LOCUS       NM_001385580            3016 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cAMP regulated phosphoprotein 21 (ARPP21), transcript
            variant 18, mRNA.
ACCESSION   NM_001385580
VERSION     NM_001385580.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3016)
  AUTHORS   Chan Moi Fat,S., McCann,E.P., Williams,K.L., Henden,L., Twine,N.A.,
            Bauer,D.C., Pamphlett,R., Kiernan,M.C., Rowe,D.B., Nicholson,G.A.,
            Fifita,J.A. and Blair,I.P.
  TITLE     Genetic analysis of GLT8D1 and ARPP21 in Australian familial and
            sporadic amyotrophic lateral sclerosis
  JOURNAL   Neurobiol Aging 101, 297 (2021)
   PUBMED   33581934
  REMARK    GeneRIF: Genetic analysis of GLT8D1 and ARPP21 in Australian
            familial and sporadic amyotrophic lateral sclerosis.
REFERENCE   2  (bases 1 to 3016)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3016)
  AUTHORS   Li,W., Liu,Z., Sun,W., Yuan,Y., Hu,Y., Ni,J., Jiao,B., Fang,L.,
            Li,J., Shen,L., Tang,B. and Wang,J.
  TITLE     Mutation analysis of GLT8D1 and ARPP21 genes in amyotrophic lateral
            sclerosis patients from mainland China
  JOURNAL   Neurobiol Aging 85, 156 (2020)
   PUBMED   31653410
  REMARK    GeneRIF: Mutation analysis of GLT8D1 and ARPP21 genes in
            amyotrophic lateral sclerosis patients from mainland China.
REFERENCE   4  (bases 1 to 3016)
  AUTHORS   Marangi,G., Orteschi,D., Milano,V., Mancano,G. and Zollino,M.
  TITLE     Interstitial deletion of 3p22.3p22.2 encompassing ARPP21 and CLASP2
            is a potential pathogenic factor for a syndromic form of
            intellectual disability: a co-morbidity model with additional copy
            number variations in a large family
  JOURNAL   Am J Med Genet A 161A (11), 2890-2893 (2013)
   PUBMED   24127197
  REMARK    GeneRIF: Interstitial deletion of 3p22.3p22.2 encompassing ARPP21
            and CLASP2 is a potential pathogenic factor for a syndromic form of
            intellectual disability.
REFERENCE   5  (bases 1 to 3016)
  AUTHORS   Need,A.C., Attix,D.K., McEvoy,J.M., Cirulli,E.T., Linney,K.L.,
            Hunt,P., Ge,D., Heinzen,E.L., Maia,J.M., Shianna,K.V., Weale,M.E.,
            Cherkas,L.F., Clement,G., Spector,T.D., Gibson,G. and
            Goldstein,D.B.
  TITLE     A genome-wide study of common SNPs and CNVs in cognitive
            performance in the CANTAB
  JOURNAL   Hum Mol Genet 18 (23), 4650-4661 (2009)
   PUBMED   19734545
REFERENCE   6  (bases 1 to 3016)
  AUTHORS   Rakhilin,S.V., Olson,P.A., Nishi,A., Starkova,N.N., Fienberg,A.A.,
            Nairn,A.C., Surmeier,D.J. and Greengard,P.
  TITLE     A network of control mediated by regulator of
            calcium/calmodulin-dependent signaling
  JOURNAL   Science 306 (5696), 698-701 (2004)
   PUBMED   15499021
REFERENCE   7  (bases 1 to 3016)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
REFERENCE   8  (bases 1 to 3016)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   9  (bases 1 to 3016)
  AUTHORS   Caporaso,G.L., Bibb,J.A., Snyder,G.L., Valle,C., Rakhilin,S.,
            Fienberg,A.A., Hemmings,H.C., Nairn,A.C. and Greengard,P.
  TITLE     Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic
            AMP-regulated phosphoprotein enriched in the basal ganglia
  JOURNAL   Neuropharmacology 39 (9), 1637-1644 (2000)
   PUBMED   10854908
REFERENCE   10 (bases 1 to 3016)
  AUTHORS   Brene,S., Lindefors,N., Ehrlich,M., Taubes,T., Horiuchi,A.,
            Kopp,J., Hall,H., Sedvall,G., Greengard,P. and Persson,H.
  TITLE     Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in
            human brain tissue
  JOURNAL   J Neurosci 14 (3 Pt 1), 985-998 (1994)
   PUBMED   8120638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC016943.7 and AC104308.3.
