LOCUS       NM_001199058            6218 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ARPIN-AP3S2 readthrough (ARPIN-AP3S2), mRNA.
ACCESSION   NM_001199058
VERSION     NM_001199058.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6218)
  AUTHORS   Mahajan,A., Go,M.J., Zhang,W., Below,J.E., Gaulton,K.J.,
            Ferreira,T., Horikoshi,M., Johnson,A.D., Ng,M.C., Prokopenko,I.,
            Saleheen,D., Wang,X., Zeggini,E., Abecasis,G.R., Adair,L.S.,
            Almgren,P., Atalay,M., Aung,T., Baldassarre,D., Balkau,B., Bao,Y.,
            Barnett,A.H., Barroso,I., Basit,A., Been,L.F., Beilby,J.,
            Bell,G.I., Benediktsson,R., Bergman,R.N., Boehm,B.O.,
            Boerwinkle,E., Bonnycastle,L.L., Burtt,N., Cai,Q., Campbell,H.,
            Carey,J., Cauchi,S., Caulfield,M., Chan,J.C., Chang,L.C.,
            Chang,T.J., Chang,Y.C., Charpentier,G., Chen,C.H., Chen,H.,
            Chen,Y.T., Chia,K.S., Chidambaram,M., Chines,P.S., Cho,N.H.,
            Cho,Y.M., Chuang,L.M., Collins,F.S., Cornelis,M.C., Couper,D.J.,
            Crenshaw,A.T., van Dam,R.M., Danesh,J., Das,D., de Faire,U.,
            Dedoussis,G., Deloukas,P., Dimas,A.S., Dina,C., Doney,A.S.,
            Donnelly,P.J., Dorkhan,M., van Duijn,C., Dupuis,J., Edkins,S.,
            Elliott,P., Emilsson,V., Erbel,R., Eriksson,J.G., Escobedo,J.,
            Esko,T., Eury,E., Florez,J.C., Fontanillas,P., Forouhi,N.G.,
            Forsen,T., Fox,C., Fraser,R.M., Frayling,T.M., Froguel,P.,
            Frossard,P., Gao,Y., Gertow,K., Gieger,C., Gigante,B., Grallert,H.,
            Grant,G.B., Grrop,L.C., Groves,C.J., Grundberg,E., Guiducci,C.,
            Hamsten,A., Han,B.G., Hara,K., Hassanali,N., Hattersley,A.T.,
            Hayward,C., Hedman,A.K., Herder,C., Hofman,A., Holmen,O.L.,
            Hovingh,K., Hreidarsson,A.B., Hu,C., Hu,F.B., Hui,J.,
            Humphries,S.E., Hunt,S.E., Hunter,D.J., Hveem,K., Hydrie,Z.I.,
            Ikegami,H., Illig,T., Ingelsson,E., Islam,M., Isomaa,B.,
            Jackson,A.U., Jafar,T., James,A., Jia,W., Jockel,K.H., Jonsson,A.,
            Jowett,J.B., Kadowaki,T., Kang,H.M., Kanoni,S., Kao,W.H.,
            Kathiresan,S., Kato,N., Katulanda,P., Keinanen-Kiukaanniemi,K.M.,
            Kelly,A.M., Khan,H., Khaw,K.T., Khor,C.C., Kim,H.L., Kim,S.,
            Kim,Y.J., Kinnunen,L., Klopp,N., Kong,A., Korpi-Hyovalti,E.,
            Kowlessur,S., Kraft,P., Kravic,J., Kristensen,M.M., Krithika,S.,
            Kumar,A., Kumate,J., Kuusisto,J., Kwak,S.H., Laakso,M., Lagou,V.,
            Lakka,T.A., Langenberg,C., Langford,C., Lawrence,R., Leander,K.,
            Lee,J.M., Lee,N.R., Li,M., Li,X., Li,Y., Liang,J., Liju,S.,
            Lim,W.Y., Lind,L., Lindgren,C.M., Lindholm,E., Liu,C.T., Liu,J.J.,
            Lobbens,S., Long,J., Loos,R.J., Lu,W., Luan,J., Lyssenko,V.,
            Ma,R.C., Maeda,S., Magi,R., Mannisto,S., Matthews,D.R., Meigs,J.B.,
            Melander,O., Metspalu,A., Meyer,J., Mirza,G., Mihailov,E.,
            Moebus,S., Mohan,V., Mohlke,K.L., Morris,A.D., Muhleisen,T.W.,
            Muller-Nurasyid,M., Musk,B., Nakamura,J., Nakashima,E., Navarro,P.,
