LOCUS       NM_005717               7266 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens actin related protein 2/3 complex subunit 5 (ARPC5),
            transcript variant 1, mRNA.
ACCESSION   NM_005717
VERSION     NM_005717.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7266)
  AUTHORS   Gao,Y., Hou,J., Fei,X., Ren,L., Lu,R., Liu,P., Liu,S., Zhu,C.,
            Wang,X. and Pan,Y.
  TITLE     TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK
            signaling pathway influences the proliferation, invasion, and
            metastasis of pancreatic cancer cells
  JOURNAL   Cell Signal 120, 111227 (2024)
   PUBMED   38744388
  REMARK    GeneRIF: TAGLN2 targeted control of ARPC5-mediated activation of
            the MEK/ERK signaling pathway influences the proliferation,
            invasion, and metastasis of pancreatic cancer cells.
REFERENCE   2  (bases 1 to 7266)
  AUTHORS   Ming,Y., Luo,C., Ji,B. and Cheng,J.
  TITLE     ARPC5 acts as a potential prognostic biomarker that is associated
            with cell proliferation, migration and immune infiltrate in gliomas
  JOURNAL   BMC Cancer 23 (1), 937 (2023)
   PUBMED   37789267
  REMARK    GeneRIF: ARPC5 acts as a potential prognostic biomarker that is
            associated with cell proliferation, migration and immune infiltrate
            in gliomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7266)
  AUTHORS   Sindram,E., Caballero-Oteyza,A., Kogata,N., Chor Mei Huang,S.,
            Alizadeh,Z., Gamez-Diaz,L., Fazlollhi,M.R., Peng,X., Grimbacher,B.,
            Way,M. and Proietti,M.
  TITLE     ARPC5 deficiency leads to severe early-onset systemic inflammation
            and mortality
  JOURNAL   Dis Model Mech 16 (7) (2023)
   PUBMED   37382373
  REMARK    GeneRIF: ARPC5 deficiency leads to severe early-onset systemic
            inflammation and mortality.
REFERENCE   4  (bases 1 to 7266)
  AUTHORS   Nunes-Santos,C.J., Kuehn,H., Boast,B., Hwang,S., Kuhns,D.B.,
            Stoddard,J., Niemela,J.E., Fink,D.L., Pittaluga,S., Abu-Asab,M.,
            Davies,J.S., Barr,V.A., Kawai,T., Delmonte,O.M., Bosticardo,M.,
            Garofalo,M., Carneiro-Sampaio,M., Somech,R., Gharagozlou,M.,
            Parvaneh,N., Samelson,L.E., Fleisher,T.A., Puel,A.,
            Notarangelo,L.D., Boisson,B., Casanova,J.L., Derfalvi,B. and
            Rosenzweig,S.D.
  TITLE     Inherited ARPC5 mutations cause an actinopathy impairing cell
            motility and disrupting cytokine signaling
  JOURNAL   Nat Commun 14 (1), 3708 (2023)
   PUBMED   37349293
  REMARK    GeneRIF: Inherited ARPC5 mutations cause an actinopathy impairing
            cell motility and disrupting cytokine signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7266)
  AUTHORS   Sadhu,L., Tsopoulidis,N., Hasanuzzaman,M., Laketa,V., Way,M. and
            Fackler,O.T.
  TITLE     ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP
            drive distinct Arp2/3-dependent actin remodeling events in CD4 T
            cells
  JOURNAL   Elife 12, e82450 (2023)
   PUBMED   37162507
  REMARK    GeneRIF: ARPC5 isoforms and their regulation by
            calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin
            remodeling events in CD4 T cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7266)
  AUTHORS   Robinson,R.C., Turbedsky,K., Kaiser,D.A., Marchand,J.B.,
            Higgs,H.N., Choe,S. and Pollard,T.D.
  TITLE     Crystal structure of Arp2/3 complex
  JOURNAL   Science 294 (5547), 1679-1684 (2001)
   PUBMED   11721045
REFERENCE   7  (bases 1 to 7266)
  AUTHORS   Gournier,H., Goley,E.D., Niederstrasser,H., Trinh,T. and Welch,M.D.
  TITLE     Reconstitution of human Arp2/3 complex reveals critical roles of
            individual subunits in complex structure and activity
  JOURNAL   Mol Cell 8 (5), 1041-1052 (2001)
   PUBMED   11741539
REFERENCE   8  (bases 1 to 7266)
  AUTHORS   Zhao,X., Yang,Z., Qian,M. and Zhu,X.
