LOCUS       NP_689498                433 aa            linear   PRI 27-APR-2025
DEFINITION  arrestin domain-containing protein 1 isoform 1 [Homo sapiens].
ACCESSION   NP_689498
VERSION     NP_689498.1
DBSOURCE    REFSEQ: accession NM_152285.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 433)
  AUTHORS   Lee,K.T., Pranoto,I.K.A., Kim,S.Y., Choi,H.J., To,N.B., Chae,H.,
            Lee,J.Y., Kim,J.E., Kwon,Y.V. and Nam,J.W.
  TITLE     Comparative interactome analysis of alpha-arrestin families in
            human and Drosophila
  JOURNAL   Elife 12, 88328 (2024)
   PUBMED   38270169
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 433)
  AUTHORS   Zhao,Q., Jiang,F., Zhuang,H., Chu,Y., Zhang,F. and Wang,C.
  TITLE     MicroRNA miR-124-3p suppresses proliferation and
            epithelial-mesenchymal transition of hepatocellular carcinoma via
            ARRDC1 (arrestin domain containing 1)
  JOURNAL   Bioengineered 13 (4), 8255-8265 (2022)
   PUBMED   35300565
  REMARK    GeneRIF: MicroRNA miR-124-3p suppresses proliferation and
            epithelial-mesenchymal transition of hepatocellular carcinoma via
            ARRDC1 (arrestin domain containing 1).
REFERENCE   3  (residues 1 to 433)
  AUTHORS   Xu,H., Yu,X., Yang,Z., Song,Q., Cheng,S., He,Z. and Dai,L.
  TITLE     PAX5-activated lncRNA ARRDC1-AS1 accelerates the autophagy and
            progression of DLBCL through sponging miR-2355-5p to regulate ATG5
  JOURNAL   Life Sci 286, 119932 (2021)
   PUBMED   34499929
  REMARK    GeneRIF: PAX5-activated lncRNA ARRDC1-AS1 accelerates the autophagy
            and progression of DLBCL through sponging miR-2355-5p to regulate
            ATG5.
REFERENCE   4  (residues 1 to 433)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 433)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 433)
  AUTHORS   Nabhan,J.F., Hu,R., Oh,R.S., Cohen,S.N. and Lu,Q.
  TITLE     Formation and release of arrestin domain-containing protein
            1-mediated microvesicles (ARMMs) at plasma membrane by recruitment
            of TSG101 protein
  JOURNAL   Proc Natl Acad Sci U S A 109 (11), 4146-4151 (2012)
   PUBMED   22315426
REFERENCE   7  (residues 1 to 433)
  AUTHORS   Shea,F.F., Rowell,J.L., Li,Y., Chang,T.H. and Alvarez,C.E.
  TITLE     Mammalian alpha arrestins link activated seven transmembrane
            receptors to Nedd4 family e3 ubiquitin ligases and interact with
            beta arrestins
  JOURNAL   PLoS One 7 (12), e50557 (2012)
   PUBMED   23236378
REFERENCE   8  (residues 1 to 433)
  AUTHORS   Rauch,S. and Martin-Serrano,J.
  TITLE     Multiple interactions between the ESCRT machinery and
            arrestin-related proteins: implications for PPXY-dependent budding
  JOURNAL   J Virol 85 (7), 3546-3556 (2011)
   PUBMED   21191027
  REMARK    GeneRIF: The authors show that WWP1 changes the ubiquitination
            status of ARRDC1, suggesting that the arrestins may provide a
            platform for ubiquitination in PPXY-dependent budding.
REFERENCE   9  (residues 1 to 433)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (residues 1 to 433)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC032346.1 and AA552336.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ420420.1, SRR1660807.74277.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371421.9/ ENSP00000360475.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..433
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     Protein         1..433
                     /product="arrestin domain-containing protein 1 isoform 1"
                     /note="arrestin domain-containing protein 1;
                     alpha-arrestin 1"
                     /calculated_mol_wt=45850
     Region          7..139
                     /region_name="Arrestin_N"
                     /note="Arrestin (or S-antigen), N-terminal domain;
                     cl22903"
                     /db_xref="CDD:451447"
     Region          162..284
                     /region_name="Arrestin_C"
                     /note="Arrestin (or S-antigen), C-terminal domain;
                     pfam02752"
                     /db_xref="CDD:460676"
     Region          296..322
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N5I2.1)"
     Region          349..372
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N5I2.1)"
     Region          402..405
                     /region_name="PPxY motif 1.
                     /evidence=ECO:0000269|PubMed:23886940"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N5I2.1)"
     Region          415..418
                     /region_name="PPxY motif 2.
                     /evidence=ECO:0000269|PubMed:23886940"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N5I2.1)"
     CDS             1..433
                     /gene="ARRDC1"
                     /coded_by="NM_152285.4:33..1334"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS7049.1"
                     /db_xref="GeneID:92714"
                     /db_xref="HGNC:HGNC:28633"
                     /db_xref="MIM:619768"
ORIGIN      
        1 mgrvqlfeis lshgrvvysp geplagtvrv rlgaplpfra irvtcigscg vsnkandtaw
       61 vveegyfnss lsladkgslp agehsfpfqf llpataptsf egpfgkivhq vraaihtprf
      121 skdhkcslvf yilsplnlns ipdieqpnva satkkfsykl vktgsvvlta stdlrgyvvg
      181 qalqlhadve nqsgkdtspv vasllqkvsy kakrwihdvr tiaevegagv kawrraqwhe
      241 qilvpalpqs alpgcslihi dyylqvslka peatvtlpvf igniavnhap vsprpglglp
      301 pgapplvvps appqeeaeae aaaggphfld pvflstkshs qrqpllatls svpgapepcp
      361 qdgspashpl hpplcistga tvpyfaegsg gpvpttstli lppeysswgy pyeappsyeq
      421 scggvepslt pes
//
