LOCUS       NM_014862               6523 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens aryl hydrocarbon receptor nuclear translocator 2
            (ARNT2), mRNA.
ACCESSION   NM_014862
VERSION     NM_014862.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6523)
  AUTHORS   Sun,X., Jing,L., Li,F., Zhang,M., Diao,X., Zhuang,J., Rastinejad,F.
            and Wu,D.
  TITLE     Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new
            dimerization modalities in the bHLH-PAS transcription factor family
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2208804119 (2022)
   PUBMED   36343253
  REMARK    GeneRIF: Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers
            reveal new dimerization modalities in the bHLH-PAS transcription
            factor family.
REFERENCE   2  (bases 1 to 6523)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6523)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6523)
  AUTHORS   Lupianez,C.B., Martinez-Bueno,M., Sanchez-Maldonado,J.M.,
            Badiola,J., Cunha,C., Springer,J., Lackner,M., Segura-Catena,J.,
            Canet,L.M., Alcazar-Fuoli,L., Lopez-Nevot,M.A., Fianchi,L.,
            Aguado,J.M., Pagano,L., Lopez-Fernandez,E., Alarcon-Riquelme,M.,
            Potenza,L., Goncalves,S.M., Luppi,M., Moratalla,L., Solano,C.,
            Sampedro,A., Gonzalez-Sierra,P., Cuenca-Estrella,M., Lagrou,K.,
            Maertens,J.A., Lass-Florl,C., Einsele,H., Vazquez,L., Loeffler,J.,
            Rios-Tamayo,R., Carvalho,A., Jurado,M. and Sainz,J.
  CONSRTM   PCRAGA Study Group
  TITLE     Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with
            the Risk of Developing Invasive Aspergillosis
  JOURNAL   Infect Immun 88 (4), e00882-19 (2020)
   PUBMED   31964743
  REMARK    GeneRIF: The meta-analysis of both populations showed that carriers
            of the ARNT2 rs1374213G, CX3CR1 rs7631529A, and CX3CR1 rs9823718G
            alleles (where the RefSeq identifier appears as a subscript) had a
            significantly increased risk of developing invasive aspergillosis
            according to a log-additive model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6523)
  AUTHORS   Jia,Y., Hao,S., Jin,G., Li,H., Ma,X., Zheng,Y., Xiao,D. and Wang,Y.
  TITLE     Overexpression of ARNT2 is associated with decreased cell
            proliferation and better prognosis in gastric cancer
  JOURNAL   Mol Cell Biochem 450 (1-2), 97-103 (2019)
   PUBMED   29948506
  REMARK    GeneRIF: Low expression of ARNT2 is associated with gastric cancer.
REFERENCE   6  (bases 1 to 6523)
  AUTHORS   Stolze,I., Berchner-Pfannschmidt,U., Freitag,P., Wotzlaw,C.,
            Rossler,J., Frede,S., Acker,H. and Fandrey,J.
  TITLE     Hypoxia-inducible erythropoietin gene expression in human
            neuroblastoma cells
  JOURNAL   Blood 100 (7), 2623-2628 (2002)
   PUBMED   12239177
REFERENCE   7  (bases 1 to 6523)
  AUTHORS   Barrow,L.L., Wines,M.E., Romitti,P.A., Holdener,B.C. and
            Murray,J.C.
  TITLE     Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2):
            structure, gene mapping, polymorphisms, and candidate evaluation
            for human orofacial clefts
  JOURNAL   Teratology 66 (2), 85-90 (2002)
   PUBMED   12210012
  REMARK    GeneRIF: There is no association of ARNT2 gene with cleft palate
            only (n = 45) and cleft lip/palate (n = 37).
REFERENCE   8  (bases 1 to 6523)
  AUTHORS   Woods,S.L. and Whitelaw,M.L.
