LOCUS       NM_004314               1315 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens ADP-ribosyltransferase 1 (ART1), mRNA.
ACCESSION   NM_004314 NM_001104538
VERSION     NM_004314.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1315)
  AUTHORS   Lin,T., Zhang,S., Tang,Y., Xiao,M., Li,M., Gong,H., Xie,H. and
            Wang,Y.
  TITLE     ART1 knockdown decreases the IL-6-induced proliferation of
            colorectal cancer cells
  JOURNAL   BMC Cancer 24 (1), 354 (2024)
   PUBMED   38504172
  REMARK    GeneRIF: ART1 knockdown decreases the IL-6-induced proliferation of
            colorectal cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1315)
  AUTHORS   Ma,X., Li,M., Liu,Y., Zhang,X., Yang,X., Wang,Y., Li,Y., Wang,J.,
            Liu,X., Yan,Z., Yu,X. and Wu,C.
  TITLE     ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis
  JOURNAL   J Mol Cell Biol 15 (7) (2024)
   PUBMED   37381178
  REMARK    GeneRIF: ARTC1-mediated VAPB ADP-ribosylation regulates calcium
            homeostasis.
REFERENCE   3  (bases 1 to 1315)
  AUTHORS   Wennerberg,E., Mukherjee,S., Spada,S., Hung,C., Agrusa,C.J.,
            Chen,C., Valeta-Magara,A., Rudqvist,N.P., Van Nest,S.J.,
            Kamel,M.K., Nasar,A., Narula,N., Mittal,V., Markowitz,G.J.,
            Zhou,X.K., Adusumilli,P.S., Borczuk,A.C., White,T.E., Khan,A.G.,
            Balderes,P.J., Lorenz,I.C., Altorki,N., Demaria,S., McGraw,T.E. and
            Stiles,B.M.
  TITLE     Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells
            mediates immune resistance in non-small cell lung cancer
  JOURNAL   Sci Transl Med 14 (636), eabe8195 (2022)
   PUBMED   35294260
  REMARK    GeneRIF: Expression of the mono-ADP-ribosyltransferase ART1 by
            tumor cells mediates immune resistance in non-small cell lung
            cancer.
REFERENCE   4  (bases 1 to 1315)
  AUTHORS   Li,Z., Yan,X., Sun,Y. and Yang,X.
  TITLE     Expression of ADP-ribosyltransferase 1 Is Associated with Poor
            Prognosis of Glioma Patients
  JOURNAL   Tohoku J Exp Med 239 (4), 269-278 (2016)
   PUBMED   27466078
  REMARK    GeneRIF: up-regulation of ART1 expression is associated with the
            aggressiveness of glioma.
REFERENCE   5  (bases 1 to 1315)
  AUTHORS   Song,G.L., Jin,C.C., Zhao,W., Tang,Y., Wang,Y.L., Li,M., Xiao,M.,
            Li,X., Li,Q.S., Lin,X., Chen,W.W. and Kuang,J.
  TITLE     Regulation of the RhoA/ROCK/AKT/beta-catenin pathway by
            arginine-specific ADP-ribosytransferases 1 promotes migration and
            epithelial-mesenchymal transition in colon carcinoma
  JOURNAL   Int J Oncol 49 (2), 646-656 (2016)
   PUBMED   27277835
  REMARK    GeneRIF: Our data suggest that ART1 could regulate EMT by
            regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its
            downstream factors (snail1, vimentin, N-cadherin and E-cadherin)
            and that it therefore plays an important role in the progression of
            colon carcinoma.
REFERENCE   6  (bases 1 to 1315)
  AUTHORS   Saxty,B.A., Yadollahi-Farsani,M., Upton,P.D., Johnstone,S.R. and
            MacDermot,J.
  TITLE     Inactivation of platelet-derived growth factor-BB following
            modification by ADP-ribosyltransferase
  JOURNAL   Br J Pharmacol 133 (8), 1219-1226 (2001)
   PUBMED   11498506
REFERENCE   7  (bases 1 to 1315)
  AUTHORS   Kefalas,P., Saxty,B., Yadollahi-Farsani,M. and MacDermot,J.
