LOCUS       NM_198399               2397 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cAMP regulated phosphoprotein 21 (ARPP21), transcript
            variant 2, mRNA.
ACCESSION   NM_198399 XM_374037 XM_944656
VERSION     NM_198399.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2397)
  AUTHORS   Chan Moi Fat,S., McCann,E.P., Williams,K.L., Henden,L., Twine,N.A.,
            Bauer,D.C., Pamphlett,R., Kiernan,M.C., Rowe,D.B., Nicholson,G.A.,
            Fifita,J.A. and Blair,I.P.
  TITLE     Genetic analysis of GLT8D1 and ARPP21 in Australian familial and
            sporadic amyotrophic lateral sclerosis
  JOURNAL   Neurobiol Aging 101, 297 (2021)
   PUBMED   33581934
  REMARK    GeneRIF: Genetic analysis of GLT8D1 and ARPP21 in Australian
            familial and sporadic amyotrophic lateral sclerosis.
REFERENCE   2  (bases 1 to 2397)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2397)
  AUTHORS   Li,W., Liu,Z., Sun,W., Yuan,Y., Hu,Y., Ni,J., Jiao,B., Fang,L.,
            Li,J., Shen,L., Tang,B. and Wang,J.
  TITLE     Mutation analysis of GLT8D1 and ARPP21 genes in amyotrophic lateral
            sclerosis patients from mainland China
  JOURNAL   Neurobiol Aging 85, 156 (2020)
   PUBMED   31653410
  REMARK    GeneRIF: Mutation analysis of GLT8D1 and ARPP21 genes in
            amyotrophic lateral sclerosis patients from mainland China.
REFERENCE   4  (bases 1 to 2397)
  AUTHORS   Marangi,G., Orteschi,D., Milano,V., Mancano,G. and Zollino,M.
  TITLE     Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 and CLASP2
            is a potential pathogenic factor for a syndromic form of
            intellectual disability: a co-morbidity model with additional copy
            number variations in a large family
  JOURNAL   Am J Med Genet A 161A (11), 2890-2893 (2013)
   PUBMED   24127197
  REMARK    GeneRIF: Interstitial deletion of 3p22.3p22.2 encompassing ARPP21
            and CLASP2 is a potential pathogenic factor for a syndromic form of
            intellectual disability.
REFERENCE   5  (bases 1 to 2397)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum Mol Genet 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   6  (bases 1 to 2397)
  AUTHORS   Rakhilin,S.V., Olson,P.A., Nishi,A., Starkova,N.N., Fienberg,A.A.,
            Nairn,A.C., Surmeier,D.J. and Greengard,P.
  TITLE     A network of control mediated by regulator of
            calcium/calmodulin-dependent signaling
  JOURNAL   Science 306 (5696), 698-701 (2004)
   PUBMED   15499021
REFERENCE   7  (bases 1 to 2397)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   8  (bases 1 to 2397)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   9  (bases 1 to 2397)
  AUTHORS   Caporaso,G.L., Bibb,J.A., Snyder,G.L., Valle,C., Rakhilin,S.,
            Fienberg,A.A., Hemmings,H.C., Nairn,A.C. and Greengard,P.
  TITLE     Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic
            AMP-regulated phosphoprotein enriched in the basal ganglia
  JOURNAL   Neuropharmacology 39 (9), 1637-1644 (2000)
   PUBMED   10854908
REFERENCE   10 (bases 1 to 2397)
  AUTHORS   Brene,S., Lindefors,N., Ehrlich,M., Taubes,T., Horiuchi,A.,
            Kopp,J., Hall,H., Sedvall,G., Greengard,P. and Persson,H.
  TITLE     Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in
            human brain tissue
  JOURNAL   J Neurosci 14 (3 Pt 1), 985-998 (1994)
   PUBMED   8120638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017805.1, AC016943.7 and
            BC036548.1.
            
            On Jun 2, 2019 this sequence version replaced NM_198399.1.
            
            Summary: This gene encodes a cAMP-regulated phosphoprotein. The
            encoded protein is enriched in the caudate nucleus and cerebellar
            cortex. A similar protein in mouse may be involved in regulating
            the effects of dopamine in the basal ganglia. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Jun
            2012].
            