            Ng,P.K., Nica,A.C., Nilsson,P.M., Njolstad,I., Nothen,M.M.,
            Ohnaka,K., Ong,T.H., Owen,K.R., Palmer,C.N., Pankow,J.S.,
            Park,K.S., Parkin,M., Pechlivanis,S., Pedersen,N.L., Peltonen,L.,
            Perry,J.R., Peters,A., Pinidiyapathirage,J.M., Platou,C.G.,
            Potter,S., Price,J.F., Qi,L., Radha,V., Rallidis,L., Rasheed,A.,
            Rathman,W., Rauramaa,R., Raychaudhuri,S., Rayner,N.W., Rees,S.D.,
            Rehnberg,E., Ripatti,S., Robertson,N., Roden,M., Rossin,E.J.,
            Rudan,I., Rybin,D., Saaristo,T.E., Salomaa,V., Saltevo,J.,
            Samuel,M., Sanghera,D.K., Saramies,J., Scott,J., Scott,L.J.,
            Scott,R.A., Segre,A.V., Sehmi,J., Sennblad,B., Shah,N., Shah,S.,
            Shera,A.S., Shu,X.O., Shuldiner,A.R., Sigurdsson,G., Sijbrands,E.,
            Silveira,A., Sim,X., Sivapalaratnam,S., Small,K.S., So,W.Y.,
            Stancakova,A., Stefansson,K., Steinbach,G., Steinthorsdottir,V.,
            Stirrups,K., Strawbridge,R.J., Stringham,H.M., Sun,Q., Suo,C.,
            Syvanen,A.C., Takayanagi,R., Takeuchi,F., Tay,W.T., Teslovich,T.M.,
            Thorand,B., Thorleifsson,G., Thorsteinsdottir,U., Tikkanen,E.,
            Trakalo,J., Tremoli,E., Trip,M.D., Tsai,F.J., Tuomi,T.,
            Tuomilehto,J., Uitterlinden,A.G., Valladares-Salgado,A.,
            Vedantam,S., Veglia,F., Voight,B.F., Wang,C., Wareham,N.J.,
            Wennauer,R., Wickremasinghe,A.R., Wilsgaard,T., Wilson,J.F.,
            Wiltshire,S., Winckler,W., Wong,T.Y., Wood,A.R., Wu,J.Y., Wu,Y.,
            Yamamoto,K., Yamauchi,T., Yang,M., Yengo,L., Yokota,M., Young,R.,
            Zabaneh,D., Zhang,F., Zhang,R., Zheng,W., Zimmet,P.Z.,
            Altshuler,D., Bowden,D.W., Cho,Y.S., Cox,N.J., Cruz,M., Hanis,C.L.,
            Kooner,J., Lee,J.Y., Seielstad,M., Teo,Y.Y., Boehnke,M.,
            Parra,E.J., Chambers,J.C., Tai,E.S., McCarthy,M.I. and Morris,A.P.
  CONSRTM   DIAbetes Genetics Replication And Meta-analysis (DIAGRAM)
            Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes
            (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D)
            Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium;
            Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in
            muylti-Ethnic Samples (T2D-GENES) Consortium
  TITLE     Genome-wide trans-ancestry meta-analysis provides insight into the
            genetic architecture of type 2 diabetes susceptibility
  JOURNAL   Nat Genet 46 (3), 234-244 (2014)
   PUBMED   24509480
REFERENCE   2  (bases 1 to 6218)
  AUTHORS   Hara,K., Fujita,H., Johnson,T.A., Yamauchi,T., Yasuda,K.,
            Horikoshi,M., Peng,C., Hu,C., Ma,R.C., Imamura,M., Iwata,M.,
            Tsunoda,T., Morizono,T., Shojima,N., So,W.Y., Leung,T.F., Kwan,P.,
            Zhang,R., Wang,J., Yu,W., Maegawa,H., Hirose,H., Kaku,K., Ito,C.,
            Watada,H., Tanaka,Y., Tobe,K., Kashiwagi,A., Kawamori,R., Jia,W.,
            Chan,J.C., Teo,Y.Y., Shyong,T.E., Kamatani,N., Kubo,M., Maeda,S.
            and Kadowaki,T.