  TITLE     Differential activities of murine single minded 1 (SIM1) and SIM2
            on a hypoxic response element. Cross-talk between basic
            helix-loop-helix/per-Arnt-Sim homology transcription factors
  JOURNAL   J Biol Chem 277 (12), 10236-10243 (2002)
   PUBMED   11782478
REFERENCE   9  (bases 1 to 6523)
  AUTHORS   Wines,M.E., Lee,L., Katari,M.S., Zhang,L., DeRossi,C., Shi,Y.,
            Perkins,S., Feldman,M., McCombie,W.R. and Holdener,B.C.
  TITLE     Identification of mesoderm development (mesd) candidate genes by
            comparative mapping and genome sequence analysis
  JOURNAL   Genomics 72 (1), 88-98 (2001)
   PUBMED   11247670
REFERENCE   10 (bases 1 to 6523)
  AUTHORS   Moffett,P. and Pelletier,J.
  TITLE     Different transcriptional properties of mSim-1 and mSim-2
  JOURNAL   FEBS Lett 466 (1), 80-86 (2000)
   PUBMED   10648817
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC051335.1, BX538026.1,
            AC108451.9 and BX647212.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014862.3.
            
            Summary: This gene encodes a member of the
            basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of
            transcription factors. The encoded protein acts as a partner for
            several sensor proteins of the bHLH-PAS family, forming
            heterodimers with the sensor proteins that bind regulatory DNA
            sequences in genes responsive to developmental and environmental
            stimuli. Under hypoxic conditions, the encoded protein complexes
            with hypoxia-inducible factor 1alpha in the nucleus and this
            complex binds to hypoxia-responsive elements in enhancers and
            promoters of oxygen-responsive genes. A highly similar protein in
            mouse forms functional complexes with both aryl hydrocarbon
            receptors and Single-minded proteins, suggesting additional roles
            for the encoded protein in the metabolism of xenobiotic compounds
            and the regulation of neurogenesis, respectively. [provided by
            RefSeq, Dec 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX538026.1, BX647212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303329.9/ ENSP00000307479.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               BC051335.1         33-142
            111-1826            BX538026.1         3-1718
            1827-1886           AC108451.9         172447-172506
            1887-2052           AC108451.9         173196-173361
            2053-2189           AC108451.9         183525-183661
            2190-2916           AC108451.9         185557-186283
            2917-6523           BX647212.1         2834-6440
FEATURES             Location/Qualifiers
     source          1..6523
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..6523
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /note="aryl hydrocarbon receptor nuclear translocator 2"
                     /db_xref="GeneID:9915"
                     /db_xref="HGNC:HGNC:16876"
                     /db_xref="MIM:606036"
     exon            1..165
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2288
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /note="ARNT protein 2; class E basic helix-loop-helix
                     protein 1"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor nuclear translocator
                     2"
                     /protein_id="NP_055677.3"
                     /db_xref="CCDS:CCDS32307.1"
                     /db_xref="GeneID:9915"
                     /db_xref="HGNC:HGNC:16876"
