LOCUS       NM_183376               4062 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens arrestin domain containing 4 (ARRDC4), mRNA.
ACCESSION   NM_183376 XM_041721
VERSION     NM_183376.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4062)
  AUTHORS   Liu,J., Meng,L., Liu,Z., Lu,M. and Wang,R.
  TITLE     Identification of HDAC9 and ARRDC4 as potential biomarkers and
            targets for treatment of type 2 diabetes
  JOURNAL   Sci Rep 14 (1), 7083 (2024)
   PUBMED   38528189
  REMARK    GeneRIF: Identification of HDAC9 and ARRDC4 as potential biomarkers
            and targets for treatment of type 2 diabetes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4062)
  AUTHORS   Meng,J., Yao,Z., He,Y., Zhang,R., Zhang,Y., Yao,X., Yang,H.,
            Chen,L., Zhang,Z., Zhang,H., Bao,X., Hu,G., Wu,T. and Cheng,J.
  TITLE     ARRDC4 regulates enterovirus 71-induced innate immune response by
            promoting K63 polyubiquitination of MDA5 through TRIM65
  JOURNAL   Cell Death Dis 8 (6), e2866 (2017)
   PUBMED   28594402
  REMARK    GeneRIF: data highlight new function of ARRDC4 in innate immunity,
            contributing to the better understanding about regulation of MDA5
            activation after EV71 infection, and also suggest ARRDC4 may serve
            as a potential target for intervention of EV71-induced inflammatory
            response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4062)
  AUTHORS   Shea,F.F., Rowell,J.L., Li,Y., Chang,T.H. and Alvarez,C.E.
  TITLE     Mammalian alpha arrestins link activated seven transmembrane
            receptors to Nedd4 family e3 ubiquitin ligases and interact with
            beta arrestins
  JOURNAL   PLoS One 7 (12), e50557 (2012)
   PUBMED   23236378
REFERENCE   4  (bases 1 to 4062)
  AUTHORS   Irvin,M.R., Shrestha,S., Chen,Y.D., Wiener,H.W., Haritunians,T.,
            Vaughan,L.K., Tiwari,H.K., Taylor,K.D., Scherzer,R., Saag,M.S.,
            Grunfeld,C., Rotter,J.I. and Arnett,D.K.
  TITLE     Genes linked to energy metabolism and immunoregulatory mechanisms
            are associated with subcutaneous adipose tissue distribution in
            HIV-infected men
  JOURNAL   Pharmacogenet Genomics 21 (12), 798-807 (2011)
   PUBMED   21897333
REFERENCE   5  (bases 1 to 4062)
  AUTHORS   Calboli,F.C., Tozzi,F., Galwey,N.W., Antoniades,A., Mooser,V.,
            Preisig,M., Vollenweider,P., Waterworth,D., Waeber,G.,
            Johnson,M.R., Muglia,P. and Balding,D.J.
  TITLE     A genome-wide association study of neuroticism in a
            population-based sample
  JOURNAL   PLoS One 5 (7), e11504 (2010)
   PUBMED   20634892
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4062)
  AUTHORS   Patwari,P., Chutkow,W.A., Cummings,K., Verstraeten,V.L.,
            Lammerding,J., Schreiter,E.R. and Lee,R.T.
  TITLE     Thioredoxin-independent regulation of metabolism by the
            alpha-arrestin proteins
  JOURNAL   J Biol Chem 284 (37), 24996-25003 (2009)
   PUBMED   19605364
  REMARK    GeneRIF: Txnip regulates cellular metabolism independent of its
            binding to thioredoxin and the arrestin domains are crucial
            structural elements in metabolic functions of alpha-arrestin
            proteins
REFERENCE   7  (bases 1 to 4062)
  AUTHORS   Knoll,B., Goldammer,M., Wojewoda,A., Flugge,J., Johne,A.,
            Mrozikiewicz,P.M., Roots,I. and Kopke,K.
  TITLE     An anomalous haplotype distribution of the arrestin
            domain-containing 4 gene (ARRDC4) haplotypes in Caucasians
  JOURNAL   Genet Test 12 (1), 147-152 (2008)
   PUBMED   18307387
  REMARK    GeneRIF: identification of variants in the ARRDC4 coding region;
            seven variants were identified; fifteen haplotypes were inferred;
            haplotypes form two clades
REFERENCE   8  (bases 1 to 4062)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290221.1, BC070100.1, DB089068.1, BC038453.1, BY797927.2,
            AC024651.13 and AA872967.1.