  TITLE     Chemotaxin-dependent translocation of immunoreactive
            ADP-ribosyltransferase-1 to the surface of human neutrophil
            polymorphs
  JOURNAL   Eur J Biochem 259 (3), 866-871 (1999)
   PUBMED   10092875
REFERENCE   8  (bases 1 to 1315)
  AUTHORS   Koch-Nolte,F., Haag,F., Braren,R., Kuhl,M., Hoovers,J.,
            Balasubramanian,S., Bazan,F. and Thiele,H.G.
  TITLE     Two novel human members of an emerging mammalian gene family
            related to mono-ADP-ribosylating bacterial toxins
  JOURNAL   Genomics 39 (3), 370-376 (1997)
   PUBMED   9119374
  REMARK    Erratum:[Genomics 1999 Jan 1;55(1):130]
REFERENCE   9  (bases 1 to 1315)
  AUTHORS   Koch-Nolte,F., Kuhl,M., Haag,F., Cetkovic-Cvrlje,M., Leiter,E.H.
            and Thiele,H.G.
  TITLE     Assignment of the human and mouse genes for muscle ecto mono
            (ADPribosyl)transferase to a conserved linkage group on human
            chromosome 11p15 and mouse chromosome 7
  JOURNAL   Genomics 36 (1), 215-216 (1996)
   PUBMED   8812442
REFERENCE   10 (bases 1 to 1315)
  AUTHORS   Okazaki,I.J., Zolkiewska,A., Nightingale,M.S. and Moss,J.
  TITLE     Immunological and structural conservation of mammalian skeletal
            muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases
  JOURNAL   Biochemistry 33 (43), 12828-12836 (1994)
   PUBMED   7947688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC060812.15, BC069102.1 and
            S74683.1.
            
            On May 17, 2019 this sequence version replaced NM_004314.2.
            
            Summary: ADP-ribosyltransferase catalyzes the ADP-ribosylation of
            arginine residues in proteins. Mono-ADP-ribosylation is a
            posttranslational modification of proteins that is interfered with
            by a variety of bacterial toxins including cholera, pertussis, and
            heat-labile enterotoxins of E. coli. The amino acid sequence
            consists of predominantly hydrophobic N- and C-terminal regions,
            which is characteristic of glycosylphosphatidylinositol
            (GPI)-anchored proteins. This gene was previously designated ART2.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069102.1, S74683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158800, SAMN03465413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250693.2/ ENSP00000250693.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC060812.15        135065-135067       c
            4-1314              BC069102.1         1-1311
            1315-1315           S74683.1           1311-1311
FEATURES             Location/Qualifiers
     source          1..1315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1315
                     /gene="ART1"
                     /gene_synonym="ART2; ARTC1; CD296; RT6"
                     /note="ADP-ribosyltransferase 1"
                     /db_xref="GeneID:417"
                     /db_xref="HGNC:HGNC:723"
                     /db_xref="MIM:601625"
     exon            1..52
                     /gene="ART1"
                     /gene_synonym="ART2; ARTC1; CD296; RT6"
                     /inference="alignment:Splign:2.1.0"
     exon            53..167
                     /gene="ART1"
                     /gene_synonym="ART2; ARTC1; CD296; RT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1088
                     /gene="ART1"