            
            Summary: This gene encodes a cAMP-regulated phosphoprotein. The
            encoded protein is enriched in the caudate nucleus and cerebellar
            cortex. A similar protein in mouse may be involved in regulating
            the effects of dopamine in the basal ganglia. Alternate splicing
            results in multiple transcript variants. [provided by RefSeq, Jun
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.164929.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMN03465402
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC016943.7         107848-107915
            69-235              AC016943.7         108067-108233
            236-277             AC016943.7         109201-109242
            278-367             AC016943.7         110079-110168
            368-512             AC016943.7         114092-114236
            513-591             AC016943.7         115660-115738
            592-651             AC016943.7         116434-116493
            652-792             AC016943.7         117218-117358
            793-901             AC016943.7         133327-133435
            902-939             AC016943.7         141792-141829
            940-1169            AC016943.7         147958-148187
            1170-1403           AC016943.7         155656-155889
            1404-1588           AC016943.7         163531-163715
            1589-1693           AC016943.7         164567-164671
            1694-1954           AC016943.7         165670-165930
            1955-2081           AC016943.7         170192-170318
            2082-2230           AC104308.3         38475-38623
            2231-3016           AC104308.3         39794-40579
FEATURES             Location/Qualifiers
     source          1..3016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..3016
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="cAMP regulated phosphoprotein 21"
                     /db_xref="GeneID:10777"
                     /db_xref="HGNC:HGNC:16968"
                     /db_xref="MIM:605488"
     exon            1..68
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            69..235
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2488
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="isoform 3 is encoded by transcript variant 18;
                     cyclic AMP-regulated phosphoprotein, 21 kD; R3H domain
                     containing 3; thymocyte cAMP-regulated phosphoprotein;
                     cAMP regulated phosphoprotein 21kDa"
                     /codon_start=1
                     /product="cAMP-regulated phosphoprotein 21 isoform 3"
                     /protein_id="NP_001372509.1"
                     /db_xref="CCDS:CCDS58824.1"
                     /db_xref="GeneID:10777"
                     /db_xref="HGNC:HGNC:16968"
                     /db_xref="MIM:605488"
                     /translation="MSEQGDLNQAIAEEGGTEQETATPENGIVKSESLDEEEKLELQR
                     RLEAQNQERRKSKSGAGKGKLTRSLAVCEESSARPGGESLQDQESIHLQLSSFSSLQE
                     EDKSRKDDSEREKEKDKNKDKTSEKPKIRMLSKDCSQEYTDSTGIDLHEFLINTLKNN
                     SRDRMILLKMEQEIIDFIADNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKS
                     VIINKTSSTRIPEQRFCEHLKDEKGEESQKRFILKRDNSSIDKEDNQSVCSQESLFVE
                     NRGNRDGSGRTSGSRQSSSENELKWSDHQRAWSSTDSDSSNRNLKPAMTKTASFGGIT
                     VLTRGDSTSSTRSTGKLSKAGSESSSSAGSSGSLSRTHPPLQSTPLVSGVAAGSPGCV
                     PYPENGIGGQVAPSSTSYILLPLEAATGIPPGSILLNPHTGQPFVNPDGTPAIYNPPT
                     SQQPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQMAGPLVTQSVQGLQASSQSVQY
                     PAVSFPPQHLLPVSPTQHFPMRDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQ
                     PAQQPSYVIASTGQQLPTGGFSGSGPPISQQVLQPPPSPQGFVQQPPPAQMPVYYYPS
                     GQYPTSTTQQYRPMAPVQYNAQRSQQMPQAAQQAGYQPVLSGQQGFQGLIGVQQPPQS
                     QNVINNQQGTPVQSVMVSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPA
                     TGMPVYCNVTPPTPQNNLRLIGPHCPSSTVPVMSASCRTNCASMSNAGWQVKF"
     exon            236..277
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            278..367
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            368..512
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            513..591
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            592..651
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            652..792
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            793..901
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            902..939
