LOCUS       NM_004312               1310 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens arrestin 3 (ARR3), mRNA.
ACCESSION   NM_004312
VERSION     NM_004312.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1310)
  AUTHORS   Niu,J., Zhu,W., Jin,X., Teng,X. and Zhang,J.
  TITLE     Novel Splicing Variants in the ARR3 Gene Cause the Female-Limited
            Early-Onset High Myopia
  JOURNAL   Invest Ophthalmol Vis Sci 65 (3), 32 (2024)
   PUBMED   38517428
  REMARK    GeneRIF: Novel Splicing Variants in the ARR3 Gene Cause the
            Female-Limited Early-Onset High Myopia.
REFERENCE   2  (bases 1 to 1310)
  AUTHORS   Ediae,G.U., Chisholm,C., Lemire,G., Campbell,F. and Boycott,K.M.
  TITLE     Pathogenic variant in the X-linked ARR3 gene associated with
            variable early-onset myopia
  JOURNAL   Am J Med Genet A 194 (2), 397-399 (2024)
   PUBMED   37795829
  REMARK    GeneRIF: Pathogenic variant in the X-linked ARR3 gene associated
            with variable early-onset myopia.
REFERENCE   3  (bases 1 to 1310)
  AUTHORS   Wang,Y., Xiao,X., Li,X., Yi,Z., Jiang,Y., Zhang,F., Zhou,L., Li,S.,
            Jia,X., Sun,W., Wang,P. and Zhang,Q.
  TITLE     Genetic and clinical landscape of ARR3-associated MYP26: the most
            common cause of Mendelian early-onset high myopia with a unique
            inheritance
  JOURNAL   Br J Ophthalmol 107 (10), 1545-1553 (2023)
   PUBMED   36180177
  REMARK    GeneRIF: Genetic and clinical landscape of ARR3-associated MYP26:
            the most common cause of Mendelian early-onset high myopia with a
            unique inheritance.
REFERENCE   4  (bases 1 to 1310)
  AUTHORS   Manning,J.J., Rawcliffe,G., Finlay,D.B. and Glass,M.
  TITLE     Cannabinoid 1 (CB1) receptor arrestin subtype-selectivity and
            phosphorylation dependence
  JOURNAL   Br J Pharmacol 180 (3), 369-382 (2023)
   PUBMED   36250246
  REMARK    GeneRIF: Cannabinoid 1 (CB1) receptor arrestin subtype-selectivity
            and phosphorylation dependence.
REFERENCE   5  (bases 1 to 1310)
  AUTHORS   van Mazijk,R., Haarman,A.E.G., Hoefsloot,L.H., Polling,J.R., van
            Tienhoven,M., Klaver,C.C.W., Verhoeven,V.J.M., Loudon,S.E.,
            Thiadens,A.A.H.J. and Kievit,A.J.A.
  TITLE     Early onset X-linked female limited high myopia in three
            multigenerational families caused by novel mutations in the ARR3
            gene
  JOURNAL   Hum Mutat 43 (3), 380-388 (2022)
   PUBMED   35001458
  REMARK    GeneRIF: Early onset X-linked female limited high myopia in three
            multigenerational families caused by novel mutations in the ARR3
            gene.
REFERENCE   6  (bases 1 to 1310)
  AUTHORS   Orsini,M.J. and Benovic,J.L.
  TITLE     Characterization of dominant negative arrestins that inhibit
            beta2-adrenergic receptor internalization by distinct mechanisms
  JOURNAL   J Biol Chem 273 (51), 34616-34622 (1998)
   PUBMED   9852134
REFERENCE   7  (bases 1 to 1310)
  AUTHORS   Sakuma,H., Murakami,A., Fujimaki,T. and Inana,G.
  TITLE     Isolation and characterization of the human X-arrestin gene
  JOURNAL   Gene 224 (1-2), 87-95 (1998)
   PUBMED   9931451
REFERENCE   8  (bases 1 to 1310)
  AUTHORS   Sakuma,H., Inana,G., Murakami,A., Higashide,T. and McLaren,M.J.
  TITLE     Immunolocalization of X-arrestin in human cone photoreceptors
  JOURNAL   FEBS Lett 382 (1-2), 105-110 (1996)
   PUBMED   8612728
REFERENCE   9  (bases 1 to 1310)
  AUTHORS   Craft,C.M., Whitmore,D.H. and Wiechmann,A.F.
  TITLE     Cone arrestin identified by targeting expression of a functional
            family
  JOURNAL   J Biol Chem 269 (6), 4613-4619 (1994)
   PUBMED   8308033
  REMARK    Erratum:[J Biol Chem 1994 Jul 1;269(26):17756]
REFERENCE   10 (bases 1 to 1310)
  AUTHORS   Murakami,A., Yajima,T., Sakuma,H., McLaren,M.J. and Inana,G.
  TITLE     X-arrestin: a new retinal arrestin mapping to the X chromosome
  JOURNAL   FEBS Lett 334 (2), 203-209 (1993)
   PUBMED   8224247
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357752.19, BG472156.1,
            AF033105.1 and BC012096.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004312.2.