  CONSRTM   DIAGRAM consortium
  TITLE     Genome-wide association study identifies three novel loci for type
            2 diabetes
  JOURNAL   Hum Mol Genet 23 (1), 239-246 (2014)
   PUBMED   23945395
REFERENCE   3  (bases 1 to 6218)
  AUTHORS   Kooner,J.S., Saleheen,D., Sim,X., Sehmi,J., Zhang,W., Frossard,P.,
            Been,L.F., Chia,K.S., Dimas,A.S., Hassanali,N., Jafar,T.,
            Jowett,J.B., Li,X., Radha,V., Rees,S.D., Takeuchi,F., Young,R.,
            Aung,T., Basit,A., Chidambaram,M., Das,D., Grundberg,E.,
            Hedman,A.K., Hydrie,Z.I., Islam,M., Khor,C.C., Kowlessur,S.,
            Kristensen,M.M., Liju,S., Lim,W.Y., Matthews,D.R., Liu,J.,
            Morris,A.P., Nica,A.C., Pinidiyapathirage,J.M., Prokopenko,I.,
            Rasheed,A., Samuel,M., Shah,N., Shera,A.S., Small,K.S., Suo,C.,
            Wickremasinghe,A.R., Wong,T.Y., Yang,M., Zhang,F., Abecasis,G.R.,
            Barnett,A.H., Caulfield,M., Deloukas,P., Frayling,T.M., Froguel,P.,
            Kato,N., Katulanda,P., Kelly,M.A., Liang,J., Mohan,V.,
            Sanghera,D.K., Scott,J., Seielstad,M., Zimmet,P.Z., Elliott,P.,
            Teo,Y.Y., McCarthy,M.I., Danesh,J., Tai,E.S. and Chambers,J.C.
  CONSRTM   DIAGRAM; MuTHER
  TITLE     Genome-wide association study in individuals of South Asian
            ancestry identifies six new type 2 diabetes susceptibility loci
  JOURNAL   Nat Genet 43 (10), 984-989 (2011)
   PUBMED   21874001
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6218)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6218)
  AUTHORS   Eriksson,N., Macpherson,J.M., Tung,J.Y., Hon,L.S., Naughton,B.,
            Saxonov,S., Avey,L., Wojcicki,A., Pe'er,I. and Mountain,J.
  TITLE     Web-based, participant-driven studies yield novel genetic
            associations for common traits
  JOURNAL   PLoS Genet 6 (6), e1000993 (2010)
   PUBMED   20585627
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027176.23, AK000495.1 and AC018988.12.
            
            On Jun 2, 2019 this sequence version replaced NM_001199058.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring C15orf38 (chromosome 15 open
            reading frame 38) and AP3S2 (adaptor-related protein complex 3,
            sigma 2 subunit) genes. The read-through transcript encodes a
            fusion protein that shares sequence identity with each individual
            gene product. [provided by RefSeq, Nov 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3542710.1, AK000495.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 10239, 348110
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AC027176.23        73092-73161         c
            71-2509             AK000495.1         1-2439
            2510-6218           AC018988.12        83666-87374         c
FEATURES             Location/Qualifiers
     source          1..6218
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..6218
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /note="ARPIN-AP3S2 readthrough"
                     /db_xref="GeneID:100526783"
                     /db_xref="HGNC:HGNC:38824"
     exon            1..209
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1302
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /note="Arp2/3 inhibition protein; C15orf38-AP3S2
                     readthrough"