                     /gene_synonym="ART2; ARTC1; CD296; RT6"
                     /EC_number="2.4.2.31"
                     /note="ADP-ribosyltransferase 2; GPI-linked
                     NAD(P)(+)--arginine ADP-ribosyltransferase 1;
                     mono(ADP-ribosyl)transferase 1; ADP-ribosyltransferase C2
                     and C3 toxin-like 1"
                     /codon_start=1
                     /product="GPI-linked NAD(P)(+)--arginine
                     ADP-ribosyltransferase 1 precursor"
                     /protein_id="NP_004305.2"
                     /db_xref="CCDS:CCDS7744.1"
                     /db_xref="GeneID:417"
                     /db_xref="HGNC:HGNC:723"
                     /db_xref="MIM:601625"
                     /translation="MQMPAMMSLLLVSVGLMEALQAQSHPITRRDLFSQEIQLDMALA
                     SFDDQYAGCAAAMTAALPDLNHTEFQANQVYADSWTLASSQWQERQARWPEWSLSPTR
                     PSPPPLGFRDEHGVALLAYTANSPLHKEFNAAVREAGRSRAHYLHHFSFKTLHFLLTE
                     ALQLLGSGQRPPRCHQVFRGVHGLRFRPAGPRATVRLGGFASASLKHVAAQQFGEDTF
                     FGIWTCLGAPIKGYSFFPGEEEVLIPPFETFQVINASRLAQGPARIYLRALGKHSTYN
                     CEYIKDKKCKSGPCHLDNSAMGQSPLSAVWSLLLLLWFLVVRAFPDGPGLL"
     exon            168..948
                     /gene="ART1"
                     /gene_synonym="ART2; ARTC1; CD296; RT6"
                     /inference="alignment:Splign:2.1.0"
     exon            949..990
                     /gene="ART1"
                     /gene_synonym="ART2; ARTC1; CD296; RT6"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1315
                     /gene="ART1"
                     /gene_synonym="ART2; ARTC1; CD296; RT6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggccatg gtggagatca gcagcagctt ccccacccag gacaaggcct agatgaggaa
       61 actgagaccc aaaaagagac agcaactggc ccagggtcac cagcatgcag atgcctgcta
      121 tgatgtctct gcttcttgtg tctgtgggcc tcatggaagc acttcaggcc cagagccacc
      181 ccatcacacg acgagacctc ttctctcaag agattcagct ggacatggcc ctggcctcct
      241 ttgatgacca gtacgctggc tgtgctgctg ccatgacagc tgctctcccg gatctcaacc
      301 acacggagtt ccaggccaac caggtgtatg cagacagctg gacactggca agcagccaat
      361 ggcaggagcg tcaggccagg tggccagagt ggagtctcag ccccacccgt ccatccccgc
      421 cacccctggg cttccgcgat gagcatgggg tggccctcct ggcctacaca gccaacagcc
      481 ccctgcacaa ggagttcaat gcagccgtgc gtgaggcggg ccgctcccgg gcccactacc
      541 tccaccactt ctccttcaag acactccatt tcctgctgac tgaggccctg cagctcctgg
      601 gcagcggcca gcgtccaccc cggtgccacc aggtgttccg aggtgtgcac ggcctgcgct
      661 tccggccagc agggccccgg gccaccgtga ggctgggggg ctttgcttct gcctccctga
      721 agcatgttgc agcccagcag tttggtgagg acaccttctt cggcatctgg acctgccttg
      781 gggcccctat caagggctac tccttcttcc ctggagagga agaggtgctg atccccccct
      841 ttgagacctt ccaagtgatc aatgccagca gactggccca gggccccgcc cgcatctacc
      901 tccgagccct gggcaagcac agcacctaca actgcgagta catcaaagac aagaagtgca
      961 agtctgggcc ttgccatctg gataattcag ccatgggtca gagccccctc tctgcagtct
     1021 ggtctttgct gctgctgctc tggttcctcg tggtgagggc ctttccagat ggtccaggcc
     1081 tcctttgatg catgagacac gggacagcct cgcctgctgc ctctgcccat cctgaggatg
     1141 ttggccatgt gtgctttcag tgtaaccaag attcctgtca atcccatctg cagggaactc
     1201 tgggaccttc tctggtagct gccagaccgg ctggtggaga aacaggagac aatctgggga
     1261 ctgaacctta cccagggctg taggagtgag actctgaata aagggttggg ccggc
//
