LOCUS       NM_005720               1511 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens actin related protein 2/3 complex subunit 1B (ARPC1B),
            mRNA.
ACCESSION   NM_005720
VERSION     NM_005720.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1511)
  AUTHORS   Zaveleta Martinez,O., Fregoso-Zuniga,A.E., Razo Requena,C.,
            Espinosa Padilla,S. and Blancas Galicia,L.
  TITLE     Description of a Novel Pathogenic Variant in the ARPC1B and a
            Severe Allergy in Two Infants
  JOURNAL   Iran J Allergy Asthma Immunol 23 (1), 122-126 (2024)
   PUBMED   38485907
  REMARK    GeneRIF: Description of a Novel Pathogenic Variant in the ARPC1B
            and a Severe Allergy in Two Infants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1511)
  AUTHORS   Peterson,A., Bennin,D., Lasarev,M., Chini,J., Beebe,D.J. and
            Huttenlocher,A.
  TITLE     Neutrophil motility is regulated by both cell intrinsic and
            endothelial cell ARPC1B
  JOURNAL   J Cell Sci 137 (3) (2024)
   PUBMED   38224139
  REMARK    GeneRIF: Neutrophil motility is regulated by both cell intrinsic
            and endothelial cell ARPC1B.
REFERENCE   3  (bases 1 to 1511)
  AUTHORS   Gao,Z., Xu,J., Fan,Y., Zhang,Z., Wang,H., Qian,M., Zhang,P.,
            Deng,L., Shen,J., Xue,H., Zhao,R., Zhou,T., Guo,X. and Li,G.
  TITLE     ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy
            resistance by blocking TRIM21-mediated degradation of IFI16 and HuR
            in glioma stem cells
  JOURNAL   J Exp Clin Cancer Res 41 (1), 323 (2022)
   PUBMED   36380368
  REMARK    GeneRIF: ARPC1B promotes mesenchymal phenotype maintenance and
            radiotherapy resistance by blocking TRIM21-mediated degradation of
            IFI16 and HuR in glioma stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1511)
  AUTHORS   Chiriaco,M., Ursu,G.M., Amodio,D., Cotugno,N., Volpi,S.,
            Berardinelli,F., Pizzi,S., Cifaldi,C., Zoccolillo,M., Prigione,I.,
            Di Cesare,S., Giancotta,C., Anastasio,E., Rivalta,B., Pacillo,L.,
            Zangari,P., Fiocchi,A.G., Diociaiuti,A., Bruselles,A.,
            Pantaleoni,F., Ciolfi,A., D'Oria,V., Palumbo,G., Gattorno,M., El
            Hachem,M., de Villartay,J.P., Finocchi,A., Palma,P., Rossi,P.,
            Tartaglia,M., Aiuti,A., Antoccia,A., Di Matteo,G. and Cancrini,C.
  TITLE     Radiosensitivity in patients affected by ARPC1B deficiency: a new
            disease trait?
  JOURNAL   Front Immunol 13, 919237 (2022)
   PUBMED   35967303
  REMARK    GeneRIF: Radiosensitivity in patients affected by ARPC1B
            deficiency: a new disease trait?
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1511)
  AUTHORS   Gamallat,Y., Zaaluk,H., Kish,E.K., Abdelsalam,R., Liosis,K.,
            Ghosh,S. and Bismar,T.A.
  TITLE     ARPC1B Is Associated with Lethal Prostate Cancer and Its Inhibition
            Decreases Cell Invasion and Migration In Vitro
  JOURNAL   Int J Mol Sci 23 (3), 1476 (2022)
   PUBMED   35163398
  REMARK    GeneRIF: ARPC1B Is Associated with Lethal Prostate Cancer and Its
            Inhibition Decreases Cell Invasion and Migration In Vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1511)
  AUTHORS   Volkmann,N., Amann,K.J., Stoilova-McPhie,S., Egile,C., Winter,D.C.,
            Hazelwood,L., Heuser,J.E., Li,R., Pollard,T.D. and Hanein,D.
  TITLE     Structure of Arp2/3 complex in its activated state and in actin
            filament branch junctions
  JOURNAL   Science 293 (5539), 2456-2459 (2001)
   PUBMED   11533442
REFERENCE   7  (bases 1 to 1511)
  AUTHORS   Linder,S., Higgs,H., Hufner,K., Schwarz,K., Pannicke,U. and
            Aepfelbacher,M.
  TITLE     The polarization defect of Wiskott-Aldrich syndrome macrophages is
            linked to dislocalization of the Arp2/3 complex
  JOURNAL   J Immunol 165 (1), 221-225 (2000)
   PUBMED   10861055
REFERENCE   8  (bases 1 to 1511)
  AUTHORS   Machesky,L.M., Reeves,E., Wientjes,F., Mattheyse,F.J., Grogan,A.,
            Totty,N.F., Burlingame,A.L., Hsuan,J.J. and Segal,A.W.
  TITLE     Mammalian actin-related protein 2/3 complex localizes to regions of
            lamellipodial protrusion and is composed of evolutionarily
            conserved proteins
  JOURNAL   Biochem J 328 (Pt 1) (Pt 1), 105-112 (1997)
   PUBMED   9359840
REFERENCE   9  (bases 1 to 1511)
  AUTHORS   Welch,M.D., DePace,A.H., Verma,S., Iwamatsu,A. and Mitchison,T.J.
  TITLE     The human Arp2/3 complex is composed of evolutionarily conserved
            subunits and is localized to cellular regions of dynamic actin
            filament assembly
  JOURNAL   J Cell Biol 138 (2), 375-384 (1997)
   PUBMED   9230079
REFERENCE   10 (bases 1 to 1511)
  AUTHORS   Rassenti,L.Z. and Kipps,T.J.
