LOCUS       NM_015683               2501 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens arrestin domain containing 2 (ARRDC2), transcript
            variant 1, mRNA.
ACCESSION   NM_015683
VERSION     NM_015683.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2501)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2501)
  AUTHORS   Shea,F.F., Rowell,J.L., Li,Y., Chang,T.H. and Alvarez,C.E.
  TITLE     Mammalian alpha arrestins link activated seven transmembrane
            receptors to Nedd4 family e3 ubiquitin ligases and interact with
            beta arrestins
  JOURNAL   PLoS One 7 (12), e50557 (2012)
   PUBMED   23236378
REFERENCE   3  (bases 1 to 2501)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF193051.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015683.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022516.1, AF193051.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222250.5/ ENSP00000222250.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2501              AF193051.1         3-2503
FEATURES             Location/Qualifiers
     source          1..2501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2501
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /note="arrestin domain containing 2"
                     /db_xref="GeneID:27106"
                     /db_xref="HGNC:HGNC:25225"
     exon            1..415
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1365
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arrestin domain-containing protein 2"
                     /codon_start=1
                     /product="arrestin domain-containing protein 2 isoform 1"
                     /protein_id="NP_056498.1"
                     /db_xref="CCDS:CCDS12370.1"
                     /db_xref="GeneID:27106"
                     /db_xref="HGNC:HGNC:25225"
                     /translation="MLFDKVKAFSVQLDGATAGVEPVFSGGQAVAGRVLLELSSAARV
                     GALRLRARGRAHVHWTESRSAGSSTAYTQSYSERVEVVSHRATLLAPDTGETTTLPPG
                     RHEFLFSFQLPPTLVTSFEGKHGSVRYCIKATLHRPWVPARRARKVFTVIEPVDINTP
                     ALLAPQAGAREKVARSWYCNRGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVLPR
                     AAVVQTQTFMARGARKQKRAVVASLAGEPVGPGQRALWQGRALRIPPVGPSILHCRVL
                     HVDYALKVCVDIPGTSKLLLELPLVIGTIPLHPFGSRSSSVGSHASFLLDWRLGALPE
                     RPEAPPEYSEVVADTEEAALGQSPFPLPQDPDMSLEGPFFAYIQEFRYRPPPLYSEED
                     PNPLLGDMRPRCMTC"
     exon            416..482
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /inference="alignment:Splign:2.1.0"
     exon            483..630
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /inference="alignment:Splign:2.1.0"
     exon            631..733
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /inference="alignment:Splign:2.1.0"
     exon            734..990
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1153
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1311
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..2501
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2481..2486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /note="hexamer: AGTAAA"
     polyA_site      2501
                     /gene="ARRDC2"
                     /gene_synonym="CLONE24945; PP2703"
                     /note="major polyA site"
ORIGIN      
        1 gattttctgc tccggttggt gagcgcgcct gcgcgttgac ggcgattttg cgttctgagg
       61 ctgcagcgtc ggcatcttga gctgccggtt cgcgagttcg aggccaggtt ccgcctgtcg
      121 tgggttcgca ccccggacgc gatgctattc gacaaggtga aagcgttctc ggtgcagttg
      181 gacggcgcga ccgcgggcgt cgagcccgtg tttagcggcg gccaggccgt ggcgggccgg
      241 gtgctgctgg agctgtcaag cgccgcgcgt gtgggtgccc tgaggctgcg cgcgcggggc
      301 cgcgcccacg tgcactggac cgagtcgcgc agcgcgggct cgagcacggc ttacacgcag
      361 agctacagtg aacgcgtgga ggtcgtgagc caccgcgcca cgctcctggc gccagatacc
      421 ggggagacca cgacgctgcc tcctgggcgc catgagttcc tgttcagctt ccagctgccc
      481 ccgaccctgg tgacatcctt cgagggcaaa cacggtagtg tccgctactg tatcaaggcc
      541 accctgcacc ggccctgggt cccagcacgc cgggcaagga aggtgttcac tgtcatcgag
      601 cctgtggaca tcaacacgcc agccctgctg gcacctcaag cgggggctcg ggaaaaggtt
      661 gcccgatcct ggtactgtaa ccgtggccta gtctcccttt cggccaagat cgaccgcaag
      721 ggctacaccc caggagaggt catccctgtc tttgccgaga tcgacaacgg ctccacacgt
      781 cctgtgctgc ctcgggcagc cgtggtgcag acacagacgt tcatggcccg aggcgcccga
      841 aagcagaaac gggcagtggt ggccagcctc gcgggcgagc cggtgggccc cgggcagcgg
      901 gcgctgtggc agggccgggc actgcggatc cccccagtgg gtccttccat cctgcactgc
      961 cgcgttctac acgtggacta cgcactcaag gtctgtgtgg atatcccagg aacgtccaag
     1021 ctgctgctgg agctgccact ggtgatcggc accattccct tgcacccttt tggcagccgt
     1081 tcctccagcg tgggcagcca cgccagcttc ctgctggact ggaggctggg ggccttgccg
     1141 gagcggcctg aggctcctcc tgagtactcg gaggtggtag ccgacactga ggaggcagcc
     1201 ttggggcaga gccccttccc gcttccgcag gaccccgaca tgagccttga aggcccgttc
     1261 ttcgcctaca tccaagagtt ccgctaccgc ccgccacccc tgtactctga ggaggatcca
     1321 aacccactct tgggggacat gaggccgcgc tgcatgactt gctgaacggc acagggaccc
     1381 ctcgaggaac aaggttgcac accagctttc agccaccatg actgtgggga gtggctggac
     1441 caagggctga cctccccgac tgcatcaaag ttggggaacc aagtctcaga gtgaggcggg
     1501 ggcctttcgg atatcacatg ggacagagga agagcccggc tggaatctga cttacctgga
     1561 ccgctgtcct tgtgaggcat tgaatgccca gtgcagtatc cgagagactg tttaataacc
     1621 tgtcttccca gccaattggt ggtgctggaa tcccctagga gccttcagtc tgggagaaac
     1681 agagccagac atagacagtt ccagcatcac agaaccagaa gaagagacct gcaactgtga
     1741 gagtccagac aggaagcaga gaaggcgtcc ttgcggaaag ggcattttag ctgaggcttt
     1801 ggagtacgaa taggagctca gcaggcagac gaatgaggaa taaaggtcag agaaggtcag
     1861 agctgagtga cgtttggaat ccaccccgtt tattgtagaa ctgggggttc agagggcagg
     1921 tgcctcagag ttgaggccac acagtgaggt ctggtgggtg aaaggaccca ggaacgaggc
     1981 gttcaggaaa gcaggttgtc agagctatgt ggagtctgtg ggtggcaggg gcagccgctc
     2041 cagcctttga agactttgaa agccagagat tcctggcgca ggcttggact tcctgggagc
     2101 tcctccaagt acccaggggc atcagagctg cctgggtgtt acatggccca gggaacccag
     2161 gttcagggta ggacaggcaa gaccagatac ccaatgtgca aagtgaaaac actgggctcc
     2221 ctgttaaacg atgaagaatt caagacagtg acagcattac gtcacccctg gggacagagg
     2281 tcagcctaag gtgacacacg gggactactg tgcttccgga ggctccctgt gtcctggagg
     2341 agaaaagcat tagagggggc agctggacaa gctcccaact gcagagtccc agccctggct
     2401 ggggcagggc cccggcctgg gactcagcat ttctgatatg ccttaagaat tcattctgtt
     2461 ttgtacaatt attttttaaa agtaaacgtg tggagaaaga a
//
