LOCUS       NM_006628               5366 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens cAMP regulated phosphoprotein 19 (ARPP19), transcript
            variant 3, mRNA.
ACCESSION   NM_006628
VERSION     NM_006628.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5366)
  AUTHORS   Padi,S.K.R., Vos,M.R., Godek,R.J., Fuller,J.R., Kruse,T.,
            Hein,J.B., Nilsson,J., Kelker,M.S., Page,R. and Peti,W.
  TITLE     Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19
  JOURNAL   Nature 625 (7993), 195-203 (2024)
   PUBMED   38123684
REFERENCE   2  (bases 1 to 5366)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5366)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5366)
  AUTHORS   Xie,F., Xie,G. and Sun,Q.
  TITLE     Long Noncoding RNA DLX6-AS1 Promotes the Progression in Cervical
            Cancer by Targeting miR-16-5p/ARPP19 Axis
  JOURNAL   Cancer Biother Radiopharm 35 (2), 129-136 (2020)
   PUBMED   32077747
  REMARK    GeneRIF: Long Noncoding RNA DLX6-AS1 Promotes the Progression in
            Cervical Cancer by Targeting miR-16-5p/ARPP19 Axis.
REFERENCE   5  (bases 1 to 5366)
  AUTHORS   Ma,Y., Liu,Y., Pu,Y.S., Cui,M.L., Mao,Z.J., Li,Z.Z., He,L., Wu,M.
            and Wang,J.H.
  TITLE     LncRNA IGFL2-AS1 functions as a ceRNA in regulating ARPP19 through
            competitive binding to miR-802 in gastric cancer
  JOURNAL   Mol Carcinog 59 (3), 311-322 (2020)
   PUBMED   31943339
  REMARK    GeneRIF: The cAMP-regulated phosphoprotein 19 (ARPP19) was a direct
            target of miR-802 and could reverse the inhibitory function of
            miR-802. These data suggest that the IGFL2-AS1/miR-802/ARPP19 axis
            plays a critical role in the progression and metastasis of gastric
            cancer.
REFERENCE   6  (bases 1 to 5366)
  AUTHORS   Chin,L.S., Singh,S.K., Wang,Q. and Murray,S.F.
  TITLE     Identification of okadaic-acid-induced genes by mRNA differential
            display in glioma cells
  JOURNAL   J Biomed Sci 7 (2), 152-159 (2000)
   PUBMED   10754390
REFERENCE   7  (bases 1 to 5366)
  AUTHORS   Heron,L., Virsolvy,A., Peyrollier,K., Gribble,F.M., Le Cam,A.,
            Ashcroft,F.M. and Bataille,D.
  TITLE     Human alpha-endosulfine, a possible regulator of
            sulfonylurea-sensitive KATP channel: molecular cloning, expression
            and biological properties
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8387-8391 (1998)
   PUBMED   9653196
REFERENCE   8  (bases 1 to 5366)
  AUTHORS   Peyrollier,K., Heron,L., Virsolvy-Vergine,A., Le Cam,A. and
            Bataille,D.
  TITLE     Alpha endosulfine is a novel molecule, structurally related to a
            family of phosphoproteins
  JOURNAL   Biochem Biophys Res Commun 223 (3), 583-586 (1996)
   PUBMED   8687439
REFERENCE   9  (bases 1 to 5366)
  AUTHORS   Brene,S., Lindefors,N., Ehrlich,M., Taubes,T., Horiuchi,A.,
            Kopp,J., Hall,H., Sedvall,G., Greengard,P. and Persson,H.
  TITLE     Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in
            human brain tissue
  JOURNAL   J Neurosci 14 (3 Pt 1), 985-998 (1994)
   PUBMED   8120638
REFERENCE   10 (bases 1 to 5366)
  AUTHORS   Horiuchi,A., Williams,K.R., Kurihara,T., Nairn,A.C. and
            Greengard,P.
  TITLE     Purification and cDNA cloning of ARPP-16, a cAMP-regulated
            phosphoprotein enriched in basal ganglia, and of a related
            phosphoprotein, ARPP-19
  JOURNAL   J Biol Chem 265 (16), 9476-9484 (1990)
   PUBMED   2160982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025917.8.