            Transcript Variant: This variant (2) uses an alternate 5' exon and
            an alternate 3' exon compared to variant 1. The resulting isoform
            (2) has a distinct and much shorter C-terminus compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.28725.1,
                                           SRR1660803.107009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BC017805.1         4-83
            81-81               AC016943.7         107373-107373
            82-472              BC017805.1         85-475
            473-473             AC016943.7         110111-110111
            474-1301            BC017805.1         477-1304
            1302-2397           BC036548.1         1791-2886
FEATURES             Location/Qualifiers
     source          1..2397
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..2397
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="cAMP regulated phosphoprotein 21"
                     /db_xref="GeneID:10777"
                     /db_xref="HGNC:HGNC:16968"
                     /db_xref="MIM:605488"
     exon            1..231
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            232..398
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..539
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cyclic AMP-regulated phosphoprotein, 21 kD; R3H domain
                     containing 3; thymocyte cAMP-regulated phosphoprotein;
                     cAMP regulated phosphoprotein 21kDa"
                     /codon_start=1
                     /product="cAMP-regulated phosphoprotein 21 isoform 2"
                     /protein_id="NP_938409.1"
                     /db_xref="CCDS:CCDS43063.1"
                     /db_xref="GeneID:10777"
                     /db_xref="HGNC:HGNC:16968"
                     /db_xref="MIM:605488"
                     /translation="MSEQGDLNQAIAEEGGTEQETATPENGIVKSESLDEEEKLELQR
                     RLEAQNQERRKSKSGAGKGKLTRSLAVCEESSARPGGESLQDQTL"
     exon            399..440
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            441..530
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            531..2397
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2359..2364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="hexamer: AATAAA"
     regulatory      2368..2373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="hexamer: ATTAAA"
     polyA_site      2379
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
     polyA_site      2397
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="major polyA site"
ORIGIN      
        1 agattttaac tctgaaaagc catttccagt gtctatagac tattgtgagc ctggagaagt
       61 agcatttagt tgggatagct tcactagagc tgcctgccaa agacttcctt ccacaggatc
      121 ttgtcgcacc agcaactgac aggagcttgg gagctcggga gcttgggaga gggcttatgt
      181 ttttaataat gtagctgtca gttcgaagcc tggaaatgtt gaccctcaaa gggcataaaa
      241 tcttgttatt ttaatttgca tctgggagaa tgtctgagca aggagacctg aatcaggcaa
      301 tagcagagga aggagggact gagcaggaga cggccactcc agagaacggc attgttaaat
      361 cagaaagtct ggatgaagag gagaaactgg aactgcagag gcggctggag gctcagaatc
      421 aagaaagaag aaaatccaag tcaggagcag gaaaaggtaa actgactcgc agccttgctg
      481 tctgtgagga atcttctgcc agaccaggag gtgaaagtct tcaggatcag actctctgaa
      541 aactgcaaat ggaaaggaat tcaaaagaat ttagattaaa agttaaataa aaagtaggca
      601 cagtagtgct gaattttcct caaaggctct cttttgataa ggctgaacca aatataatcc
      661 caagtatcct ctctccttcc ttgttggaga tgtcttacct ctcagctccc caaaatgcac
      721 ttgcctataa gaaacacaat tgctggttca tatgaaactt aggaaatagt gaataaggtg
      781 catttaactt tggagaaata cttttatggc tttggtggag atttctcaat actgcaaaag
      841 ttgtccagaa atgaatctga gctgatggtg actttaagtt aatattatta atatatcact
      901 gcatattttt acccttattt ttgctcctta cagcaagatt agtaggttat aaaaatttaa
      961 atttaaacaa aattatttca tgacaaaatg ggaaacttca catcatactt atttttgttt
     1021 gcctttcagg catcatatta gcttttataa aaaatggtct tgctgctgaa attgtactta
     1081 ttttatcaga ggctgggtgc agtcaagaca aaagtaaaat ggtttacctg agcccagggg
     1141 agggaaaatt gattaagata tcattatttt tgtttggttt ggttttgctt ttttcctctt
     1201 actttaattg aaatactctg aattcccctc atggaaacag agagcattga gagcactttc
     1261 tttaaaagga ccaaaaataa attcctaata gattttgtcc taagagagtg tttttttttc
     1321 tagcatcatt ttctttacat gccactcatg tcataaggca tggacaggct atctttcagt
     1381 ggccattact atgtttcgta cacatgcttt attttacttg ggctctgaga aatgtgtggc
     1441 tttccttcag cattttattt gtgcttctct ttttaatgga gattgaaaag ggagaataat
     1501 gtgaatatca cggcttatat tattaaatgt tgattgatgg cttgtaatgt actgcacaca
     1561 atatatgtta actctgcaga atgacagacc ctgggagaag taatgcccca gttgtccccc
     1621 actcctaatg ccaggcagag aaggacagcc tttatagact taatctgctt tttgtcccat
     1681 ttgacaaggt accaggagga aattttttaa gggatcaact gtatcacagt gcccactctg
     1741 gacctaagtc tagtgtatcc atacaattgg tgcagagaaa taaggtgtaa atggtgcttt
     1801 gttcctgctg gttccaagct cagaaaccaa gactagcttt gtaggagaga atgagagcct
     1861 gcaagcctct ctttggattg gctgaggagt ggtgggagca gggggttgat agaaaacatc
     1921 cagacacaca tataagcaag tggccgtgct acctttttag agaataaaga aacagacttt
     1981 tgagtttata tgcaatgcct tcattaggta ccaccggcac ttacaaaatg tgcggactga
     2041 atcccagaga acactggcag atgtatacag tatatggatt gtatcgcttc cccaatgttt
     2101 gtaaattcac agtatttgga aaactgcctt cattttccag tgtgggaaaa actcttgcta
     2161 cctgtattac ttgatctcag acccatacct gatggttcag tctgtcctta agttaaaaga
     2221 attttgcttt tctaatgtta tactatttac ctgtcagtgt attactgcaa cttgaatcac
     2281 tcttttactg ttgttggata taaacttatc ctgtaccaat gtatttatta acacttgtat
     2341 tttattattg agcatatcaa taaaaatatt aaaaaataac agattgtttt ttaccaa
//
