LOCUS       NM_024590               4603 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens arylsulfatase family member J (ARSJ), transcript
            variant 1, mRNA.
ACCESSION   NM_024590
VERSION     NM_024590.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4603)
  AUTHORS   He,J., Kelly,T.N., Zhao,Q., Li,H., Huang,J., Wang,L., Jaquish,C.E.,
            Sung,Y.J., Shimmin,L.C., Lu,F., Mu,J., Hu,D., Ji,X., Shen,C.,
            Guo,D., Ma,J., Wang,R., Shen,J., Li,S., Chen,J., Mei,H., Chen,C.S.,
            Chen,S., Chen,J., Li,J., Cao,J., Lu,X., Wu,X., Rice,T.K., Gu,C.C.,
            Schwander,K., Hamm,L.L., Liu,D., Rao,D.C., Hixson,J.E. and Gu,D.
  TITLE     Genome-wide association study identifies 8 novel loci associated
            with blood pressure responses to interventions in Han Chinese
  JOURNAL   Circ Cardiovasc Genet 6 (6), 598-607 (2013)
   PUBMED   24165912
REFERENCE   2  (bases 1 to 4603)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   3  (bases 1 to 4603)
  AUTHORS   Obaya,A.J.
  TITLE     Molecular cloning and initial characterization of three novel human
            sulfatases
  JOURNAL   Gene 372, 110-117 (2006)
   PUBMED   16500042
  REMARK    GeneRIF: The identification, molecular cloning and initial
            characterization of three new members of this human gene family is
            reported.
REFERENCE   4  (bases 1 to 4603)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
REFERENCE   5  (bases 1 to 4603)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA884606.1, BC089445.1, AY875938.1, BG661302.1, AC104779.4 and
            AI087279.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024590.3.
            
            Summary: Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate
            esters from sulfated steroids, carbohydrates, proteoglycans, and
            glycolipids. They are involved in hormone biosynthesis, modulation
            of cell signaling, and degradation of macromolecules (Sardiello et
            al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.6489.1,
                                           SRR1660803.190889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315366.8/ ENSP00000320219.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-555               DA884606.1         1-555
            556-813             BC089445.1         1-258
            814-2613            AY875938.1         1-1800
            2614-2933           BG661302.1         228-547
            2934-4122           AC104779.4         7286-8474           c
            4123-4603           AI087279.1         12-492              c
FEATURES             Location/Qualifiers
     source          1..4603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q26"
     gene            1..4603
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
                     /note="arylsulfatase family member J"
                     /db_xref="GeneID:79642"
                     /db_xref="HGNC:HGNC:26286"
                     /db_xref="MIM:610010"
     exon            1..1211
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             814..2613
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
                     /EC_number="3.1.6.12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; arylsulfatase J"
                     /codon_start=1
                     /product="arylsulfatase J isoform 1 precursor"
                     /protein_id="NP_078866.3"
                     /db_xref="CCDS:CCDS43264.1"
                     /db_xref="GeneID:79642"
                     /db_xref="HGNC:HGNC:26286"
                     /db_xref="MIM:610010"
                     /translation="MAPRGCAGHPPPPSPQACVCPGKMLAMGALAGFWILCLLTYGYL
                     SWGQALEEEEEGALLAQAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTPT
                     LDKLAAEGVKLENYYVQPICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATL
                     PQKLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPGMC
                     GYDLYENDNAAWDYDNGIYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPG
                     RYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTA
                     GGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQI
                     DEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIR
                     VQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSVWLFNITADPYERVDL
                     SNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPWYKEETKKKKPSK
                     NQAEKKQKKSKKKKKKQQKAVSGSTCHSGVTCG"
     exon            1212..4603
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3678..3683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
                     /note="hexamer: ATTAAA"
     polyA_site      3709
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
                     /note="major polyA site"
     regulatory      3767..3772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
                     /note="hexamer: AATAAA"
     polyA_site      3791
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
     regulatory      4581..4586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
                     /note="hexamer: AATAAA"
     polyA_site      4603
                     /gene="ARSJ"
                     /gene_synonym="ASJ"
ORIGIN      
        1 agtttgcagc gcctgcgccg ggtgcgccaa ctacgcaaag accaagcggg ctccgcgcgg
       61 accggccgcg gggctaggga cccggctttg gccttcaggc tccctagcag cggggaaaag
      121 gaattgctgc ccggagtttc tgcggaggtg gagggagatc aggaaacggc ttcttcctca
      181 cttcgccgcc tggtgagtgt cggggagatt ggcaaacgcc taggaaagga ctggggaaaa
      241 tagccctggg aaagtggaga aggtgatcag gaggccggtc cactacggca gtttatctgt
      301 ctgatcagag ccagacgcga cgcgtccact tcgcagttct ttccaggtgt ggggaccgca
      361 ggacagacgg ccgatcccgc cgccctccgt accagcactc ccaggagagt cagcctcgct
      421 ccccaacgtc gagggcgctc tggccacgaa aagttcctgt ccactgtgat tctcaattcc
      481 ttgcttggtt tttttctcca gagaactttt gggtggagat attaactttt ttcttttttt
      541 tttccttggt ggaagctgct ctagggaggg gggaggagga ggagaaagtg aaatgtgctg
      601 gagaagagcg agccctcctt gttcttccgg agtcccatcc attaagccat cacttctgga
      661 agattaaagt tgtcggacat ggtgacagct gagaggagag gaggatttct tgccaggtgg
      721 agagtcttca ccgtctgttg ggtgcatgtg tgcgcccgca gcggcgcggg gcgcgtggtt
      781 ctccgcgtgg agtctcacct gggacctgag tgaatggctc ccaggggctg tgcggggcat
      841 ccgcctccgc cttctccaca ggcctgtgtc tgtcctggaa agatgctagc aatgggggcg
      901 ctggcaggat tctggatcct ctgcctcctc acttatggtt acctgtcctg gggccaggcc
      961 ttagaagagg aggaagaagg ggccttacta gctcaagctg gagagaaact agagcccagc
     1021 acaacttcca cctcccagcc ccatctcatt ttcatcctag cggatgatca gggatttaga
     1081 gatgtgggtt accacggatc tgagattaaa acacctactc ttgacaagct cgctgccgaa
     1141 ggagttaaac tggagaacta ctatgtccag cctatttgca caccatccag gagtcagttt
     1201 attactggaa agtatcagat acacaccgga cttcaacatt ctatcataag acctacccaa
     1261 cccaactgtt tacctctgga caatgccacc ctacctcaga aactgaagga ggttggatat
     1321 tcaacgcata tggtcggaaa atggcacttg ggtttttaca gaaaagaatg catgcccacc
     1381 agaagaggat ttgatacctt ttttggttcc cttttgggaa gtggggatta ctatacacac
     1441 tacaaatgtg acagtcctgg gatgtgtggc tatgacttgt atgaaaacga caatgctgcc
     1501 tgggactatg acaatggcat atactccaca cagatgtaca ctcagagagt acagcaaatc
     1561 ttagcttccc ataaccccac aaagcctata tttttatata ttgcctatca agctgttcat
     1621 tcaccactgc aagctcctgg caggtatttc gaacactacc gatccattat caacataaac