            
            On Jun 2, 2019 this sequence version replaced NM_006628.5.
            
            Summary: The 19-kD cAMP-regulated phosphoprotein plays a role in
            regulating mitosis by inhibiting protein phosphatase-2A (PP2A; see
            MIM 176915) (summary by Gharbi-Ayachi et al., 2010 [PubMed
            21164014]).[supplied by OMIM, Feb 2011].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            lacks an in-frame exon in the CDS. The encoded isoform (2) is
            shorter than isoform 1. Both variants 3 and 4 encode isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.123244.1,
                                           SRR1803617.272375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2149178
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249822.9/ ENSP00000249822.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AC025917.8         113269-113451       c
            184-306             AC025917.8         101521-101643       c
            307-5366            AC025917.8         91466-96525         c
FEATURES             Location/Qualifiers
     source          1..5366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..5366
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /note="cAMP regulated phosphoprotein 19"
                     /db_xref="GeneID:10776"
                     /db_xref="HGNC:HGNC:16967"
                     /db_xref="MIM:605487"
     exon            1..183
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..477
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /note="isoform 2 is encoded by transcript variant 3;
                     cyclic AMP phosphoprotein, 19 kD; cAMP-regulated
                     phosphoprotein 19kDa"
                     /codon_start=1
                     /product="cAMP-regulated phosphoprotein 19 isoform 2"
                     /protein_id="NP_006619.1"
                     /db_xref="CCDS:CCDS32242.1"
                     /db_xref="GeneID:10776"
                     /db_xref="HGNC:HGNC:16967"
                     /db_xref="MIM:605487"
                     /translation="MSAEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPG
                     GSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPTAAPDKTEVTGDHIPTPQDLPQRK
                     PSLVASKLAG"
     exon            184..306
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /inference="alignment:Splign:2.1.0"
     exon            307..5366
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1199..1204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /note="hexamer: AATACA"
     polyA_site      1225
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /note="major polyA site"
     regulatory      5149..5154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /note="hexamer: AATAAA"
     polyA_site      5177
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
     regulatory      5199..5204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /note="hexamer: ATTAAA"
     polyA_site      5224
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
     regulatory      5345..5350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
                     /note="hexamer: ATTAAA"
     polyA_site      5366
                     /gene="ARPP19"
                     /gene_synonym="ARPP-16; ARPP-19; ARPP16; ENSAL"
ORIGIN      
