LOCUS       NM_182616               7587 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens actin related protein 2/3 complex inhibitor (ARPIN),
            transcript variant 1, mRNA.
ACCESSION   NM_182616
VERSION     NM_182616.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7587)
  AUTHORS   Park,M.J., Jeong,E., Lee,E.J., Choi,H.J., Moon,B.H., Kang,K. and
            Chang,S.
  TITLE     RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer Cells
            via ARPIN
  JOURNAL   Mol Cells 46 (6), 351-359 (2023)
   PUBMED   36921992
  REMARK    GeneRIF: RNA Editing Enzyme ADAR1 Suppresses the Mobility of Cancer
            Cells via ARPIN.
REFERENCE   2  (bases 1 to 7587)
  AUTHORS   Simanov,G., Dang,I., Fokin,A.I., Oguievetskaia,K., Campanacci,V.,
            Cherfils,J. and Gautreau,A.M.
  TITLE     Arpin Regulates Migration Persistence by Interacting with Both
            Tankyrases and the Arp2/3 Complex
  JOURNAL   Int J Mol Sci 22 (8), 4115 (2021)
   PUBMED   33923443
  REMARK    GeneRIF: Arpin Regulates Migration Persistence by Interacting with
            Both Tankyrases and the Arp2/3 Complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7587)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7587)
  AUTHORS   Jubrail,J., Africano-Gomez,K., Herit,F., Mularski,A.,
            Bourdoncle,P., Oberg,L., Israelsson,E., Burgel,P.R., Mayer,G.,
            Cunoosamy,D.M., Kurian,N. and Niedergang,F.
  TITLE     Arpin is critical for phagocytosis in macrophages and is targeted
            by human rhinovirus
  JOURNAL   EMBO Rep 21 (1), e47963 (2020)
   PUBMED   31721415
  REMARK    GeneRIF: Arpin is critical for phagocytosis in macrophages and is
            targeted by human rhinovirus.
REFERENCE   5  (bases 1 to 7587)
  AUTHORS   Li,Y., Qiu,J., Pang,T., Guo,Z., Su,Y., Zeng,Q. and Zhang,X.
  TITLE     Restoration of Arpin suppresses aggressive phenotype of breast
            cancer cells
  JOURNAL   Biomed Pharmacother 92, 116-121 (2017)
   PUBMED   28531800
  REMARK    GeneRIF: ARPIN is down-regulated in breast cancer cells and
            predicts poor prognosis in breast cancer patients. Data suggest
            that restoration of ARPIN in breast cancer cells suppresses cell
            proliferation, colony formation, cell cycle distribution, invasion
            in vitro, and tumorigenesis in vivo (xenograft experiments in nude
            mice); Arpin acts as tumor suppressor in breast cancer and is
            associated with inhibition of Akt signaling.
REFERENCE   6  (bases 1 to 7587)
  AUTHORS   Li,T., Zheng,H.M., Deng,N.M., Jiang,Y.J., Wang,J. and Zhang,D.L.
  TITLE     Clinicopathological and prognostic significance of aberrant Arpin
            expression in gastric cancer
  JOURNAL   World J Gastroenterol 23 (8), 1450-1457 (2017)
   PUBMED   28293092
  REMARK    GeneRIF: Low Arpin levels are associated with clinicopathological
            variables and a poor prognosis in gastric cancer patients
REFERENCE   7  (bases 1 to 7587)
  AUTHORS   Liu,X., Zhao,B., Wang,H., Wang,Y., Niu,M., Sun,M., Zhao,Y., Yao,R.
            and Qu,Z.
  TITLE     Aberrant expression of Arpin in human breast cancer and its
            clinical significance
  JOURNAL   J Cell Mol Med 20 (3), 450-458 (2016)
   PUBMED   26648569
  REMARK    GeneRIF: Arpin downregulation may contribute to the initiation and
            development of breast cancer metastasis.
REFERENCE   8  (bases 1 to 7587)
  AUTHORS   Fetics,S., Thureau,A., Campanacci,V., Aumont-Nicaise,M., Dang,I.,
            Gautreau,A., Perez,J. and Cherfils,J.
  TITLE     Hybrid Structural Analysis of the Arp2/3 Regulator Arpin Identifies
            Its Acidic Tail as a Primary Binding Epitope
  JOURNAL   Structure 24 (2), 252-260 (2016)
   PUBMED   26774128
  REMARK    GeneRIF: Data reveal that Arpin is comprised of an elongated
            globular core from which the C-terminal tail extends as a linear
            peptide, thus forming a primary epitope that is readily available
            to tether Arpin to interacting proteins.
