LOCUS       NM_001080523            1667 bp    mRNA    linear   PRI 12-SEP-2024
DEFINITION  Homo sapiens arrestin domain containing 5 (ARRDC5), transcript
            variant 2, mRNA.
ACCESSION   NM_001080523 XM_928471
VERSION     NM_001080523.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027319.5.
            
            On May 17, 2019 this sequence version replaced NM_001080523.2.
            
            Transcript Variant: This variant (2) lacks an alternate exon and
            uses an alternate in-frame splice site in the 5'-CDS, compared to
            variant 1. It encodes isoform 2, which has the same N- and C-
            termini, but is shorter, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.70600.1,
                                           SRR5189667.302754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000650722.2/
                                                ENSP00000498235.1
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-324               AC027319.5         50281-50604
            325-530             AC027319.5         56301-56506
            531-1667            AC027319.5         61604-62740
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1667
                     /gene="ARRDC5"
                     /note="arrestin domain containing 5"
                     /db_xref="GeneID:645432"
                     /db_xref="HGNC:HGNC:31407"
                     /db_xref="MIM:620944"
     exon            1..324
                     /gene="ARRDC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1058
                     /gene="ARRDC5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     arrestin domain-containing protein 5"
                     /codon_start=1
                     /product="arrestin domain-containing protein 5 isoform 2"
                     /protein_id="NP_001073992.2"
                     /db_xref="CCDS:CCDS45929.2"
                     /db_xref="GeneID:645432"
                     /db_xref="HGNC:HGNC:31407"
                     /db_xref="MIM:620944"
                     /translation="MSVVKSIELVLPEDRIYLAGSSIKGQVILTLNSTLVDPIVKVEL
                     VGRGYVEWSEEAGASCDYSRNVICNNKADYVHKTKTFPVEDNWLSAGSHTFDFHFNLP
                     PRLPSTFTSKFGHVFYFVQASCMGREHILAKKRMYLLVQGTSTFHKETPFQNPLFVEA
                     EEKVSYNCCRQGTVCLQIQMERNTFTPGEKVVFTTEINNQTSKCIKTVVFALYAHIQY
                     EGFTPSAERRSRLDSSELLRQEANTPVTRFNTTKVVSTFNLPLLLSVSSSTQDGEIMH
                     TRYELVTTVHLPWSLTSLKAKVPIIITSASVDSAICQLSEDGVLPVNPDHQN"
     exon            325..530
                     /gene="ARRDC5"
                     /inference="alignment:Splign:2.1.0"
     exon            531..1667
                     /gene="ARRDC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1077..1082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARRDC5"
                     /note="hexamer: ATTAAA"
     polyA_site      1099
                     /gene="ARRDC5"
                     /note="major polyA site"
ORIGIN      
        1 agggccaacg aaccgggaat ttcagggaca tgggggacag agaggaatgt ctctctaccc
       61 cccaaccccc catgtctgtg gtgaagtcga tcgaattagt gctgcccgag gatagaatct
      121 acctggctgg ctccagcata aaagggcagg tgatcttaac cctgaacagc accctggtgg
      181 accccatagt gaaggtggag ctcgtgggaa ggggttacgt cgaatggagt gaagaagccg
      241 gggcatcctg tgattatagc agaaatgtta tttgcaacaa caaggcagac tacgtgcata
      301 agacaaagac attcccagtg gaggataatt ggttaagtgc aggcagccac acctttgact
      361 tccatttcaa cttacctccc aggcttcctt ctaccttcac cagcaaattt ggccatgtct
      421 tctatttcgt acaagcttcc tgcatgggca gggaacacat tttagccaag aagaggatgt
      481 acttattggt tcaaggaact tccaccttcc acaaagaaac cccattccag aaccccttgt
      541 tcgtggaggc tgaggagaaa gtctcctaca actgctgccg ccagggcact gtctgtttgc
      601 aaatccagat ggaaaggaac accttcacgc caggagagaa ggtcgtcttc acaacagaga
      661 tcaacaacca gaccagcaaa tgcatcaaga cggtcgtatt cgccctgtat gcccacatac
      721 agtacgaggg cttcacgccc agtgcagagc ggcggtctcg gctggacagc agcgagcttc
      781 tgaggcagga ggccaacacc cccgtgaccc gcttcaacac caccaaggtt gtcagcacct
      841 tcaacctgcc gttgctgctg tccgtgagca gcagcacgca ggacggtgag atcatgcaca
      901 ctcgctacga gctggtcacc accgtgcacc tgccctggtc cctgaccagc ctcaaggcca
      961 aagttcccat catcatcacc agcgcctcag tggactctgc catctgccag ctgtcagagg
     1021 acggagtgtt acccgtgaac ccagatcacc agaattaagt gcccgaactt ttaaatatta
     1081 aaagctttat tagtctctac caggaggaag ccctctctct tgcacaggtg actctcagag
     1141 gagtcgagga gtgggcaaca ggttgtctgc aacctcccca agctctagcg gtttaggtat
     1201 ctgtgtctcc cctccctaga actatcactg aatgcctgga atggacaaag gaaaccggga
     1261 aggtctccca ggacccaaac ccggcataac ctgccttttc caccctgagt ctgccccagc
     1321 ctactggggt ctcacagtgc caagaccagg ggtcctactt ggggagaatt ctcccctctg
     1381 ctaatgtctg gttgtattgg ctgtcacaac tgcaggggat cgggggagaa gagtcttatt
     1441 ggcgtggaga gggtggaggc cagggacgct gttcagcacc ctgcagtgtc caggacggcc
     1501 cccacaatca ggaattgttt atcctgaatg tcaacagtac caagggggct gagcatggtg
     1561 gctcattcct gtaatcccag gactttagga ggccatggct ggaggatcac ttgagaccag
     1621 gagtttgaga caagcctggg caacactgtg agacccccat ctctaca
//