     1681 aggaggagat atgctgccat gctttcctgc ttagatgaag caatcaacaa cgtgacattg
     1741 gctctaaaga cttatggttt ctataacaac agcattatca tttactcttc agataatggt
     1801 ggccagccta cggcaggagg gagtaactgg cctctcagag gtagcaaagg aacatattgg
     1861 gaaggaggga tccgggctgt aggctttgtg catagcccac ttctgaaaaa caagggaaca
     1921 gtgtgtaagg aacttgtgca catcactgac tggtacccca ctctcatttc actggctgaa
     1981 ggacagattg atgaggacat tcaactagat ggctatgata tctgggagac cataagtgag
     2041 ggtcttcgct caccccgagt agatattttg cataacattg accccatata caccaaggca
     2101 aaaaatggct cctgggcagc aggctatggg atctggaaca ctgcaatcca gtcagccatc
     2161 agagtgcagc actggaaatt gcttacagga aatcctggct acagcgactg ggtcccccct
     2221 cagtctttca gcaacctggg accgaaccgg tggcacaatg aacggatcac cttgtcaact
     2281 ggcaaaagtg tatggctttt caacatcaca gccgacccat atgagagggt ggacctatct
     2341 aacaggtatc caggaatcgt gaagaagctc ctacggaggc tctcacagtt caacaaaact
     2401 gcagtgccgg tcaggtatcc ccccaaagac cccagaagta accctaggct caatggaggg
     2461 gtctggggac catggtataa agaggaaacc aagaaaaaga agccaagcaa aaatcaggct
     2521 gagaaaaagc aaaagaaaag caaaaaaaag aagaagaaac agcagaaagc agtctcaggt
     2581 tcaacttgcc attcaggtgt tacttgtgga taagcacaaa tatttcctgt ttggttaaac
     2641 tttaatcagt tcttatcttt catctgtttc ctaggtaaac cagcaaattt ggctcgataa
     2701 tatcgctggc ctaagcgtca ggcttgtttt catgctgtgc cactccagag acttctgcca
     2761 cctggccgcc acactgaaaa ctgtcctgct cagtgccaag gtgctactct tgcaagccac
     2821 acttagagag agtggagatg tttatttctc ttgctccttt agaaaacgtg gtgagtcctg
     2881 agttccactg ctgtgcttca gtcaactgac caaacactgc tttgaattat aggaggagaa
     2941 caataaccta ccatccgcaa gcatgctaat ttgatggaag ttacagggta taccatccgc
     3001 aagcatgcta atttgatgga agttacaggg tagcatgatt aaaactacct ttgataaatt
     3061 acagtcaaag attgtgtcac ctcaaaggcc ttgaagaata tattttcttg gtgaattttt
     3121 gtatgtctgt catatgacac ttgggttttt taattaattc tattttatat atatatatat
     3181 gtttcttttc ctgtgaaaag ctgtttttct cacatgtgaa cagcttgcac ctcattttac
     3241 catgcgtgag ggaatggcaa ataagaatgt ttgagcacac tgcccacaat gaatgtaact
     3301 attttctaaa cactttacta gaagaacatt tcagtataaa aaacctaatt tatttttaca
     3361 gaaaaatatt ttgttgtttt tataaaaagt tatgcaaatg actttatttt atttttattt
     3421 cctgcatacc attagaataa ttttatttca tttcttcaaa ttaccaagca ctgtaatact
     3481 ataaattaat gtaatactgt gtgaattcag actataaaaa acatcattca gaaaacttta
     3541 taatcgtcat tgttcaacca agattttgaa tgtaataaga tgaatatatt ccttacaaat
     3601 tacttggaaa ttcaatgttt gtgcagagtt gagacaactt tattgtttct atcataaact
     3661 atttatgtat cttaattatt aaaatgattt actttatggc actagaaaat ttactgtggc
     3721 ttttctgatc taacttctag ctaaaattgt atcattggtc ctaaaaaata aaaatcttta
     3781 ctaataggca attgaaggaa tggtttgcta acaaccacag taatataata tgattttaca
     3841 gatagatgct tccccttggc tatgacatgg agaaagattt tcccataata ataactaaca
     3901 tttatattag gttggtgcaa aactagttgc ggtttttccc attaaaagta ataaacttac
     3961 tcttatacaa agtggacact gtggggagat acagagaaat ggaagatacg gatcctgcct
     4021 ggagtaggta accttgcttg gaaaccccac atgcaaacgt catgaggaga attaaaggag
     4081 tattatcagt aatgaagttt atcatgggtc atcaatgagc atagattggt gtggatcctg
     4141 tagaccctgg tgttttcttt gaagtgccct ctcctaatgc agaggccttg aagcttacag
     4201 tatacacttg aaaagtcaca gatagctaga attatgatct ttgaagttat aactgtgatc
     4261 tgaaaatgtg tgtggtggta tgacagcata ccattaaata catttacatc acagctcaaa
     4321 ggactgtgat ataatccatt tatatcacaa ctcaaaggac tgtgatataa tccatttata
     4381 tcacagctca cagtttctga aaatgtataa aagaatctat aatctagtac tgaaattact
     4441 aaattgggta agatgattta aatgatttta attttaacat tttatttcta gaatatatgg
     4501 ctccatttta ttttatagtg taaagttgta tttcctaaag tttgtgtttt gtcgacagta
     4561 tcttttaaat gagtcttaaa aataaaggca tattgttcat gtt
//
