatgaatttt aaggataacc atggaatagc cctgatggca
      421 tatatttccg aagctcaaga gcaaactccc ttttaccatc tgttcagtga agctgtgaag
      481 atggctggcc aatctcgaga agattatatc tatggcttcc agttcaaagc tttccacttt
      541 tacctcacaa gagccctgca gttgctgaga aaaccttgtg aggccagttc caaaactgtg
      601 gtatatagaa caagccaggg cacttcattt acatttggag ggctaaacca agccaggttt
      661 ggccatttta ccttggcata ttcagccaaa cctcaggctg ctaatgacca gctcactgtg
      721 ttatccatct acacatgcct tggagttgac attgaaaatt ttcttgataa agaaagtgaa
      781 agaattactt taatacctct gaatgaggtt tttcaagtgt cacaggaggg ggctggcaat
      841 aaccttatcc ttcaaagcat aaacaagacc tgcagccatt atgagtgtgc atttctaggt
      901 ggactaaaaa ccgaaaactg tattgagaac ctagaatatt ttcaacccat ctatgtctac
      961 aaccctggtg agaaaaacca gaagcttgaa gaccatagtg agaaaaactg gaagcttgaa
     1021 gaccatggtg agaaaaacca gaagcttgaa gaccatggtg tgaaaatcct tgaacccacc
     1081 caaatacctg gaatgaaaat tccagaacct tttccactac ctgaagataa aagtcaagga
     1141 aatatcaaca atcctactcc aggtccagtt cctgttccag gtcccaaaag ccatccttct
     1201 gcatcctcgg gcaaactgct gcttccacag tttgggatgg tcatcatttt aatcagtgtt
     1261 tctgctataa atctctttgt tgctctgtag tttgatgcat tgtttatctt tcttattctt
     1321 tacttgaaat aactataggg atccacagga gatcaaaagg aatgatgtat tttttacgtg
     1381 ttggccaaag tcactggata aaatgagaat tgtatatttg ttattcattt tgcaaattca
     1441 gaaagttggt ccagatatat gtcacagaac ttttcacttg tatactactc ttacaatgga
     1501 aaaaaatccc gaaaactgta tacttctgat taaattcaat aaaagatttt gattaga
//