                     /codon_start=1
                     /product="uncharacterized protein LOC100526783"
                     /protein_id="NP_001185987.1"
                     /db_xref="GeneID:100526783"
                     /db_xref="HGNC:HGNC:38824"
                     /translation="MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDV
                     SRHSILDTHGRKERYYVLYIRPSHIHRRKFDAKGNEIEPNFSATRKVNTGFLMSSYKV
                     EAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRL
                     KTRGDGPFLDSLAKLEAGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDG
                     AEDEEWPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVF
                     CVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETN
                     MNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEIPRNINIGDLNIKVPNLSQ
                     FV"
     exon            210..285
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..418
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..625
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..789
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..881
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..993
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1065
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1173
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..6218
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2490..2495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /note="hexamer: AATACA"
     polyA_site      2512
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /note="major polyA site"
     regulatory      3234..3239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /note="hexamer: AATAAA"
     polyA_site      3261
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
     regulatory      6194..6199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /note="hexamer: AATAAA"
     polyA_site      6218
                     /gene="ARPIN-AP3S2"
                     /gene_synonym="ARPIN; C15orf38; C15orf38-AP3S2"
                     /note="major polyA site"
ORIGIN      
        1 attcccggat ccgccggctg ggaatcgcgg gtccccgcgc gtcctgcagc acttcccgcg
       61 ccgcgccccc agcccagtgc gccggctctg tgccggggtg cccgggcggt cgggagaatg
      121 agccgcatct accacgacgg cgcgctccgg aacaaggcgg tgcagagcgt ccggctgcca
      181 ggggcctggg accccgccgc ccaccagggg ggaaatggtg tcctgctgga gggagaactg
      241 atcgatgtat ctcggcacag catcttggac actcatggca ggaaggagcg ctactacgtg
      301 ctgtatatcc ggcccagtca catccatcgc cgtaaattcg acgccaaggg aaatgaaatc
      361 gagcccaact tcagcgccac caggaaggtg aacacgggct tcctcatgtc gtcctacaag
      421 gtggaagcca agggggacac tgacaggctc acgcccgagg cgctgaaggg gctggtcaac
      481 aagccagagc tgctcgcgct gacagagagc ctcacccccg accacacagt ggcgttctgg
      541 atgcccgagt cagagatgga ggtgatggaa ctcgagctgg gggccggggt acggctgaag
      601 actcggggcg atggtccctt cctggattca ttggccaaac ttgaggctgg aacagtgacc
      661 aagtgtaatt tcactggtga tggaaagaca ggggcatcct ggacagacaa catcatggcc
      721 caaaagtgtt cgaagggggc tgcagcggag atccgagagc agggggatgg ggcagaggac
      781 gaggagtggc cagaagaaat tcaacagcag attgttcgag agactttcca tctagtcctc
      841 aagcgggatg acaacatctg taacttcttg gagggtggaa gtttgattgg tggctctgac
      901 tacaaactga tctaccggca ctatgctacc ctctactttg tattttgtgt ggattcctca
