LOCUS       NM_001668               4710 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens aryl hydrocarbon receptor nuclear translocator (ARNT),
            transcript variant 1, mRNA.
ACCESSION   NM_001668
VERSION     NM_001668.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4710)
  AUTHORS   Sun,X., Jing,L., Li,F., Zhang,M., Diao,X., Zhuang,J., Rastinejad,F.
            and Wu,D.
  TITLE     Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new
            dimerization modalities in the bHLH-PAS transcription factor family
  JOURNAL   Proc Natl Acad Sci U S A 119 (46), e2208804119 (2022)
   PUBMED   36343253
  REMARK    GeneRIF: Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers
            reveal new dimerization modalities in the bHLH-PAS transcription
            factor family.
REFERENCE   2  (bases 1 to 4710)
  AUTHORS   Cooper,A.M., Nutter,C.A., Kuyumcu-Martinez,M.N. and Wright,C.W.
  TITLE     Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear
            Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies
  JOURNAL   Mol Cell Biol 42 (5), e0050321 (2022)
   PUBMED   35404107
  REMARK    GeneRIF: Alternative Splicing of the Aryl Hydrocarbon Receptor
            Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid
            Malignancies.
REFERENCE   3  (bases 1 to 4710)
  AUTHORS   Zhang,M., Hu,Y., Yang,F., Zhang,J., Zhang,J., Yu,W., Wang,M.,
            Lv,X., Li,J., Bai,T. and Chang,F.
  TITLE     Interaction between AhR and HIF-1 signaling pathways mediated by
            ARNT/HIF-1beta
  JOURNAL   BMC Pharmacol Toxicol 23 (1), 26 (2022)
   PUBMED   35473600
  REMARK    GeneRIF: Interaction between AhR and HIF-1 signaling pathways
            mediated by ARNT/HIF-1beta.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4710)
  AUTHORS   Scheel,J., Hussong,R., Schrenk,D. and Schmitz,H.J.
  TITLE     Variability of the human aryl hydrocarbon receptor nuclear
            translocator (ARNT) gene
  JOURNAL   J Hum Genet 47 (5), 217-224 (2002)
   PUBMED   12032587
REFERENCE   5  (bases 1 to 4710)
  AUTHORS   Scheel,J. and Schrenk,D.
  TITLE     Genomic structure of the human Ah receptor nuclear translocator
            gene (hARNT)
  JOURNAL   Hum Genet 107 (4), 397-399 (2000)
   PUBMED   11129342
REFERENCE   6  (bases 1 to 4710)
  AUTHORS   Salomon-Nguyen,F., Della-Valle,V., Mauchauffe,M., Busson-Le
            Coniat,M., Ghysdael,J., Berger,R. and Bernard,O.A.
  TITLE     The t(1;12)(q21;p13) translocation of human acute myeloblastic
            leukemia results in a TEL-ARNT fusion
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6757-6762 (2000)
   PUBMED   10829078
REFERENCE   7  (bases 1 to 4710)
  AUTHORS   Yamaguchi,Y. and Kuo,M.T.
  TITLE     Functional analysis of aryl hydrocarbon receptor nuclear
            translocator interactions with aryl hydrocarbon receptor in the
            yeast two-hybrid system
  JOURNAL   Biochem Pharmacol 50 (8), 1295-1302 (1995)
   PUBMED   7488247
REFERENCE   8  (bases 1 to 4710)
  AUTHORS   Wang,G.L., Jiang,B.H., Rue,E.A. and Semenza,G.L.
  TITLE     Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS
            heterodimer regulated by cellular O2 tension
  JOURNAL   Proc Natl Acad Sci U S A 92 (12), 5510-5514 (1995)
   PUBMED   7539918
REFERENCE   9  (bases 1 to 4710)
  AUTHORS   Reyes,H., Reisz-Porszasz,S. and Hankinson,O.