  TITLE     Interactions among subunits of human Arp2/3 complex: p20-Arc as the
            hub
  JOURNAL   Biochem Biophys Res Commun 280 (2), 513-517 (2001)
   PUBMED   11162547
REFERENCE   9  (bases 1 to 7266)
  AUTHORS   Machesky,L.M., Reeves,E., Wientjes,F., Mattheyse,F.J., Grogan,A.,
            Totty,N.F., Burlingame,A.L., Hsuan,J.J. and Segal,A.W.
  TITLE     Mammalian actin-related protein 2/3 complex localizes to regions of
            lamellipodial protrusion and is composed of evolutionarily
            conserved proteins
  JOURNAL   Biochem J 328 (Pt 1) (Pt 1), 105-112 (1997)
   PUBMED   9359840
REFERENCE   10 (bases 1 to 7266)
  AUTHORS   Welch,M.D., DePace,A.H., Verma,S., Iwamatsu,A. and Mitchison,T.J.
  TITLE     The human Arp2/3 complex is composed of evolutionarily conserved
            subunits and is localized to cellular regions of dynamic actin
            filament assembly
  JOURNAL   J Cell Biol 138 (2), 375-384 (1997)
   PUBMED   9230079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN291383.1, AL137800.12,
            AF006088.1 and AI148784.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005717.3.
            
            Summary: This gene encodes one of seven subunits of the human
            Arp2/3 protein complex. The Arp2/3 protein complex has been
            implicated in the control of actin polymerization in cells and has
            been conserved through evolution. The exact role of the protein
            encoded by this gene, the p16 subunit, has yet to be determined.
            Alternatively spliced transcript variants encoding different
            isoforms have been observed for this gene. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF006088.1, AK129598.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359856.11/ ENSP00000352918.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CN291383.1         159-171
            14-14               AL137800.12        136314-136314       c
            15-100              CN291383.1         173-258
            101-1110            AF006088.1         1-1010
            1111-1111           AL137800.12        127545-127545       c
            1112-1915           AF006088.1         1012-1815
            1916-1919           AI148784.1         9-12                c
            1920-7266           AL137800.12        121390-126736       c
FEATURES             Location/Qualifiers
     source          1..7266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..7266
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /note="actin related protein 2/3 complex subunit 5"
                     /db_xref="GeneID:10092"
                     /db_xref="HGNC:HGNC:708"
                     /db_xref="MIM:604227"
     exon            1..267
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..580
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Arp2/3 protein complex subunit p16; arp2/3 complex 16 kDa
                     subunit; actin related protein 2/3 complex, subunit 5,
                     16kDa"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 5
                     isoform 1"
                     /protein_id="NP_005708.1"
                     /db_xref="CCDS:CCDS1357.1"
                     /db_xref="GeneID:10092"
                     /db_xref="HGNC:HGNC:708"
                     /db_xref="MIM:604227"
                     /translation="MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDS
                     CLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNG
                     VDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV"
     exon            268..340
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            341..517
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /inference="alignment:Splign:2.1.0"
     exon            518..7266
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /note="hexamer: AATAAA"
     regulatory      1911..1916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /note="hexamer: AATAAT"
     polyA_site      1915
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /note="major polyA site"
     polyA_site      1942
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
     regulatory      4834..4839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /note="hexamer: CATAAA"
     polyA_site      4846
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
     regulatory      6550..6555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /note="hexamer: AATAAA"
     polyA_site      6570
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
     regulatory      7242..7247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
                     /note="hexamer: AATAAA"
     polyA_site      7266
                     /gene="ARPC5"
                     /gene_synonym="ARC16; dJ127C7.3; IMD113; p16-Arc"
ORIGIN      
        1 agtcggcgac gcctcagagc ggaagaggga agtgaatcag gcgccgggta gtgggttgct
       61 gggctgggct tgctgaggta gaggcagcgc caagaagagg cctttgccgc tggtcgggat
      121 tgggatgtcg aagaacacag tgtcgtcggc ccgcttccgg aaggtggacg tggatgaata
      181 tgacgagaac aagttcgtgg acgaagaaga tgggggcgac ggccaggccg ggcccgacga
      241 gggcgaggtg gactcctgcc tgcggcaagg aaacatgaca gctgccctac aggcagctct
      301 gaagaacccc cctatcaaca ccaagagtca ggcagtgaag gaccgggcag gcagcattgt
      361 cttgaaggtg ctcatctctt ttaaagctaa tgatatagaa aaggcagttc aatctctgga
      421 caagaatggt gtggatctcc taatgaagta tatttataaa ggatttgaga gcccgtctga
      481 caatagcagt gctatgttac tgcaatggca tgaaaaggca cttgctgctg gaggagtagg
      541 gtccattgtt cgtgtcttga ctgcaagaaa aactgtgtag tctggcagga agtggattat
      601 ctgcctcggg agtgggaatt gctggtacaa agaccaaaac aaccaaatgc caccgctgcc
      661 ctgtgggtag catctgtttc tctcagcttt gccttcttgc tttttcatat ctgtaaagaa
      721 aaaaattaca tatcagttgt cctttaatga aaattgggat aatatagaag aaattgtgtt
      781 aaaatagaag tgtttcatcc tttcaaaacc atttcagtga tgtttatacc aatctgtata
      841 tagtataatt tacattcaag tttaattgtg caacttttaa cccctgttgg ctggtttttt
      901 gttctgtttt gttttgtatt atttttaact aatactgaga gatttggtca gaatttgagg
      961 ccagtttcct agctcattgc tagtcaggaa atgatattta taaaaaatat gagagactgg
     1021 cagctattaa cattgcaaaa ctggaccata tttcccttat ttaataagca aaatatgttt
     1081 ttggaataag tggtgggtga ataccactgc taagttatag ctttgttttt gcttgcctcc
     1141 tgattatctg tactgtgggt ttaagtatgc tactttctct cagcatccaa taatcatggc
     1201 ccctcaattt atttgtggtc acccagggtt cagagcaaga agtcttgctt tatacaaatg
     1261 tatccataaa atatcagagc ttgttgggca tgaacatcaa acttttgttc cactaatatg
     1321 gctctgtttg gaaaaaactg caaatcagaa agaatgattt gcagaaagaa agaaaaacta
     1381 tggtgtaatt taaactctgg gcagcctctg aatgaaatgc tactttcttt agaaatataa
     1441 tagctgcctt agacattatg aggtatacaa ctagtattta agataccatt taatatgccc
     1501 cgtaaatgtc ttcagtgttc ttcagggtag ttgggatctc aaaagatttg gttcagatcc
     1561 aaacaaatac acattctgtg ttttagctca gtgttttcta aaaaaagaaa ctgccacaca
     1621 gcaaaaaatt gtttactttg ttggacaaac caaatcagtt ctcaaaaaat gaccggtgct
     1681 tataaaaagt tataaatatc gagtagctct aaaacaaacc acctgaccaa gagggaagtg