      961 gagagtgaac ttggaatctt ggacctcatc caggtttttg tggaaactct ggataagtgt
     1021 ttcgaaaatg tgtgtgaatt ggatttgatc ttccatatgg ataaggtgca ctacatcctc
     1081 caggaggtgg tgatgggtgg gatggtgttg gaaacaaaca tgaatgaaat cgtggctcag
     1141 attgaggctc aaaacaggct ggagaaatcc gagggtggcc tttcagcagc ccctgcgcgg
     1201 gctgtgtctg ctgtgaaaaa catcaacctg ccagagattc ctcggaacat caacattggc
     1261 gatctcaaca tcaaagttcc caacctgtcc cagtttgtct gaggatcaag tattggcctg
     1321 aaatagagtc cttaagacaa gcaaagacaa gcaaggcaag cacgtctgga aacagaaccc
     1381 attttgagcc ttagaagagt caagcctcag gacctggaaa ctttgtgtct ggggaagact
     1441 gtttggcatg gaatagggaa gggattccta ttgacactgc tcgggtgcac ccagttctca
     1501 catgtgcagt catgccgttc tctgatgcat acggccactg cagatgtgag gggccctgcc
     1561 ttcctcagta gggagtcaac atgcccaagt catttgcacc tttacctctc acatggatgc
     1621 tcccaagggt tagggactgc attgagcagg cccacctgct tcccagaacc tcctcactag
     1681 ggctgagcac cttctctgag tagagtcttc atccttagca ccacagactt ctgaggtcct
     1741 gtgcccttta cttgctggtg aggtgtcata ggtagaaaag ggctggccct tcagatctgg
     1801 gggtgtggtg agtggcaagt aagggcagaa ttttaggaga accagagtca cccgctggct
     1861 ctactgagat tgttacaccc agaatccttt tgtgtttttt tgtggttttt tttttttgag
     1921 gtggagtctt gctctgtcac ccaggctgga gtgctgtggt gcaatctcgg ctcactgcaa
     1981 cctctgcttc ccgggttcaa gcatttctcc tgtctcagcc tccccagtag ctgggattac
     2041 aggcacccac caccatgccc agctaattgt tgtatgttta gtagagacag ggtttcacca
     2101 tgttggccag gctgggctcg aactcctgga cctcaagtga tctacccgcc ttggcctccc
     2161 aaagtgctgg cattacaggt gtgagccacc gtgcccggcc accagaatcc tttggtatag
     2221 ccaagccttt tggttaccgc ctcatgaaga atatgcttcc cgcattgtcc tagtcccagt
     2281 tgtattctca caggtgttat gtgcaggaca caatccaaat cataaacctg gctcatgccc
     2341 aacacatttc tgctaatagg gagagggacc caccacacac ccacacatgc cagaggtccc
     2401 tcctcacaga ggagagggcc tgtgtctgta gaaggttaaa gctgacaaca tgtgaaacat
     2461 cccagaatta tgactcttcc caagtttaaa atacattctc ctcatgagag cagaaggttt
     2521 gttgctgtgt tgtgaatgat gagctgcctc catagggaac ccactgccac ctgggccagc
     2581 ttctggagca tgagaacctg agccagggtc acccttgtgg ggcctggaca tgacgcacgc
     2641 tggctgcgac taggagcagg gctgcctctt ctccctcccc aaggtctgct tgtgggcacg
     2701 ctctgttccc tcaggtgcca ttctcccagg gcttaggcgc ccataaatgt tctttctgtg
     2761 gtggagtagg gcctcctgct tccatactgt cgcatgggct agatctcagg tgtggtgttg
     2821 agccacctta agatgagggc tgcttcgcag taaagtttcc agcctgggcc cctcttgggc
     2881 cttctggctg gggaccctca gcctcctgat gctgttgcag ggcaggtctg agagggtgcc
     2941 cagcagcacc cggtgtcagg gccaccttgt tttccatttt tgaacagcgc tccctgtggt
     3001 ttgtgcccac tgctcaatac agcctccgat cctcactctt gaaagctcca tgataagcac
     3061 agagatgggc agtgtgggtc agaaggtggg ccgcttcctg tggaagaggg aagtgtaggt
     3121 gaatagatat caaaacccct gatgtcattc ttttgagggg ttggattttc ttttttctgg
     3181 cagacatttc agtacattca catttctctc acatttgctg aatgtgagat cagaataaag
     3241 gagatcggcg tttatttcgt accttctgta agttggcatg agcaagatca ttcaactgtc
     3301 cttacaacag gcattcttat ccccattttg cagatgacga aagtagaccc agctccagta
     3361 accttccctt agattacacg gggctgagat ctgagactgt tcacttgact ccactgtcct
     3421 tttctttcct cgctgcttaa gatggcttct cccaatgtta tcatcttctt ttttatagat
     3481 aaggaaactg agcctcagag agtctgactt ctcacaaacc gtggtctaaa taggcttgat
     3541 tttctaaggt ggccagtgat catgtcatag agtataagag ccaaagagtc gtctgtgtcc