REFERENCE   9  (bases 1 to 7587)
  AUTHORS   Deng,W.S., Zhang,J., Ju,H., Zheng,H.M., Wang,J., Wang,S. and
            Zhang,D.L.
  TITLE     Arpin contributes to bacterial translocation and development of
            severe acute pancreatitis
  JOURNAL   World J Gastroenterol 21 (14), 4293-4301 (2015)
   PUBMED   25892881
  REMARK    GeneRIF: Arpin protein affects the expression of tight junction
            proteins and may have an impact on bacterial translocation in
            severe acute pancreatitis.
REFERENCE   10 (bases 1 to 7587)
  AUTHORS   Dang,I., Gorelik,R., Sousa-Blin,C., Derivery,E., Guerin,C.,
            Linkner,J., Nemethova,M., Dumortier,J.G., Giger,F.A.,
            Chipysheva,T.A., Ermilova,V.D., Vacher,S., Campanacci,V.,
            Herrada,I., Planson,A.G., Fetics,S., Henriot,V., David,V.,
            Oguievetskaia,K., Lakisic,G., Pierre,F., Steffen,A., Boyreau,A.,
            Peyrieras,N., Rottner,K., Zinn-Justin,S., Cherfils,J., Bieche,I.,
            Alexandrova,A.Y., David,N.B., Small,J.V., Faix,J., Blanchoin,L. and
            Gautreau,A.
  TITLE     Inhibitory signalling to the Arp2/3 complex steers cell migration
  JOURNAL   Nature 503 (7475), 281-284 (2013)
   PUBMED   24132237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB285255.1, AC027176.23, BC053602.1, AK055252.1 and BM023230.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182616.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the  longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.231591.1,
                                           SRR1660803.240932.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357484.10/ ENSP00000350075.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DB285255.1         40-44
            6-25                AC027176.23        73137-73156         c
            26-1096             BC053602.1         1-1071
            1097-1186           AC027176.23        61616-61705         c
            1187-1993           BC053602.1         1162-1968
            1994-3535           AC027176.23        59267-60808         c
            3536-5146           AK055252.1         1-1611
            5147-5271           AC027176.23        57531-57655         c
            5272-5987           AK055252.1         1737-2452
            5988-6061           BM023230.1         16-89               c
            6062-7587           AC027176.23        55215-56740         c
FEATURES             Location/Qualifiers
     source          1..7587
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..7587
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="actin related protein 2/3 complex inhibitor"
                     /db_xref="GeneID:348110"
                     /db_xref="HGNC:HGNC:28782"
                     /db_xref="MIM:615543"
     exon            1..209
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..798
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0552 protein C15orf38; arp2/3 inhibition protein"
                     /codon_start=1
                     /product="arpin isoform 1"
                     /protein_id="NP_872422.1"
                     /db_xref="CCDS:CCDS42080.1"
                     /db_xref="GeneID:348110"
                     /db_xref="HGNC:HGNC:28782"
                     /db_xref="MIM:615543"
                     /translation="MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDV
                     SRHSILDTHGRKERYYVLYIRPSHIHRRKFDAKGNEIEPNFSATRKVNTGFLMSSYKV
                     EAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRL
                     KTRGDGPFLDSLAKLEAGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDG
                     AEDEEWDD"
     exon            210..285