     1741 agcttgtgct tagtatttac attggatgcc agttttgtaa tcactgactt atgtgcaaac
     1801 tggtgcagaa attctataaa ctctttgctg tttttgatac ctgctttttg tttcattttg
     1861 ttttgttttg taaaaatgat aaaacttcag aaaataaaat gtcagtgttg aataatttat
     1921 ttttctctga ctttaacaat tatgaatgta tggttaatta agaggaaagg ttttctgctt
     1981 ctaccaccaa gtactgtact cttaacaaga acagtttggt agggttttta taagactata
     2041 tagatataag atgatagaga agagagtcat gaatgatgtc agagcactac tgaagccttt
     2101 ggagtgattc catagccttc tggatggcag ctgaatacct atatgtagta tcactgccca
     2161 aagacctaga ctagaaagtg caaagtagct tagcagctgc agtcattcac tcccagcctc
     2221 caaaattctc tttctttcac ctcaaatcta tttcttgtac ttacctactc acagcgactt
     2281 ctgtttgctt tcgatcttca cctgactaga ttcccacttt aaaacacttc caggcaattc
     2341 agggtcctat gggtgaagat aagctaagca ataggtatta ttcttaaata ttacttagag
     2401 atggggactt gctatgctgc ccaggctgga gtgcagtggc tgttcacagg tgtgatcata
     2461 gtgcactgag gcctcaaact cctggcttca agcagtcctg cctcagcctc ccgaaaaggt
     2521 ggaactacag gcacatgcca ctgtgcctta gccaataggt attagaggta gtcaagtagg
     2581 tatagcataa ccaattacaa actttaaaat caaatgatac tgaatgcttt ttcataaaat
     2641 ccttcttaac atcactttca taactgaagc gtttggaaaa attctggagt tcatatttgt
     2701 tcacaagaat gggtgggtgt atttagaatc tgccagtcta tcagctttac tgaggggaga
     2761 tactaaaaat atttaacaag tagtataata tagagaccga gtcaaaatgg atactagctg
     2821 gaaacaactg gttcaactgt tgcctcctga ctaaatgtca gcccagggta tagtaaccat
     2881 gacacagtac tatccttggt gaagagttgg gaataggatt aattgcggaa aaaatatata
     2941 taaatgccat aggacacttt tagcacaaaa gtagttgttt acctcccatt ctcctccttt
     3001 aatctcagtg cttttactat ttggtttctt ttttggcatt ttacaaaagg gaagaaatgg
     3061 aaaacatacc ccttcttggt cattgggtaa cagcaccatt tcggtaacag tcatacttga
     3121 tgacaagtat gatgatattt taaggacatg aacatgggtg aaatcaatgt gtagatggta
     3181 caaattaacc gaattctttt taaagcattt cctgtggatc ccaggatcat gaggacataa
     3241 cagaagaata aggtctgaat cttgttcacc agtttgctct cagcctaatt gggaagtaag
     3301 gttaagcacc tgaaaattat gtcatacaaa aaaaaagaga attaacgtca tacaatttag
     3361 catttgactg taaatgcagt tagtcaatgt tgggagaaca acaaaatcag ggtggatcag
     3421 agtatttaaa gtgagacatt aatttgaact aatcctttgg aggggcagaa aggacaaacg
     3481 gtccaagtga aatgaacaga gtagaaagag aaagttaaaa gtgggtttaa tagtcactgt
     3541 tcttgcagtt ttaatgtttt ttgttttgtt ttgttttgtt ttgttttgtt ttgttttttt
     3601 tgagacagag tctcgctctg tggcccaggc gggagtgcag tggcgcgatc tcggctcact
     3661 gcaagctctg cctcctgggt tcacgccatt ctcctgcctc agcctcccaa gtagctggga
     3721 ctacaggcgc ccgccaccac gcccggctaa ttttttgtat ttttagtaga gacggggttt
     3781 cattcaccgt gttagccagg atggtctcga tctcctgacc tcgtgatccg cccacctcgg
     3841 cctcccaaag tgctgggatt acatgcgtga gccaccgcgc ccagctgcag ttttaatgtt
     3901 tttaacataa gaattctaga tggtgcaaat tattaacagg atcagaaact atctccgtga
     3961 tagattcaag aaagtaaaat tataggaaat cataatgttt tattagctga aatagacatt
     4021 gatgatcact tagtttaacc ccatgtataa aggtaaaaaa gaaaattaat taattaattt
     4081 tttttttttg agatggagtc ttgctctgtt gctcaggctg gagtgcaatg gcacaatctc
     4141 ggctcactgc agcctccacc tcccaggctc aagcgattct cctgcctcag cctcctgagt
     4201 agctcggatt acaggcacgc atcaccgtgc ccagctaatt tttgtatttt taggagagat
     4261 ggggtttcac catgttgccc aggctggtct tgaactcctg acctcaggtg atccaccctc
     4321 ctccgcctcc caaagcactg ggattacagg cgtgaccacc gcgcccagcc agattgatta
     4381 atttttagat acacaatttt tcctttagat ttacaactaa catcccctta cagacaaaat
     4441 atgttaaaag caccaaaata attgaaaaac acacccaatt aaggaacaga ccaacggcct