     3601 ctccatttaa ctgatgttga agccgaagcc caaggtggta aatgttatgt tgagggtcac
     3661 aaatccagag ccacatccct cttcttgagt tcgtttgtta cgtggtttaa tgcattactg
     3721 caggacagcc cttatgctag atttcctggg atagcctaga ttttgaatgt tttgcctgcc
     3781 agaaaccaat ggttttaaaa aatcattgag tggtcctaca gattcaaagc gagcatccaa
     3841 acatccctca catggcctct tacaatgaca taaaactgaa gcccactttt ttatttggaa
     3901 aactcaatcc ctttggacaa gccacaataa tttttcatta actacttgag gttgcctgca
     3961 aattcagcta gctttccagc ctgctatcag caaagccata aacatctttt ttaaaaatag
     4021 gttaaggttg gccaggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccgag
     4081 gcgggcagat cacgaggtca ggagatcgag accatcctag ctaacacagt gaaaacccat
     4141 ctctactaaa aatacaaaaa attggccagc cgtggtagtg gacacctgta gtcccagcta
     4201 ctcaggaggc tgcggcagga gaatggcatg aacccgggag gcagagcttg cagtgagcca
     4261 agatcgcacc actacactcc agcctgggca acacagcaag actccgtctc aaaaaaaaaa
     4321 aaaaaaaaaa taggttaagg ttgtatagaa tactaggctt tccttttttt gtgagatggg
     4381 ggtctcacac tgtggctcag gctggagtgc agtggtgtga tcatggctca ctgcagcctc
     4441 gaagccccgg ggtcaagtga tcctctcacc tcagcctcct aggtagctgg aaccacaggc
     4501 acgcaaccac cactcctggc tagttttatt tttttagtag aataaggtct cactatgttg
     4561 cacaggctgg tctctaactc cttacctcaa gccatcctcc cgccttggcc tcccaaacat
     4621 gttgggatta caggtgtgag ccactggacc tggccaaata ctgggttttc agtgctcact
     4681 gccactaata aaaatctgaa attctttcat tatgcaattt ctaagtgcct ggtgagggcc
     4741 aagctcagtt ctaggctctg aagattaaga gagaaacaag gctctgtctg ctcctgttgt
     4801 ctctgtgagc atctttgaca gagtgctcag attgttggga tatagtgcat cggactggca
     4861 gcctgaattt gtggagaccg cagtcagtaa ctttgtgata tatggaatat ttagaggaca
     4921 gtaacccatt tccctacgcc ctacctgatc acatcgtgcc ctgctgggcc ataccccaaa
     4981 cagcccacct tcctctaggc ctggccatgg ccctgtgcct gccacattga ggattaagtc
     5041 aggatatctt gagccctctc aaatccctgt ttattcaggc ctctgccaca tatagagcca
     5101 gccttctgtc cccaccactt ccactaccat ggagcccact tagtaaaacg ctctctgggc
     5161 ccagcttcgc cagaaaagac accaggggag caaggctcaa accaggggca gctaaatctg
     5221 atcttgtgga ccagtctcta gtaagggctt tcagcgtggc tgtctgtcca ttgctttcca
     5281 aataggatgc agcaatgatt ggtacatggg tattaagatc ggtagtaggg gctagtccaa
     5341 gtttagcaat agccaaactg gagagcctct gaagtatgag agtcccagag ggatttgtca
     5401 gctcctggca gacatcctga ttttcacctt cctgagtcta ccctacccca gagggtgcca
     5461 gtctcactgt ggtgatggtt agcccagtgt gtgctgcact cacacaccag cacggggtcc
     5521 gtgcttgcag gctggtggat gctgtcctct gggttaagac tgtctccctt ctcgggagca
     5581 ctggagggtt ctccatctgc gtgtttcagt ggaagttggc agatacgaaa acaggcccct
     5641 atagggaagc agttccatga aaatgattaa ttctttccaa aagacttaaa attttttcct
     5701 atttcaattt tcctttcaaa aaaggaaata cattcatgta gttcaaaact taagaaaaca
     5761 aaagtctgtt cagcaaaaga ctcccactcc ggttccccaa acgctgagcc ccacccccca
     5821 tccctggtag caagaagtgt ttccaatttt aaggttaaga aacaaagtcc ctggatttgt
     5881 gttagggatg tcttcctgag agtgggttgt gttccgtttg accctggcgg ttgacctcgg
     5941 cccactagga tcatgccgcc ctctccaggg aggagggcct ccccatcacc ctgtacagtg
     6001 gcaccccagc cctggcactg cccgcccttg ctcagcgtac ctttcccatg gcactctgac
     6061 gtactggatg tttggtttct gaagttactg gctgtttacc ctgccgggat gtaagcccct
     6121 ccagggcagg ggcttgtctc gtgttcagtg ctgcatccca gctgctgggc acggtacctg
     6181 gtccatggcg ttcaataaat aactgttgga tgagtgaa
//