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            286..418
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            419..625
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            626..789
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /inference="alignment:Splign:2.1.0"
     exon            790..7587
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      943..948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="hexamer: AACAAG"
     polyA_site      964
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="major polyA site"
     regulatory      1701..1706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="hexamer: AGTAAA"
     polyA_site      1720
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
     regulatory      5985..5990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="hexamer: TATAAA"
     polyA_site      5994
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="major polyA site"
     regulatory      6041..6046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="hexamer: AATACA"
     polyA_site      6061
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
     regulatory      6184..6189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="hexamer: ATTAAA"
     polyA_site      6206
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
     regulatory      7567..7572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
                     /note="hexamer: CATAAA"
     polyA_site      7587
                     /gene="ARPIN"
                     /gene_synonym="C15orf38"
ORIGIN      
        1 attcccggat ccgccggctg ggaatcgcgg gtccccgcgc gtcctgcagc acttcccgcg
       61 ccgcgccccc agcccagtgc gccggctctg tgccggggtg cccgggcggt cgggagaatg
      121 agccgcatct accacgacgg cgcgctccgg aacaaggcgg tgcagagcgt ccggctgcca
      181 ggggcctggg accccgccgc ccaccagggg ggaaatggtg tcctgctgga gggagaactg
      241 atcgatgtat ctcggcacag catcttggac actcatggca ggaaggagcg ctactacgtg
      301 ctgtatatcc ggcccagtca catccatcgc cgtaaattcg acgccaaggg aaatgaaatc
      361 gagcccaact tcagcgccac caggaaggtg aacacgggct tcctcatgtc gtcctacaag
      421 gtggaagcca agggggacac tgacaggctc acgcccgagg cgctgaaggg gctggtcaac
      481 aagccagagc tgctcgcgct gacagagagc ctcacccccg accacacagt ggcgttctgg
      541 atgcccgagt cagagatgga ggtgatggaa ctcgagctgg gggccggggt acggctgaag
      601 actcggggcg atggtccctt cctggattca ttggccaaac ttgaggctgg aacagtgacc
      661 aagtgtaatt tcactggtga tggaaagaca ggggcatcct ggacagacaa catcatggcc
      721 caaaagtgtt cgaagggggc tgcagcggag atccgagagc agggggatgg ggcagaggac
      781 gaggagtggg atgactgagg gacgtggctg cctctggggg caccagcacc ttctgtagca
      841 ttgtggaaca tttcttccat gaacttctac tctggagctg gagagaacag tctgccaagt
      901 cttacctggt tcttccccat agccaccttg gaatactctt tgaacaagct ctgctaaaac
      961 caaacccatg accactgtgt tggtggtggg gcctcatgct gtggctcagg gagggcccct
     1021 ccctgcatgt gagtctagcc ttcctagaca ttacatgatg accctttaaa aaaaaattag
     1081 agatggaggt ctcactatgt tgcccaggct gatctcaaac tcctggactc aagcgatcca
     1141 cccccctcca cctcccaagg tgttgggatt acaggcgtga gccactgcac ccagcctcat
     1201 gttgaccctg gccctggata gcagctttgt ttgtagaggc aggtggtggg agagacccta
     1261 ggacagcctg agagtaactg gacctggtat tggtgcggag tggggaatat cccttgtcta
     1321 aatgcagagc agctgagaga agttagcggg gctcttcctc cgttctcatt gtttcctgct
     1381 ttccttcccc acccacccct tcctcagcac tctgtgttgt agcctgtact atcctgcttc
     1441 aagcctccgt gtcccttgta ccttccccct accttgagtt gccagttctt tactccctca
     1501 aatgttccca tgccacctct ggggtttctg ttatctgaca tccctggctg ctttcctggt
     1561 agatgccatt cccagagagg ccaacagcgt tcccaggcgt ggctggctgg tccgcatctc
     1621 tcagactcac tctgccaggc tacagttttg agaatacctt ttttgttgtt gttttgtacc
     1681 tggagaactt tttatgaatg agtaaatctt cagaaaggaa ttcctccacc cttactgggt