            
            On Nov 22, 2018 this sequence version replaced NM_183376.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070100.1, BC028704.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268042.7/ ENSP00000268042.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK290221.1         1-20
            21-167              BC070100.1         1-147
            168-544             DB089068.1         173-549
            545-1230            BC070100.1         525-1210
            1231-1322           BC038453.1         268-359
            1323-1487           BC070100.1         1303-1467
            1488-1900           BY797927.2         206-618
            1901-3754           AC024651.13        25005-26858         c
            3755-4062           AA872967.1         13-320              c
FEATURES             Location/Qualifiers
     source          1..4062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.2"
     gene            1..4062
                     /gene="ARRDC4"
                     /note="arrestin domain containing 4"
                     /db_xref="GeneID:91947"
                     /db_xref="HGNC:HGNC:28087"
                     /db_xref="MIM:619788"
     exon            1..466
                     /gene="ARRDC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1416
                     /gene="ARRDC4"
                     /codon_start=1
                     /product="arrestin domain-containing protein 4"
                     /protein_id="NP_899232.2"
                     /db_xref="CCDS:CCDS10377.1"
                     /db_xref="GeneID:91947"
                     /db_xref="HGNC:HGNC:28087"
                     /db_xref="MIM:619788"
                     /translation="MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLL
                     EASEPVALRALRLEAQGRATAAWGPSTCPRASASTAALAVFSEVEYLNVRLSLREPPA
                     GEGIILLQPGKHEFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKREL
                     QVVSHVDVNTPALLTPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEI
                     ENCSSRLIVPKAAIFQTQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPP
                     VTPSILDCCIIRVDYSLAVYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSM
                     DMSWLTLTLPEQPEAPPNYADVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRF
                     QPPPLYSEVDPHPSDVEESQPVSFIL"
     exon            467..533
                     /gene="ARRDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            534..681
                     /gene="ARRDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            682..784
                     /gene="ARRDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1041
                     /gene="ARRDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1204
                     /gene="ARRDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1359
                     /gene="ARRDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..4062
                     /gene="ARRDC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2282..2287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARRDC4"
                     /note="hexamer: AATAAA"
     polyA_site      2305
                     /gene="ARRDC4"
     regulatory      4044..4049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARRDC4"
                     /note="hexamer: AATAAA"
     polyA_site      4062
                     /gene="ARRDC4"
                     /note="major polyA site"
ORIGIN      
        1 gacaggcctc tcggcgagcc ggtgccccat cgggtaccgc acggctgccg cggcggcctt
       61 accctgccgc gagcgcctgt gacagcggcg ccgctgtgct cgcgaccccg gctccgggcc
      121 tctgccgacc tcaggggcag gaaagagtcg cccggcggga tgggcgggga ggctgggtgc
      181 gcggcggccg tgggtgccga gggccgcgtg aagagcctgg gtctggtgtt cgaggacgag
      241 cgcaagggct gctattccag cggcgagaca gtggccgggc acgtgctgct ggaggcgtcc
      301 gagccggtgg ccctgcgcgc gctgcgcctg gaggcccagg ggcgcgccac cgccgcctgg
      361 ggcccgagca cctgcccccg cgcctcggcc agcaccgcgg ccctggctgt cttctcggag
      421 gtggagtacc tgaacgtgcg cctcagcctg cgggagcccc cggccggtga aggcatcatt
      481 ttattacagc ctggaaaaca tgaatttcca tttcgctttc aacttccatc tgaacctttg
      541 gtcacctcgt ttactgggaa atatggaagc attcagtact gtgtgcgggc agtgttggaa
      601 cgacccaagg tacctgatca gagtgtaaag cgggaactcc aggttgttag tcatgtcgat