  TITLE     Identification of the Ah receptor nuclear translocator protein
            (Arnt) as a component of the DNA binding form of the Ah receptor
  JOURNAL   Science 256 (5060), 1193-1195 (1992)
   PUBMED   1317062
REFERENCE   10 (bases 1 to 4710)
  AUTHORS   Hoffman,E.C., Reyes,H., Chu,F.F., Sander,F., Conley,L.H.,
            Brooks,B.A. and Hankinson,O.
  TITLE     Cloning of a factor required for activity of the Ah (dioxin)
            receptor
  JOURNAL   Science 252 (5008), 954-958 (1991)
   PUBMED   1852076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK293027.1, AL355860.12,
            BC041121.1 and BU730937.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001668.3.
            
            Summary: This gene encodes a protein containing a basic
            helix-loop-helix domain and two characteristic PAS domains along
            with a PAC domain. The encoded protein binds to ligand-bound aryl
            hydrocarbon receptor and aids in the movement of this complex to
            the nucleus, where it promotes the expression of genes involved in
            xenobiotic metabolism. This protein is also a co-factor for
            transcriptional regulation by hypoxia-inducible factor 1.
            Chromosomal translocation of this locus with the ETV6 (ets variant
            6) gene on chromosome 12 have been described in leukemias.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041121.1, SRR11853561.1585.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358595.10/ ENSP00000351407.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK293027.1         171-173
            4-17                AL355860.12        77227-77240         c
            18-598              BC041121.1         1-581
            599-599             AL355860.12        37057-37057         c
            600-2913            BC041121.1         583-2896
            2914-4671           AL355860.12        10396-12153         c
            4672-4710           BU730937.1         25-63               c
FEATURES             Location/Qualifiers
     source          1..4710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..4710
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="aryl hydrocarbon receptor nuclear translocator"
                     /db_xref="GeneID:405"
                     /db_xref="HGNC:HGNC:700"
                     /db_xref="MIM:126110"
     exon            1..57
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2402
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dioxin receptor, nuclear translocator; hypoxia-inducible
                     factor 1, beta subunit; class E basic helix-loop-helix
                     protein 2; hypoxia inducible factor 1 subunit beta"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor nuclear translocator
                     isoform 1"
                     /protein_id="NP_001659.1"
                     /db_xref="CCDS:CCDS970.1"
                     /db_xref="GeneID:405"
                     /db_xref="HGNC:HGNC:700"
                     /db_xref="MIM:126110"
                     /translation="MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRR
                     PGLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRR
                     NKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLT
                     DQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDV
                     DKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDP
                     VSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSK
                     FCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELL
                     GKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPY
                     SDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQT
                     ELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINA
                     DQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQ
                     ISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSSFSSMSLP
                     GAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSS
                     SEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPPFSE"
     exon            58..169
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            170..214
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            215..259
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            260..304
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            305..518
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            519..732
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            733..835
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            836..901
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            902..987
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1064
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1199
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1274
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1426
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1537
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1610
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1731
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1834
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1982
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2145
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2312
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..4710
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4303..4308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="hexamer: AACAAA"
     polyA_site      4329
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="major polyA site"
     regulatory      4689..4694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
                     /note="hexamer: ATTAAA"
     polyA_site      4710
                     /gene="ARNT"
                     /gene_synonym="ARNT1; bHLHe2; HIF-1-beta; HIF-1beta;
                     HIF1-beta; HIF1B; HIF1BETA; TANGO"
ORIGIN      
        1 ggggtggcgc ggcggcggtg gcatctgcgg ccatggcggc gactactgcc aaccccgaaa
       61 tgacatcaga tgtaccatca ctgggtccag ccattgcctc tggaaactct ggacctggaa
      121 ttcaaggtgg aggagccatt gtccagaggg ctattaagcg gcgaccaggg ctggattttg
      181 atgatgatgg agaagggaac agtaaatttt tgaggtgtga tgatgatcag atgtctaacg
      241 ataaggagcg gtttgccagg tcggatgatg agcagagctc tgcggataaa gagagacttg
      301 ccagggaaaa tcacagtgaa attgaacggc ggcgacggaa caagatgaca gcctacatca
      361 cagaactgtc agatatggta cccacctgta gtgccctggc tcgaaaacca gacaagctaa
      421 ccatcttacg catggcagtt tctcacatga agtccttgcg gggaactggc aacacatcca
      481 ctgatggctc ctataagccg tctttcctca ctgatcagga actgaaacat ttgatcttgg
      541 aggcagcaga tggctttctg tttattgtct catgtgagac aggcagggtg gtgtatgtgt
      601 ctgactccgt gactcctgtt ttgaaccagc cacagtctga atggtttggc agcacactct
      661 atgatcaggt gcacccagat gatgtggata aacttcgtga gcagctttcc acttcagaaa
      721 atgccctgac agggcgtatc ctggatctaa agactggaac agtgaaaaag gaaggtcagc
      781 agtcttccat gagaatgtgt atgggctcaa ggagatcgtt tatttgccga atgaggtgtg
      841 gcagtagctc tgtggaccca gtttctgtga ataggctgag ctttgtgagg aacagatgca
      901 ggaatggact tggctctgta aaggatgggg aacctcactt cgtggtggtc cactgcacag
      961 gctacatcaa ggcctggccc ccagcaggtg tttccctccc agatgatgac ccagaggctg
     1021 gccagggaag caagttttgc ctagtggcca ttggcagatt gcaggtaact agttctccca
     1081 actgtacaga catgagtaat gtttgtcaac caacagagtt catctcccga cacaacattg
     1141 agggtatctt cacttttgtg gatcaccgct gtgtggctac tgttggctac cagccacagg
     1201 aactcttagg aaagaatatt gtagaattct gtcatcctga agaccagcag cttctaagag
     1261 acagcttcca acaggtagtg aaattaaaag gccaagtgct gtctgtcatg ttccggttcc
     1321 ggtctaagaa ccaagaatgg ctctggatga gaaccagctc ctttactttc cagaaccctt
     1381 actcagatga aattgagtac atcatctgta ccaacaccaa tgtgaagaac tctagccaag
     1441 aaccacggcc tacactctcc aacacaatcc agaggccaca actaggtccc acagctaatt
     1501 tacccctgga gatgggctca ggacagctgg cacccaggca gcagcaacag caaacagaat