                     /db_xref="MIM:606036"
                     /translation="MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGG
                     KRRSGMDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDK
                     LTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRV
                     IYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTV
                     KKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQ
                     YAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVP
                     TEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKL
                     KGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEV
                     HQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGISASEKK
                     MMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQISRQ
                     LNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGIGTSHTYPADPSSYSPLSSPATSSP
                     SGNAYSSLANRTPGFAESGQSSGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQTE
                     VFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE"
     exon            166..280
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            281..328
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            329..542
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            543..756
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            757..859
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            860..925
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1011
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1088
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1223
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1298
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1450
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1523
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1647
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1747
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1886
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2052
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2189
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2190..6523
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6498..6503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /note="hexamer: AATAAA"
     polyA_site      6523
                     /gene="ARNT2"
                     /gene_synonym="bHLHe1; WEDAS"
                     /note="major polyA site"
ORIGIN      
        1 gccgcccgcc cgcgccgtcc tttgtgtggc ggcggcggcg cctgggcctg accgggtccc
       61 cggggctgag cgccgggctc cgcgccgccc ctcccgcgcc cctgccaagc gggcgcctat
      121 cctctccgag caagatggca accccggcgg cggtcaaccc tccggaaatg gcttcagaca
      181 tacctggatc tgtgacgttg cccgttgccc ccatggcggc caccggacag gtgaggatgg
      241 cgggggccat gcctgcccgt ggaggaaagc ggcgttccgg aatggacttc gatgatgaag
      301 atggtgaagg ccccagtaaa ttttcaagag agaatcatag tgaaatcgaa aggcgcagac
      361 ggaacaagat gactcagtac atcacggagc tctccgacat ggtccccaca tgcagcgcac
      421 tggctcggaa gccagacaag ctcaccatcc tccgcatggc cgtctcgcac atgaagtcca
      481 tgaggggtac agggaacaag tccaccgatg gcgcgtacaa gccttccttc ctcacagagc
      541 aggaactgaa gcatctcatc cttgaagcag ctgatggatt tctgtttgtg gtggctgctg
      601 agacagggcg agtgatttat gtgtctgact ccgtcacccc tgttctgaac cagccccagt
      661 cagagtggtt tgggagcaca ctgtatgaac aggtgcatcc tgatgacgtg gagaagctga
      721 gagagcaact gtgcacctca gaaaactcaa tgacaggccg gatcttggac ctgaagactg
      781 ggacggtcaa gaaagaaggg cagcagtcat ccatgaggat gtgcatgggc tcgcggcggt
