LOCUS       NM_004313               1778 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens arrestin beta 2 (ARRB2), transcript variant 1, mRNA.
ACCESSION   NM_004313
VERSION     NM_004313.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Feng,M., Wang,R., Deng,L., Yang,Y., Xia,S., Liu,F. and Luo,L.
  TITLE     Arrestin beta-2 deficiency exacerbates periodontal inflammation by
            mediating activating transcription factor 6 activation and abnormal
            remodelling of the extracellular matrix
  JOURNAL   J Clin Periodontol 51 (6), 742-753 (2024)
   PUBMED   38267365
  REMARK    GeneRIF: Arrestin beta-2 deficiency exacerbates periodontal
            inflammation by mediating activating transcription factor 6
            activation and abnormal remodelling of the extracellular matrix.
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Li,H.Z., Wang,Y.F., Shao,X.X., Liu,Y.L., Xu,Z.G., Wang,S.L. and
            Guo,Z.Y.
  TITLE     FAM237A, rather than peptide PEN and proCCK56-63, binds to and
            activates the orphan receptor GPR83
  JOURNAL   FEBS J 290 (13), 3461-3479 (2023)
   PUBMED   36853120
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Wang,L., Moonen,J.R., Cao,A., Isobe,S., Li,C.G., Tojais,N.F.,
            Taylor,S., Marciano,D.P., Chen,P.I., Gu,M., Li,D., Harper,R.L.,
            El-Bizri,N., Kim,Y.M., Stankunas,K. and Rabinovitch,M.
  TITLE     Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes Pulmonary
            Hypertension
  JOURNAL   Circ Res 132 (5), 545-564 (2023)
   PUBMED   36744494
  REMARK    GeneRIF: Dysregulated Smooth Muscle Cell BMPR2-ARRB2 Axis Causes
            Pulmonary Hypertension.
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Ren,H., Liu,Y., Tan,Z., Luo,G., Zhang,M., Li,S., Tang,T. and
            Zhao,L.
  TITLE     A Common Variant of ARRB2 Promoter Region Associated with the
            Prognosis of Heart Failure
  JOURNAL   Hum Hered 88 (1), 68-78 (2023)
   PUBMED   37100034
  REMARK    GeneRIF: A Common Variant of ARRB2 Promoter Region Associated with
            the Prognosis of Heart Failure.
REFERENCE   6  (bases 1 to 1778)
  AUTHORS   Le Gouill,C., Parent,J.L., Rola-Pleszczynski,M. and Stankova,J.
  TITLE     Role of the Cys90, Cys95 and Cys173 residues in the structure and
            function of the human platelet-activating factor receptor
  JOURNAL   FEBS Lett 402 (2-3), 203-208 (1997)
   PUBMED   9037196
REFERENCE   7  (bases 1 to 1778)
  AUTHORS   Calabrese,G., Sallese,M., Stornaiuolo,A., Stuppia,L., Palka,G. and
            De Blasi,A.
  TITLE     Chromosome mapping of the human arrestin (SAG), beta-arrestin 2
            (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes
  JOURNAL   Genomics 23 (1), 286-288 (1994)
   PUBMED   7695743
REFERENCE   8  (bases 1 to 1778)
  AUTHORS   Parruti,G., Peracchia,F., Sallese,M., Ambrosini,G., Masini,M.,
            Rotilio,D. and De Blasi,A.
  TITLE     Molecular analysis of human beta-arrestin-1: cloning, tissue
            distribution, and regulation of expression. Identification of two
            isoforms generated by alternative splicing
  JOURNAL   J Biol Chem 268 (13), 9753-9761 (1993)
   PUBMED   8486659
REFERENCE   9  (bases 1 to 1778)
  AUTHORS   Attramadal,H., Arriza,J.L., Aoki,C., Dawson,T.M., Codina,J.,
            Kwatra,M.M., Snyder,S.H., Caron,M.G. and Lefkowitz,R.J.
  TITLE     Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene
            family
  JOURNAL   J Biol Chem 267 (25), 17882-17890 (1992)
   PUBMED   1517224
REFERENCE   10 (bases 1 to 1778)
  AUTHORS   Rapoport,B., Kaufman,K.D. and Chazenbalk,G.D.
  TITLE     Cloning of a member of the arrestin family from a human thyroid
            cDNA library
  JOURNAL   Mol Cell Endocrinol 84 (3), R39-R43 (1992)
   PUBMED   1587386
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG723452.1, BC007427.2 and
            AF106941.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004313.3.