            
            Summary: The protein encoded by this gene is a non-visual arrestin
            which binds to agonist-activated, phosphorylated G protein-coupled
            receptors. This binding uncouples the receptor from the
            heterotrimeric G protein, resulting in termination of the G
            protein-coupled receptor signaling. The encoded protein also is a
            part of the centrosome, interacting with gamma-tubulin to help
            regulate proper centrosome function. [provided by RefSeq, May
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF033105.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307959.9/ ENSP00000311538.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL357752.19        111255-111255       c
            2-18                BG472156.1         32-48
            19-344              AF033105.1         1-326
            345-1145            BC012096.1         374-1174
            1146-1310           AF033105.1         1128-1292
FEATURES             Location/Qualifiers
     source          1..1310
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1310
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /note="arrestin 3"
                     /db_xref="GeneID:407"
                     /db_xref="HGNC:HGNC:710"
                     /db_xref="MIM:301770"
     exon            1..39
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            40..77
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1236
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /note="arrestin 4; C-arrestin; retinal cone arrestin-3;
                     arrestin 3 retinal (X-arrestin)"
                     /codon_start=1
                     /product="arrestin-C"
                     /protein_id="NP_004303.2"
                     /db_xref="CCDS:CCDS14399.1"
                     /db_xref="GeneID:407"
                     /db_xref="HGNC:HGNC:710"
                     /db_xref="MIM:301770"
                     /translation="MSKVFKKTSSNGKLSIYLGKRDFVDHVDTVEPIDGVVLVDPEYL
                     KCRKLFVMLTCAFRYGRDDLEVIGLTFRKDLYVQTLQVVPAESSSPQGPLTVLQERLL
                     HKLGDNAYPFTLQMVTNLPCSVTLQPGPEDAGKPCGIDFEVKSFCAENPEETVSKRDY
                     VRLVVRKVQFAPPEAGPGPSAQTIRRFLLSAQPLQLQAWMDREVHYHGEPISVNVSIN
                     NCTNKVIKKIKISVDQITDVVLYSLDKYTKTVFIQEFTETVAANSSFSQSFAVTPILA
                     ASCQKRGLALDGKLKHEDTNLASSTIIRPGMDKELLGILVSYKVRVNLMVSCGGILGD
                     LTASDVGVELPLVLIHPKPSHEAASSEDIVIEEFTRKGEEESQKAVEAEGDEGS"
     exon            78..108
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            109..169
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            170..214
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            215..414
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            415..474
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            475..542
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            543..678
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            679..763
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            764..836
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            837..974
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1058
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1082
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1135
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1145
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1310
                     /gene="ARR3"
                     /gene_synonym="ARRX; cArr; MYP26"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctggag actgatgtga acttcatctc tctccccaga aaaggctcaa catcaactat
       61 atagccaaca tgtccaaggt gtttaagaag accagctcca atgggaagct ctccatctac
      121 ctggggaaac gggacttcgt ggaccatgtg gacacggtgg aacccattga cggtgttgtc
      181 ctggttgatc ctgagtactt aaaatgtcga aagttgtttg tcatgttgac atgtgccttt
      241 cgctatggcc gtgatgactt ggaagtgatt ggtctgacgt tccgaaaaga tctgtatgtg
      301 cagaccctgc aagtggtccc agctgaatcc agcagccctc aggggcccct cacagtccta
      361 caggagcgac tactgcacaa gctaggggac aatgcctacc cctttaccct gcagatggtg
      421 accaacctgc cctgttctgt gacactgcag ccaggtcctg aagatgcagg aaagccctgt
      481 gggattgact ttgaagtgaa gagtttctgt gctgaaaacc cagaggagac agtctccaag
      541 agagactatg tgcggctggt tgtccggaaa gtacaatttg caccaccgga ggcaggccct
      601 ggcccctcag cccagaccat ccgccgcttc cttctgtcag ctcagcccct acaactccag
      661 gcctggatgg acagggaggt tcactaccac ggagaaccca tctctgtcaa tgtttctatc
      721 aacaactgca ccaacaaggt catcaaaaaa atcaagattt cagttgacca gatcacagat
      781 gttgtcctgt attcactaga caagtacacc aagactgtgt tcattcagga attcacggag
      841 actgtagctg ctaattccag cttctcccag agctttgcag taaccccaat cctggctgcc
      901 agctgccaga aacggggcct ggcactggat ggcaaactta agcatgaaga taccaacctg
      961 gcctctagca caattattag accgggaatg gacaaagagc tgctggggat cctggtgtcc
     1021 tacaaagtca gagtcaacct gatggtgtcc tgtggtggca tcctaggaga cctgacagcc
     1081 agcgatgttg gtgtggagct acccttggtc ctgatccatc cgaagccatc tcatgaggcc
     1141 gctagctctg aggacatagt catcgaggag tttacgcgga aaggcgagga ggagagccag
     1201 aaggctgtgg aggctgaggg agatgagggg agctgagcac ctcgctctgg tgcccgtctg
     1261 tgtgggagcc cccactgtaa cactctaata aatcagtttg ttcagatgtg
//
