LOCUS       NM_001011719            2482 bp    mRNA    linear   PRI 14-FEB-2024
DEFINITION  Homo sapiens arylsulfatase family member H (ARSH), mRNA.
ACCESSION   NM_001011719 XM_293401
VERSION     NM_001011719.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2482)
  AUTHORS   Sardiello,M., Annunziata,I., Roma,G. and Ballabio,A.
  TITLE     Sulfatases and sulfatase modifying factors: an exclusive and
            promiscuous relationship
  JOURNAL   Hum Mol Genet 14 (21), 3203-3217 (2005)
   PUBMED   16174644
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112653.5 and AY875940.1.
            
            On Sep 3, 2019 this sequence version replaced NM_001011719.1.
            
            Summary: Sulfatases, such as ARSH, hydrolyze sulfate esters from
            sulfated steroids, carbohydrates, proteoglycans, and glycolipids.
            They are involved in hormone biosynthesis, modulation of cell
            signaling, and degradation of macromolecules (Sardiello et al.,
            2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381130.3/ ENSP00000370522.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC112653.5         130556-130622       c
            68-1756             AY875940.1         1-1689
            1757-2482           AC112653.5         103057-103782       c
FEATURES             Location/Qualifiers
     source          1..2482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.33"
     gene            1..2482
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /note="arylsulfatase family member H"
                     /db_xref="GeneID:347527"
                     /db_xref="HGNC:HGNC:32488"
                     /db_xref="MIM:300586"
     exon            1..159
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1756
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /note="ASH"
                     /codon_start=1
                     /product="arylsulfatase H"
                     /protein_id="NP_001011719.1"
                     /db_xref="CCDS:CCDS35198.1"
                     /db_xref="GeneID:347527"
                     /db_xref="HGNC:HGNC:32488"
                     /db_xref="MIM:300586"
                     /translation="MTRNARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVR
                     LTQHLAAASMCTPSRAAFLTGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKL
                     LQHRGYRTGLIGKWHLGLSCASRNDHCYHPLNHGFHYFYGVPFGLLSDCQASKTPELH
                     RWLRIKLWISTVALALVPFLLLIPKFARWFSVPWKVIFVFALLAFLFFTSWYSSYGFT
                     RRWNCILMRNHEIIQQPMKEEKVASLMLKEALAFIERYKREPFLLFFSFLHVHTPLIS
                     KKKFVGRSKYGRYGDNVEEMDWMVGKILDALDQERLANHTLVYFTSDNGGHLEPLDGA
                     VQLGGWNGIYKGGKGMGGWEGGIRVPGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIG
                     GGILSQDRVIDGQNLMPLLEGRASHSDHEFLFHYCGVYLHTVRWHQKDCATVWKAHYV
                     TPKFYPEGTGACYGSGICSCSGDVTYHDPPLLFDISRDPSEALPLNPDNEPLFDSVIK
                     KMEAAIREHRRTLTPVPQQFSVFNTIWKPWLQPCCGTFPFCGCDKEDDILPMAP"
     exon            160..281
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     exon            282..407
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     exon            408..831
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     exon            832..968
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1103
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1266
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1388