     1561 tggacatggt accaggaaga gatggactgg ccagctacaa tcattcccag gtggttcagc
     1621 ctgtgacaac cacaggacca gaacacagca agccccttga gaagtcagat ggtttatttg
     1681 cccaggatag agatccaaga ttttcagaaa tctatcacaa catcaatgcg gatcagagta
     1741 aaggcatctc ctccagcact gtccctgcca cccaacagct attctcccag ggcaacacat
     1801 tccctcctac cccccggccg gcagagaatt tcaggaatag tggcctagcc cctcctgtaa
     1861 ccattgtcca gccatcagct tctgcaggac agatgttggc ccagatttcc cgccactcca
     1921 accccaccca aggagcaacc ccaacttgga cccctactac ccgctcaggc ttttctgccc
     1981 agcaggtggc tacccaggct actgctaaga ctcgtacttc ccagtttggt gtgggcagct
     2041 ttcagactcc atcctccttc agctccatgt ccctccctgg tgccccaact gcatcgcctg
     2101 gtgctgctgc ctaccctagt ctcaccaatc gtggatctaa ctttgctcct gagactggac
     2161 agactgcagg acaattccag acacggacag cagagggtgt gggtgtctgg ccacagtggc
     2221 agggccagca gcctcatcat cgttcaagtt ctagtgagca acatgttcaa caaccgccag
     2281 cacagcaacc tggccagcct gaggtcttcc aggagatgct gtccatgctg ggagatcaga
     2341 gcaacagcta caacaatgaa gaattccctg atctaactat gtttcccccc ttttcagaat
     2401 agaactattg gggtgaggat aaggggtggg ggagaaaaaa tcactgtttg tttttaaaaa
     2461 gcaaatcttt ctgtaaacag aataaaagtt cctctccctt cccttccctc acccctgaca
     2521 tgtaccccct ttcccttctg gctgttcccc tgctctgttg cctctctaag gtaacattta
     2581 tagaagaaat ggaatgaatc tccaaggctt ttaggactgt ctgaaaattt gaggctgggt
     2641 gaagttaaaa cacctttcct tatgtctcct gacctgaaat tgtatagtgt tgatttgtgc
     2701 tgagatcaag aggcaggtta gaagaacctg acatccactg tttgccttgg atagtatggc
     2761 ttgtttttgg aaagaaattc tgaagagagt ggaggagagg agaaatgtcc tcatatttga
     2821 ggaccatgaa acattgtagg tatatatggg gctttagcaa gtttgagcat aggctctttt
     2881 tgctgcctgt gagcagtccc tctggaaaga aacatgtgag taagtgagag agagtgtgtg
     2941 tgtatgtgtg tgtgtgtgtg tgtgcgcaca catgcttctg tatttcactc tttctcccta
     3001 ttagggagtt atgcaaaatt tgtccccgat tttacctttg tctttctgtg tacttttcaa
     3061 agagtcctaa ggagttaaat cttccaggta ttttccactt agtattgcag ccaaagaata
     3121 tttaaataaa cgtctttgct gcgcttgcat ccatgcccag ccaatataca actgtaaagc
     3181 aaatatagaa agtcggctgt tgatacgatt gtctgttatc gaacacattc agtgataaag
     3241 ctgggttact gctgcttttg gtgctctcac cttatctgga agatctgcaa acattaccta
     3301 aataggctgg caagataaac actttctgga acccgagact tggccataaa gataatgctg
     3361 catttttctg tcagaatcac atatgatgtg tgttctgtag aggttatttc tgcatggaaa
     3421 ctcaacttct tggattagcc gtcccagtga aaatcctcat tgttggagtg taaaccaaat
     3481 acgaagccct cttgcaaagt agcctctttc atcccatact caaaataccc agtttagcaa
     3541 gcaactgaga tttaagtctc tctggcccta agaggttttt cctctttgct ccctccaatc
     3601 ttgagattgg gttttgcttt agagtgcaag tatcataatt ccgtatgata gatggggcct
     3661 ggacacccat ctcaacaggg tcacttggta attaacaata gccatataaa tgcggataca
     3721 ggttactacc ctcacccttt accttcctca ggtaacagtc gtagatacca gctttttttt
     3781 tttttttttt aaattggctt tggccagtag ctaaagtgca agactgaatt aatgagaaga
     3841 tatattaaat gtagtcatag gggactgagg agcaagggtg gccttgaaga ggccaaagga
     3901 atgtccattt gctgagtttc ccttccttat gtctccagtc tggtgccagg tagtggagta
     3961 aaaaaggaga cagtttattt ttttattcta tgtgcacact tacagtatac atatatattt
     4021 atatcacaat ttacgaaacc aaaaagttga gtttccaatg gaacccttgt tttttaataa
     4081 tcgacttttt aaatgtgatc aggactataa tattgtacag ttattatagg gcttttgggg
     4141 aaggggagga tagcgagaag atgctctggg ggttttgttt ttgcttttcc ttcagggttt
     4201 tatttttgac tgttttgttt tcttgttggc catttctgta ttgctggcat ctgtgctaag
     4261 ctttacagtg gcaaaaataa tgacatgtag caaagatttt caaacaaaat attttttcct
     4321 tttgtaaaat ttcttgtgtt gtgtgatctt gattgcggct ttatcattcc tttccagttc
     4381 ataaacaaca ggcacccaca accagaggaa tctatagttt aagctccaga catacaaaca
     4441 taaggcacat tgtgtcttta atttcaggaa tcagaaatca tagggttctg atcacattgc
     4501 acgcctcccc cctcacttgt cctcctgatc ctgacacatt ctgagtaaca tcagcaggaa
     4561 tgctctgacc atgaggtggg ggttttgggg tgggcgttgc ctgggttctt gggagagagg
     4621 ggaagagtcg ggacttgaaa accactaggg cacatctgga tgccttcccc cagtatgtcc
     4681 ttttctggat taaaatgagt gaaatttaaa
//