      661 gtcaacacac cagcattatt aacccctgta ttgaaaactc aagagaaaat ggttggctgt
      721 tggtttttca cttctggtcc agtctcgctg agtgccaaaa ttgaaagaaa gggatactgt
      781 aatggagaag ctattccaat ctatgcagaa atagaaaatt gttcctctcg tctgattgtt
      841 ccaaaggctg ctattttcca aacgcagaca tatttggcta gtggaaaaac aaagaccatt
      901 cgacacatgg tcgccaatgt gcgaggaaac cacatcgctt ctgggagcac agacacatgg
      961 aatgggaaaa cgctaaaaat cccacctgtt actccatcca tcctggattg ctgcattatc
     1021 agagtggact attccttagc tgtatacatt cacattcctg gtgctaaaaa attgatgctc
     1081 gaactgccat tagtgatcgg tacaattcca tataatggtt ttggcagcag aaactccagc
     1141 attgccagcc agttcagtat ggatatgagc tggttgacac tgaccctgcc agagcagcct
     1201 gaagcaccac caaattatgc agatgtggta tcagaggaag aattctctag acacattcct
     1261 ccttaccctc aaccccctaa ctgtgaggga gaagtgtgct gtcctgtgtt tgcctgtata
     1321 caagaattcc ggtttcaacc cccacctctt tattcagagg ttgacccaca tcctagcgac
     1381 gtagaagaga gccagcctgt ttccttcatt ctctgaacgt atttcagaaa tcactgtgtt
     1441 catcatcaaa ttagaatgtt ggttcttttc cttctgcctt tttgggaaag agacaggaaa
     1501 gattcacttg aaaacataaa tgaacgtcaa gactgaaggc aatagaaatt aaagaatgtg
     1561 agaaagttct ggtgggccgg caggattgcc gcacaagttt atatgatggt cgtatatata
     1621 tccctgttaa aaactgggat gaagatgtgc aaagtcacag aatgtaatgg aagtcctgat
     1681 ggttacagag taagtgaaag ggtgcctgcg ctgacgtgag agaaaggaat ctgtaaacag
     1741 tggaaacact gtgggagttt cccatggtga agagtggaac gaaggcgata tgaactgaag
     1801 gggtgaagac ttgattttgg agagggcaac aaaacaaggg tgtgtgtgca taggagaatg
     1861 gcccactcca aatacgaagt gagatcctga gtctttgggt gcttcatgat ttcctaccat
     1921 attcaggcct aaagacattg aaaaagcatc ttttcttgag atcatggtca tatgaggtcc
     1981 taatgaagta ctacagtttt cattctttca agggtagact aaaatatagt ttataaatcg
     2041 gcagtacggt attatgaaac caagaaaggg tttcttgaaa agcttgtcgg ttcaaagagg
     2101 aaagatgaat ttcaatgtga aaacacgttt tgttgagggc tgtacttttt acccccttta
     2161 agtgctttaa caggatatac gtttgatttt cctcatatct tatttaccta ggagcatgta
     2221 agagaaagaa gggagagaaa aggttgcatc tgcaggatgc cttgataact acacagtccc
     2281 aaataaaagg cctttttcta acctacctct aatggggtta tcagatatgt ttttaaatct
     2341 ctcgccctga gtactcttct tgggagttgc tgctgtttac agccacagtc tcatctatca
     2401 ctaaatatga aactgggcca aggggaaaat tcagtaagtt agcgttaaat ggaagtaaat
     2461 atatgtatac ctaagagaat gtcaaaataa acaccaaacc aaaagaaggt aggagtgcca
     2521 tttttagaaa agacacaact ttaattcctg tcaagagacc taggtctact gatggcagtc
     2581 actgcattgt acattattcc agttcttcag taattctgtt taaactgtga ttttctttat
     2641 tgtgttggtg caatatttta ttatcattta acctcaggat attcagacca acaggattgt
     2701 gttgctgctg aaagtctgag cagtgtttta ccgtccccag cccccctccc acatggtcac
     2761 atgttcactt gcttttcctt ccatctgttg gttttgtgag ctgagagcat ctctggacac
     2821 atggaaggga gccagggatt cctgtgatac agattttgaa ccagcagagt actttggttt
     2881 tcttcatgtc ctaagggttt gatccagaaa ccctggtgct tcccctgcag aatactgtac
     2941 ttcatttaac agaatgattg atttttcttt caatcagcat gttcaccaaa aatagaaaag
     3001 ttcttctaag gttaaatttt gtatttaaaa gttagttggc catttgatca gggaattttc
     3061 tacacacatt aggcaaatgt atgcttttca tcctctgggc ttacctctct cctctgcaat
     3121 cctggaagca tcgtgcatag ttctttcatt gtaagccgct atttaaattc ccacaatgca
     3181 aaactgttag accagtaatt gtgctactga aattgtcaca aaacgttatt ccttgatttg
     3241 gtttttaaat tttgctttcg tgtgtgtgtc tttaaacagg taatgtgtat ttaagtgttg
     3301 tctaaacagt tgatttttac tttagaaaag atcatcttca actgtttatt gacttctgag
     3361 ttatatagtt catgccctgc caaggcattg ttcgactcca tgatactaaa acataatgaa
     3421 agaaacaaac tccagtatgg agaagagaaa gtttaattat ttggttccat ctagaaaagc
     3481 aacaacttaa aggaatcctt cactaggatt gtcttatcac ctttattaga taaatcatga
     3541 agtgtccctg tgaaattgaa gtgaaactat ctctgtagga cttaagagaa tagctaaaag
     3601 gtgtgacttg ccttattgaa atgatactgg catatctgac tgtaagcagt aggttgaaga
     3661 tatcatttta tgaatgtgga gaattctaca ttgaaacaga aaatacctgg gaatgaagat
     3721 taaaaatgta gctgctgtta tttgcttggt tattcccctc ttgctcttct ttagtttgaa
     3781 aaaacaaaaa cgtggccttg gaattttcat tttgatgcag aaattttgaa attgaaaatg
     3841 tgcatgtttt ggtgcacaaa atccttctgt gggcaaaact ttgtttttgt tttgcacagt
     3901 aagaaacaat aggcaagcgt tatgtttttg gtaagttaac tatgaaagct ttcttatttt
     3961 tattattaaa aatgtaacaa tttaacccac aggaaaaaaa attactttgt atgcttgttt
     4021 gaaccctatg ggttcgtttt attaataaaa ttattacact aa
//
