LOCUS       NM_001201539            2165 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens arylsulfatase F (ARSF), transcript variant 3, mRNA.
ACCESSION   NM_001201539
VERSION     NM_001201539.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2165)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 2165)
  AUTHORS   Cao,W. and Garcia-Blanco,M.A.
  TITLE     A serine/arginine-rich domain in the human U1 70k protein is
            necessary and sufficient for ASF/SF2 binding
  JOURNAL   J Biol Chem 273 (32), 20629-20635 (1998)
   PUBMED   9685421
REFERENCE   3  (bases 1 to 2165)
  AUTHORS   Puca,A.A., Zollo,M., Repetto,M., Andolfi,G., Guffanti,A., Simon,G.,
            Ballabio,A. and Franco,B.
  TITLE     Identification by shotgun sequencing, genomic organization, and
            functional analysis of a fourth arylsulfatase gene (ARSF) from the
            Xp22.3 region
  JOURNAL   Genomics 42 (2), 192-199 (1997)
   PUBMED   9192838
REFERENCE   4  (bases 1 to 2165)
  AUTHORS   Parenti,G., Meroni,G. and Ballabio,A.
  TITLE     The sulfatase gene family
  JOURNAL   Curr Opin Genet Dev 7 (3), 386-391 (1997)
   PUBMED   9229115
  REMARK    Review article
REFERENCE   5  (bases 1 to 2165)
  AUTHORS   Franco,B., Meroni,G., Parenti,G., Levilliers,J., Bernard,L.,
            Gebbia,M., Cox,L., Maroteaux,P., Sheffield,L., Rappold,G.A.,
            Andria,G., Petit,C. and Ballabio,A.
  TITLE     A cluster of sulfatase genes on Xp22.3: mutations in
            chondrodysplasia punctata (CDPX) and implications for warfarin
            embryopathy
  JOURNAL   Cell 81 (1), 15-25 (1995)
   PUBMED   7720070
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022389.1 and AC112653.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001201539.1.
            
            Summary: This gene is a member of the sulfatase family, and more
            specifically, the arylsulfatase subfamily. Members of the subfamily
            share similarity in sequence and splice sites, and are clustered
            together on chromosome X, suggesting that they are derived from
            recent gene duplication events. Sulfatases are essential for the
            correct composition of bone and cartilage matrix. The activity of
            this protein, unlike that of arylsulfatase E, is not inhibited by
            warfarin. Multiple alternatively spliced variants, encoding the
            same protein, have been identified.[provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381127.6/ ENSP00000370519.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1799              BC022389.1         1-1799
            1800-1800           AC112653.5         24806-24806         c
            1801-2164           BC022389.1         1801-2164
            2165-2165           AC112653.5         24441-24441         c
FEATURES             Location/Qualifiers
     source          1..2165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.33"
     gene            1..2165
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /note="arylsulfatase F"
                     /db_xref="GeneID:416"
                     /db_xref="HGNC:HGNC:721"
                     /db_xref="MIM:300003"
     exon            1..193
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            194..232
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1994
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /EC_number="3.1.6.1"
                     /codon_start=1
                     /product="arylsulfatase F precursor"
                     /protein_id="NP_001188468.1"
                     /db_xref="CCDS:CCDS14123.1"
                     /db_xref="GeneID:416"
                     /db_xref="HGNC:HGNC:721"
                     /db_xref="MIM:300003"
                     /translation="MRPRRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGD
                     LGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNR
                     RVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFD
                     YYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLL
                     IFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLE
                     RHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGL
                     RNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVP
                     AGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFHYCG
                     SYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPPLLFD
                     LSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSELNQGRTWLKPCC
                     GVFPFCLCDKEEEVSQPRGPNEKR"
     exon            233..382
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            383..504
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            505..627
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            628..1051
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1188
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1323
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1486
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1611
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..2165
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /note="hexamer: ATTAAA"
     polyA_site      2165
                     /gene="ARSF"
                     /gene_synonym="ASF"
                     /note="major polyA site"
ORIGIN      
        1 agtggagaca ggctctcacc atgttgacca ggctggtctc gaactcccga cctcaagtga
       61 tccgccggcc tcggcctccc aaagtgctgg gattacaggc gtgaaccacc actcctggcc
      121 cttctgttac ttttccactg ctgttgagat agaagtcact gttgggatcc aacctttttg
      181 tttgtataaa ctgacaacaa gaaggtattc caagctgcac aatgaggccc aggagaccct
      241 tggtcttcat gtctttggtg tgtgcactct tgaacacatg ccaggcacac agggtgcatg
      301 acgacaagcc taatattgtc ctaatcatgg ttgatgacct gggtattgga gatctgggct
      361 gctacggcaa tgacaccatg aggacgcctc acatcgaccg ccttgccagg gaaggcgtgc
      421 gactgactca gcacatctct gccgcctccc tctgcagccc aagccggtcc gcgttcttga
      481 cgggaagata ccccatccga tcaggtatgg tttctagtgg taatagacgt gtcatccaaa
      541 atcttgcagt ccccgcaggc ctccctctta atgagacaac acttgcagcc ttgctaaaga
      601 agcaaggata cagcacgggg cttataggca aatggcacca aggcttgaac tgcgactccc
      661 gaagtgacca gtgccaccat ccatataatt atgggtttga ctactactat ggcatgccgt
      721 tcactctcgt tgacagctgc tggccggacc cctctcgtaa cacggaatta gcctttgaga
      781 gtcagctctg gctctgtgtg cagctagttg ccattgccat cctcacccta acctttggga
      841 agctgagcgg ctgggtctct gttccctggc tcctgatctt ctccatgatt ctgtttattt
      901 tcctcttggg ctatgcttgg ttctccagcc acacgtcccc tttatactgg gactgcctcc
      961 tcatgcgggg gcacgagatc acggagcagc ccatgaaggc tgaacgagct ggatccatta
     1021 tggtgaagga agcgatttcc tttttagaaa ggcacagtaa ggaaactttc cttctctttt
     1081 tctcctttct tcacgtgcac acacctctcc ccaccacgga cgatttcact ggcaccagca
     1141 agcatggctt gtatggggat aatgtggaag agatggactc catggtgggc aagattcttg
     1201 atgctatcga tgattttggc ctaaggaaca acacccttgt ctactttaca tcagatcacg
     1261 gagggcattt ggaagctagg cgagggcatg cccaacttgg tggatggaat ggaatataca
     1321 aaggtggaaa aggcatgggg ggctgggaag gtggaatccg cgtcccagga attgtccgat
     1381 ggcctggaaa ggtaccagct ggacggttga ttaaggaacc tacaagttta atggatattt
     1441 taccaactgt cgcatcagtg tcaggaggaa gtctccctca ggacagggtc attgacggcc
     1501 gagacctcat gcccttgctg cagggcaacg tcaggcactc ggagcatgaa tttcttttcc
     1561 actactgtgg ctcctacctg cacgccgtgc ggtggatccc caaggacgac agtgggtcag
     1621 tttggaaggc tcactatgtg accccggtat tccagccacc agcttctggt ggctgctatg
     1681 tcacctcatt atgcagatgt ttcggagaac aggttaccta ccacaacccc cctctgctct
     1741 tcgatctctc cagggacccc tcagagtcca cacccctgac acctgccaca gagcccctcc
     1801 atgattttgt gattaaaaag gtggccaacg ccctgaagga acaccaggaa accatcgtgc
     1861 ctgtgaccta ccaactctca gaactgaatc agggcaggac gtggctgaag ccttgctgtg
     1921 gggtgttccc attttgtctg tgtgacaagg aagaggaagt ctctcagcct cggggtccta
     1981 acgagaagag ataattacaa tcaggctacc agaggaagcc tttggtccta acgagaagag
     2041 ataattacaa tcaggctacc aaaggaagca ctaactttgg tgctttcaag ttggcaagga
     2101 gtgcatttaa tagtcaataa attcatctac cattccagat tattaaaggc ccactggttg
     2161 ttcca
//