      841 ctttcatctg caggatgagg tgtggaaatg ctcctttgga ccaccttcct ctaaacagaa
      901 taaccaccat gaggaaaagg ttcaggaatg gccttggccc tgtgaaagaa ggagaagccc
      961 aatatgctgt ggtccactgt acaggataca tcaaggcctg gccaccagca ggaatgacca
     1021 tacctgaaga agacgctgat gtgggacaag gcagtaaata ttgcctcgtg gcaattggga
     1081 gactccaggt gaccagctct cctgtatgca tggacatgaa tgggatgtcg gtgcccacag
     1141 agttcttatc ccggcataac tccgatggaa tcatcacatt tgtggatcca agatgtatca
     1201 gtgtgattgg ctaccaaccc caggatcttc tgggaaagga cattttggaa ttctgccacc
     1261 ctgaggatca aagccatctg cgtgagagct tccagcaggt ggttaagctg aaaggccaag
     1321 tcctgtcggt catgtatcga tttcgcacca agaaccggga gtggatgttg atccgcacca
     1381 gcagcttcac attccagaat ccctattctg atgagattga gtacatcatc tgcaccaaca
     1441 ccaacgtcaa gcaacttcag caacagcagg cagaattgga agtgcaccag agagatggat
     1501 tgtcatcgta tgacttatcc caggtccccg tccccaacct accagccggt gttcatgagg
     1561 ccgggaagtc cgtggaaaag gcggatgcaa tcttctccca ggaaagagat cctcggtttg
     1621 ctgaaatgtt tgcaggaatt agtgcatcgg agaagaagat gatgagctca gcctctgcag
     1681 caggaaccca gcagatctac tcccaaggaa gcccatttcc ctctggacac tccgggaagg
     1741 ccttcagctc ttcagtggtt catgtgcctg gagtgaatga tattcagtcc tcttcttcca
     1801 cgggccagaa catgtcccaa atctcccggc agctaaacca gagtcaggtg gcatggacag
     1861 ggagtcgtcc gccctttccg ggacagcaaa tcccatctca gtccagcaag actcagtcat
     1921 ctccctttgg gattggaacg agccacacct acccggcaga cccctcttcc tacagccccc
     1981 tctccagccc agctacctcc tcgccaagtg ggaatgccta ctccagtctt gccaacagga
     2041 ctccagggtt cgctgaaagt ggacaaagta gcgggcagtt ccaagggcgg ccctcggaag
     2101 tctggtcgca gtggcaaagc cagcaccatg gccagcagag cggtgagcag cactcccacc
     2161 agcagcccgg tcagactgaa gtgttccagg acatgctgcc catgccagga gatccaaccc
     2221 aggggactgg caactataac atcgaagact ttgccgacct gggcatgttt ccaccgtttt
     2281 ctgagtagct gcggccagag tgaggctcct gctgtacagt gccacccata ctgtgatgtc
     2341 gatgcccatg tgaatgaggc ccaccctcgc cctgcttgcc ctgccgcagg ccccccacca
     2401 gaagccatct cccccgctgt gtgtccccag gcgcatcatt gctccactct cccctgcagc
     2461 cgcggctgct cggccactga ccaggggccc tggcagacat taggggatca gttgtattta
     2521 ttgtatttta tctgtgtgtg ctcaggaggt gagcctagtg ggtccttaag tttggttgtg
     2581 aataatctct tgatagacaa tttataccca tgaaagttca gccaatgccc agagtgacca
     2641 agcagcacca gcaggcctgc ccaggatgct gaaagcagat ttcttcttga tttcacttct
     2701 gatggatgca tggggctctg ggggaatgct gggaaaatgg gcaagcagag tgcacagccc
     2761 tcgttctgcc agctggagcc aagaagcaca gagacacaga ggcgcctgcc cctcagctcc
     2821 gctggtctgt ctgtgcatcc actgtgccgt gggacatatg taatttgtgc agtgtgacat
     2881 ggacttgctg tcctaatgga tgtgttgtgc cttgtgtctg tcatgtgtgg ccagcgtgat
     2941 tgtatagaat ccagagtatg tagagagcca aaatgtgtgg ccctgtcccc aagctcagca
     3001 ccaccggcca tgaccagagg ttgctcggcc cagggtctgg gagctgggct aacaggctga
     3061 cacttcggca gggtcaccag gaggcacagc taggggcatg ctcacatggg taggtcagtt
     3121 ctttggtcca agcctctggt gcagattcaa gctcctcctc ttagaggaag cagctccttc
     3181 ctcccacagg agccccaagg gagcactcac cctcctccca attggatctg aatagctgtg
     3241 ttcctgatcc cacataagca tgtctcatcc ttgccccact ggtgagagga ggaccttgtg
     3301 cctgcccaga gcctgcagga cagcacgcct tgaggtcaga ggcctggccc ttctttacag
     3361 atgtagatag cagggtagga cgcccaggcc ttctcacatg ggcaccatga aacactttct
     3421 tccaggccac ctgagccttc gttcttcagc ccgactggag gaacagcagc tctgggaggc
     3481 acagagtgca ggtctcaggg gcagaagaca tgggttccag ttctggttct gccacacacc
     3541 caccggcctt gaatttctct ggtggtctca agacaagaac aagagctgac tctagaatct
     3601 tctgcctggc tgacctctga gcccatgatc cctggcttgc tgtgcttctc ttggatttga