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1169
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1403
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1588
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1693
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1954
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2081
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2230
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..3016
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2970..2975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="hexamer: AATAAA"
     polyA_site      3016
                     /gene="ARPP21"
                     /gene_synonym="ARPP-21; R3HDM3; RCS; TARPP"
                     /note="major polyA site"
ORIGIN      
        1 gtattcacaa gtgtgtgtaa agggggtgtg gatgggacaa ctgcatctgc ctcttgtgca
       61 tgccttgggg cataaaatct tgttatttta atttgcatct gggagaatgt ctgagcaagg
      121 agacctgaat caggcaatag cagaggaagg agggactgag caggagacgg ccactccaga
      181 gaacggcatt gttaaatcag aaagtctgga tgaagaggag aaactggaac tgcagaggcg
      241 gctggaggct cagaatcaag aaagaagaaa atccaagtca ggagcaggaa aaggtaaact
      301 gactcgcagc cttgctgtct gtgaggaatc ttctgccaga ccaggaggtg aaagtcttca
      361 ggatcaggaa tcaattcatt tacagctttc cagtttttcc agcctgcaag aggaggataa
      421 atctaggaaa gatgactctg aaagagaaaa agaaaaggat aaaaacaaag ataaaacctc
      481 tgaaaaaccc aagatcagaa tgttatcaaa agattgcagc caagaataca cggattctac
      541 aggcatagac ttacacgagt ttctgattaa cacattaaag aataattcca gggacaggat
      601 gatacttttg aaaatggagc aggaaattat tgatttcatt gctgacaaca ataatcatta
      661 taaaaagttc cctcagatgt catcgtatca gaggatgctt gtccatcgag tggcagctta
      721 ttttggattg gatcacaatg tggatcaaac aggaaaatct gttatcatca acaagaccag
      781 cagcaccaga ataccagagc aaaggttttg tgaacattta aaagatgaaa aaggtgaaga
      841 atcccagaag cggtttatct tgaagcgaga taactctagt attgataaag aagacaatca
      901 gtcagtttgc tcccaggaaa gcctttttgt ggaaaacagg ggcaacagag atggctcagg
      961 gagaacatct gggagtcgac agagcagctc agaaaatgaa ctcaagtggt ctgaccacca
     1021 aagggcctgg agcagcacag actccgacag ttccaaccgc aatctaaagc ccgccatgac
     1081 caagacggcg agttttgggg gcatcacggt gctgaccagg ggtgacagca cttccagtac
     1141 taggagtacc gggaagctgt ccaaagcagg ttccgagtct tccagcagtg caggctcctc
     1201 aggatcgctg tcccgcaccc atccacctct ccagagcaca cccctagtct caggtgtggc
     1261 agctggctct ccaggctgtg tgccttatcc agagaatgga atagggggcc aggttgctcc
     1321 cagcagcacc agctacatcc tccttccact tgaagctgca acaggcatcc cgcctggaag
     1381 catccttctt aatccacaca caggccagcc ctttgtgaat cccgatggaa ctcctgcaat
     1441 atacaaccca cccaccagtc agcagcccct gcgaagcgcc atggtggggc agtcccaaca
     1501 gcagccacca cagcagcagc cctccccgca gccccaacag caggtccagc caccgcagcc
     1561 acagatggca ggccctctgg tcactcagtc tgtccagggg ctgcaggctt cctcccagtc
     1621 agtgcaatat ccagcagtct cttttcctcc ccagcacctc ctacctgtgt ctccaacgca
     1681 gcactttccc atgagagatg atgtggcaac acagtttggc cagatgaccc tgagccggca
     1741 gtcctcgggg gagactcctg aacccccatc aggtcctgtc tacccatcct cccttatgcc
     1801 acagccggcc cagcagccca gctatgtaat cgcctctaca ggccagcagc ttcctacagg
     1861 aggattctca ggctctggcc ctcccatctc ccagcaggtc ctccagcccc ctccctcacc
     1921 acagggattt gtgcaacagc ctccgcctgc acagatgcct gtatattatt acccatctgg
     1981 tcagtaccct acctcaacca cgcaacagta ccggcccatg gccccggttc agtacaacgc
     2041 tcagaggagt caacagatgc cacaggcagc acagcaagca ggttaccagc cagtcttgtc
     2101 tggtcaacag ggattccaag gcctaatagg agtgcagcag ccacctcaga gtcagaacgt
     2161 gataaataac caacaaggaa ctccggtgca aagcgtgatg gtttcctacc caacaatgtc
     2221 ttcttatcag gtgccaatga cccagggttc tcaaggactg ccccagcagt cataccaaca
     2281 gccaatcatg ctacctaacc aggcaggtca agggtcactc ccagccactg gaatgcctgt
     2341 ttactgtaat gtcacaccgc ccacccctca gaacaacctt aggctgattg gcccacactg
     2401 cccctccagc actgtcccag tgatgtcagc tagctgcaga acaaactgtg caagtatgag
     2461 caatgctggt tggcaggtca aattctgaga gctctggctg tggtacattt cttcagatat
     2521 ttctcatggc ctttgatgga agaggaacaa ggtgggaaaa ctggctgagg acttaagtat
     2581 tcactcaaca ctcaaatgat tgctgctggt attctgtaaa aaataaacaa agactaatat
     2641 acacgttagc tggttaatgg tgcatatttc tgtcatgtct gctaggtatg cctttatagc
     2701 ttagctagtg acatgaattc atcaaggtaa gattttctcc taccactgaa taccactgtg
     2761 tagattataa tatccctaat ttggattagt tttgtacttt gtgttgagtt tgtgatgcta
     2821 aaagtattta aaaattatat actaaatcac attgtaccaa agctgtaatg gaaaagcaaa
     2881 gaagaattga tgaattgaag gaataattta tatacattat agagttttct tttttaatgg
     2941 atatatactg tattgtagtg tttaatcaaa ataaaactat ttgaccttat ggaggaaggt
     3001 catgttttta ccacca
//