        1 gtcataaggc ggcggccatt ttcgcgggcg gaggcggccc ggcgggccct gggagagctg
       61 ggacgggcgg cggccgggtg gcctcggcca cccgctaatt gcatcttttc ccggcgtctc
      121 gtctgcagag ggagcactat gtctgcggaa gtccccgagg cagcctccgc ggaggagcag
      181 aaggaaatgg aagataaagt gactagtcca gagaaagcag aagaagcaaa attaaaagca
      241 agatatcctc atctgggaca aaagcctgga ggttcagatt tcttaaggaa acggttgcag
      301 aaagggcaaa aatattttga ttctggggat tacaacatgg ctaaagcaaa aatgaagaac
      361 aagcaacttc ctactgcagc tccggataag acggaggtca ctggtgacca cattcccact
      421 ccgcaagacc ttcctcaacg gaagccgtcc cttgttgcta gcaagctggc tggctgatta
      481 agaggctgaa ctgcatgaat ctgctaaatc tcattatttc tccttaatat gttacttatc
      541 tactttttat ttcctttcat tcactagtca tttgagactg acagctttgc aggtagcagt
      601 agtgtgtgct gctattgtgg aatatacgtg tgtagagttt ttgattagtt taacagtgca
      661 ctggtgaaga ggacatgtta gagcaacata agtaaactac ttgaaaatag ttgtatatat
      721 tacctaactt ctagtgtagt actggttcta acaagtaaca agcaagtttt aaaattttaa
      781 tgttttggct ttcattactt catcttaatt atagctttgt atgttactct tatttaatat
      841 aatctctatt gtattgattt cttctgtatt taccttttgg attttgtaaa acagaagttt
      901 aagaccacaa gttagaagaa aggtcacata tttcaaacac aactagatgg ggctctgaaa
      961 gatttgtatc tctgtgcttg aacttgaatg gccttaaacc tgtttcagct ttaacagtag
     1021 aattttactt gggcaatatt tgcccattct ggtgtaactt atgtgactct agtgcttaac
     1081 agctgccgtt gaagctaata ttcagttctg tagagttaga ataccttttg ttgttgaaga
     1141 tgtgaatgaa gtatgcatgt gcattaactg ttgaattcac ttttgtgcca tttttgtaaa
     1201 tacagtagtt ttgcacaacc tctcacaaat gtctgtatta atttcacata cttaaaaagt
     1261 agataatgtg ccaaccagaa gcacaagagt tcctacacaa aactctgtaa atcattatag
     1321 cttttgtata ataagagtag tttacaatct cgggcttata gaataccaaa ctgaaatctt
     1381 agttcaatct gccatagact taagcttttc atttgttact aatatccatg acattcagtg
     1441 gccttgtgca aatacgatat gttgcttagg catatctttt gtcctatgca gaacctttca
     1501 ttttgatttt tatgaaagtt gcaattcatg taatttatat aaacttttta aatgtagaaa
     1561 ctttttactt ccacactcag ttttggagac cctagaataa aaggcttcaa tactctgcat
     1621 tccatgccct ctgccacctg cttttttttc ccctttgttc tttgactcaa atggtattga
     1681 gctgtttgtt gtatatggaa gcataggtgt ctatatcctt actcttttat ataacacaat
     1741 aatggcgttt tccttctaat ttctcagttg ttaacttctt tctctttttt ttttaggata
     1801 gggccttgct ctgtcacctg agctctagtg cagtagtgca atcacagctc actgcaacct
     1861 tactcctagg ctcaagttaa ctattcttga tcctttatta ttactaatat tctacaattg
     1921 tttaaataaa aggaacttta taatgaaacg gttcggaata ctggctcaag aacctatgtc
     1981 aagatgagct gaattttggt aaattatttt aggaattatg acaagctaat tgaattaggc
     2041 ttgtgacaat tagagtaatt tacatgacag gtaaaactcc tattaaaaat gtttagatgt
     2101 ttgcttctgt agatgtcact ttagtaaaat accaatttag ttttacttgt ggcttatcta
     2161 gttagaactt agcagacttt actgggacaa gtttactgct cttgtaggag ctcctctcac
     2221 aagtagttgt aatgctgtag catgatactc aggatcagta gcttgagatg ctactatttt
     2281 tctcttcatc tttgacttgc agagagcctc ccgtttttgg atccaggcat cttttctgaa
     2341 tcctggttcc atcagtatac ctgctctcct atgaccccaa atcatagtca atggtgcctc
     2401 aaacatagca ccttaagtta aaggctgcct agtgctctga ggaaagcttg ctgattatct
     2461 tcctgatcta ctcaccccaa aaggcagaaa agcaacacag tcactgctgt ggtcatttgt
     2521 aatgtaaaga tcagttatat atatatattt gtaatgagag caagtatata ctcattatag
     2581 aatcaattta agaagtttaa aataacccag agtagaattt ctatatctag tcttggtttt
     2641 tttcatgaat atttgcaagt aattaccatt aaattcacac atgaaagatt aatctgaaag