     1741 tattgtcagg tgtaaacggc ctttcagctg agcaatgttc ctatgagaag gaagccattt
     1801 ctcttggctc atgaacactg ccttttgggt agtataccca cacccagatc tgtgaagaga
     1861 cctggaattg aagtctccat gtcgtcagga cttggtggca tgtggatctt gcttgacttg
     1921 ggaaaagaga gggtggtggt gaactaataa ttatggagtc cccctaatgt gtcgaacaca
     1981 atgctagatg atttccatga taataattac tcatacttgt gctaagcact tgcgatatcg
     2041 tacttctcac aacagtccat gaggtactga ttattattcc cattttctca tgagactaaa
     2101 gctcagagct ctaggatagt atacagtggc aagaggaatt tacatccaag cactcagatt
     2161 tcaaagccca cattcttaac taccggacta ttcatattac agagcaggaa aagggtctca
     2221 gacaggttaa gcaacctgcc cagagtcaca cagctaatga gtagcagaat caggattcaa
     2281 acccagagct gtcaaaagca aaccttatgt tccttccact gtcccctgct tccttgccct
     2341 tcagaaaggt cttggaaaca ggggccagag gatgtggtag ccacttcact ggtgttctgt
     2401 gtctgaatgg gactttctca caggcaggcc atgctgggac ctcagccatg ggggtggcca
     2461 gggaggtggt tgagcagaag gatagctggg gacactgact gggggtagag tcacccagtg
     2521 tctttagaca tcctgctgtc taaagcactg tgtccaaagg gtatggcaca cttatatgga
     2581 caggtcacca ttccaaacaa ggaggcccag tgtgtcaata ggagaggtcc taaagcaaca
     2641 aaaagggcgg ggtgtcttgg atgggcttca ggaagggaaa gaccattgtg tctggagctc
     2701 agagaatggg ggctggtgtt tgagatgagg ctggagattg ggcatggcat cctcacgcat
     2761 gttaaggaat tggggacttt atccttaaca tcctggaagc cagtgatccc atggagagtg
     2821 agaagatctg atctgtgttt caaaggtcac ttgactgccg agcagctgga ggcgagttgc
     2881 tcctttagga gactgctgca gttgcctggg tgagaggcta gaggggtctg gtctatagca
     2941 gtggcagggg agatggaaag aagagaatga tttgaggggc attcgggggg caaaatcaac
     3001 aggacctggg gggagacgaa gggatcaaga atgatgccca gattctgggt gagtggcagt
     3061 gctgtggtgc acaagtagtg atgttatgtt tccgggtgac ctgctgttta gcaggagccc
     3121 agcctgtggc taagaagtat agagaactga aactagctcc ctagggatgg gaaaaccaag
     3181 tgggctgagg ataagaacag ggccccaggg ctgggtgcag tcgctcacgc ctgtaatctt
     3241 agcactttgg gaggccgagg tgggcggatc acttgaggtc aggagttcga aaccagcctg
     3301 atcaacacag tgaaaccccg tctctaccaa aaaatacaaa aattacccgg acatggtggc
     3361 acatgcctgt agttccagcg ccttgggagg ctgaggcatg agaatttctt gaacccggga
     3421 ggtggaggtt gcagtgagct gagattgcca ctgcactcca gcctgggcaa cacagtgaga
     3481 ccctgtctca aaaaaaaaaa aaaaaaaaag aatagggtcc caggctcagc aggtagggac
     3541 actgaggtaa aatcctattc cctaggacta gggactagga agggagaaaa taggaagctg
     3601 ctgtggcata ggcatctgca tgggcagatg gtgaggccaa agcccctgat tttgccatac
     3661 ctcctgccct ggtcaggact ggttcaggca ttagggcagg cccagccagg gcagaagcct
     3721 tcctagatac acctgtgggg agttgaggaa ctacagcagg gctgaaaccc tgctttcagg
     3781 ggcccccatg tggctggtag gggcagcttt tggaagctag actggatcct attactcccc
     3841 agatgaaaag ttcaaattcc ttaatacaac tcagagctca tcacaatgtc acaaccctcc
     3901 tttctcggct cgcttcctcc ttaagagctc tggggcgatt ctttcagacc agcctgaggg
     3961 atcttccaca ggttgttaat agggctagaa acaaaaagtg gtggtgtttc tatgatctaa
     4021 tttgttggaa caaacgtagt gttaaactca aacatttctg taggatttct tggagcttta
     4081 actatactaa catttactgt aactcttcag gacagggtat gattacgtat ttcccacatt
     4141 tctttggtca gagaacccgt ttttgtgagg agcatttcat gggacagctg ttgtgagaaa
     4201 cagtttggga agggctgtgt tggtcccatg gaggggctgg ctgttcccag agcaggtcac
     4261 tcccccactt gcattgcctt gcctggactc ttttcttgga gggaggtccc tttcctctac
     4321 ccatctgaat ttttttttct tccaccagtg tccagcttgc ctttcaccat gggcctaatg
     4381 atggaaatta cagttatttt gtatcttcaa acagaaccaa gcaaatcctc tgagcttcat
     4441 tcatatggga aattttcttt ctttcttttt tttttttttg agatggaatt tcgctcttgt
     4501 tgcccaggct ggagtgcaat ggctcaatct cggctcactg caacctccac ctcccaggtt
     4561 caagagtttc tcctgcctca gcaggaggat tactgtaatc ccaagtagct gggattacag
     4621 gcctgcgcca ccacgactag ctaattttgt acttttagta gagatgcgat ttcaccatgt