  TITLE     Lack of allelic exclusion in B cell chronic lymphocytic leukemia
  JOURNAL   J Exp Med 185 (8), 1435-1445 (1997)
   PUBMED   9126924
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU143525.1, BC002562.2 and
            CB105406.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 9, 2018 this sequence version replaced NM_005720.3.
            
            Summary: This gene encodes one of seven subunits of the human
            Arp2/3 protein complex. This subunit is a member of the SOP2 family
            of proteins and is most similar to the protein encoded by gene
            ARPC1A. The similarity between these two proteins suggests that
            they both may function as p41 subunit of the human Arp2/3 complex
            that has been implicated in the control of actin polymerization in
            cells. It is possible that the p41 subunit is involved in
            assembling and maintaining the structure of the Arp2/3 complex.
            Multiple versions of the p41 subunit may adapt the functions of the
            complex to different cell types or developmental stages. This
            protein also has a role in centrosomal homeostasis by being an
            activator and substrate of the Aurora A kinase. [provided by
            RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314818.1, SRR5189661.74884.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646101.2/ ENSP00000496599.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AU143525.1         56-67
            13-1496             BC002562.2         1-1484
            1497-1511           CB105406.1         155-169
FEATURES             Location/Qualifiers
     source          1..1511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1511
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /note="actin related protein 2/3 complex subunit 1B"
                     /db_xref="GeneID:10095"
                     /db_xref="HGNC:HGNC:704"
                     /db_xref="MIM:604223"
     exon            1..52
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     exon            53..129
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1184
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /note="ARP2/3 protein complex subunit p41; arp2/3 complex
                     41 kDa subunit; actin related protein 2/3 complex, subunit
                     1B, 41kDa"
                     /codon_start=1
                     /product="actin-related protein 2/3 complex subunit 1B"
                     /protein_id="NP_005711.1"
                     /db_xref="CCDS:CCDS5661.1"
                     /db_xref="GeneID:10095"
                     /db_xref="HGNC:HGNC:704"
                     /db_xref="MIM:604223"
                     /translation="MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTK
                     VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCV
                     RWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAG
                     SCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVA
                     WVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAA
                     GMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISV
                     LSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK"
     exon            130..234
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     exon            235..457
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     exon            458..565
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     exon            566..772
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     exon            773..848
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1054
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1145
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1511
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1420
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
                     /note="major polyA site"
     polyA_site      1447
                     /gene="ARPC1B"
                     /gene_synonym="ARC41; IMD71; p40-ARC; p41-ARC; PLTEID"
ORIGIN      
        1 agagccggtt cggcgcgtcg actgcccaga gtccgcggcc ggggcgcggg aggagccaag
       61 ccgccatggc ctaccacagc ttcctggtgg agcccatcag ctgccacgcc tggaacaagg
      121 accgcaccca gattgccatc tgccccaaca accatgaggt gcatatctat gaaaagagcg
      181 gtgccaaatg gaccaaggtg cacgagctca aggagcacaa cgggcaggtg acaggcatcg
      241 actgggcccc cgagagtaac cgtattgtga cctgcggcac agaccgcaac gcctacgtgt
      301 ggacgctgaa gggccgcaca tggaagccca cgctggtcat cctgcggatc aaccgggctg
      361 cccgctgcgt gcgctgggcc cccaacgaga acaagtttgc tgtgggcagc ggctctcgtg
      421 tgatctccat ctgttatttc gagcaggaga atgactggtg ggtttgcaag cacatcaaga
      481 agcccatccg ctccaccgtc ctcagcctgg actggcaccc caacaatgtg ctgctggctg
      541 ccggctcctg tgacttcaag tgtcggatct tttcagccta catcaaggag gtggaggaac
      601 ggccggcacc caccccgtgg ggctccaaga tgccctttgg ggaactgatg ttcgaatcca
      661 gcagtagctg cggctgggta catggcgtct gtttctcagc cagcgggagc cgcgtggcct
      721 gggtaagcca cgacagcacc gtctgcctgg ctgatgccga caagaagatg gccgtcgcga
      781 ctctggcctc tgaaacacta ccactgctgg cgctgacctt catcacagac aacagcctgg
      841 tggcagcggg ccacgactgc ttcccggtgc tgttcaccta tgacgccgcc gcggggatgc
      901 tgagcttcgg cgggcggctg gacgttccta agcagagctc gcagcgtggc ttgacggccc
      961 gcgagcgctt ccagaacctg gacaagaagg cgagctccga gggtggcacg gctgcgggcg
     1021 cgggcctaga ctcgctgcac aagaacagcg tcagccagat ctcggtgctc agcggcggca
     1081 aggccaagtg ctcgcagttc tgcaccactg gcatggatgg cggcatgagt atctgggatg
     1141 tgaagagctt ggagtcagcc ttgaaggacc tcaagatcaa atgacctgtg aggaatatgt
     1201 tgccttcatc ctagctgctg gggaagcggg gagaggggtc agggaggcta atggttgctt
     1261 tgctgaatgt ttctggggta ccaatacgag ttcccatagg ggctgctccc tcaaaaaggg
     1321 aggggacaga tggggagctt ttcttaccta ttcaaggaat acgtgccttt ttcttaaatg
     1381 ctttcattta ttgaaaaaaa aaaaaaatgc ccccaaagca ctatgctggt catgaactgc
     1441 ttcaaaatgt ggaggtaata aaatgcaact gtgtaaaaaa aaaaaaaaaa aaaaaagtaa
     1501 ttatggacat g
//