            
            Summary: Members of arrestin/beta-arrestin protein family are
            thought to participate in agonist-mediated desensitization of
            G-protein-coupled receptors and cause specific dampening of
            cellular responses to stimuli such as hormones, neurotransmitters,
            or sensory signals. Arrestin beta 2, like arrestin beta 1, was
            shown to inhibit beta-adrenergic receptor function in vitro. It is
            expressed at high levels in the central nervous system and may play
            a role in the regulation of synaptic receptors. Besides the brain,
            a cDNA for arrestin beta 2 was isolated from thyroid gland, and
            thus it may also be involved in hormone-specific desensitization of
            TSH receptors. Multiple alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice junction at the 3' end of an exon compared to variant 3. The
            resulting isoform (1) lacks an alternate internal segment compared
            to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1168240.1,
                                           SRR3476690.993650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269260.7/ ENSP00000269260.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BG723452.1         149-176
            29-929              BC007427.2         1-901
            930-1335            AF106941.1         893-1298
            1336-1778           BC007427.2         1308-1750
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1778
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /note="arrestin beta 2"
                     /db_xref="GeneID:409"
                     /db_xref="HGNC:HGNC:712"
                     /db_xref="MIM:107941"
     exon            1..113
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1320
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arrestin 3; beta-arrestin-2; non-visual arrestin-3"
                     /codon_start=1
                     /product="beta-arrestin-2 isoform 1"
                     /protein_id="NP_004304.1"
                     /db_xref="CCDS:CCDS11050.1"
                     /db_xref="GeneID:409"
                     /db_xref="HGNC:HGNC:712"
                     /db_xref="MIM:107941"
                     /translation="MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLV
                     DPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQ
                     DRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSH
                     KRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVN
                     VHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTIT
                     PLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGG
                     DVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFA
                     RLRLKGMKDDDYDDQLC"
     exon            114..144
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            145..205
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            206..250
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..447
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..507
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..575
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            576..711
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..796
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            797..869
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1007
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1091
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1171
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1226
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1778
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1759..1764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /note="hexamer: AATAAA"
     polyA_site      1778
                     /gene="ARRB2"
                     /gene_synonym="ARB2; ARR2; BARR2"
                     /note="major polyA site"
ORIGIN      
        1 gcattggcgc ggggaggagc agggatcttg gcagcgggcg aggaggctgc gagcgagccg
       61 cgaaccgagc gggcggcggg cgcgcgcacc atgggggaga aacccgggac cagggtcttc
      121 aagaagtcga gccctaactg caagctcacc gtgtacttgg gcaagcggga cttcgtagat
      181 cacctggaca aagtggaccc tgtagatggc gtggtgcttg tggaccctga ctacctgaag
      241 gaccgcaaag tgtttgtgac cctcacctgc gccttccgct atggccgtga agacctggat
      301 gtgctgggct tgtccttccg caaagacctg ttcatcgcca cctaccaggc cttccccccg
      361 gtgcccaacc caccccggcc ccccacccgc ctgcaggacc ggctgctgag gaagctgggc
      421 cagcatgccc accccttctt cttcaccata ccccagaatc ttccatgctc cgtcacactg
      481 cagccaggcc cagaggatac aggaaaggcc tgcggcgtag actttgagat tcgagccttc
      541 tgtgctaaat cactagaaga gaaaagccac aaaaggaact ctgtgcggct ggtgatccga
      601 aaggtgcagt tcgccccgga gaaacccggc ccccagcctt cagccgaaac cacacgccac
      661 ttcctcatgt ctgaccggtc cctgcacctc gaggcttccc tggacaagga gctgtactac
      721 catggggagc ccctcaatgt aaatgtccac gtcaccaaca actccaccaa gaccgtcaag
      781 aagatcaaag tctctgtgag acagtacgcc gacatctgcc tcttcagcac cgcccagtac
      841 aagtgtcctg tggctcaact cgaacaagat gaccaggtat ctcccagctc cacattctgt
      901 aaggtgtaca ccataacccc actgctcagc gacaaccggg agaagcgggg tctcgccctg
      961 gatgggaaac tcaagcacga ggacaccaac ctggcttcca gcaccatcgt gaaggagggt
     1021 gccaacaagg aggtgctggg aatcctggtg tcctacaggg tcaaggtgaa gctggtggtg
     1081 tctcgaggcg gggatgtctc tgtggagctg ccttttgttc ttatgcaccc caagccccac
     1141 gaccacatcc ccctccccag accccagtca gccgctccgg agacagatgt ccctgtggac
     1201 accaacctca ttgaatttga taccaactat gccacagatg atgacattgt gtttgaggac
     1261 tttgcccggc ttcggctgaa ggggatgaag gatgacgact atgatgatca actctgctag
     1321 gaagcggggt gggaagaagg gaggggatgg ggttgggaga ggtgagggca ggattaagat
     1381 ccccactgtc aatgggggat tgtcccagcc cctcttccct tcccctcacc tggaagcttc
     1441 ttcaaccaat cccttcacac tctctccccc atccccccaa gatacacact ggaccctctc
     1501 ttgctgaatg tgggcattaa ttttttgact gcagctctgc ttctccagcc ccgccgtggg
     1561 tggcaagctg tgttcatacc taaattttct ggaaggggac agtgaaaaga ggagtgacag
     1621 gagggaaagg gggagacaaa actcctactc tcaacctcac accaacacct cccattatca
     1681 ctctctctgc ccccattcct tcaagaggag accctttggg gacaaggccg tttctttgtt
     1741 tctgagcata aagaagaaaa taaatctttt actaagca
//