     2701 atcagagacc atgttattcc tgaccacgat agaactgctc ctgtggtttg ggacaagtaa
     2761 taaaacaact gcttgagttt tgtttgtaaa atacataatt aatatttgac ctacctcaaa
     2821 atgtattgag gatctgtgaa atgctaagtg cccaaaataa aatattgctg attgtctttt
     2881 tattaaaagt aaatttcctc attaagccaa cctgccttct gtaagtcaca gtgcttaaat
     2941 ctcaggattt ttcattagga gagacctgtc gttaaggatt tgtaggtata attgcttagc
     3001 ctccattatt ggtgcttggg atagagaggt tttagatttt tgtttttttt ttgttctgcc
     3061 tcaaagctca gtttattgaa gacatttgta agctattgga tcatcacttg aatcaagatt
     3121 ttgactagtg agcttaattg tccatttctt acaatttcaa agttacagtc tcagaaatgg
     3181 ttaattttaa taactgtcct atcataaatt aatgttggaa taaattgaag ttgttgataa
     3241 atacttcatg aaaactaaag tctgaaataa attacttgtt ttatgtccaa tagctactac
     3301 atttgataga acagttttga ggaacatttc attcttgaac gcagcatctg acatggttct
     3361 cagcaagttg gaatagtaag gattattggc ttgtttcgat gagtggaagc ggcatgtttg
     3421 tagcatacaa gttattcaat aatcttgtgc tgatgaccta aaaatatgtc ttaactattc
     3481 atcaaggaaa gcctggtgaa gcctttactt gttactactt caacagttgg aattagttgc
     3541 tctttttact tgatgaaaca aaactatacc tctgaatatt tatggatact ttttactaaa
     3601 tcaggcttgt gttcttaatc caaattagta aagttttatg gaagctgaaa tgtaatacag
     3661 tagtctcccc ttatctgtaa gagatacatt ccaagacccc tagtggatgc ctgaaacctc
     3721 agatagtact gaacccttta tcaactatgt tttttcagtc tgacaaccaa ggcggctact
     3781 aagtgactaa ggggcaggta gtatacagtg tggataagca ggacaaaggg gtgattcaca
     3841 tcccaggcag gacagagcag gagatcatga gatttcatca ctcaggatgg cttgtgattt
     3901 attttatttt attctttttt ttttttgaga tggagtctca ctcttgccca ggctggagtg
     3961 cagtggtgcg atcttggctc actgcaacct ctgcctcctg ggttcaagca gttctcctgc
     4021 ctcagcctcc caagtagctg ggattacagg cgtccgccac catgcccagc caatttttgt
     4081 acttttagta gagatggggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc
     4141 aggtgatcca ctcgcctcgg cctcccaaag tgctgggatt ataggcatgt gccaccatgc
     4201 ccggccggct tatgatttaa aacatgaatt gtttatttct ggaattttcc acataatatt
     4261 tttggaccaa ggttgcctca ggtaacaaac tacagaaagt gaaattgcag ataaagggga
     4321 ttactgctcc tctgctctaa aattggtgtt tgggtgatca gaagcaggta gccaatggga
     4381 agagcacttc tgagtgataa ctaaagcagt ttggtggcct tttcacattc tccaatgttc
     4441 aaacatattt tccactttcc attttctctt tcacctcatt ttgcctctct atcccccatc
     4501 cctgcttatt tcttaagccc attgatggca ctcattaaat tgtatttagg gctaatgagt
     4561 cattgttcct taatatcgtt ttcaatatgc cacaatttag gacacattta aaattttcta
     4621 aaacaatatc ctaatcaata ttgactaatt tgagccacat tcccaactct aactcagcac
     4681 acactgccag tcttccccaa tatctgtctc ctctcaattc cccaccacac cttataaaat
     4741 tgtaatcaaa gatatctcac tctgtcattg ttaatctaag aataaaaaca ctgactttaa
     4801 tacggtttta ctaagtttca accttctaat taggtaggcc tctaggtatt ctgcagatca
     4861 ctgctggtct tgatagccat taatatatgt ttgtattatg ttatttttca actaaatcgc
     4921 agttggaaaa aaacatattt aatattatgc ccttggatct gttactgcat cactagcact
     4981 tgtgatgcaa tagaacactt cgcctgtact gaaagggcca agagtaaatg ccttgttttg
     5041 tttttttgtt ttgttttgtt ttgctttttg ttaaaacatg tctatagagt tggcagttaa
     5101 tgctgaattt gtcaaatacc ccttccaaaa ttatacttgt atttaaaaaa taaatggatc
     5161 tacctaattt ctattgattt aatttgcagt tttgtcttat taaagtggta tgtttttcag
     5221 tgtatttttt ctgaagttga tctctttaca tttcagctat tactgtatgc aggaagaaac
     5281 tgacttgtaa tctttgattt tttttttttt tttgcatttg taaaggcttt gtacttaagg
     5341 taggattaaa tgtttgcaga ttgtga
//
