LOCUS       NM_001198793            3987 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ARPC4-TTLL3 readthrough (ARPC4-TTLL3), mRNA.
ACCESSION   NM_001198793
VERSION     NM_001198793.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3987)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022382.4, BC025289.1 and AC018809.5.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring ARPC4 (actin related protein
            2/3 complex, subunit 4) and TTLL3 (tubulin tyrosine ligase-like
            family, member 3) genes. The read-through transcript encodes a
            fusion protein that shares sequence identity with each individual
            gene product. [provided by RefSeq, Nov 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 10093, 26140
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-566               AC022382.4         42417-42982         c
            567-3032            BC025289.1         1-2466
            3033-3160           AC022382.4         1-128               c
            3161-3987           AC018809.5         142733-143559       c
FEATURES             Location/Qualifiers
     source          1..3987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..3987
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /note="ARPC4-TTLL3 readthrough"
                     /db_xref="GeneID:100526693"
                     /db_xref="HGNC:HGNC:38830"
     exon            1..577
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     CDS             575..2452
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /note="ARPC4-TTLL3 read-through transcript; Actin-related
                     protein 2/3 complex subunit 4; Arp2/3 complex 20 kDa
                     subunit"
                     /codon_start=1
                     /product="ARPC4-TTLL3 fusion protein"
                     /protein_id="NP_001185722.1"
                     /db_xref="GeneID:100526693"
                     /db_xref="HGNC:HGNC:38830"
                     /translation="MTATLRPYLSAVRATLQAALCLENFSSQVVERHNKPEVEVRSSK
                     ELLLQPVTISRNEKEKVLIEGSINSVRVSIAVKQADEIEKILCHKFMRFMMMRAENFF
                     ILRRKPVEQKKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLDSSAMGD
                     SDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDEVDAN
                     SFFPRCYCLGAEDDKKAFIGDKQPKKQEKNPVLVSPEFVDEALCACEEYLSNLAHMDI
                     DKDLEAPLYLTPEGWSLFLQRYYQVVHEGAELRHLDTQVQRCEDILQQLQAVVPQIDM
                     EGDRNIWIVKPGAKSRGRGIMCMDHLEEMLKLVNGNPVVMKDGKWVVQKYIERPLLIF
                     GTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQKHLENS
                     CHRHPLLPPDNMWSSQRFQAHLQEMGAPNAWSTIIVPGMKDAVIHALQTSQDTVQCRK
                     ASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRMLDR
                     NCDTGAFELIYKQPVTTSPASTPRPSCLLPMYSDTRARSSDDSTASWWALRPCRPQAR
                     P"
     exon            578..696
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            697..808
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            809..904
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1073
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1171
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1286
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1482
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1631
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1875
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2311
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..3987
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /note="hexamer: AATAAA"
     polyA_site      3035
                     /gene="ARPC4-TTLL3"
                     /gene_synonym="ARC20; ARPC4; p20-ARC"
                     /note="major polyA site"
ORIGIN      
        1 gggtgggaag aaggtgggcc tcgagcaaag ccgctagagg tggggtgcgg gtggtcggcc
       61 tcaggcgagc cccggggcac agcccggggc gggaggcgga gcttggcggc cgagatctcc
      121 gcgctgcagt tagccccgcc gagcgccagg agctgcgggt aggaggggcg agagaaagga
      181 tgggggtaca gaaccggaag aaacgaaggg ctcgtccgct tcggcttgtc ctaatttggt
      241 gcccaatctg aagctgggct gtaccattgc atacctgggg gaggctgtgg caaaggtgac
      301 aagaaggccg aaggcacaaa gggaagctgc acccattcct ggaggagctt aaatagtgac
      361 tcgagtgcaa gaatttaaaa ataccgagac agccctaggt ggaaaacttc cggaaggccc
      421 aagcgttcgt aagggctctc taccccgctc ggagcataga tggtaccgtc cggaagtccg