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2482
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /note="hexamer: AATAAA"
     polyA_site      2482
                     /gene="ARSH"
                     /gene_synonym="sulfatase"
                     /note="major polyA site"
ORIGIN      
        1 tgctttcagg agctgctggc tgtcagtgtc cctgtgctgt ttgttttgcg gtgttgatgg
       61 cacatttatg acaagaaacg ccagacccaa cattgtcctg ctgatggcag atgaccttgg
      121 agtgggggat ttgtgctgct acggtaataa ctcagtgagc acacctaata ttgaccgcct
      181 ggcaagtgaa ggagtgaggc ttacccagca tctcgcagct gcttccatgt gcaccccaag
      241 tcgggctgcc ttcctgaccg gccggtaccc catcagatca gggatggtgt ctgcctacaa
      301 cctgaaccgt gccttcacgt ggcttggtgg gtcaggtggt cttcccacca atgaaacgac
      361 ttttgccaag ctgctgcagc accgtggcta ccgcacggga ctcataggca aatggcacct
      421 gggtttgagc tgcgcctctc ggaatgatca ctgttaccac ccgctcaacc atggttttca
      481 ctacttttac ggggtgcctt ttggactttt aagcgactgc caggcatcca agacaccaga
      541 actgcaccgc tggctcagga tcaaactgtg gatctccacg gtagcccttg ccctggttcc
      601 ttttctgctt ctcattccca agttcgcccg ctggttctca gtgccatgga aggtcatctt
      661 tgtctttgct ctcctcgcct ttctgttttt cacttcctgg tactctagtt atggatttac
      721 tcgacgttgg aattgcatcc ttatgaggaa ccatgaaatt atccagcagc caatgaaaga
      781 ggagaaagta gcttccctca tgctgaagga ggcacttgct ttcattgaaa ggtacaaaag
      841 ggaacctttt ctcctctttt tttccttcct gcacgtacat actccactca tctccaaaaa
      901 gaagtttgtt gggcgcagta aatatggcag gtatggggac aatgtagaag aaatggattg
      961 gatggtgggt aaaatcctgg atgccctgga ccaggagcgc ctggccaacc acaccttggt
     1021 gtacttcacc tctgacaacg ggggccacct ggagcccctg gacggggctg ttcagctggg
     1081 tggctggaac gggatctaca aaggtggcaa aggaatggga ggatgggaag gaggtatccg
     1141 tgtgccaggg atattccggt ggccgtcagt cttggaggct gggagagtga tcaatgagcc
     1201 caccagctta atggacatct atccgacgct gtcttatata ggcggaggga tcttgtccca
     1261 ggacagagtg attgacggcc agaacctaat gcccctgctg gaaggaaggg cgtcccactc
     1321 cgaccacgag ttcctcttcc actactgtgg ggtctatctg cacacggtca ggtggcatca
     1381 gaaggactgt gcaactgtgt ggaaagctca ttatgtgact cctaaattct accctgaagg
     1441 aacaggtgcc tgctatggga gtggaatatg ttcatgttcg ggggatgtaa cctaccacga
     1501 cccaccactc ctctttgaca tctcaagaga cccttcagaa gcccttccac tgaaccctga
     1561 caatgagcca ttatttgact ccgtgatcaa aaagatggag gcagccataa gagagcatcg
     1621 taggacacta acacctgtcc cacagcagtt ctctgtgttc aacacaattt ggaaaccatg
     1681 gctgcagcct tgctgtggga ccttcccctt ctgtgggtgt gacaaggaag atgacatcct
     1741 tcccatggct ccctgagacc atgcggacca cgtgttaccc accacaaact tactgttaca
     1801 atggtcatag gagcagagct cacctgactg attcattcca tttgggataa aaactgatgg
     1861 cccaacccat tgttttatcc tcagaaatca gttctttcaa gagctcggtg aaattaaagt
     1921 gggcccatat aacagtgaac ctggagggga gcatttgttg tataattttt ttctagtata
     1981 taattgtgcc attgcccaag gaaaagagca aatcaaggtg acttcagcag attcttgtag
     2041 agcttttgtt cctagaattc atggaagcat caggtccaat gtcataagtt agaaacttct
     2101 gcttgcagat tctataccca ggcatgctag ctttctaata aatcatgata agtacttaat
     2161 tttttcatga agcagagggt cacataaaac ttgaagtagt gctgttatag tcagtttgac
     2221 ttcttgattt tctctctttc cttcttttct cttcctgtcc gatacgcatc tggttatgag
     2281 aaaaaatgct gggctgaagt tcttgacttt gcttcctcgt agctatatca tcgtggaaat
     2341 gtctctgtga tttggtttct tcatgtgtaa aataaggaaa accagtgtct acttcacaga
     2401 gtagctatga ggattacatg cattaattaa tgtgaaattg ccttgtgtag aataagcagt
     2461 caataaatgt tattattaca aa
//