     3661 ggagagttta tgaatccatc cccctgtttt cagggacctc tgccttctcc cacacccctt
     3721 acactagtga ggactccttc ggcctcttgt gtttccttcc ttttgtgacc attacgcccc
     3781 ctccctgttt cttatcacca gcccatcagc ccactgactc ccatatggta gaaaaggtac
     3841 cgtggctgct gcagggcaca tggagggacc taccctctgg gaaagccctt gtgtccctcc
     3901 cagagtcctt caggtaggcc ctcgcagatg ctgcttgctc agaaacaacc cgtgcatccc
     3961 tgcccatgga ttctgcagga cctagaagag tggcattggt tctaggaacc tgagagtgga
     4021 gtgaggccag catgcaggaa ggagtttgga gagagtgttt gctgtgatcc attgaaagct
     4081 ccacattaaa ccccagccct gtctggccag ggagatccat gtgctcaatg ttgctggggg
     4141 acctacaaaa gtcaaacatt gctcagtaaa atgcctttgg ctggtcgcca gctgtgcatg
     4201 actgcagttc ctagactcta acttaacccc aactttgcag tttctagagc tttttgtctg
     4261 taatggtgat tgggtctcca ctgtagatgc atgcagtgtt cactccaacc tcagaggctt
     4321 tcttgcttct ggggaaatgg caggtggttg aaaccctgca catcctccca gggccagccc
     4381 cagaatgggc ctttctctgc ctgccctgcc cttggggcca cctctgcctc cagcaggctt
     4441 gagcttgccc caggccttgg gcataattat ttccccccaa aaaaggcaca aaaataggtt
     4501 ttggatcaaa gaagtgtttc tcagtgaaat gaaaacagtc tttttatagc ctttagcttg
     4561 tgagtttgga agtttggggg gtcttatgtt tgttttgcct cttctgtttc ttggaggaga
     4621 gttgaggctt ttcttaggtg catacacaga cccaggtgaa cacgctgact gtgaacctgc
     4681 cctgtatccg gagctgtgct gggcactgag gggatgcaac aaaattagga gaggatcctt
     4741 gctcccaacg tctacttctc ctacctcaac aggggtccag ggtgcagtga actcagttct
     4801 tggcccttgg gtgaggattc atggatgaat gaaagctaga cctgatgggg aggcattatg
     4861 actaaatagg cccagcctcc ttcccttcca gctctgtcct aggagcatag gcgggaaatc
     4921 tgagtagagt ctgactgcag tttttgctta tgatttgtaa aagccgtcat ggggtcaata
     4981 agaaaatagg ggtgatggag ggggagaagc ccaggactgg gagaatcgca catgccccag
     5041 gggttttcac caaggatttt caagacaaac tggagtaaga attaaagccc cagaggattt
     5101 aattatcctg gtttgcaaaa gagcctccca tgccagtacc gcccagcctt ggaggccgga
     5161 atgctcatgg cccctgtggt ctgcttgtcc ttcagcccat gcccagcaga tacctctctg
     5221 actggagacg ggctcaaagc tggattagaa aggggagagg cacttgtgac tttgtttgac
     5281 tctgtgactc acttcctcgc tcacaccttg tttgaactac tggactttca actggctttc
     5341 cttaggtcag gcaagcagac agctccccac tgaagaggtc tgtacagtga caacccgggc
     5401 cggcagcaag gacacagatg cagccacagt aaggctccat caggactggg tcagtgatgg
     5461 caacaggatg gccaaggatg gctctagaac actctgtcca tgcgtcactc cccccagttt
     5521 tatttttagc tttggcttca gggagtgaca gccatcacaa atagccacat tctgctctac
     5581 tctccaacat accagattct acactgttgt tatttcatga gacgtgaatg ttgcagagag
     5641 tggggggatt ctggttgtta aggaacttac actggggagc tttactcttc cgtgtcaaca
     5701 atgtgactac atgttctcca gattagccac acatgcaaac atcagtgtcc ttctagcttt
     5761 agccgagaaa gaaaccagtc ccagggaatg aatggtggtc tccccactcc cggcagcact
     5821 ttaggcagcc cataagctat gcgagaatgt gaacgctcac cttgctccgt cacggttctg
     5881 acctaccaca taaacaggaa gaagccagtg accggaacag ctctaggaat aacaagtcag
     5941 aatagaagtg tcctttatat taccagaaaa tatgggcttg gcctaagtcg ctgtctccta
     6001 acctgccggg gtcattcccc accaaacacc ccatactaag gagccatgag ccacctggac
     6061 attcaccttt tctttgacca tctggagtct ggggcaactt aaggaggcac cacacagtgg
     6121 tgcaggcaca tttccaagcg taggtgtccc tggcttttgt ggccaaagct agtgttatgg
     6181 tcaacaacag gccagggtct gtggggcact gaccttgaaa gtggcaaaat ggaggtttca
     6241 caggctgtgc gggagcagga cggcttgctt catctaacaa tctcagtttc ctttaaaaaa
     6301 agaaagaaag gaaaagattt cataagcagg tgtcagtgga cagtttaagt acttaaccat
     6361 ttctctttct tcttatggat gtgaactgtg ctgtggataa atcatttgta tttcttgaat
     6421 gttctctatg actaacagtt attaagtcgg ttgtgtatat gtgtaactaa tgtaactgcc
     6481 ttttaaaatt tcattacaat aaaaatgact ttgctctgaa caa
//