      481 ggcggagacc gtagctgcgc ttctcgcgaa agggcaggca tcgcggggct ggccacttcc
      541 gtacttccgc tttccggccc agccagcgcc cgcgatgact gccactctcc gcccctacct
      601 gagtgccgtg cgggccacat tgcaggctgc cctctgcctg gagaacttct cctcccaggt
      661 tgtggaacga cacaacaagc cggaagtgga agtcaggagt agcaaagagc tcctgttaca
      721 acctgtgacc atcagcagga atgagaagga aaaggttctg attgagggct ccatcaactc
      781 tgtccgggtc agcattgctg tgaaacaggc tgatgagatc gagaagattt tgtgccacaa
      841 gttcatgcgc ttcatgatga tgcgagcaga gaacttcttt atccttcgaa ggaagcctgt
      901 ggagcagaag aagatcttta caatccaagg ctgctacccg gtgatccggt gtctcttgcg
      961 ccggaggggc tgggtggaga agaagatggt ccatcgctca ggccccaccc tgctgccacc
     1021 ccagaaggat ctggatagct cagcgatggg tgacagtgac accactgagg atgaggatga
     1081 agatgaggac gaggagttcc agccatcaca gctgttcgac ttcgatgatt tactgaaatt
     1141 tgatgaccta gatggaacac atgctctgat ggtgggtcta tgtctcaatc tccggaattt
     1201 gccgtggttt gatgaggttg atgccaactc cttcttccca cgctgctact gcctgggggc
     1261 tgaggatgac aaaaaagcct tcataggaga caagcagccc aagaaacagg agaaaaaccc
     1321 agtgttggtg tccccagagt ttgtggatga agctctgtgt gcgtgcgagg agtaccttag
     1381 caacttggcc cacatggaca tcgacaagga cctggaggcc ccgctgtacc tcacccccga
     1441 gggctggtcc ctcttcctcc agcgctacta ccaagtggtc cacgaagggg cagaactcag
     1501 gcacctcgac actcaggtcc agcgctgtga ggacatcctg cagcagctgc aggccgtggt
     1561 accccagata gacatggaag gggatcgcaa catctggatc gtgaagccag gagccaagtc
     1621 ccgcggacga ggcatcatgt gcatggacca cctggaggag atgctgaagc tggtgaacgg
     1681 caaccccgtg gtgatgaagg acggcaagtg ggtggtgcag aagtatattg agcggcccct
     1741 cctcatcttt ggcaccaagt ttgacctcag acagtggttc ctggtaactg actggaaccc
     1801 acttaccgtg tggttctacc gcgacagcta tatccgcttt tccacgcagc ccttctccct
     1861 gaagaacctg gacaactcag tgcacctgtg caacaactcc atccagaagc acctggagaa
     1921 ctcatgccat cggcatccac tgcttccgcc agacaacatg tggtctagcc agaggttcca
     1981 ggcccacctg caggagatgg gtgccccaaa tgcttggtcc accatcatcg tgcctggcat
     2041 gaaggatgct gtgatccacg cacttcagac ctcccaggac accgtgcagt gtcggaaggc
     2101 cagctttgag ctctatggcg ctgacttcgt gttcggggag gacttccagc cctggctgat
     2161 tgagatcaac gccagcccca cgatggcacc ctccacagca gtcactgccc ggctctgtgc
     2221 tggcgtgcaa gctgacaccc tgcgcgtggt cattgaccgg atgctggacc gcaactgtga
     2281 cacaggagcc tttgagctca tctataagca gcccgtcacc acttccccag cctccacacc
     2341 aaggcccagc tgccttctcc ccatgtactc cgacaccagg gccaggtcct cagacgacag
     2401 cacagcaagc tggtgggcac taaggccctg tcgaccacag gcaaggcctt gaggactcta
     2461 cccacggcta aggtcttcat ttccctccca ccgaaccttg atttcaaggt ggcacccagc
     2521 atcctgaagc caagaaaggt gggcctcgac ctgtgactca cacccagtgg acagtgctga
     2581 gcacggggtc agggctggag ggcacaggca gagggcagct cccaggctgg ctggcacccc
     2641 aagggaagag ctggtctccc tcagaagccc cttcctccac agacttctga tcatctccct
     2701 cttctcccct cctttcacac cgaggctcct gctctcctgt gcctccgagg cccccagctg
     2761 gaagtgcctt gttgcctctg ccctttgaag tcggaacaat tcctagcacc tgtcggaagg
     2821 tcaaggccaa aggcaaattc aaggccagac tgtgacaaac ccagggctga ggcctgcccc
     2881 atgaagaggc tgagccccct gaaacccctg ccccttgttg gtacattcca gaggcgcagg
     2941 ggcctggggg atatgaagct agggaagccc ctgcttcgat tccccactgc ccttgtcctg
     3001 gatccaacac caaataaaaa gaaacaagtg aagtatttgg ggcttgactc cattgctgtt
     3061 ggagggtcaa gagtggatgg ggcgaggccg tgtaccccag ggtccacagc aagagcctga
     3121 ggccatcagc agctcctccg tgcagcgagg cccagaattc ccacctaagg acagacatgg
     3181 ggcttcctat ttagggactc ccccagcatc tccgatccag gggtggggag cgtgagcctt
     3241 cactttacag atgaagaaac tgagtctgaa agaggaggca tggcttaccc aagatcacgt
     3301 ggcagtgagt cgacgcaggg acatattgcc agaactgccg agcactggga gccccccaac
     3361 cccagagaac aagccaagct agcagaatga cacctaccgg gcataggaac gttaatgcca
     3421 tgagacaggg gaaggaattg gccttgccta aacctcagcc cttctgcaga gggcatgggt
     3481 ctatcccttc ttcagcaagg ggccaaggtc acctaaaaat gaaacatcca ataagccaca
     3541 cccacctgaa gaaaagtgtg gcactgctta gttgtagtgg gttgaactgt ggtcccctga
     3601 aaagagatgt ctacttggac cctgtgaatg tgaccttatg tgggaaaaga gtctttgtag
     3661 ctgggtatgg tggctcacac ctgttatccc agcactttga gaggccaagg caggagatcg
     3721 cttgagcccg caagttcaag accagtctgg gcaacatggt gaaaccgttt ctacagaaaa
     3781 ttagctgggt gtggtggcac acacctgtag tcctagctac tcgggaggcc taggtgggag
     3841 gattacctga gcctgggaag atcaaaactg tggtgagctg tgatcacgcc actgcgctct
     3901 gagcctggga gacagagtga aaccctaaat caaaaaaaaa aaaaaaggtc tttgcagatg
     3961 taaataaatt taagatctta aatgaga
//