     4681 tggctaggct ggtctcgaac tcctgacctc aggtgatcca ccctcctcag cctcccaaag
     4741 tgctgggatt acaggcatga gccacagtgc cggacattat gggaaaattt tttgagggac
     4801 taaactaatc tccacaaata gcaatgcatt taggaaatat atttaaaggg gaaaaaaaga
     4861 ctcatagttt cactcagtca tgttcataat ttttagtatt tgggtttttt agcatgtaat
     4921 ttgtgtacat agttttggtt tttgtaaact tgcatagggg ttttctggta caaactggaa
     4981 aacctgctag acaaattctg aaacatctgt aatgcttgta ggtagttgtt gtaacactat
     5041 gcccacacat aatcactttc catattgctg catagtcttt gtaaccattt ttcttcttct
     5101 tttttttgag atggagtttt gctcttgttg cccaggctgg agtgcaatgg cgcgatcttg
     5161 gcccactgca acctctgcct cccgggttca agctattctg ctgccttagc ctcccgagta
     5221 gctgggatta caggcacacg ccaccacgcc cggctagttt ttgtattttt agtagagacg
     5281 gggtttcacc atgtcagcca ggcttttctt gaacttctga tctcaagtga tcctcactcc
     5341 tcagcctccc aaattgctgg gattacaggc gtgagccacc acgcccacct gtaaccatta
     5401 tttttaagat tgctaccatt ggatagttct gtcatggtcc aacttttgga tatttaaaat
     5461 tgatccctgt gtggctaaca gaattaatgt ttccaaaaat gttgaaaatt atatagttct
     5521 cttaattccc cacctctaac tatatttttg ggttatttct ttaggaacag atgcccagga
     5581 gtcatattac tgagaatcta gaaatctttt gcaaagttct tgttatattg ccaaattgct
     5641 tcccaaaagg gttgttctaa accataattt caccagcaat gtaggggaga accattttta
     5701 tgctgccctt gtgagaattg ggtatgaaaa catttttaaa atgatttttg atgaggtgaa
     5761 aataatattt gaatatattt taatttgcct ttcccccact tatagtgagc ttaaacattt
     5821 tttccttttc ctagctgtat ttctcccttt gttattcgtt ctttcgtcca tttatctact
     5881 ggggagatgg ggagtgttat ctttttagtt tatcagttat ttgcatttta aatataacca
     5941 tttgccatat tttaacaacg atttttccat taaataattc tttttataaa aaaactttat
     6001 atatctgttg atgttttgtg atttttattg cttctaagct aatacagatt tttggatctt
     6061 attcaatttc gctttcttct gtttaggtta ttatctggtt ttatacctaa ctacttattt
     6121 tcaaattgct aaccagttat cctaatagta tttactgaat tccttcccac tcctacatca
     6181 catattaaaa ttattttatg cctaaattat ttataatatt tcagttattc ttcctataat
     6241 tacaatttga accatcaaag taggttttca tagttggcag agctagttct tcttcataat
     6301 tctgtttcag aattttcttt gatattcttc ctcaacattt taaacatttt gtcaagtttc
     6361 agtgcaactg acttttggtt tttatttatt taaaaactgg gccatgccgg gcgcagtggc
     6421 tcacgcctgt aatcccagca cttcgggaga ctgagatggg tgaatcactt gaggtcagga
     6481 gtttgagacc agactggcca atgtggtgaa accccatctc tactaaaaat acaaaaattt
     6541 gctgggcatg gtggcatgtg cctgtaatcc cagctactgg ggaggctgaa gcaggagaat
     6601 tgtttgaacc cgggagacgg aggttgcagt gagccaagat tgtgccactg cactccagcc
     6661 tgggcaacag agtgagactc catctcaaac aaacaaacaa acaaacaaac aaaaaactgg
     6721 actaggcgtg gtggcggttt gggagactga ggctggagga ttgcctgagg ccagcagttt
     6781 gaggttacag tgaggtatga ctgtgccact gcactccaac ctgggtaaga ccctatctct
     6841 gaaaaacaaa caagcaaacc ccagaactct ggctgcaaaa gtagtacata tttctttgaa
     6901 ggaaaaaaag gaaaacttga taatcctacc acccaaagat gtttttaaat cacttatgtg
     6961 gtactcagtt atgtgccatg cactgtccaa gtgcttacaa atattatact aactcccttt
     7021 gtgtttataa caactgtctg aagtcagtag actcattttc cagttttcca gtttaggaaa
     7081 ctgatattac accttttcta cagatgggga aacttgccca gggtgcccag gcagtccgca
     7141 gaaccatgct ttgaatcagg gcagtgtggt tccagggtcc tgtacagatc aaacaccctg
     7201 actctgccat tccatcagat acatgattca tattttggtg tatttgcctc caatcttgag
     7261 caaagtgggt tgtccctgta catactttgt gtaatctttt agcttaacag gtgtcatgaa
     7321 cacttccgta tcataaatct ttcccagcat gatttttatt atctatttaa tatttctcat
     7381 attcaatgta gaacaatgca cttaaccaat ttctcatttt tgtaataatt ttcttcccat
     7441 tttcccctgt aataacactg ctgagatata tatttttttc ttcttttttt tactgttctg
     7501 aagatactct ggcagaaatg tatgttcctc aggctaaatc ttttcacaca tccacaatca
     7561 ttttatcata aattctagag ctggaaa
//