     4501 ctgtagaacc aagtgccctt aaacaaggct gcttctgtcc atattcctgc cgcgggacct
     4561 ctgccccact ccctctcccc ctcaccccaa tgtcactagt acaatatgtg aaaaccccaa
     4621 tgtgaaaacg ttctgtgcag gtgcctcttg tatgattcca gatatggagg aggcccggga
     4681 agcccacaga ggtacagcat gtcatctgcc tcaaggtggt gctacttcac cacattgatg
     4741 atccaaccac aagcaacatg ggacacagca ttcactttaa catttctatt ttcctttatc
     4801 atttctgtta cttgagtgtg taagagtaat caacataaat aatctatgtt tacatctctt
     4861 atttctctct gaaacagttc cctagaatcc acaccacatg aaacacaaat tgagtagtgt
     4921 atgacccacc tgaattccaa agcattctaa aactcccgta ttttccagcc tagcagttag
     4981 ctcctgctct gcaagacaca ccctcttgac cttgctgcta gactgtatgg gccccctgaa
     5041 gtcatagtag ctggctctta ctcatcccca cattcacttg gcatagttga tgttcaacaa
     5101 atatctcttg gttgcataac attgaacgag ccaagtcacc taagaaatcc ttaatttata
     5161 cacaggttct tagggtacct gaatagggca acacatcaga agtacaaatt gagaactata
     5221 caaagagtaa aataattctt gggttcaaat accctagagc caatcaagtt tagtcacaaa
     5281 gaatttcaat tcacttcaat gtggacagtt aagaagggaa tttatcagcc ttaggtggaa
     5341 atcagagcca ccatgagtac cacgtgcagc ccctatagtg tttagctttg ccagaagtca
     5401 ccagagaaag tggctgagga acagaattcc agctcatatc tggctaacag tggcactatg
     5461 ggagtttata tgatctgttc attattctgt ggcatcacct tctaagagca gagatgtgac
     5521 ccaatacccc ttgttttcct taaagataac cattaaatta tatccatgaa tttatatcac
     5581 cgtccttgac tttatacgta gatttttcta attctgtcaa cccttagggt aatgaataac
     5641 ttaaatggcc aatgcctctg aataacatca tacttccttt tgtttctcca aaaattgaat
     5701 caagatgcca gggcaactaa gattttcttc aatttgctaa gttaaaggtc agtgtattca
     5761 ttagccaatg gttctgtatt ttattcattt tagtttttat tcgttttcaa ataatttgtt
     5821 catattgttc aatattcaaa aggtaagaaa tatgtactgt ggtaattttc cattccaccc
     5881 tagttcctct tttgacaacc aactattgtc acttaattct taggcatcct tccagataca
     5941 gtgtatgcat ttacaggcaa atacctatat aagattttac ccctttgtgt acataaatac
     6001 taacatacta tatatagtgt tctgttcctt gcttttttca ttaacagtat attttggtgg
     6061 taatttccta tcaatacata aagaacttcc ttattccctt cagaggcatt tgaaccagag
     6121 caattccttc ttgaatagaa gctgggtaaa ataaggctga gacctactgg gctgcattcc
     6181 cagatggtta aggcattcta agtcacagga tgagatagga ggtcaacaca agataccggt
     6241 cataaagacc ttgctgataa aacagtttgc agtaaagaag ctggccaaaa cccaccaaat
     6301 ccaagatggc aatgaaagtg acctctgcct ctggccatcc tcaccgctac gctcccaccg
     6361 gcaccatgac agtttacaaa tgccatggca acatcaggaa gttatcctat atggtctaaa
     6421 aaggggaggc atgaataata caccccttgt ttagcatatc atcaagaaat aaccgttaaa
     6481 atgggcaacc agcagccctc ggggctgctc tgcctatgga gtagccattc tttattcctt
     6541 tactttctta ataaacttgc tttaacttta cagactggcc ttgaattctt tcttgtgtga
     6601 gatccaagaa cgctcacttg gggtctggat tgggaccact ttccgataac aattttattt
     6661 ttatgactgc ataataattc tattatataa ataaatgtac cataatttac ttaaccattt
     6721 ccctattgat ttaggtggtt tctgatcttt tgcagttaca aacagtgcta cagtgaatag
     6781 cattatacac aagtcatttt acatatgttc aagcctattt gtagatcaat tcctaaaagt
     6841 gaaagttaag gtcagttgga gggcatttaa gggagatatt gctaaattgc ctttcttaaa
     6901 ggttttatca attatacttt ctccagccgt gtagaagaat gcatgttttc ccaccccttt
     6961 acctattcta tgtgtttgtc ataaaacatt ttttaatctt ttcaaatctg atgttttaaa
     7021 aatggtatca tatatttgca tttctcttaa tgtaaatgag attgcacatc ttttcacatg
     7081 cctaatagcc agttgtattt tcttttctat atttttgtat ttctatattt tctttgccct
     7141 tttgatggtc tttttcttac tgatttgtag gagctctttt caacaggaat gtcaaatatt
     7201 tcttgcattt tgagtttcgc tttataatag cttttactat aaataaaaag gttattttta
     7261 ttttta
//
